EP4011323B1 - Dispositif de libération de progestérone - Google Patents

Dispositif de libération de progestérone

Info

Publication number
EP4011323B1
EP4011323B1 EP20849556.4A EP20849556A EP4011323B1 EP 4011323 B1 EP4011323 B1 EP 4011323B1 EP 20849556 A EP20849556 A EP 20849556A EP 4011323 B1 EP4011323 B1 EP 4011323B1
Authority
EP
European Patent Office
Prior art keywords
progesterone
flexible extensions
tube
animal
eyelets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP20849556.4A
Other languages
German (de)
English (en)
Other versions
EP4011323A4 (fr
EP4011323A1 (fr
EP4011323C0 (fr
Inventor
Osnir Y WATANABE
Adriano ORDOZ BARISSA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wta Watanabe Tecnologia Aplicada Ltda
Original Assignee
Wta Watanabe Tecnologia Aplicada Eirele Epp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from BR202019016494-3U external-priority patent/BR202019016494Y1/pt
Application filed by Wta Watanabe Tecnologia Aplicada Eirele Epp filed Critical Wta Watanabe Tecnologia Aplicada Eirele Epp
Publication of EP4011323A1 publication Critical patent/EP4011323A1/fr
Publication of EP4011323A4 publication Critical patent/EP4011323A4/fr
Application granted granted Critical
Publication of EP4011323C0 publication Critical patent/EP4011323C0/fr
Publication of EP4011323B1 publication Critical patent/EP4011323B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D1/00—Surgical instruments for veterinary use
    • A61D1/08—Veterinary obstetrical instruments or devices

Definitions

  • the present invention refers to a device for slow release of progesterone for veterinary use mainly used for estrus synchronization protocols.
  • Devices for low release of progesterone of veterinary use intended in estrus synchronization comprising a body with material impregnated with progesterone followed by two or more flexible extensions to support the internal walls of the animal vagina.
  • these devices are applied to the animal body with the aid of an applicator tube and a plunger.
  • the device is inserted into this applicator tube, which therefore has a larger diameter than the device itself.
  • the tube is inserted into the animal's vaginal canal to a depth close to the position wherein the device should remain, close to the cervix.
  • a plunger is pressed inside the applicator tube, pushing the device out of the applicator tube.
  • this same tube is used to apply another device for slow release of progesterone to another animal. This is because, due to its dimensions and its resistant material, the cost of the tube is considerable and should not be neglected. However, before its reuse it is necessary to wash and sanitize this tube. This does not, however, guarantee the complete sterilization of the tube, remaining a risk of contamination of other animals. In addition, the washing procedure is laborious and costly.
  • United States patent application US 6663608 B2 discloses an intra vaginal device which is of a variable geometry and which includes a silicone matrix impregnated with progesterone, the confirmation and content of the progesterone impregnated matrix being such as to optimise effectiveness with a lower initial loading of progesterone.
  • Mexican patent application MX 2017002461 A discloses an intravaginal device with an engageable progesterone active tube comprising a support injected into a Y-shaped inert polymeric material having adhesive symmetrical tabs in an opposite arrangement with each other and an interlocking distal appendix interposed by a body wherein the progesterone-containing tubular section is inserted for subsequent application in the vagina of an animal.
  • United State patent application US 9555225 A discloses an intraruminal sustained release capsule which is capable of delivering a sustained release dose of a first medicament to an animal, as well as either or both of a dump dose of a second medicament or mineral, and an exit dose of a third medicament or mineral.
  • the capsule can have a dissolvable overcap molded from plasticized starch enabling a dump dose of medicament to be held between the overcap and one end of the capsule.
  • a piston within the body of the capsule can be modified to enable it to accommodate an exit dose of medicament within its hollow interior which is aligned with an aperture at the end of the capsule which enables release of the medicaments to the rumen.
  • the overcap dissolves and separates from the capsule to release the dump dose of medicament.
  • the sustained release medicament is then dispensed via the apertured end, followed by the release of the exit dose of medicament (if present).
  • a device for slow release of progesterone which objectives are to allow application to the animal with no need to use a large reusable applicator with a plunger, and with no need to wash the applicator, with less risk of causing injury to the animal, which allows greater precision of application and positioning within the animal body.
  • a device for slow release of progesterone in an animal comprising a body impregnated with progesterone, two flexible extensions extending from one end of the body, and which ends opposite the body curve in spaced apart, each of the two flexible extensions comprising an eyelet in the portion near the ends curving away from each other, the eyelets of the two flexible extensions being axially aligned with each other with the flexible extensions in an extended position; a removable tube coupled to the end of the body opposite the flexible extensions; a cable that passes through the inside of the body and the inside of the tube, with a first end close to the flexible extensions being connected to a pin coupled to the eyelets, and a second free end extending out of the body and tube on the side opposite the flexibles extensions; the pin being coupled to the eyelets aligned with the flexible extensions in the extended position; and the pin being actuated by cable and decoupled from the eyelets, with the flexible extensions being unlocked and in a curved position.
  • the device for slow release of progesterone object of the present invention, consists of a device for slow release of progesterone in an animal comprising a body 1 at least partially impregnated with progesterone, followed by two flexible extensions 2 extending from one end of the body.
  • a body 1 at least partially impregnated with progesterone
  • two flexible extensions 2 extending from one end of the body.
  • these flexible extensions 2 can be tensioned and extended, being parallel to each other, as illustrated in figure 2 .
  • Each of the two flexible extensions comprises an eyelet 6 in the portion close the ends curving away.
  • the eyelets 6 at both ends are axially aligned with each other when the flexible extensions are in the extended position, so that the two eyelets intersect concentrically when the flexible extensions 2 are extended and aligned with the body 1.
  • the device also comprises a removable tube 3 attached to the end of the body opposite the flexible extensions, as illustrated in figure 3 , and a cable 4 passing through the inside of the body 1, better illustrated in figure 4 .
  • This cable also passes through the inside of the tube 3 at the application time of the device for slow release of progesterone to the animal body, as shown in figure 3 .
  • the removable tube preferably has a diameter smaller than the diameter of the body 1 impregnated with progesterone.
  • the end of the cable 4 close to the flexible extensions is connected to a pin 5 intended to be coupled to the eyelets 6.
  • the opposite end of the cable is a free end extending out of the body 1 and tube 3 on the side opposite the extensions. This free end will be used to pull the device for slow release of progesterone out of the animal body after use.
  • the flexible extensions 2 are tensioned and stretched, with the eyelets 6 aligned.
  • the pin 5 is then coupled inside the two aligned eyelets, as shown in figures 3 and 5 .
  • the flexible extensions 2 are in the tensioned and extended position, parallel to each other, which facilitates the device application inside the vagina of the animal.
  • the device application to the animal body is performed with the flexible extensions 2 tensioned and stretched, introducing the applicator device on the side of the flexible extensions inside the animal vaginal canal, and pushing the device inwards to the ideal depth, for example, close to the cervix, with the aid of the removable tube 3.
  • a part of the handle 4 remains exposed outside the animal vagina even after the device is introduced.
  • the cable is activated, pulling it out of the removable tube 3 until pin 5 is detached from the eyelets 6, unlocking the flexible extensions 2.
  • the flexible extensions 2 are detached, and their extremities tend to return to the curved position away from each other, supporting each other and exerting pressure inside the animal body responsible for fixing the device in the ideal position.
  • the removable tube 3 is detached from the body 1 by pulling it lightly, so that the free end of the handle 4 remains exposed outside the animal vagina. This allows the device to be removed simply after the end of the estrus synchronization procedure, simply by pulling the device out of the animal vagina by the free end of the cable 4.
  • Removable tube 3 is preferably made of disposable, lightweight and low-cost material and cannot be used with other devices for slow release of progesterone, thus reducing the overall cost of the product and the risk of contamination.
  • Body 1 can be made as a single piece with openings, as shown in figures 3 and 4 .
  • the body 1 can be comprised of a support 12 and a detachable piece 11 impregnated with progesterone coupled around the support 12.
  • the removable piece is preferably a cylinder made of polymeric material. Because this part 11 is removable, this allows it to be discarded and replaced with a similar new removable part 11. In this way, the device for slow release of progesterone according to the present model can be easily reused several times, being only necessary to sterilize it and replace the removable part 11 with a new part.
  • the present invention reduces this risk, since the application of the device is performed by guiding the device itself inside the vaginal canal with the aid of the removable tube that is also part of the device, therefore, with no need to apply a force of plunger against the animal to release the body with progesterone.
  • the removable tube 3 has dimensions smaller than the progesterone-impregnated body itself, and smaller than the state-of-the-art applicator tubes, which also contributes to reducing the risk of injury.
  • the embodiment of the device according to the present model which is handled and guided directly by the removable tube, being exempt of large tubes and plungers, allows for the person applying the device inside the animal body to have a greater sensitivity in the application, consequently having a better idea of the depth at which the device is being applied, and better precision in its positioning.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Surgical Instruments (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Catching Or Destruction (AREA)

Claims (5)

  1. Dispositif de libération lente de progestérone dans un animal, comprenant :
    un corps (1) au moins partiellement imprégné de progestérone ;
    deux extensions flexibles (2) s'étendant à partir d'une extrémité du corps (1), et dont les extrémités opposées au corps s'incurvent en s'éloignant l'une de l'autre, et un câble (4),
    caractérisé par
    chacune des deux extensions flexibles (2) comprenant un œillet (6) dans la partie proche des extrémités s'incurvant en s'éloignant, les œillets (6) des deux extensions flexibles étant alignés axialement l'un par rapport à l'autre, avec les extensions flexibles dans une position étendue ;
    un tube amovible (3) couplé à l'extrémité du corps opposée aux extensions flexibles (2) ;
    le câble (4) traversant l'intérieur du corps (1) et l'intérieur du tube (3), une première extrémité proche des extensions flexibles (2) étant reliée à une broche (5) couplée aux œillets (6), et une seconde extrémité libre s'étendant à l'extérieur du corps (1) et du tube (3) sur le côté opposé aux extensions flexibles (2) ;
    la broche (5) étant couplée aux œillets alignés (6), avec les extensions flexibles (2) dans la position étendue ; et
    la broche (5) étant actionnée par le câble et découplée des œillets (6), dans lequel les extensions flexibles (2) sont déverrouillées et adoptent une position incurvée.
  2. Dispositif selon la revendication 1, caractérisé en ce que le tube amovible (3) est réalisé en un matériau jetable.
  3. Dispositif selon la revendication 1 ou 2, caractérisé en ce que le tube amovible (3) a un diamètre inférieur au diamètre du corps (1) imprégné de progestérone.
  4. Dispositif selon l'une quelconque des revendications 1 à 3, caractérisé en ce que le corps est constitué d'un support (12) et d'une partie amovible (11) imprégnée de progestérone, couplée au support.
  5. Dispositif selon l'une quelconque des revendications 1 à 4, caractérisé en ce que le corps (1) est constitué d'une seule pièce.
EP20849556.4A 2019-08-08 2020-06-25 Dispositif de libération de progestérone Active EP4011323B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BR202019016494-3U BR202019016494Y1 (pt) 2019-08-08 Dispositivo para liberação lenta de progesterona
PCT/BR2020/050227 WO2021022348A1 (fr) 2019-08-08 2020-06-25 Dispositif de libération de progestérone

Publications (4)

Publication Number Publication Date
EP4011323A1 EP4011323A1 (fr) 2022-06-15
EP4011323A4 EP4011323A4 (fr) 2023-05-03
EP4011323C0 EP4011323C0 (fr) 2025-08-20
EP4011323B1 true EP4011323B1 (fr) 2025-08-20

Family

ID=74502446

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20849556.4A Active EP4011323B1 (fr) 2019-08-08 2020-06-25 Dispositif de libération de progestérone

Country Status (3)

Country Link
EP (1) EP4011323B1 (fr)
MX (1) MX2022001529A (fr)
WO (1) WO2021022348A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7741552B2 (ja) * 2022-02-09 2025-09-18 国立研究開発法人農業・食品産業技術総合研究機構 腟内投与具、卵巣機能制御方法、及び製剤を家畜の腟内に投与するためのキット
JP2023116253A (ja) * 2022-02-09 2023-08-22 国立研究開発法人農業・食品産業技術総合研究機構 卵巣機能制御方法及び卵巣機能制御用キット

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE35992B1 (en) * 1971-01-22 1976-07-21 Agrophysics Inc Device for insertion into the reproductive tract and metho
US3854476A (en) * 1973-04-05 1974-12-17 R Dickinson Intra-vaginal device and method
FR2536987B1 (fr) * 1982-07-19 1985-10-31 Serimed Sterilet endo-uterin pour les animaux tels que les chiennes
EP0990425B1 (fr) * 1995-03-23 2003-01-15 Advanced Animal Technology Limited Dispositif pour administrer une substance
NZ286492A (en) * 1996-05-01 1998-02-26 Dec International Nz Ltd Subst Intra vaginal devices for synchronising oestrus of animals is made up of cured silicone rubber material with 5% by weight of progesterone
NZ314937A (en) * 1997-05-28 1999-11-29 Dec Res Intravaginal device for controlling fertility in pigs characterised by shape
AU750746B2 (en) * 1998-10-05 2002-07-25 Advanced Animal Technology Limited Improvements in and relating to retention apparatus
BE1012613A3 (fr) * 1999-04-16 2001-01-09 Wildemeersch Dirk Procede de retenue et d'actionnement d'un inserteur de sterilet, et inserteur permettant l'application de ce procede.
BR0205843B1 (pt) * 2001-02-02 2012-12-11 dispositivo intravaginal contendo progesterona, útil como indutor do cio em bovinos produtores de carne e leite, assim como processo para sua fabricação.
CN2525961Y (zh) * 2002-01-18 2002-12-18 西安辰烁生物制品（集团）有限公司 同期发情诱导器
BRPI0802661A2 (pt) * 2008-05-08 2010-01-19 Grascon Do Brasil Ltda Lab dispositivo vaginal para liberaÇço lenta de progesterona (hormânio) utilizado em fÊmeas bovinas
BR112012002271B1 (pt) * 2009-07-31 2020-06-16 Merial, Inc Cápsulas de liberação sustentada
CN201537164U (zh) * 2009-12-01 2010-08-04 张煦喆 动物立体宫内活性节育器
WO2012021127A2 (fr) * 2010-08-10 2012-02-16 Stroud Brad R Procédé et appareil pour réduire le nombre de spermatozoïdes utilisés dans l'insémination artificielle du bétail
US9801660B2 (en) * 2014-07-31 2017-10-31 Palo Alto Research Center Incorporated Implantable fluid delivery devices, systems, and methods
US10278675B2 (en) * 2014-07-31 2019-05-07 Palo Alto Research Center Incorporated Implantable estrus detection devices, systems, and methods
BR102015010670B1 (pt) * 2015-05-11 2022-11-08 Wta- Watanabe Tecnologia Aplicada Eirele - Epp Dispositivo de narina para liberação lenta de hormônios e seus usos
BR202016004731Y1 (pt) * 2016-03-02 2020-06-09 Ouro Fino Saude Animal Ltda dispositivo intravaginal com tubo de ativo de progesterona acoplável

Also Published As

Publication number Publication date
EP4011323A4 (fr) 2023-05-03
EP4011323A1 (fr) 2022-06-15
BR202019016494U2 (pt) 2021-02-09
EP4011323C0 (fr) 2025-08-20
WO2021022348A1 (fr) 2021-02-11
MX2022001529A (es) 2022-05-02

Similar Documents

Publication Publication Date Title
US4620534A (en) Apparatus for insertion of an intravaginal article
EP4011323B1 (fr) Dispositif de libération de progestérone
AU2011322726B2 (en) Intra-uterine insertion device
DE2812587A1 (de) Vorrichtung und verfahren zum einsetzen eines intrauterinpessars in die uterushoehle
US20090023980A1 (en) Animal Insemination Sheath Apparatus
CZ286820B6 (en) Device for introducing intrauterine corpuscle
EP0600864A1 (fr) Drain, dispositif servant a appliquer ce drain et procede servant a appliquer un drain sinusal.
KR100867721B1 (ko) 한방용 침 어셈블리
HU180047B (en) Apparatus for moving in materials into the tuba vterina
KR102209279B1 (ko) 동물용 연속주사기 보조장치
US3050060A (en) Speculum liner and insemination rod combination
US20170119513A1 (en) Improved device for the atraumatic transfer of a material or substance with a reproductive, therapeutic or diagnostic purpose into female mammals
KR101956671B1 (ko) 밀대의 전진 또는 후퇴가 제한되는 구조의 체내 액체 삽입 장치
US8323178B2 (en) Animal insemination sheath and methods of use
CN115243649B (zh) 一种带有锁定部分的子宫内系统
JP7650889B2 (ja) 係止部を有する子宮内システムのための挿入器具
EP1741409A1 (fr) Appareil pour insémination artificielle d'animaux avec un cathéter gonflable
BR202019016494Y1 (pt) Dispositivo para liberação lenta de progesterona
JP3115745U (ja) 動物用微量人工授精器具
KR101993597B1 (ko) 주사기
CN110152179B (zh) 一种密封医用棉签
CA2130105A1 (fr) Dispositif intra-uterin combine avec applicateur
HK40076391A (en) An inserter for an intrauterine system with a locking part
HK40076392A (en) An intrauterine system with a locking part
KR200398757Y1 (ko) 동물에 대한 인공수정장치

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20220218

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

RAP3 Party data changed (applicant data changed or rights of an application transferred)

Owner name: WTA - WATANABE TECNOLOGIA APLICADA EIRELE - EPP

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20230331

RIC1 Information provided on ipc code assigned before grant

Ipc: A61F 6/08 20060101ALI20230327BHEP

Ipc: A61D 1/08 20060101ALI20230327BHEP

Ipc: A61D 7/00 20060101AFI20230327BHEP

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230525

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

INTG Intention to grant announced

Effective date: 20250520

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602020057119

Country of ref document: DE

RAP4 Party data changed (patent owner data changed or rights of a patent transferred)

Owner name: WTA - WATANABE TECNOLOGIA APLICADA LTDA

U01 Request for unitary effect filed

Effective date: 20250918

U07 Unitary effect registered

Designated state(s): AT BE BG DE DK EE FI FR IT LT LU LV MT NL PT RO SE SI

Effective date: 20250926

P04 Withdrawal of opt-out of the competence of the unified patent court (upc) registered

Free format text: CASE NUMBER: UPC_APP_336859_1/2023

Effective date: 20250926

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20251220

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20251120

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20250820

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20251121

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20250820

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20251120

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20250820

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20250820