EP4103038A4 - System, device and method for determining and/or assessing brain related conditions based on pupil light response - Google Patents

System, device and method for determining and/or assessing brain related conditions based on pupil light response Download PDF

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Publication number
EP4103038A4
EP4103038A4 EP21753272.0A EP21753272A EP4103038A4 EP 4103038 A4 EP4103038 A4 EP 4103038A4 EP 21753272 A EP21753272 A EP 21753272A EP 4103038 A4 EP4103038 A4 EP 4103038A4
Authority
EP
European Patent Office
Prior art keywords
determining
related conditions
conditions based
light response
assessing brain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21753272.0A
Other languages
German (de)
French (fr)
Other versions
EP4103038A1 (en
Inventor
Ygal Rotenstreich
Ifat SHER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tel HaShomer Medical Research Infrastructure and Services Ltd
Original Assignee
Tel HaShomer Medical Research Infrastructure and Services Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tel HaShomer Medical Research Infrastructure and Services Ltd filed Critical Tel HaShomer Medical Research Infrastructure and Services Ltd
Publication of EP4103038A1 publication Critical patent/EP4103038A1/en
Publication of EP4103038A4 publication Critical patent/EP4103038A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/02—Subjective types, i.e. testing apparatus requiring the active assistance of the patient
    • A61B3/06—Subjective types, i.e. testing apparatus requiring the active assistance of the patient for testing light sensitivity, e.g. adaptation; for testing colour vision
    • A61B3/063—Subjective types, i.e. testing apparatus requiring the active assistance of the patient for testing light sensitivity, e.g. adaptation; for testing colour vision for testing light sensitivity, i.e. adaptation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/11—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring interpupillary distance or diameter of pupils
    • A61B3/112—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring interpupillary distance or diameter of pupils for measuring diameter of pupils
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/251—Means for maintaining electrode contact with the body
    • A61B5/256—Wearable electrodes, e.g. having straps or bands
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • A61B5/332—Portable devices specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4058—Detecting, measuring or recording for evaluating the nervous system for evaluating the central nervous system
    • A61B5/4064—Evaluating the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6823—Trunk, e.g., chest, back, abdomen, hip
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683—Means for maintaining contact with the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Physiology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Eye Examination Apparatus (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
EP21753272.0A 2020-02-11 2021-02-11 System, device and method for determining and/or assessing brain related conditions based on pupil light response Pending EP4103038A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062972668P 2020-02-11 2020-02-11
PCT/IL2021/050170 WO2021161318A1 (en) 2020-02-11 2021-02-11 System, device and method for determining and/or assessing brain related conditions based on pupil light response

Publications (2)

Publication Number Publication Date
EP4103038A1 EP4103038A1 (en) 2022-12-21
EP4103038A4 true EP4103038A4 (en) 2023-10-25

Family

ID=77292855

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21753272.0A Pending EP4103038A4 (en) 2020-02-11 2021-02-11 System, device and method for determining and/or assessing brain related conditions based on pupil light response

Country Status (4)

Country Link
EP (1) EP4103038A4 (en)
CN (1) CN115426935A (en)
IL (1) IL295444A (en)
WO (1) WO2021161318A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230405327A1 (en) * 2022-06-09 2023-12-21 The Alfred E. Mann Foundation For Scientific Research Vagus nerve stimulation pupillometry for electrode selection and titration
CN115299871A (en) * 2022-08-30 2022-11-08 首都师范大学 Light reflection inspection method and device, light reflection inspection equipment and storage medium
CN115414033B (en) * 2022-11-03 2023-02-24 京东方艺云(杭州)科技有限公司 A Method and Device for Determining Abnormal Eye Use Behavior of a User
CN119385591B (en) * 2024-06-12 2025-05-27 浙江大学 Functional detection system and method for nigral dopaminergic nerve degeneration through eyes
WO2026062089A1 (en) 2024-09-19 2026-03-26 Eth Zurich Pupillometry system for computer-implemented assessment of presymptomatic alzheimer's risk in users
CN120732347B (en) * 2025-08-26 2026-01-30 汇视医疗投资科技研发(广州)有限公司 Contrast sensitivity function detection method and system

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1127534A2 (en) * 2000-02-24 2001-08-29 Matsushita Electric Works, Ltd. Non-invasive brain function examination
US20160262611A1 (en) * 2013-10-30 2016-09-15 Tel HaShomer Medical Research Infrastructure and S ervices Ltd. Pupillometers and systems and methods for using a pupillometer
US20170347878A1 (en) * 2014-12-16 2017-12-07 Singapore Health Services Pte Ltd A method and system for monitoring and/or assessing pupillary responses
WO2018203828A1 (en) * 2017-05-02 2018-11-08 Singapore Health Services Pte Ltd Hand held ophthalmic and neurological screening device

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011016029A2 (en) * 2009-08-02 2011-02-10 Tel Hashomer Medical Research Infrastructure And Services Ltd System and method for objective chromatic perimetry analysis using pupillometer
EP3046460B1 (en) * 2013-09-19 2022-04-20 Children's National Medical Center Apparatus for determining physiologic perturbations of a patient
EP3110308B1 (en) * 2014-02-28 2023-09-06 Board of Regents, The University of Texas System System for traumatic brain injury detection using oculomotor tests
US20190191995A1 (en) * 2017-07-28 2019-06-27 Pupilscan Corporation Systems and Methods for Capturing and Analyzing Pupil Images to Determine Toxicology and Neurophysiology

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1127534A2 (en) * 2000-02-24 2001-08-29 Matsushita Electric Works, Ltd. Non-invasive brain function examination
US20160262611A1 (en) * 2013-10-30 2016-09-15 Tel HaShomer Medical Research Infrastructure and S ervices Ltd. Pupillometers and systems and methods for using a pupillometer
US20170347878A1 (en) * 2014-12-16 2017-12-07 Singapore Health Services Pte Ltd A method and system for monitoring and/or assessing pupillary responses
WO2018203828A1 (en) * 2017-05-02 2018-11-08 Singapore Health Services Pte Ltd Hand held ophthalmic and neurological screening device

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BERMAN G ET AL: "Decreased retinal sensitivity in depressive disorder: a controlled study", ACTA PSYCHIATRICA SCANDINAVICA, MUNKSGAARD, COPENHAGEN, DE, vol. 137, no. 3, 15 January 2018 (2018-01-15), pages 231 - 240, XP071044664, ISSN: 0001-690X, DOI: 10.1111/ACPS.12851 *
PALANCA-CASTAN NICOLAS ET AL: "Chromatic pupillometry for the characterization of the pupillary light reflex in Octodon degus", EXPERIMENTAL EYE RESEARCH, ACADEMIC PRESS LTD, LONDON, vol. 190, 2 November 2019 (2019-11-02), XP086022673, ISSN: 0014-4835, [retrieved on 20191102], DOI: 10.1016/J.EXER.2019.107866 *
See also references of WO2021161318A1 *

Also Published As

Publication number Publication date
EP4103038A1 (en) 2022-12-21
CN115426935A (en) 2022-12-02
WO2021161318A1 (en) 2021-08-19
IL295444A (en) 2022-10-01

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