EP4213629A1 - Formulation de fongicides à base de cuivre et de bactéricide - Google Patents

Formulation de fongicides à base de cuivre et de bactéricide

Info

Publication number
EP4213629A1
EP4213629A1 EP21802018.8A EP21802018A EP4213629A1 EP 4213629 A1 EP4213629 A1 EP 4213629A1 EP 21802018 A EP21802018 A EP 21802018A EP 4213629 A1 EP4213629 A1 EP 4213629A1
Authority
EP
European Patent Office
Prior art keywords
composition
copper
weight
amount
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21802018.8A
Other languages
German (de)
English (en)
Inventor
Pedro Gonzalez
Juan Daniel DZUL PUC
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adama Makhteshim Ltd
Original Assignee
Adama Makhteshim Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adama Makhteshim Ltd filed Critical Adama Makhteshim Ltd
Publication of EP4213629A1 publication Critical patent/EP4213629A1/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/16—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/16—Heavy metals; Compounds thereof
    • A01N59/20—Copper
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P3/00—Fungicides

Definitions

  • the present invention concerns a unique fungicide and bactericide formulation which contain copperbased fungicide as active ingredient, tannic acid and a buffering system.
  • Copper-based pesticides are widely used in agrochemical products to control a wide range of fungal, bacterial, and other pests. Copper was one of the first elements used as a plant fungicide and its discovery can be traced back to the famous origin of bordeaux mixture, containing a mixture of copper sulfate (CuSO4) and slaked lime, used for downy mildew control in French vineyards.
  • CuSO4 copper sulfate
  • slaked lime used for downy mildew control in French vineyards.
  • Copper-based fungicides are divided into compounds that are highly soluble in water such as cupric acetate, cupric chloride and cupric chlorate, cupric formate, cupric hexafluorosilicate, cupric nitrate, cupric chromate, copper sulfate pentahydrate and bordeaux mixture; and compounds such as copper hydroxide, copper oxychloride sulfate (COCS), and tribasic copper sulfate (cupric sulfate, tricupric hydroxide, hemihydrate) which also known as "fixed" coppers that are relatively less soluble in water.
  • COCS copper oxychloride sulfate
  • cupric sulfate, tricupric hydroxide, hemihydrate tribasic copper sulfate
  • Copper-based fungicides are important, due to their low costs and their protectant/preventative characteristics and abilities to inhibit fungal spore germination and hyphal penetration.
  • the fungal control is provided when the copper particles slowly dissolve in contact with water releasing Cu+2 ions.
  • Copper fungicides formulations vary in the efficiency of Cu+2 ion release which is dependent upon the copper source. Moreover, the concentration of copper ions on the leaves depends on the equilibrium established with the complexed and soluble forms of copper (Menkissoglu and Lindow 1991).
  • the performance of the formulation is therefore highly dependent on its technology for generating a stable complex allowing moderate and long-lasting effect of release of copper ions. It is known that copper is toxic when the dissolved form penetrates into plant tissue. In general, the use of spray additives such as foliar nutrients, and any surfactants with penetrating characteristics should be avoided when applying copper-based fungicides.
  • SC compositions containing copper sulphate pentahydrate and tannate complex of picro ammonium formate were disclosed in US 4544666 and US 4673687. These compositions contain picric acid which has many disadvantages and is known as an explosive compound that should be handled very carefully.
  • compositions of the present invention comprising water soluble copper-based fungicide cause less plant injury than known formulations in the market.
  • the invention provides novel, improved safer and greener copper-based fungicide compositions which have low copper content and does not use the addition of unwanted surfactants.
  • compositions of the invention show high bioavailability of long-acting copper when diluted in water and shows an effective control against fungal-infected cultures compared to other traditional copperbased products.
  • compositions of the present invention reduce eye irritancy.
  • the present invention therefore provides an agrochemical composition comprising a) a buffering system; b) tannic acid and c) a copper-based fungicide.
  • the invention also provides a method for reducing phytotoxicity by applying a composition comprising a) a buffering system; b) tannic acid and c) a copper-based fungicide to a locus.
  • the present invention also provides the use of a buffering system for stabilizing liquid compositions of a copper-based fungicide.
  • the present invention provides methods for reducing eye irritancy and aquatic toxicity by applying the disclosed compositions.
  • the term "about” when used in connection with a numerical value includes ⁇ 10% from the indicated value.
  • all ranges directed to the same component or property herein are inclusive of the endpoints, are independently combinable, and include all intermediate points and ranges. It is understood that where a parameter range is provided, all integers within that range, and tenths thereof, are also provided by the invention.
  • the term "effective amount” refers to an amount of the active component that is commercially recommended for use to control and/or prevent pest. The commercially recommended amount for each active component, often specified as application rates of the commercial formulation, may be found on the label accompanying the commercial formulation. The commercially recommended application rates of the commercial formulation may vary depending on factors such as the plant species and the pest to be controlled.
  • the term "pest” includes, but is not limited to, unwanted phytopathogenic harmful fungi, unwanted insect, unwanted nematode, and weed.
  • the term "pesticide” broadly refers to an agent that can be used to prevent, control and/or kill a pest.
  • the term is understood to include but is not limited to fungicides, insecticides, nematicides, herbicides, acaricides, parasiticides or other control agents.
  • fungicides insecticides, nematicides, herbicides, acaricides, parasiticides or other control agents.
  • specific compounds of each class see "The Pesticide Manual Thirteenth Edition” (British Crop Protection Council, Hampshire, UK, 2003), as well as “The e-Pesticide Manual, Version 3" (British Crop Protection Council, Hampshire, UK, 2003-04), the contents of each of which are incorporated herein by reference in their entirety.
  • locus includes not only areas where the pest may already be developed, but also areas where pests have yet to emerge, and also to areas under cultivation. Locus includes the plant or crop and propagation material of the plant or crop. Locus also includes the area surrounding the plant or crop and the growing media of the plant or crop, such as soil and crop field.
  • plant or “crop” includes reference to whole plants, plant organs (e.g. leaves, stems, twigs, roots, trunks, limbs, shoots, fruits etc.), plant cells, or plant seeds. This term also encompasses plant crops such as fruits, spores, corms, bulbs, rhizomes, sprouts basal shoots, stolons, and buds and other parts of plants, including seedlings and young plants, which are to be transplanted after germination or after emergence from soil.
  • plant organs e.g. leaves, stems, twigs, roots, trunks, limbs, shoots, fruits etc.
  • plant cells or plant seeds. This term also encompasses plant crops such as fruits, spores, corms, bulbs, rhizomes, sprouts basal shoots, stolons, and buds and other parts of plants, including seedlings and young plants, which are to be transplanted after germination or after emergence from soil.
  • ha refers to hectare
  • the term "Copper dose” represents the quantity of active ingredient provided by the formulation.
  • the present invention provides a fungicide composition comprising a) a buffering system; b) tannic acid and c) a copper-based fungicide.
  • the buffering system is a combination of a carboxylic acid and a base.
  • the carboxylic acid is selected from acetic acid, formic acid, citric acid, propionic acid, butyric acid and/or any combination thereof. In a preferred embodiment, the carboxylic acid is acetic acid.
  • the amount of the carboxylic acid is of about 22% to about 38% by weight, based on the total weight of the composition. In a preferred embodiment, the amount of the carboxylic acid is of about 25% to about 30% by weight, based on the total weight of the composition.
  • the base is ammonium hydroxide.
  • the amount of the base is of about 19% to about 24 % by weight, based on the total weight of the composition. In a preferred embodiment, the amount of the base is of about 20% to about 21% by weight, based on the total weight of the composition.
  • the carboxylic acid is added in excess with respect to the base.
  • the weight ratio between the carboxylic acid and the base is of about 0.9:1 to about 1.8:1. In a preferred embodiment, the weight ratio between the carboxylic acid and the base is of about 1.2:1 to about 1.4:1.
  • the amount of tannic acid in the composition is of about 0.49 % to about 0.51 % by weight, based on the total weight of the composition. In a preferred embodiment, the amount of tannic acid in the composition is of about 0.5% by weight, based on the total weight of the composition.
  • the copper-based fungicide is selected from cupric acetate, cupric chloride, cupric chlorate, cupric formate, cupric hexafluorosilicate, cupric nitrate, cupric chromate, copper sulfate pentahydrate, bordeaux mixture, copper hydroxide, copper oxychloride sulfate (COCS), tribasic copper sulfate such as cupric sulfate, tricupric hydroxide, hemihydrate and/or any combination thereof.
  • COCS copper oxychloride sulfate
  • the copper-based fungicide is selected from cupric acetate, cupric chloride, cupric chlorate, cupric formate, cupric hexafluorosilicate, cupric nitrate, cupric chromate, copper sulfate pentahydrate, bordeaux mixture and any combination thereof.
  • the copper-based fungicide is selected from copper sulfate pentahydrate, bordeaux mixture and/or any combination thereof.
  • the amount of the copper-based fungicide is of about 16% to about 24 % by weight, based on the total weight of the composition. In a preferred embodiment, the amount of copperbased fungicide is of about 18% to 22% by weight, based on the total weight of the composition.
  • compositions of the invention comprising a) a buffering system which is a combination of a carboxylic acid and a base; b) tannic acid and c) a copper-based fungicide.
  • compositions of the invention comprising a) a buffering system which is a combination of acetic acid and ammonium hydroxide; b) tannic acid and c) bordeaux mixture as a copper-based fungicide.
  • the copper content of the copper-based fungicide is from about 40 g/l to about 500 g/l. In a preferred embodiment, the copper content is from about 50 g/l to about 300 g/l. In a more preferred embodiment, the copper content is from about 50 g/l to about 100 g/l. In a particularly preferred embodiment, the copper content is about 66 g/l.
  • the molar ratio between the carboxylic acid to the copper-based fungicide is of about 3.5:1 to about 25:1. In a preferred embodiment, the molar ratio between the carboxylic acid to the copper-based fungicide is of about 10:1 to about 18:1. In a preferred embodiment, the molar ratio between the carboxylic acid to the copper-based fungicide is of about 15:1 to about 18:1.
  • the molar ratio between the base to copper-based fungicide is of about 3.7:1 to about 17:1. In a preferred embodiment, the molar ratio between the base to copper-based fungicide is of about 10:1 to about 16:1. In a preferred embodiment, the molar ratio between the base to copperbased fungicide is of about 11:1 to about 15:1.
  • composition of the present invention is further comprising stabilizers.
  • the stabilizers are selected from the salts of propionic acid, sodium salt of butyric acid, sodium salt of valeric acid and any combination thereof. In a preferred embodiment the stabilizer is the salt of propionic acid.
  • the origin of the salt is may be selected from sodium, calcium, magnesium, potassium, lithium and/or any combination thereof. In a preferred embodiment the origin of the salt is sodium.
  • the stabilizer is sodium salt of propionic acid.
  • the amount of the stabilizer is of about 0.8% to about 1.0% by weight, based on the total weight of the composition. In a preferred embodiment, the amount of the stabilizer is of about 0.9% by weight, based on the total weight of the composition.
  • compositions of the invention comprising a) a buffering system which is a combination of acetic acid and ammonium hydroxide; b) tannic acid; c) bordeaux mixture as a copperbased fungicide and a stabilizer.
  • compositions of the invention comprising a) a buffering system which is a combination of acetic acid and ammonium hydroxide; b) tannic acid; c) bordeaux mixture as a copper-based fungicide and sodium salt of propionic acid as the stabilizer.
  • the composition of the present invention further comprising additives.
  • additives are anti-freezing agents, anti-foaming agents, thickening agent, rheological agent, and any other additional additive which is known from common practice in the formulation industry and any combination thereof.
  • the additive is selected from thickening agent and rheological agent.
  • the rheological agent is Xanthan Gum.
  • compositions of the invention comprising a) a buffering system which is a combination of acetic acid and ammonium hydroxide; b) tannic acid; c) bordeaux mixture as a copperbased fungicide, a stabilizer and an additive.
  • compositions of the invention comprising a) a buffering system which is a combination of acetic acid and ammonium hydroxide; b) tannic acid; c) bordeaux mixture as a copper-based fungicide, sodium salt of propionic acid as the stabilizer and rheological agent as an additive.
  • compositions of the invention comprising a) a buffering system which is a combination of acetic acid and ammonium hydroxide; b) tannic acid; c) bordeaux mixture as a copper-based fungicide, sodium salt of propionic acid as the stabilizer and Xanthan Gum as the rheological agent.
  • compositions of the invention comprising a) acetic acid in amount of about 28% and ammonium hydroxide in amount of about 20%, by weight, based on the total weight of the composition; b) tannic acid in amount of about 0.5% by weight, based on the total weight of the composition; c) bordeaux mixture in amount of about 18% by weight, based on the total weight of the composition; sodium salt of propionic acid in amount of about 0.9% by weight, based on the total weight of the composition and Xanthan Gum in amount of about 0.3% by weight, based on the total weight of the composition.
  • the composition of the present invention is applied in an amount from about 0.4 L/ha to about 5 L/ha. In some embodiments, the composition of the present invention is applied in an amount from about 1 L/ha to about 4 L/ha. In some embodiments, the composition of the present invention is applied in an amount from about 2.5 L/ha to about 3.5 L/ha.
  • compositions of the invention copper fungicide, carboxylic acid, base and tannic acid obtained through an integrated manufacturing process generating a supersaturated solution that is stabilized during its preparation for optimal use in crop protection with : (a) carboxylic acid that together with the salt formed from the same acid, which creates a buffering system that allows it to remain stable in dilution by acid buffering of the dilution medium and ensure better application to the plant and (b) with a rheological agent to ensure stability as a concentrated product during its half-life but no dispersant agent required.
  • compositions of the present invention are designed to make a special interaction of the ingredients without the use of dispersants.
  • the interaction is created initially during formulation (copper interaction instead of dispersion) with the ingredients and then with the water under dilution.
  • compositions of the invention are prepared by the following addition order: a) buffering system; b) tannic acid and c) a copper-based fungicide.
  • the present invention also provides a method of controlling phytopathogenic harmful fungi and/or bacteria in a field of crop comprising applying an effective amount of the compositions disclosed herein to a field of crop so as to thereby control the phytopathogenic harmful fungi and/or bacteria in the field of crop.
  • the crop is selected from the group consisting of cotton, grapevines, fruit, vegetables, such as Rosaceae sp.
  • Ribesioidae sp. for example pome fruit such as apples and pears, but also stone fruit such as apricots, cherries, almonds and peaches, and berry fruits such as strawberries
  • Ribesioidae sp. Juglandaceae sp.
  • Betulaceae sp. Anacardiaceae sp., Fagaceae sp., Moraceae sp., Oleaceae sp., Actinidaceae sp., Lauraceae sp., Musaceae sp. (for example banana trees and plantations), Rubiaceae sp.
  • Theaceae sp. for example coffee
  • Theaceae sp. Sterculiceae sp.
  • Rutaceae sp. for example lemons and grapefruit
  • Solanaceae sp. for example tomatoes
  • Liliaceae sp. for example lettuce
  • Umbelliferae sp. for example lettuce
  • Umbelliferae sp. for example lettuce
  • Alliaceae sp. for example leeks, onions
  • Papilionaceae sp. for example peas
  • main crop plants such as Gramineae sp.
  • Asteraceae sp. for example sunflowers
  • Brassicaceae sp. for example white cabbage, red cabbage, broccoli, cauliflower, Brussels sprouts, Pak Choi, kohlrabi, radishes, and rapeseed, mustard, horseradish and cress
  • Fabaceae sp. for example beans, peanuts
  • Papilionaceae sp. for example soya beans
  • Solanaceae sp. for example potatoes), Chenopodiaceae sp.
  • the crop is selected from the group consisting of Fruit trees, vines and Vegetables.
  • the crop is selected from the group consisting of Pome fruits such as apple and pear; Stone Fruits such as Peach, apricot and almond; Tree nuts such as Walnut, hazelnut; Vines such as Grapes, Kiwi and Hop, other tree crops such as olive, citrus, avocado; Fruiting vegetables such as Tomato, Pepper and cucumber; Root & tuber such as Potato and Carrot; Leafy Vegetables such as Lettuce and Cabbage; Oil crops such as sunflower and oil Seed Rape; Cereals such as Wheat, Rye, Barely and Rice; Small fruits like blackberry and blueberry; Ornamentals like roses and Azalea and Herbs like mint and basil.
  • Pome fruits such as apple and pear
  • Stone Fruits such as Peach, apricot and almond
  • Tree nuts such as Walnut, hazelnut
  • Vines such as Grapes, Kiwi and Hop, other tree crops such as olive, citrus, avocado
  • Fruiting vegetables such as Tomato, Pepper and cucumber
  • Root & tuber such as Potato and Carrot
  • Non-limiting examples of pathogens of fungal diseases which may be treated in accordance with the invention include: diseases caused by powdery mildew pathogens, for example Blumeria species, for example Blumeria graminis, Podosphaera species, for example Podosphaera leucotricha, Sphaerotheca species, for example Sphaerotheca fuliginea, Uncinula species, for example Uncinula necator, for example Erysiphe species; diseases caused by rust disease pathogens, for example Gymnosporangium species, for example Gymnosporangium sabinae ; Hemileia species, for example Hemileia vastatrix; Phakopsora species, for example Phakopsora pachyrhizi or Phakopsora meibomiae Puccinia species, for example Puccinia recondita, Puccinia graminis oder Puccinia striif ormis, Uromyces species
  • brassicaer Phytophthora species, for example Phytophthora infestans, Plasmopara species, for example Plasmopara viticola, Pseudoperonospora species, for example Pseudoperonospora humuli or Pseudoperonospora cubensis, Pythium species, for example Pythium ultimum, leaf blotch diseases and leaf wilt diseases caused, for example, by Alternaria species, for example Alternaria solani, Cercospora species, for example Cercospora beticola, Cladosporium species, for example Cladosporium cucumerinunr, Cochliobolus species, for example Cochliobolus sativus (conidial form: Drechslera, syn: Helminthosporium) or Cochliobolus miyabeanus, Colletotrichum species, for example Colletotrichum lindemuthianum, Cor
  • Pseudomonas species for example Pseudomonas syringae pv. lachrymans, Erwinia species, for example Erwinia amylovora, Liberibacter species, for example Liberibacter asiaticus, Xylella species, for example Xylella fastidiosa, Ralstonia species, for example Ralstonia solanacearum, Dickeya species, for example Dickeya solanv, Clavibacter species, for example Clavibacter michiganensis, Streptomyces species, for example Streptomyces scabies, diseases of soya beans: fungal diseases on leaves, stems, pods and seeds caused, for example, by Alternaria leaf spot (Alternaria spec atrans tenuissima), Anthracnose (Colletotrichum gloesporioides dematium var.
  • phytophthora rot (Phytophthora megasperma), brown stem rot (Phialophora gregata), pythiumrot (Pythium aphanidermatum, Pythium irregulare, Pythium debaryanum, Pythium myriotylum, Pythium ultimum), rhizoctonia root rot, stem decay, and damping-off (Rhizoctonia solani), sclerotinia stem decay (Sclerotinia sclerotiorum), sclerotinia southern blight (Sclerotinia rolfsii), thielaviopsis root rot (Thielaviopsis basicola).
  • the phytopathogenic harmful fungi is selected from Taphrina spp., Monilia spp., Venturia spp., Stemphylium spp., Alternaria spp., Sphaerotheca spp., Podosphaera spp., Glomerella spp.
  • Xanthomonas spp. Pseudomonas spp., Erwinia spp., Botryosphaeria spp., Plasmopara spp., Pseudoperonospora spp., Peronospora spp., Bremia spp, Phytophthora spp., Pythium spp., Sclerotinia spp., Septoria spp., Uncinula spp., Puccinia spp., Pyricularia spp.,. Elsinoe spp., Kuehneola spp. Phakopsora spp., Colletotrichum Spp., Cladosporium spp., Corynespora spp.
  • the present invention relates to the use of a buffering system for stabilizing liquid composition of a copper-based fungicide.
  • the buffering system stabilize liquid composition of copper-based fungicides and tannic acid.
  • the liquid composition is in the form of a suspension concentrate.
  • the buffering system is a combination of a carboxylic acid and a base.
  • the carboxylic acid is selected from acetic acid, formic acid, citric acid, propionic acid, butyric acid and/or any combination thereof. In a preferred embodiment, the carboxylic acid is acetic acid.
  • the amount of the carboxylic acid is of about 22% to about 38% by weight, based on the total weight of the composition. In a preferred embodiment, the amount of the carboxylic acid is of about 25% to about 30% by weight, based on the total weight of the composition.
  • the base is ammonium hydroxide. In some embodiments, the amount of the base is of about 19% to about 24 % by weight, based on the total weight of the composition. In a preferred embodiment, the amount of the base is of about 20% to about 21% by weight, based on the total weight of the composition.
  • the carboxylic acid is added in excess with respect to the base.
  • the weight ratio between the carboxylic acid and the base is of about 0.9:1 to about 1.8:1. In a preferred embodiment, the weight ratio between the carboxylic acid and the base is of about 1.2:1 to about 1.4:1.
  • the copper-based fungicide is selected from cupric acetate, cupric chloride, cupric chlorate, cupric formate, cupric hexafluorosilicate, cupric nitrate, cupric chromate, copper sulfate pentahydrate, bordeaux mixture, copper hydroxide, copper oxychloride sulfate (COCS), copper oxide, tribasic copper sulfate such as cupric sulfate, tricupric hydroxide, hemihydrate and/or any combination thereof.
  • the copper-based fungicide is selected from cupric acetate, cupric chloride, cupric chlorate, cupric formate, cupric hexafluorosilicate, cupric nitrate, cupric chromate, copper sulfate pentahydrate, bordeaux mixture and/or any combination thereof.
  • the copper-based fungicide is selected from copper sulfate pentahydrate, bordeaux mixture and any combination thereof.
  • the amount of the copper-based fungicide is of about 16% to about 24% by weight, based on the total weight of the composition. In a preferred embodiment, the amount of copperbased fungicide is of about 18% to 22% by weight, based on the total weight of the composition.
  • the molar ratio between the carboxylic acid to the copper-based fungicide is of about 3.5:1 to about 18:1. In a preferred embodiment, the molar ratio between the carboxylic acid to the copper-based fungicide is of about 10:1 to about 18:1. In a preferred embodiment, the molar ratio between the carboxylic acid to the copper-based fungicide is of about 15:1 to about 18:1.
  • the molar ratio between the base to copper-based fungicide is of about 3.7:1 to about 17:1. In a preferred embodiment, the molar ratio between the base to copper-based fungicide is of about 10:1 to about 16:1. In a preferred embodiment, the molar ratio between the base to copperbased fungicide is of about 11:1 to about 15:1. In some embodiments, the buffering system stabilize the liquid composition of copper-based further comprising tannic acid.
  • the amount of tannic acid in the composition is of about 0.49 % to about 0.51% by weight, based on the total weight of the composition. In a preferred embodiment, the amount of tannic acid in the composition is of about 0.5% by weight, based on the total weight of the composition.
  • composition of the present invention further comprising stabilizers.
  • the stabilizers are selected from the salts of propionic acid, sodium salt of butyric acid, sodium salt of valeric acid and/or any combination thereof. In a preferred embodiment the stabilizer is the salt of propionic acid.
  • the origin of salt may be selected from sodium, calcium, magnesium, potassium, lithium and/or any combination thereof. In a preferred embodiment the origin of the salt is sodium.
  • the stabilizer is sodium salt of propionic acid.
  • the amount of the stabilizer is of about 0.8% to about 1.0% by weight, based on the total weight of the composition. In a preferred embodiment, the amount of the stabilizer is of about 0.9% by weight, based on the total weight of the composition.
  • the composition of the present invention further comprising additives.
  • additives are anti-freezing agents, anti-foaming agents, thickening agent, rheological agent, and any other additional additive which is known from common practice in the formulation industry and any combination thereof.
  • the additive is selected from thickening agent and rheological agent.
  • the rheological agent is Xanthan Gum.
  • the composition of the present invention is applied in an amount from about 0.4 L/ha to about 5 L/ha. In some embodiments, the composition of the present invention is applied in an amount from about 1 L/ha to about 4 L/ha. In some embodiments, the composition of the present invention is applied in an amount from about 2.5 L/ha to about 3.5 L/ha.
  • the invention relates to a method for reducing phytotoxicity by applying a composition comprising: a) a buffering system; b) tannic acid and c) a copper-based fungicide to a locus.
  • the buffering system is a combination of a carboxylic acid and a base.
  • the carboxylic acid is selected from acetic acid, formic acid, citric acid, propionic acid, butyric acid and/or any combination thereof. In a preferred embodiment, the carboxylic acid is acetic acid.
  • the amount of the carboxylic acid is of about 22% to about 38% by weight, based on the total weight of the composition. In a preferred embodiment, the amount of the carboxylic acid is of about 25% to about 30% by weight, based on the total weight of the composition.
  • the base is ammonium hydroxide.
  • the amount of the base is of about 19% to about 24 % by weight, based on the total weight of the composition. In a preferred embodiment, the amount of the base is of about 20% to about 21% by weight, based on the total weight of the composition.
  • the carboxylic acid is added in excess with respect to the base.
  • the weight ratio between the carboxylic acid and the base is of about 0.9:1 to about 1.8:1. In a preferred embodiment, the weight ratio between the carboxylic acid and the base is of about 1.2:1 to about 1.4:1.
  • the amount of tannic acid in the composition is of about 0.49 % to about 0.51% by weight, based on the total weight of the composition. In a preferred embodiment, the amount of tannic acid in the composition is of about 0.5% by weight, based on the total weight of the composition.
  • the copper-based fungicide is selected from cupric acetate, cupric chloride, cupric chlorate, cupric formate, cupric hexafluorosilicate, cupric nitrate, cupric chromate, copper sulfate pentahydrate, bordeaux mixture, copper hydroxide, copper oxychloride sulfate (COCS), copper oxide, tribasic copper sulfate such as cupric sulfate, tricupric hydroxide, hemihydrate and/or any combination thereof.
  • the copper-based fungicide is selected from cupric acetate, cupric chloride, cupric chlorate, cupric formate, cupric hexafluorosilicate, cupric nitrate, cupric chromate, copper sulfate pentahydrate, bordeaux mixture and any combination thereof.
  • the copper-based fungicide is selected from copper sulfate pentahydrate, bordeaux mixture and/or any combination thereof.
  • the amount of the copper-based fungicide is of about 16% to about 24% by weight, based on the total weight of the composition. In a preferred embodiment, the amount of copperbased fungicide is of about 18% to 22% by weight, based on the total weight of the composition.
  • compositions of the invention comprising a) a buffering system which is a combination of a carboxylic acid and a base; b) tannic acid and c) a copper-based fungicide.
  • compositions of the invention comprising a) a buffering system which is a combination of acetic acid and ammonium hydroxide; b) tannic acid and c) bordeaux mixture as a copper-based fungicide.
  • the copper content of the copper-based fungicide is from about 40 g/l to about 500 g/l. In a preferred embodiment, the copper content is from about 50 g/l to about 300 g/l. In a more preferred embodiment, the copper content is from about 50 g/l to about 100 g/l. In a particularly preferred embodiment, the copper content is about 66 g/l.
  • the molar ratio between the carboxylic acid to the copper-based fungicide is of about 3.5:1 to about 18:1. In a preferred embodiment, the molar ratio between the carboxylic acid to the copper-based fungicide is of about 10:1 to about 18:1. In a preferred embodiment, the molar ratio between the carboxylic acid to the copper-based fungicide is of about 15:1 to about 18:1.
  • the molar ratio between the base to copper-based fungicide is of about 3.7:1 to about 17:1. In a preferred embodiment, the molar ratio between the base to copper-based fungicide is of about 10:1 to about 16:1. In a preferred embodiment, the molar ratio between the base to copperbased fungicide is of about 11:1 to about 15:1.
  • composition of the present invention further comprising stabilizers.
  • the stabilizers are selected from the salts of propionic acid, sodium salt of butyric acid, sodium salt of valeric acid and any combination thereof. In a preferred embodiment the stabilizer is the salt of propionic acid.
  • the origin of salt may be selected from sodium, calcium, magnesium, potassium, lithium and any combination thereof. In a preferred embodiment the origin of the salt is sodium.
  • the stabilizer is sodium salt of propionic acid.
  • compositions of the invention comprising a) a buffering system which is a combination of acetic acid and ammonium hydroxide; b) tannic acid; c) bordeaux mixture as a copperbased fungicide and a stabilizer.
  • compositions of the invention comprising a) a buffering system which is a combination of acetic acid and ammonium hydroxide; b) tannic acid; c) bordeaux mixture as a copper-based fungicide and sodium salt of propionic acid as the stabilizer.
  • the amount of stabilizer is of about 0.8% to about 1.0% by weight, based on the total weight of the composition. In a preferred embodiment, the amount of stabilizer is of about 0.9% by weight, based on the total weight of the composition.
  • the composition of the present invention further comprising additives.
  • additives are anti-freezing agents, anti-foaming agents, thickening agent, rheological agent, and any other additional additive which is known from common practice in the formulation industry and any combination thereof.
  • the additive is selected from thickening agent and rheological agent.
  • the rheological agent is Xanthan Gum.
  • compositions of the invention comprising a) a buffering system which is a combination of acetic acid and ammonium hydroxide; b) tannic acid; c) bordeaux mixture as a copperbased fungicide, a stabilizer and an additive.
  • compositions of the invention comprising a) a buffering system which is a combination of acetic acid and ammonium hydroxide; b) tannic acid; c) bordeaux mixture as a copper-based fungicide, sodium salt of propionic acid as the stabilizer and rheological agent as an additive.
  • compositions of the invention comprising a) a buffering system which is a combination of acetic acid and ammonium hydroxide; b) tannic acid; c) bordeaux mixture as a copper-based fungicide, sodium salt of propionic acid as the stabilizer and Xanthan Gum as the rheological agent.
  • compositions of the invention comprising a) acetic acid in amount of about 28% and ammonium hydroxide in amount of about 20%, by weight, based on the total weight of the composition; b) tannic acid in amount of about 0.5% by weight, based on the total weight of the composition; c) bordeaux mixture in amount of about 18% by weight, based on the total weight of the composition; sodium salt of propionic acid in amount of about 0.9% by weight, based on the total weight of the composition and Xanthan Gum in amount of about 0.3% by weight, based on the total weight of the composition.
  • the composition of the present invention is applied in an amount from about 0.4 L/ha to about 5 L/ha. In some embodiments, the composition of the present invention is applied in an amount from about 1 L/ha to about 4 L/ha. In some embodiments, the composition of the present invention is applied in an amount from about 2.5 L/ha to about 3.5 L/ha.
  • the present invention also provides a method for reducing eye irritancy by applying the disclosed composition.
  • the present invention also provides a method for reducing aquatic toxicity by applying the disclosed composition.
  • compositions of the present invention are formulated as suspension concentrate (SC).
  • the formulations of the invention provide stable SC formulations of copper fungicide, optionally in combination with further active ingredients, preferably selected from fungicides, for treatment of plants.
  • compositions and/or combinations of the invention may comprise further one or more active fungicidal, bactericidal, insecticidal or herbicidal ingredients.
  • the compositions of the invention comprise one or more active insecticidal, bactericidal or fungicidal ingredients, more preferably one or more active fungicidal or bactericidal ingredients, more preferably one or more active fungicidal ingredients.
  • Non limiting examples of active fungicidal mixing partners are metalaxyl, zoxamide, fluopicolide, ametoctradin, amisulbrom, cymoxanil, mandipropamid, dimethomorph, captan, folpet, mancozeb, difenoconazole, metconazole, tebuconazole, azoxystrobin, picoxystrobin, trifloxystrobin, pydiflumetofen, fluxapyroxad, fluopyram and any combination thereof.
  • the present invention likewise provides a suspension obtainable by mixing water with the liquid compositions of the invention.
  • the mixing ratio of water to suspension concentrate may be in the range from 1500:1 to 1:1, preferably 500:1 to 10:1.
  • the dilution is achieved by pouring the concentrates of the invention into the water.
  • agitation for example stirring.
  • agitation is generally unnecessary.
  • dilutions are typically conducted at temperatures in the range from 00°C to 50°C, especially at 5 °C to 40 °C or at ambient temperature.
  • the water used for dilution is generally tap water.
  • the water may, however, already contain water soluble or finely dispersed compounds which are used in crop protection, for instance nutrients, fertilizers or pesticides.
  • various kinds of oils, wetting agents, adjuvants, buffers, fertilizers or micronutrients and further pesticides e.g. herbicides, insecticides, fungicides, growth regulators, safeners, elicitors
  • pesticides e.g. herbicides, insecticides, fungicides, growth regulators, safeners, elicitors
  • These may be added to the compositions of the invention in a weight ratio of 1:100 to 100:1, preferably 1:10 to 10:1.
  • compositions of the invention typically from a pre-dosing system, a backpack sprayer, a spraying tank, a spraying aircraft, drone or an irrigation system; the compositions of the invention is typically diluted to the desired deployment concentration with water, buffer and/or further auxiliaries, which affords the ready-to-use spray liquid or agrochemical composition of the invention.
  • a pre-dosing system typically a backpack sprayer, a spraying tank, a spraying aircraft, drone or an irrigation system
  • the compositions of the invention is typically diluted to the desired deployment concentration with water, buffer and/or further auxiliaries, which affords the ready-to-use spray liquid or agrochemical composition of the invention.
  • 20 to 2000 liters, preferably 50 to 1000 liters, of the ready-to-use spray liquid are deployed per hectare of useful agricultural area.
  • compositions of the invention are applied mainly by spraying, especially spraying of the leaves.
  • Application can be conducted by spraying techniques known to those skilled in the art, for example using water as carrier and amounts of spray liquid of about 50 to 1000 liters per hectare, for example from 100 to 200 liters per hectare.
  • Tannic acid was further added (0.5 parts) and well diluted in the system.
  • the objective of the trial was to evaluate the phytotoxicity and selectivity of formulation A and Phyton 27 vs market standards in the control of downy mildew in grape.
  • the trial was carried out in on a susceptible variety of wine grape, in the municipality of Ribadumia, Spain.
  • trial protocol included a multiple product spray plan (up to 8 or more applications) throughout the crop growth cycle, 7-10 days apart according to local weather conditions, of the formulation A at 2,5 L/ha, 3 L/ha, 3,5 l/ha and 4 L/ha, with various Bordeaux mix based commercial products (for France: Bouille Bodelaise RSR Disperss, for Italy: Poltiglia Disperss, for Portugal: Caldo Bordoles RSR Disperss) applied at 6 kg/ha as reference standard.
  • the presence of russeting on fruit skin was visually assessed at harvest time or when fruits were fully developed, classifying fruits in 3 classes (A: no visible russeting, B: russeting present but commercially acceptable, C: heavy russeting, fruit depreciated or not commercially acceptable).
  • a filed trail was set up on 2021 in a commercial vineyard located in Italy with the aim to compare the efficacy of the Formulation A and other commercial products with similar characteristics against downy mildew (Plasmopara viticola).
  • the trial was set up as RGB (randomized block design) according to EPPO guidelines.
  • trial protocol included a spray plan with up to 10 applications throughout the crop growth cycle, about 7 days apart according to local weather conditions, of Formulation A at 3,5 L/ha and 4 L/ha and Bordoflow new at 2,6 L/ha and 5 L/ha.
  • Formulation A and the standard Bordoflow new in addition to their recommended label rate, were tested at additional lower rate in terms of metallic copper delivered per ha.
  • Table 3 demonstrate that formulation A shows better efficacy than the commercial product Bordoflow new (SC formulation) on both bunch and leaf. It is shown that formulation A achieves better efficacy than bordoflow new even in lower Copper dose and in lower application rates.

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  • Life Sciences & Earth Sciences (AREA)
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Abstract

La présente invention concerne une nouvelle composition comprenant a) un système tampon ; b) de l'acide tannique et c) un fongicide à base de cuivre. L'invention concerne également un procédé de réduction de la phytotoxicité en appliquant une composition comprenant : a) un système tampon ; b) de l'acide tannique et c) un fongicide à base de cuivre sur un site. L'invention concerne en outre l'utilisation d'un système tampon pour stabiliser une composition liquide d'un fongicide à base de cuivre.
EP21802018.8A 2020-09-16 2021-09-13 Formulation de fongicides à base de cuivre et de bactéricide Pending EP4213629A1 (fr)

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US202063078912P 2020-09-16 2020-09-16
PCT/IL2021/051110 WO2022059002A1 (fr) 2020-09-16 2021-09-13 Formulation de fongicides à base de cuivre et de bactéricide

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DK182194B1 (en) * 2024-06-28 2025-11-13 Michael Stolberg Rohr Method of separating and/or removing haulms, use of the method, apparatus for performing the method, and use of the apparatus

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US4020180A (en) * 1972-02-04 1977-04-26 Mineral Research & Development Corporation Noncorrosive cuprammonia fungicide and method for using same
US4673687A (en) * 1983-04-22 1987-06-16 Source Technology Biologicals, Inc. New chemotherapeutic agents for the control of plant and animal diseases
US4544666A (en) 1983-04-22 1985-10-01 Phyton/Ag, Inc. Chemotherapeutic agents for the control of plant diseases
US20060116313A1 (en) * 2004-11-30 2006-06-01 Denise Geitz Compositions comprising tannic acid as corrosion inhibitor
US20060177519A1 (en) * 2004-12-21 2006-08-10 Hartfeldt Will H Chemotherapeutic agents for the control of plant and animal diseases
US20060178431A1 (en) * 2004-12-21 2006-08-10 Hartfeldt Will H Chemotherapeutic agents for the control of plant and animal diseases
GB0902429D0 (en) * 2009-02-13 2009-04-01 Probe Ind Ltd Compositions and their use
US20170055534A1 (en) * 2015-08-25 2017-03-02 Phyton Corporation Process for treating plants to control bacterial and fungal growth

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