EP4218996B1 - Appareil mélangeur, système mélangeur et procédé pour mélanger des substances dans conteneurs fermés - Google Patents

Appareil mélangeur, système mélangeur et procédé pour mélanger des substances dans conteneurs fermés Download PDF

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Publication number
EP4218996B1
EP4218996B1 EP23159223.9A EP23159223A EP4218996B1 EP 4218996 B1 EP4218996 B1 EP 4218996B1 EP 23159223 A EP23159223 A EP 23159223A EP 4218996 B1 EP4218996 B1 EP 4218996B1
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EP
European Patent Office
Prior art keywords
mixing apparatus
plate
retainer
containers
base plate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP23159223.9A
Other languages
German (de)
English (en)
Other versions
EP4218996A1 (fr
Inventor
Dominic Erb
Philipp RIEDEL
Christian Strebel
Gero FEHR
Klaus LUN
Christoph KARTHAUS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tecan Trading AG
Original Assignee
Tecan Trading AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Publication of EP4218996A1 publication Critical patent/EP4218996A1/fr
Application granted granted Critical
Publication of EP4218996B1 publication Critical patent/EP4218996B1/fr
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B01F31/23—Mixing the contents of independent containers, e.g. test tubes by pivoting the containers about an axis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B01F31/201—Holders therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/22—Control or regulation
    • B01F35/221—Control or regulation of operational parameters, e.g. level of material in the mixer, temperature or pressure
    • B01F35/2214—Speed during the operation
    • B01F35/22142—Speed of the mixing device during the operation
    • B01F35/221422—Speed of rotation of the mixing axis, stirrer or receptacle during the operation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/30—Driving arrangements; Transmissions; Couplings; Brakes
    • B01F35/32—Driving arrangements
    • B01F35/325—Driving reciprocating or oscillating stirrers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/40—Mounting or supporting mixing devices or receptacles; Clamping or holding arrangements therefor
    • B01F35/42—Clamping or holding arrangements for mounting receptacles on mixing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials

Definitions

  • the present invention relates to a mixing apparatus, in particular for mixing substances in closed containers.
  • ampoules can be arranged on a swivel table that can be swiveled by means of a drive.
  • the swivel table comprises individual specific holders for ampoules with different diameters or the swivel table comprises a pattern of fingers that protrude from the table top of the swivel table and between which different ampoules can be arranged, with smaller ampoules rolling back and forth between the fingers when swiveled.
  • a holder for ampoules is mounted on two sides so that it can rotate, and the holder can be pivoted by means of a drive.
  • An ampoule can be inserted into each container receptacle of the holder.
  • One object of the present invention is to provide a mixing apparatus in which the risk of confusion is reduced and in which the insertion and removal of the containers containing substances to be mixed is facilitated.
  • the confusion of containers is to be avoided, particularly in the case of patient samples.
  • a mixing apparatus comprises a drive unit with a drive and with a shaft that can be pivoted about a pivot axis and is operatively connected to the drive, a pivot mount that is arranged on the shaft, the pivot axis being aligned substantially horizontally, the pivot mount comprising a base plate and at least one retainer spaced therefrom, the pivot mount being designed in such a way that holders for containers can be inserted in the direction of the pivot axis between the base plate and the at least one retainer.
  • the drive unit comprises a housing in which an electro-mechanical drive, with or without a gear, is arranged.
  • the drive unit can comprise a belt drive.
  • the swivel mount can be swiveled around the swivel axis by any angle in both directions. This means that the swivel mount can be swiveled back and forth by any angle using the drive unit, for example, or the swivel mount can be rotated around the swivel axis once or several times in one of the two directions of rotation.
  • Powders or fluids such as suspensions or emulsions, can therefore be mixed.
  • whole blood i.e. blood plasma or blood serum
  • the substances to be mixed can be filled into test tubes or ampoules.
  • Ampoules comprise glass or plastic containers that are closed at the top with a lid that includes a septum.
  • the septum comprises a soft plastic, for example made of PTFE or silicone, which can be pierced with a pipette needle or tip.
  • a Lids are screwed onto the open-topped container with a thread.
  • the mixing device comprises a control unit with which the swivel angle, the swivel speed and the swivel direction can be adjusted. By setting these values, an optimal mixture of the substances can be achieved.
  • receptacles are provided on the side of the base plate facing the at least one retainer, which are aligned in the direction of the pivot axis and into which the holders for containers can be inserted.
  • the receptacles comprise elevations which can protrude into complementary recesses in the holders.
  • the elevations are elements which extend directly from the base plate of the swivel receptacle.
  • the elevations can be pins, for example pins with a circular cross-section. However, other cross-sections are also conceivable.
  • the elevations can also be slot nuts, for example for T-slots or dovetail grooves.
  • the receptacles can comprise recesses into which complementary elevations of the holders can protrude and which also form a pin-groove connection or a slot nut-groove connection.
  • the receptacles are arranged one after the other along the pivot axis.
  • the receptacles comprise first receptacles which are arranged in a region of the base plate close to the shaft and second receptacles, which are arranged in an area of the base plate remote from the shaft.
  • the holders can be inserted with a first end in the first receptacle and with a second end in the second receptacle. The position and orientation of each holder are thus clearly and reliably defined.
  • additional mounts can be provided that are aligned with it.
  • the additional mounts give the holders additional support or they allow the insertion of shorter holders that do not extend over the entire length of the swivel mount.
  • receptacles are arranged next to one another in a direction transverse to the pivot axis. This means that several identical or different holders can be inserted next to one another into the pivot receptacle, whereby the contents of several containers can be mixed simultaneously.
  • the receptacles are arranged symmetrically with respect to the pivot axis.
  • the mixing apparatus comprises first spacers, which can be inserted into the receptacles and into which the holders for the containers can be inserted, and second spacers, which are arranged between the receptacles and on which the holders for the containers can rest.
  • the spacers increase the distance between the inserted holders and the base plate of the swivel receptacle. This is advantageous if shorter vessels are to be inserted into the holders and the upper end the vessels used should have essentially the same distance from the base plate as the longer vessels.
  • graduating the thickness of the spacers it is possible to ensure that the upper ends of the common vessels are essentially aligned with one another when they are in the mixer. Different spacers can be arranged on the swivel mount at the same time, which means that different vessels can be arranged in the mixer at the same time and their upper ends are essentially aligned with one another.
  • a drive plate is provided in a first end region of the base plate, which is aligned substantially perpendicular to the base plate and substantially perpendicular to the pivot axis and which connects the shaft to the base plate.
  • the base plate is connected to the at least one retainer through the drive plate.
  • a support element is provided in a second end region of the base plate opposite the first end region, which support element comprises a cylindrical outer surface whose axis is congruent with the pivot axis.
  • the base plate is connected to the at least one retainer by the support element.
  • the support element comprises a plate which is aligned substantially perpendicular to the base plate and the pivot axis.
  • the support element comprises a central opening and the base plate protrudes at least partially through the central opening.
  • At least one connector is provided which connects the drive plate to the support element.
  • the drive plate comprises at least one groove for receiving the at least one retainer.
  • elevations can be provided on the drive plate in which the at least one retainer is held or with which the at least one retainer is guided or clamped.
  • elevations can be ribs or pins.
  • the support element comprises at least one fixing for fastening the at least one retainer.
  • a fixing can comprise an at least partially detachable element.
  • the fixing can be pivotable and can comprise a fixing element.
  • a fixing can also be provided on the drive plate, with which the at least one retainer can be detachably fastened.
  • the mixing apparatus comprises a bearing unit with at least one roller on which the support element is rotatably mounted with the outer surface.
  • the bearing unit is located with respect to the pivoting mount of the Drive unit opposite.
  • the support element is pivotably mounted in the bearing unit, flush with the shaft. Because the pivot mount is mounted on both sides, the corresponding bearings and the pivot mount do not have to be dimensioned as stable, which means that they take up less space and less mass has to be moved.
  • the bearing unit comprises two or more rollers on which the support element is rotatably mounted with the outer surface. At least one of the rollers can be spring-mounted. At least one of the rollers can be driven synchronously with the drive unit.
  • the drive unit and the bearing unit are arranged on a common connecting plate.
  • the connecting plate can be designed to be completely closed or it can comprise at least one recess in the area of the pivot mount.
  • the at least one retainer comprises at least one plate with at least one through-opening, wherein the through-openings are arranged such that, when the holders are inserted, they are aligned with the container receptacles formed in the holders.
  • the inner dimensions of the through openings are smaller than the inner dimensions of the container receptacles of the insertable holders.
  • the inner dimensions of the through opening can also be smaller than the outer dimensions of the lid of the container.
  • the at least one retainer comprises a first plate and a second plate, wherein the distance between the base plate and the first plate is greater than that between the base plate and the second plate.
  • the two plates can be independent of each other or can be connected to each other.
  • the first plate and the second plate are integrally formed together.
  • At least one tab is integrally formed and substantially flush with the at least one plate.
  • At least one rib is formed integrally with the at least one plate, which extends along the pivot axis over at least a portion of the at least one plate.
  • the at least one rib can be formed in one or both lateral edge regions of each plate. Alternatively or additionally, ribs can be arranged between the two edge regions of each plate.
  • At least one tab is formed integrally with the at least one rib and spaced parallel to the at least one plate.
  • the at least one tab can be arranged in one or both of the two free ends of the retainer.
  • the mixing apparatus comprises at least one encoder with which the position of the swivel mount can be determined.
  • the mixing apparatus comprises at least one locking device with which the position of the pivoting mount can be fixed.
  • the mixing apparatus comprises at least one holder for containers, which is inserted between the base plate and the at least one retainer.
  • the at least one holder can additionally be inserted into the receptacles.
  • each holder comprises a plurality of container receptacles arranged along a longitudinal axis, which are formed between the two ends.
  • the container receptacles can, for example, be countersunk holes with a circular cross-section. However, other cross-sections are also possible.
  • Each container receptacle can comprise at least one lateral opening, which extends laterally outwards from the respective container receptacle transversely to the longitudinal axis. The at least one opening can be a slot or a window.
  • Each container receptacle can comprise two lateral openings, which are arranged opposite one another with respect to the longitudinal axis and which, together with the container receptacle, form a passage in the holder.
  • Each container receptacle can therefore be assigned a slot and a window, two slots or two windows.
  • a clamping tab can be provided for each container receptacle, or for each window of the holder, which protrudes through the window into the respective container receptacle, whereby a container received therein can be held in a clamped manner.
  • a tab plate can be provided on the holder. which encompasses all clamping tabs.
  • the clamping tabs can be formed integrally with the rest of the holder.
  • the mentioned designs of the mixing apparatus can be used in any combination, provided they do not contradict each other.
  • a mixing plant according to the invention comprises a machine stand on which a mixing apparatus according to the invention is arranged.
  • the mixing plant can comprise a work surface which is arranged on the machine stand and wherein the mixing apparatus is arranged on the work surface.
  • the mixing system comprises a pipetting unit with which fluids can be added to or removed from containers located in the mixing apparatus.
  • the pipetting unit comprises a transport unit on which pipette tips are arranged and with which the pipette tips can be moved horizontally and/or vertically in an area above the machine stand or above the work surface.
  • the mixing system comprises a reading unit with which markings on the containers to be received by the mixing apparatus can be read.
  • the markings can be selected from the group comprising 1D barcode, 2D barcode, RFID tag and the like.
  • the reading unit can also recognize markings which are attached to the holders for receiving the containers. With The reading unit also shows in which position the container holder has a container and which position is empty. It is also possible to see whether all the container holders inserted into the mixer are completely inserted between the base plate and the retainer.
  • the insertion can be an insertion, for example if the swivel mount comprises cylindrical pins and the holder is provided with corresponding complementary holes.
  • the insertion can also be a pushing in, for example if the swivel mount comprises sliding blocks and the holder is provided with a corresponding complementary groove.
  • fastening elements that fix the retaining element in the corresponding receptacles can be removed and the retaining element can then be lifted off and placed in another location independently of the mixing device.
  • the retaining element can be pushed linearly away from the area above the swivel mount using a sliding mechanism.
  • the retaining element can be pivoted away from the area above the swivel mount in a plane using a twisting mechanism. If the retaining element is fixed to the swivel mount, then the holder under the retaining element must be pushed into the swivel mount, for example along the swivel axis.
  • the contents of a mother tube which contains whole blood, for example, can be mixed on its own or with additional substances.
  • part of the whole blood can be pipetted from the mother tube to a daughter tube.
  • the daughter tube can be empty beforehand or can contain a substance, such as a reagent.
  • the contents of the daughter tube can then be mixed again.
  • the holder with the containers arranged in it can be removed from the mixing device and fed into an analysis device.
  • To remove and/or add fluids from containers that are closed by a lid that includes a septum it is necessary to pierce the septum, for example with a pipette needle.
  • the Figure 1 shows a perspective view of a mixing apparatus 100 according to the invention.
  • the mixing apparatus 100 comprises a drive unit 1 with a drive 10, a control unit 12 and with a shaft 11 which can be pivoted about a substantially horizontal pivot axis A and which is operatively connected to the drive 10.
  • the mixing apparatus 100 further comprises a pivot mount 2 which is arranged on the shaft 11.
  • the pivot mount 2 comprises a base plate 20 and a retainer 4 spaced therefrom, the pivot mount 2 being designed such that holders 3 for containers can be inserted in the direction of the pivot axis A between the base plate 20 and the retainer 4.
  • a circular disk-shaped drive plate 21 connects the shaft 11 to the base plate 20.
  • the drive plate 21 is essentially perpendicular to the swivel base A and essentially perpendicular to the base plate 20.
  • a circular disk-shaped support plate 22 is provided, which is aligned parallel and flush with the drive plate 21.
  • the outer diameters of the two circular disks are essentially identical.
  • the retainer 4 in this embodiment a retaining plate with holes, is detachably arranged between the drive plate 21 and the support plate 22.
  • the retainer 4 can be fixed with a pivotable fixation 211 and in the Support plate 22 with a pivotable fixation 222.
  • elevations 200 in the form of sliding blocks are provided on the base plate 20, on the side facing the retainer 4, elevations 200 in the form of sliding blocks are provided.
  • a reading unit 82 with a limiter 83 is provided on the side of the support plate 22 opposite the drive side.
  • the reading unit 82 can be used to read markings on the holder 3 and/or on the containers arranged in the holder 3.
  • the support plate 22 is supported on two rollers 50 of a bearing unit 5 and is rotatably mounted.
  • the drive unit 1, the bearing unit 5, the reading unit 82 and the limiter 83 are arranged on a common connecting plate 6.
  • the Figure 2 shows the mixing apparatus 100 of the Figure 1 without the housing and the drive 10 of the drive unit 1, without the retainer 4, without the reading unit 82 and without the limiter 83.
  • the drive plate 21 and the support plate 22 are connected to one another by two rod-shaped connectors 23.
  • the connectors 23 are designed and arranged such that the retainer 4 can rest evenly on both connectors 23 when installed.
  • a pattern of T-slot nuts 200 is arranged on the base plate 20 of the pivot mount 2.
  • a double row of T-slot nuts is arranged in both end regions of the base plate 20 and a single row in a central region of the base plate 20.
  • Containers 7 are arranged in the inserted holder 3; sample tubes with a pierceable lid are shown, ie with a lid with a pierceable septum.
  • the Figure 3A shows the retainer 4 of the Figure 1 .
  • the retainer 4 comprises a bent sheet with holes 40, with two first plates 41, or with two edge plates 41 and with a second plate 42, or with a central plate 42.
  • the two edge plates 41 are flush with one another and the central plate 42 is parallel to the two edge plates 41.
  • Continuous tabs 43 are provided on the two free ends of the retainer 4, which are flush with the corresponding plates.
  • Ribs 44 extend essentially along the entire length of the retainer on the lateral outer boundary of the respective edge plate 41. Due to the one-piece design of the retainer 4, the offset of the first plate 41 to the second plate 42 creates a rib 44 in each transition area.
  • the Figure 3B shows an alternative embodiment of the retainer 4 of the Figure 1 with only a first plate 41 and a second plate 42.
  • Separate tabs 43 are provided, which are arranged only at one of the two free ends of the retainer.
  • only one rib 44 is formed in the transition area between the two plates 41, 42.
  • the Figure 3C shows a sectional view of the mixing apparatus 100 of the Figure 1 transverse to the axis A, by a high container 7 and by a low container 70.
  • the high container 7 is inserted between the base plate 20 and the first plate 41 of the retainer 4 and the low Container 70 between the base plate 20 and the second plate 42 of the retainer 4.
  • the Figure 4 shows a perspective view of a second embodiment of a swivel mount 2 with an alternative retainer 400.
  • Grooves 210 are provided in the drive plate 21, into which the retainers 400 can be inserted.
  • a fixation 222 is provided on the support plate 22, with which the retainers 400 can be detachably fastened.
  • the connectors 23 are designed as laterally arranged round rods.
  • a central opening 221 is provided in the support plate 22, through which the base plate 20 protrudes and through which the holders for containers can be inserted.
  • holders with high containers can be inserted into the retainers 400. If deeper containers are to be inserted, the retainers 400 must be rotated by 180 degrees so that the outward-facing surface of the plate 401 faces the base plate 20 and that the open end of the retainer 400 faces the drive plate 21.
  • the Figure 5 shows a perspective bottom view of the retainer 400 of the Figure 4 .
  • the retainer 400 comprises a plate 401 with a slot 402 which extends substantially over the entire length of the plate.
  • the width of the slot 402 is smaller than the external dimensions of the container closures and is larger than the piercing area of the container closures.
  • ribs 403 extend over substantially the entire length of the Retainer 400.
  • a first free end of the retainer 400 is open and a second free end opposite the first free end is laterally closed.
  • a first tab 404 is provided at the open end of the retainer 400, which is parallel and slightly offset to the plate 401 in the region of the plate 401 and protrudes beyond the latter at the first free end of the retainer 400.
  • a second tab 405 is provided at the closed end of the retainer 400, which is parallel and slightly offset to the ribs 403 in the region of the ribs and protrudes beyond the latter at the second free end of the retainer.
  • the Figure 6 shows a holder with containers inserted into it as in the Figure 2 .
  • the holder 3 extends along the longitudinal axis L, has container receptacles 32 which comprise two lateral slots 320 and has clamping tabs 322 which are formed integrally with the rest of the holder 3 and which protrude into the interior of the container receptacles 32.
  • the holder 3 comprises a groove 33 which is arranged on the underside of the holder 3, i.e. on the side of the holder 3 which is opposite the container receptacles 32.
  • a T-slot is shown.
  • a dovetail groove or another retaining groove can also be provided.
  • the groove 33 extends along the longitudinal axis L, at least over the area of the holder 3 which comprises the container receptacles 32.
  • the groove 33 is open at the first end 30 of the holder 3 so that the elevations 200 of the pivot receptacle 2 can be easily inserted into the groove 33.
  • a handle 34 is arranged, with by which the holder 3 can be easily grasped by hand.
  • a recess 340 is provided in the handle 34, which enables the reading unit 82 to recognize that the holder 3 is completely inserted into the pivoting receptacle 2.
  • the Figure 7 shows a perspective view of a mixing system with a mixing apparatus 100 according to the invention, which is pivoted and a non-pivoted mixing apparatus 100. Both apparatuses are arranged with receiving elements 800 on the work surface 80, which are arranged on the machine stand 8.
  • the mixing system further comprises the pipetting unit 81 with the transport unit 810 and the pipette tips 811.
  • the transport unit 810 can move the pipette tips 811 over the work surface 80 in a first horizontal direction X, in a second horizontal direction Y and in a vertical direction Z.
  • the reading unit 82 and the limiter 83 are arranged next to the mixing devices 100 on the work surface 80.
  • the reading unit 82 is also aligned and fastened with the receiving elements 800 on the work surface 80. In front of the reading unit 82, holders can be pushed over the receiving elements 800 in order to recognize the markings on the holders 3 and/or on the containers arranged in the holders 3.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Accessories For Mixers (AREA)

Claims (18)

  1. Un appareil de mélange (100) comprenant :
    une unité d'entraînement (1) pourvue d'un entraînement (10) et d'une tige (11) pouvant pivoter autour d'un axe de pivotement (A) orienté de façon sensiblement horizontale, laquelle tige étant en liaison active avec l'entraînement (10),
    un logement pivotant (2) disposé sur la tige (11),
    le logement pivotant (2) comprenant une plaque de base (20) et au moins un dispositif de retenue (4,400) espacé de celle-ci, le logement pivotant (2) étant conçu de telle sorte qu'il est possible d'introduire des supports (3) pour des récipients (7,70) dans le sens de l'axe de pivotement (A) entre la plaque de base (20) et le au moins un dispositif de retenue (4,400),
    dans lequel le au moins un dispositif de retenue (4,400) comprend au moins une plaque (41;401,42) avec au moins une ouverture de passage (40;402), les ouvertures de passage (40;402) étant disposées de telle sorte qu'elles sont, lorsque les supports (3) sont insérés, alignées avec les logements de récipients (32) formés dans les supports (3),
    dans lequel le au moins un dispositif de retenue (4) comprend une première plaque (41) et une deuxième plaque (42), la distance entre la plaque de base (20) et la première plaque (41) étant supérieure à la distance entre la plaque de base (20) et la deuxième plaque (42).
  2. L'appareil de mélange (100) selon la revendication 1, comprenant une unité de commande (12) permettant de régler l'angle de pivotement, la vitesse de pivotement et le sens de pivotement, le logement pivotant (2) pouvant être pivoté autour de l'axe de pivotement (A) dans les deux sens et selon n'importe quel angle.
  3. L'appareil de mélange (100) selon l'une des revendications précédentes, dans lequel il est prévu sur le côté de la plaque de base (2) orienté à l'opposé du au moins un dispositif de retenue (4,400) des logements (200) qui sont orientés dans le sens de l'axe de pivotement (A) et dans lesquels il est possible d'introduire les supports (3) pour des récipients (7).
  4. L'appareil de mélange (100) selon l'une des revendications précédentes, dans lequel la plaque de base (20) est reliée au moins un dispositif de retenue (4,400) par le biais de la plaque d'entraînement (21).
  5. L'appareil de mélange (100) selon la revendication 1, dans lequel la plaque de base (20) est reliée au moins un dispositif de retenue (4,400) par l'élément d'appui (22), l'élément d'appui (22) comprenant une plaque qui est orientée de façon sensiblement perpendiculaire à la plaque de base (20) et à l'axe de pivotement (A), l'élément d'appui (22) comprenant une ouverture centrale (221) et la plaque de base (20) faisant saillie au moins partiellement à travers l'ouverture centrale (221).
  6. L'appareil de mélange (100) selon la revendication 1 ou 5, dans lequel il est prévu au moins un connecteur (23) qui raccorde la plaque d'entraînement (21) à l'élément d'appui (22).
  7. L'appareil de mélange (100) selon l'une des revendications 1 ou 4 à 6, dans lequel la plaque d'entraînement (21) comprend au moins une encoche (210) pour recevoir le au moins un dispositif de retenue (4,400).
  8. L'appareil de mélange (100) selon l'une des revendications 1 ou 5 à 7, dans lequel l'élément d'appui (22) comprend au moins une fixation (222) pour fixer le au moins un dispositif de retenue (4,400).
  9. L'appareil de mélange (100) selon la revendication 1, dans lequel les dimensions intérieures des trous de passage (40;402) sont inférieures aux dimensions intérieures des récipients (32) des supports insérables (3).
  10. L'appareil de mélange (100) selon la revendication 1 ou 9, dans lequel au moins une languette (43;404) est formée conjointement avec au moins une plaque (41;401,42).
  11. L'appareil de mélange (100) selon l'une des revendications 1 à 10, dans lequel au moins une nervure (44;403) est formée conjointement avec l'au moins une plaque (41;401,42), qui s'étend le long de l'axe de pivotement (A) sur au moins une partie de l'au moins une plaque (41;401,42).
  12. L'appareil de mélange (100) selon la revendication 11, dans lequel au moins une languette (405) est formée conjointement avec l'au moins une nervure (403) et espacée parallèlement à l'au moins une plaque (401).
  13. L'appareil de mélange (100) selon l'une des revendications précédentes, comprenant au moins un support (3) pour les récipients (7,70), lequel support est introduit entre la plaque de base (20) et le au moins un dispositif de retenue (4,400).
  14. Un système mélangeur comprenant :
    un support de machine (8) sur lequel est agencé un appareil de mélange (100) selon l'une des revendications 1 à 13, comprenant une unité de pipetage (81) permettant d'introduire ou de prélever du fluide dans les récipients (7,70) se trouvant dans l'appareil de mélange (100), l'unité de pipetage (81) comprenant une unité de transport (810) sur laquelle sont disposés des embouts de pipette (811) et qui permet de déplacer les embouts de pipette (811) à l'horizontal et/ou à la verticale dans une zone au-dessus du support de machine (8) ou au-dessus de la surface de travail (80).
  15. Le système de mélangeur selon la revendication 14, comprenant une unité de lecture (82) disposée sur le support de machine (8) ou sur la plaque de liaison (6) de l'appareil de mélange (100) et qui permet de lire les marquages des récipients (7,70) devant être pris par l'appareil de mélange (100) et/ou des supports (3) devant être pris par l'appareil de mélange (100).
  16. Un procédé pour faire fonctionner un appareil de mélange (100) ou un système mélangeur, comprenant les étapes consistant à :
    - fournir un appareil de mélange (100) selon l'une des revendications 1 à 13 ;
    - introduire un support (3) avec à l'intérieur des récipients (7,70) disposés entre la plaque de base (20) et le au moins un dispositif de retenue (4,400) dans le sens de l'axe de pivotement (A) ; et
    - faire pivoter le logement pivotant (2) autour de l'axe de pivotement (A) grâce à l'unité d'entraînement (1).
  17. Le procédé selon la revendication 16, comprenant l'étape consistant à :
    - lire les marquages d'un support (3) et/ou des récipients (7,70) disposés dans un support (3) à l'aide de l'unité de lecture (82) avant ou pendant l'introduction du support (3).
  18. Le procédé selon la revendication 16 ou 17, comprenant au moins une des étapes suivantes consistant à :
    - prélever, à l'aide de l'unité de pipetage (81), des fluides des récipients (7,70) se trouvant dans l'appareil de mélange (100) après avoir fait pivoter le logement pivotant (2) ;
    - introduire des fluides, à l'aide de l'unité de pipetage (81), dans les récipients (7, 70) se trouvant dans l'appareil de mélange (100) avant de faire pivoter le logement pivotant (2).
EP23159223.9A 2018-07-25 2019-07-24 Appareil mélangeur, système mélangeur et procédé pour mélanger des substances dans conteneurs fermés Active EP4218996B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18185420.9A EP3599013A1 (fr) 2018-07-25 2018-07-25 Appareil de mélange
PCT/EP2019/069871 WO2020020923A1 (fr) 2018-07-25 2019-07-24 Appareil mélangeur, installation de mélange et procédé pour le mélange de substances dans des contenants fermés
EP19742060.7A EP3826757B1 (fr) 2018-07-25 2019-07-24 Appareil de mélange

Related Parent Applications (2)

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EP19742060.7A Division EP3826757B1 (fr) 2018-07-25 2019-07-24 Appareil de mélange
EP19742060.7A Division-Into EP3826757B1 (fr) 2018-07-25 2019-07-24 Appareil de mélange

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EP4218996A1 EP4218996A1 (fr) 2023-08-02
EP4218996B1 true EP4218996B1 (fr) 2024-07-31

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EP21191494.0A Active EP3932532B1 (fr) 2018-07-25 2018-07-25 Appareil de mélange, installation de mélange et procédé de mélange de substances dans des récipients fermés
EP18185420.9A Withdrawn EP3599013A1 (fr) 2018-07-25 2018-07-25 Appareil de mélange
EP23159223.9A Active EP4218996B1 (fr) 2018-07-25 2019-07-24 Appareil mélangeur, système mélangeur et procédé pour mélanger des substances dans conteneurs fermés
EP19742060.7A Active EP3826757B1 (fr) 2018-07-25 2019-07-24 Appareil de mélange

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EP21191494.0A Active EP3932532B1 (fr) 2018-07-25 2018-07-25 Appareil de mélange, installation de mélange et procédé de mélange de substances dans des récipients fermés
EP18185420.9A Withdrawn EP3599013A1 (fr) 2018-07-25 2018-07-25 Appareil de mélange

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US (2) US11969700B2 (fr)
EP (4) EP3932532B1 (fr)
CN (2) CN116550196A (fr)
WO (1) WO2020020923A1 (fr)

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Also Published As

Publication number Publication date
US12370512B2 (en) 2025-07-29
CN116550196A (zh) 2023-08-08
US11969700B2 (en) 2024-04-30
EP3932532A1 (fr) 2022-01-05
CN112469496A (zh) 2021-03-09
WO2020020923A1 (fr) 2020-01-30
EP3826757A1 (fr) 2021-06-02
EP4218996A1 (fr) 2023-08-02
EP3826757B1 (fr) 2023-04-26
US20210260541A1 (en) 2021-08-26
EP3599013A1 (fr) 2020-01-29
EP3932532B1 (fr) 2026-03-18
CN112469496B (zh) 2023-06-16
US20240252997A1 (en) 2024-08-01

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