EP4221689A4 - FORMULATIONS OF BOSENTAN MONOHYDRATE-LOADED SELF-ANOEMULGATING ACTIVE INGREDIENT RELEASE SYSTEMS (SEDDS) WITH LONG-CHAIN MONO- AND DIGLYCERIDE MIXTURES - Google Patents

FORMULATIONS OF BOSENTAN MONOHYDRATE-LOADED SELF-ANOEMULGATING ACTIVE INGREDIENT RELEASE SYSTEMS (SEDDS) WITH LONG-CHAIN MONO- AND DIGLYCERIDE MIXTURES Download PDF

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Publication number
EP4221689A4
EP4221689A4 EP21895278.6A EP21895278A EP4221689A4 EP 4221689 A4 EP4221689 A4 EP 4221689A4 EP 21895278 A EP21895278 A EP 21895278A EP 4221689 A4 EP4221689 A4 EP 4221689A4
Authority
EP
European Patent Office
Prior art keywords
anoemulgating
sedds
formulations
long
active ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21895278.6A
Other languages
German (de)
French (fr)
Other versions
EP4221689A1 (en
Inventor
Zeynep Safak TEKSIN
Duygu YILMAZ USTA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gazi Universitesi
Original Assignee
Gazi Universitesi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gazi Universitesi filed Critical Gazi Universitesi
Publication of EP4221689A1 publication Critical patent/EP4221689A1/en
Publication of EP4221689A4 publication Critical patent/EP4221689A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP21895278.6A 2020-11-23 2021-11-22 FORMULATIONS OF BOSENTAN MONOHYDRATE-LOADED SELF-ANOEMULGATING ACTIVE INGREDIENT RELEASE SYSTEMS (SEDDS) WITH LONG-CHAIN MONO- AND DIGLYCERIDE MIXTURES Pending EP4221689A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2020/18841A TR202018841A2 (en) 2020-11-23 2020-11-23 FORMULATION OF BOSENTAN MONOHYDRATE LOADED SELF-NANOEMULSIFIED DRUG CARRIER SYSTEMS (SNEDDS) PREPARED WITH LONG-CHAIN MONO AND DIGLYCERIDE MIXTURES
PCT/TR2021/051258 WO2022108572A1 (en) 2020-11-23 2021-11-22 Formulations of bosentan monohydrate loaded self-nanoemulsifying drug delivery systems (snedds) prepared with long-chain mono and diglyceride mixtures

Publications (2)

Publication Number Publication Date
EP4221689A1 EP4221689A1 (en) 2023-08-09
EP4221689A4 true EP4221689A4 (en) 2024-11-13

Family

ID=75576062

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21895278.6A Pending EP4221689A4 (en) 2020-11-23 2021-11-22 FORMULATIONS OF BOSENTAN MONOHYDRATE-LOADED SELF-ANOEMULGATING ACTIVE INGREDIENT RELEASE SYSTEMS (SEDDS) WITH LONG-CHAIN MONO- AND DIGLYCERIDE MIXTURES

Country Status (3)

Country Link
EP (1) EP4221689A4 (en)
TR (1) TR202018841A2 (en)
WO (1) WO2022108572A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021076081A2 (en) * 2019-10-14 2021-04-22 Teksin Zeynep Safak Bosentan monohydrate loaded liquid self nanoemulsifying drug carrier system and tablet formulation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009095933A2 (en) * 2008-01-10 2009-08-06 Msn Laboratories Limited Improved and novel process for the preparation of bosentan
KR101058860B1 (en) * 2008-10-20 2011-08-23 조선대학교산학협력단 Self-emulsifying nanoemulsion composition of poorly soluble drug using hydrogenated coco-glyceride
EP2696857A1 (en) * 2011-04-11 2014-02-19 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical composition comprising bosentan

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021076081A2 (en) * 2019-10-14 2021-04-22 Teksin Zeynep Safak Bosentan monohydrate loaded liquid self nanoemulsifying drug carrier system and tablet formulation

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GUNNAM SAILAJA ET AL: "Formulation and Evaluation of Self-emulsifying Drug Delivery System of Bosentan", ASIAN JOURNAL OF PHARMACEUTICS 12(2), 1 June 2018 (2018-06-01), pages S822 - S833, XP093211579, Retrieved from the Internet <URL:http://asiapharmaceutics.info/index.php/ajp/article/view/2674/1023> [retrieved on 20241003] *
PANIGRAHI KAHNU CHARAN ET AL: "QBD-based systematic development of Bosentan SNEDDS: Formulation, characterization and pharmacokinetic assessment", JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, vol. 47, 1 October 2018 (2018-10-01), FR, pages 31 - 42, XP093087747, ISSN: 1773-2247, DOI: 10.1016/j.jddst.2018.06.021 *
See also references of WO2022108572A1 *
VADLAMUDI HARINI CHOWDARY ET AL: "In vitro characterization studies of self-microemulsified bosentan systems", JOURNAL DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol. 43, no. 6, 16 February 2017 (2017-02-16), US, pages 989 - 995, XP093087862, ISSN: 0363-9045, DOI: 10.1080/03639045.2017.1287720 *

Also Published As

Publication number Publication date
WO2022108572A1 (en) 2022-05-27
EP4221689A1 (en) 2023-08-09
TR202018841A2 (en) 2021-01-21

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