EP4226153A4 - MARKER FOR EARLY DETECTION OF PROLIFERATIVE DISORDERS OF COLON CELLS - Google Patents

MARKER FOR EARLY DETECTION OF PROLIFERATIVE DISORDERS OF COLON CELLS

Info

Publication number
EP4226153A4
EP4226153A4 EP21878257.1A EP21878257A EP4226153A4 EP 4226153 A4 EP4226153 A4 EP 4226153A4 EP 21878257 A EP21878257 A EP 21878257A EP 4226153 A4 EP4226153 A4 EP 4226153A4
Authority
EP
European Patent Office
Prior art keywords
marker
early detection
proliferative disorders
colon cells
colon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21878257.1A
Other languages
German (de)
French (fr)
Other versions
EP4226153A1 (en
Inventor
Brian D. O'DONOVAN
Shivani MAHAJAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Freenome Holdings Inc
Original Assignee
Freenome Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Freenome Holdings Inc filed Critical Freenome Holdings Inc
Publication of EP4226153A1 publication Critical patent/EP4226153A1/en
Publication of EP4226153A4 publication Critical patent/EP4226153A4/en
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57535—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the large intestine, e.g. colon, rectum or anus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Library & Information Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP21878257.1A 2020-10-05 2021-09-30 MARKER FOR EARLY DETECTION OF PROLIFERATIVE DISORDERS OF COLON CELLS Pending EP4226153A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063087728P 2020-10-05 2020-10-05
PCT/US2021/052816 WO2022076237A1 (en) 2020-10-05 2021-09-30 Markers for the early detection of colon cell proliferative disorders

Publications (2)

Publication Number Publication Date
EP4226153A1 EP4226153A1 (en) 2023-08-16
EP4226153A4 true EP4226153A4 (en) 2025-03-19

Family

ID=81126715

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21878257.1A Pending EP4226153A4 (en) 2020-10-05 2021-09-30 MARKER FOR EARLY DETECTION OF PROLIFERATIVE DISORDERS OF COLON CELLS

Country Status (8)

Country Link
US (2) US12372528B2 (en)
EP (1) EP4226153A4 (en)
JP (1) JP2023545012A (en)
KR (1) KR20230079198A (en)
CN (1) CN116670510A (en)
AU (1) AU2021358002A1 (en)
CA (1) CA3194607A1 (en)
WO (1) WO2022076237A1 (en)

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WO2019060716A1 (en) 2017-09-25 2019-03-28 Freenome Holdings, Inc. Methods and systems for sample extraction
AU2020283042B2 (en) 2019-05-31 2026-02-19 Freenome Holdings, Inc. Methods and systems for high-depth sequencing of methylated nucleic acid
CA3178302A1 (en) 2020-03-31 2021-10-07 Freenome Holdings, Inc. Methods and systems for detecting colorectal cancer via nucleic acid methylation analysis
WO2022076237A1 (en) 2020-10-05 2022-04-14 Freenome Holdings, Inc. Markers for the early detection of colon cell proliferative disorders
AU2021409465A1 (en) 2020-12-21 2023-08-03 Freenome Holdings, Inc. Markers for the early detection of colon cell proliferative disorders
CA3257890A1 (en) * 2022-06-03 2023-12-07 Freenome Holdings, Inc. Markers for the early detection of colon cell proliferative disorders
JP2024064128A (en) * 2022-10-27 2024-05-14 チューニングフォーク・バイオ・インク Antigen discovery method and antigen discovery system

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GB2494741A (en) * 2011-06-27 2013-03-20 Ambergen Inc Detecting autoantibodies to MAP4K4, IGFBP3, p53 and IGFBP2 in colorectal cancer patients
US20130072400A1 (en) * 2010-05-13 2013-03-21 Consejo Superior De Investigaciones Cientificas Method for the diagnosis/prognosis of colorectal cancer
EP3193173A1 (en) * 2016-01-14 2017-07-19 Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts Serological autoantibodies as biomarker for colorectal cancer
US20190204324A1 (en) * 2015-07-10 2019-07-04 Korea Research Institute Of Bioscience And Biotechnology Antigenic composition for detecting auto-antibody with specific response to exosomal protein eif3a, and method for diagnosing liver cancer using antigenic composition
US20200116722A1 (en) * 2017-05-22 2020-04-16 Edith Cowan University Biomarkers of disease

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US7270960B2 (en) 2001-08-29 2007-09-18 Pacific Northwest Research Institute Diagnosis of ovarian carcinomas
US7727720B2 (en) 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
ES2393318T3 (en) 2005-06-23 2012-12-20 Keygene N.V. Strategies for the identification and detection of high performance polymorphisms
US7754429B2 (en) 2006-10-06 2010-07-13 Illumina Cambridge Limited Method for pair-wise sequencing a plurity of target polynucleotides
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WO2019100024A1 (en) 2017-11-20 2019-05-23 Freenome Holdings, Inc. Methods for reduction in required material for shotgun sequencing
WO2019147663A1 (en) 2018-01-24 2019-08-01 Freenome Holdings, Inc. Methods and systems for abnormality detection in the patterns of nucleic acids
EP3785269A4 (en) 2018-03-29 2021-12-29 Freenome Holdings, Inc. Methods and systems for analyzing microbiota
CN119753091A (en) 2018-04-02 2025-04-04 格里尔公司 Assay plate for amplifying cfDNA molecules associated with cancer
JP7455757B2 (en) * 2018-04-13 2024-03-26 フリーノーム・ホールディングス・インコーポレイテッド Machine learning implementation for multianalyte assay of biological samples
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WO2022076237A1 (en) 2020-10-05 2022-04-14 Freenome Holdings, Inc. Markers for the early detection of colon cell proliferative disorders
AU2021409465A1 (en) 2020-12-21 2023-08-03 Freenome Holdings, Inc. Markers for the early detection of colon cell proliferative disorders
WO2022204358A1 (en) 2021-03-26 2022-09-29 Freenome Holdings, Inc. Methods and systems for detecting cancer via nucleic acid methylation analysis
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JP2024528704A (en) 2021-07-20 2024-07-30 フリーノム ホールディングス，インク． Compositions and methods for improved resolution of 5-hydroxymethylated cytosine in nucleic acid sequencing
WO2023147472A1 (en) 2022-01-28 2023-08-03 Freenome Holdings, Inc. Methods and systems for risk stratification of colorectal cancer
EP4499877A4 (en) 2022-03-25 2026-04-08 Freenome Holdings Inc TCR/BCR Profiling for Cell-Free Nucleic Acid Detection of Cancer
CA3257890A1 (en) 2022-06-03 2023-12-07 Freenome Holdings, Inc. Markers for the early detection of colon cell proliferative disorders
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CN120167013A (en) 2022-06-23 2025-06-17 福瑞诺姆控股公司 Methods and compositions for enriching nucleic acid molecules for sequencing

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* Cited by examiner, † Cited by third party
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EP2444811A1 (en) * 2009-05-25 2012-04-25 Consejo Superior de Investigaciones Cientificas (CSIC) Methods for the diagnosis or prognosis of colorectal cancer
US20130072400A1 (en) * 2010-05-13 2013-03-21 Consejo Superior De Investigaciones Cientificas Method for the diagnosis/prognosis of colorectal cancer
GB2494741A (en) * 2011-06-27 2013-03-20 Ambergen Inc Detecting autoantibodies to MAP4K4, IGFBP3, p53 and IGFBP2 in colorectal cancer patients
US20190204324A1 (en) * 2015-07-10 2019-07-04 Korea Research Institute Of Bioscience And Biotechnology Antigenic composition for detecting auto-antibody with specific response to exosomal protein eif3a, and method for diagnosing liver cancer using antigenic composition
EP3193173A1 (en) * 2016-01-14 2017-07-19 Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts Serological autoantibodies as biomarker for colorectal cancer
US20200116722A1 (en) * 2017-05-22 2020-04-16 Edith Cowan University Biomarkers of disease

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Title
See also references of WO2022076237A1 *

Also Published As

Publication number Publication date
CN116670510A (en) 2023-08-29
EP4226153A1 (en) 2023-08-16
JP2023545012A (en) 2023-10-26
US20250369972A1 (en) 2025-12-04
US20230243830A1 (en) 2023-08-03
CA3194607A1 (en) 2022-04-14
WO2022076237A1 (en) 2022-04-14
US12372528B2 (en) 2025-07-29
KR20230079198A (en) 2023-06-05
AU2021358002A1 (en) 2023-06-08

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