EP4393934A4 - Process for the preparation of a cytidine 5'-diphosphate compound - Google Patents

Process for the preparation of a cytidine 5'-diphosphate compound

Info

Publication number
EP4393934A4
EP4393934A4 EP22861466.5A EP22861466A EP4393934A4 EP 4393934 A4 EP4393934 A4 EP 4393934A4 EP 22861466 A EP22861466 A EP 22861466A EP 4393934 A4 EP4393934 A4 EP 4393934A4
Authority
EP
European Patent Office
Prior art keywords
cytidine
preparation
diphosphate compound
diphosphate
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP22861466.5A
Other languages
German (de)
French (fr)
Other versions
EP4393934A1 (en
Inventor
Takumi Miyazaki
Kazunari Fukumoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyowa Hakko Bio Co Ltd
Original Assignee
Kyowa Hakko Bio Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Bio Co Ltd filed Critical Kyowa Hakko Bio Co Ltd
Publication of EP4393934A1 publication Critical patent/EP4393934A1/en
Publication of EP4393934A4 publication Critical patent/EP4393934A4/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
EP22861466.5A 2021-08-26 2022-08-26 Process for the preparation of a cytidine 5'-diphosphate compound Pending EP4393934A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/JP2021/031429 WO2023026449A1 (en) 2021-08-26 2021-08-26 Method for producing cytidine 5'-diphosphate compound
PCT/JP2022/032235 WO2023027178A1 (en) 2021-08-26 2022-08-26 Method for producing cytidine-5'-diphosphate compound

Publications (2)

Publication Number Publication Date
EP4393934A1 EP4393934A1 (en) 2024-07-03
EP4393934A4 true EP4393934A4 (en) 2025-08-27

Family

ID=85322541

Family Applications (1)

Application Number Title Priority Date Filing Date
EP22861466.5A Pending EP4393934A4 (en) 2021-08-26 2022-08-26 Process for the preparation of a cytidine 5'-diphosphate compound

Country Status (8)

Country Link
US (1) US20250215036A1 (en)
EP (1) EP4393934A4 (en)
JP (1) JPWO2023027178A1 (en)
KR (1) KR20240036673A (en)
CN (1) CN117881685A (en)
AU (1) AU2022333819B2 (en)
CA (1) CA3230006A1 (en)
WO (2) WO2023026449A1 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4886869A (en) * 1972-02-23 1973-11-15
CN101096380B (en) * 2007-05-10 2010-11-03 南通秋之友生物科技有限公司 Method for purifying citicoline from biotransformation or multienzyme reaction liquid
CN104592335A (en) * 2014-12-24 2015-05-06 江西科技师范大学 Method for synthesizing nucleoside diphosphonic acid choline sodium salts
CN103819522B (en) * 2014-02-27 2015-09-09 江南大学 A kind of method of purifying citicoline in her Sa yeast bio conversion fluid eastwardly

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0631306B2 (en) * 1985-07-12 1994-04-27 武田薬品工業株式会社 Process for producing crystals of cytidine-5'-choline diphosphate monohydrate
IT1229238B (en) * 1989-05-08 1991-07-26 Istituto Chemioterapico PROCEDURE FOR THE PREPARATION OF L-ALPHA-GLYCERYLPHOSPHORYLCHOLINE AND ALPHA-GLYCERYLPHOSPHORYLETHANOLAMINE.
JP3369236B2 (en) 1992-01-30 2003-01-20 協和醗酵工業株式会社 Method for producing choline cytidine diphosphate
JP3097326B2 (en) 1992-06-11 2000-10-10 石川島播磨重工業株式会社 Horizontal rolling mill
JP2917755B2 (en) 1993-07-02 1999-07-12 株式会社大林組 How to dismantle underground structures
JPWO2007105789A1 (en) * 2006-03-15 2009-07-30 協和発酵バイオ株式会社 Methods for purifying nucleosides and nucleotides
CN101130797A (en) 2007-08-01 2008-02-27 张剑 Ubelin manufacturing technique
CN101538300B (en) * 2008-03-19 2011-11-30 南京工业大学 Salting-out and dissolution crystallization method of citicoline
KR101130797B1 (en) 2011-10-04 2012-03-28 (주)대한과학 Door apparatus for autoclave

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4886869A (en) * 1972-02-23 1973-11-15
CN101096380B (en) * 2007-05-10 2010-11-03 南通秋之友生物科技有限公司 Method for purifying citicoline from biotransformation or multienzyme reaction liquid
CN103819522B (en) * 2014-02-27 2015-09-09 江南大学 A kind of method of purifying citicoline in her Sa yeast bio conversion fluid eastwardly
CN104592335A (en) * 2014-12-24 2015-05-06 江西科技师范大学 Method for synthesizing nucleoside diphosphonic acid choline sodium salts

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FLORIDI A. ET AL: "Analysis by High Performance Liquid Chromatography of The Water-Soluble Precursors of Choline and Ethanolamine Phosphoglycerides in the Rat Brain", JOURNAL OF LIQUID CHROMATOGRAPHY, vol. 2, no. 9, 1 January 1979 (1979-01-01), US, pages 1375 - 1392, XP093296814, ISSN: 0148-3919, DOI: 10.1080/01483917908060144 *
KAITARANTA J K ET AL: "Elsevier Scientific Publishing Company, Amsterdam -Printed in The Netherlands", 15 October 1980 (1980-10-15), XP093296802, Retrieved from the Internet <URL:https://www.sciencedirect.com/science/article/pii/S0021967300825431> *
See also references of WO2023027178A1 *

Also Published As

Publication number Publication date
WO2023027178A1 (en) 2023-03-02
KR20240036673A (en) 2024-03-20
AU2022333819B2 (en) 2025-04-17
WO2023026449A1 (en) 2023-03-02
CN117881685A (en) 2024-04-12
CA3230006A1 (en) 2023-03-02
EP4393934A1 (en) 2024-07-03
AU2022333819A1 (en) 2024-03-14
US20250215036A1 (en) 2025-07-03
JPWO2023027178A1 (en) 2023-03-02

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Ipc: C07H 19/10 20060101AFI20250721BHEP