ES2019025A6 - Procedimiento para preparar una composicion farmaceutica liquida de desmopresina. - Google Patents
Procedimiento para preparar una composicion farmaceutica liquida de desmopresina.Info
- Publication number
- ES2019025A6 ES2019025A6 ES9000213A ES9000213A ES2019025A6 ES 2019025 A6 ES2019025 A6 ES 2019025A6 ES 9000213 A ES9000213 A ES 9000213A ES 9000213 A ES9000213 A ES 9000213A ES 2019025 A6 ES2019025 A6 ES 2019025A6
- Authority
- ES
- Spain
- Prior art keywords
- desmopressin
- pharmaceutical composition
- aqueous liquid
- cmc
- combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000007788 liquid Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 108010000437 Deamino Arginine Vasopressin Proteins 0.000 abstract 2
- NFLWUMRGJYTJIN-NXBWRCJVSA-N desmopressin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSCCC(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O)=O)CCC(=O)N)C1=CC=CC=C1 NFLWUMRGJYTJIN-NXBWRCJVSA-N 0.000 abstract 2
- 229960004281 desmopressin Drugs 0.000 abstract 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 abstract 1
- 239000001768 carboxy methyl cellulose Substances 0.000 abstract 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/095—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR UNA COMPOSICION FARMACEUTICA LIQUIDA DE DESMOPRESINA, QUE COMPRENDE (A) FORMAR UNA PRIMERA SOLUCION ACUOSA QUE COMPRENDE DESMOPRESINA BIOLOGICAMENTE ACTIVA; (B) ESTERILIZAR DICHA SOLUCION; (C) FORMAR UNA SEGUNDA SOLUCION ACUISA QUE COMPRENDE CARBOXIMETILCELULOSA SOLUBRE EN AGUA; (D) ESTERILIZAR EATA ULTIMA SOLUCION; (E) COMBINAR DICHAS SOLUCIONES ACUOSAS PRIMERA Y SEGUNDA FORMANDO UNA COMPOSICION FARMACEUTICA ACUOSA ESTERIL ESTANDO LA CARBOXIMETILCELULOSA Y LA DESMOPRESINA EN UNA RELACION DE APROXIMADAMENTE 100:1 A APROXIMADAMENTE 200:1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30486289A | 1989-01-30 | 1989-01-30 | |
| US43575389A | 1989-11-14 | 1989-11-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2019025A6 true ES2019025A6 (es) | 1991-05-16 |
Family
ID=26974270
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9000213A Expired - Lifetime ES2019025A6 (es) | 1989-01-30 | 1990-01-24 | Procedimiento para preparar una composicion farmaceutica liquida de desmopresina. |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0381345B1 (es) |
| AT (1) | ATE108326T1 (es) |
| DE (1) | DE69010518T2 (es) |
| ES (1) | ES2019025A6 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69329795T2 (de) * | 1992-10-02 | 2001-07-05 | Genetics Institute, Inc. | Zusammensetzung, welche den koagulationsfaktor viii beinhaltet; verfahren zu deren herstellung und die benutzung eines oberflächenaktiven stoffes als stabilisator |
| RU2135204C1 (ru) * | 1993-06-29 | 1999-08-27 | Ферринг Б.В. | Составы для назального введения десмопрессина |
| US6288030B1 (en) | 1993-12-22 | 2001-09-11 | Amgen Inc. | Stem cell factor formulations and methods |
| GB0210397D0 (en) * | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
| ES2319054B1 (es) | 2007-08-06 | 2010-02-12 | Gp Pharm S.A. | Composicion farmaceutica oral de desmopresina. |
| WO2015050983A1 (en) * | 2013-10-01 | 2015-04-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of modulating erythropoiesis with arginine vasopressin receptor 1b molecules |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0300036A4 (en) * | 1987-01-30 | 1989-06-14 | Biomed Res Consultants Ltd | PHARMACEUTICAL COMPOSITIONS BASED ON VASOPRESSIN. |
-
1990
- 1990-01-22 EP EP90300622A patent/EP0381345B1/en not_active Expired - Lifetime
- 1990-01-22 AT AT90300622T patent/ATE108326T1/de not_active IP Right Cessation
- 1990-01-22 DE DE69010518T patent/DE69010518T2/de not_active Expired - Fee Related
- 1990-01-24 ES ES9000213A patent/ES2019025A6/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69010518D1 (de) | 1994-08-18 |
| ATE108326T1 (de) | 1994-07-15 |
| EP0381345A1 (en) | 1990-08-08 |
| EP0381345B1 (en) | 1994-07-13 |
| DE69010518T2 (de) | 1994-11-03 |
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