ES2049692T1 - Compuestos fluorados como agentes transportadores de oxigeno. - Google Patents

Compuestos fluorados como agentes transportadores de oxigeno.

Info

Publication number
ES2049692T1
ES2049692T1 ES92923941T ES92923941T ES2049692T1 ES 2049692 T1 ES2049692 T1 ES 2049692T1 ES 92923941 T ES92923941 T ES 92923941T ES 92923941 T ES92923941 T ES 92923941T ES 2049692 T1 ES2049692 T1 ES 2049692T1
Authority
ES
Spain
Prior art keywords
oxygen transport
transport agents
fluorine compounds
atoms
ch2r
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ES92923941T
Other languages
English (en)
Inventor
Stephen Randolph Cooper
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford University Innovation Ltd
Original Assignee
Oxford University Innovation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford University Innovation Ltd filed Critical Oxford University Innovation Ltd
Publication of ES2049692T1 publication Critical patent/ES2049692T1/es
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/164—Unsaturated ethers containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
    • C07C205/40—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups and esterified hydroxy groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/04—Saturated ethers
    • C07C43/10—Saturated ethers of polyhydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/63—Halogen-containing esters of saturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE DESCRIBEN NUEVOS COMPUESTOS QUE TIENEN TIPICAMENTE LA FORMULA CH3C(CH2R)3 O ZCH2C(CH2R)3 DONDE R ES UN GRUPO FLUOROHIDROCARBURO O PERFLUOROCARBURO QUE CONTIENE PREFERENTEMENTE 4 A 16 ATOMOS DE CARBONO Y MAS ATOMOS F QUE ATOMOS H. Z ES UN GRUPO HIDROFILICO QUE PUEDE VOLVER EL COMPUESTO AUTOEMULSIFICABLE. LOS COMPUESTOS SON UTILES CON AGENTES TRANSPORTADORES DE OXIGENO EN VIVO PARA CUYOS PROPOSITOS SE UTILIZAN EMULSIONES ACUOSAS COMO SUSTITUTO DE SANGRE.
ES92923941T 1991-11-29 1992-11-27 Compuestos fluorados como agentes transportadores de oxigeno. Pending ES2049692T1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919125454A GB9125454D0 (en) 1991-11-29 1991-11-29 Oxygen transport agents

Publications (1)

Publication Number Publication Date
ES2049692T1 true ES2049692T1 (es) 1994-05-01

Family

ID=10705469

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92923941T Pending ES2049692T1 (es) 1991-11-29 1992-11-27 Compuestos fluorados como agentes transportadores de oxigeno.

Country Status (7)

Country Link
EP (1) EP0577785B1 (es)
JP (1) JPH06504797A (es)
AT (1) ATE175189T1 (es)
DE (2) DE69228058T2 (es)
ES (1) ES2049692T1 (es)
GB (1) GB9125454D0 (es)
WO (1) WO1993011098A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201521524D0 (en) * 2015-12-07 2016-01-20 Mexichem Fluor Sa De Cv Compound

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1618090A1 (de) * 1967-02-03 1970-11-05 Boehringer Sohn Ingelheim Verfahren zur Herstellung herbizid wirksamer Ester von Polyalkoholen
US3600415A (en) * 1968-08-01 1971-08-17 Allied Chem Fluorinated amides
GB1338430A (en) * 1970-11-04 1973-11-21 Allied Chem Fluorocarbon diols diols dicarboxylic acids and derivatives thereof
DE2731226A1 (de) * 1977-07-11 1979-01-25 Dow Chemical Co Trifluormethansulfonate
FR2602774B1 (fr) * 1986-07-29 1990-10-19 Atta Nouvelles molecules amphiphiles polyhydroxylees et perfluoroalkylees ayant des proprietes tensioactives

Also Published As

Publication number Publication date
EP0577785B1 (en) 1998-12-30
DE577785T1 (de) 1994-04-28
WO1993011098A1 (en) 1993-06-10
JPH06504797A (ja) 1994-06-02
ATE175189T1 (de) 1999-01-15
EP0577785A1 (en) 1994-01-12
DE69228058T2 (de) 1999-05-20
GB9125454D0 (en) 1992-01-29
DE69228058D1 (de) 1999-02-11

Similar Documents

Publication Publication Date Title
DK0791571T3 (da) Benzoylderivater
ATE169797T1 (de) Desinfektionsmittel und ihre verwendung zur haut- und schleimhautdesinfektion
SE8503680L (sv) Indolderivat
GR3020953T3 (en) Agents for preserving wood or composite-wood materials against insects
ATE144498T1 (de) Herstellung von substituierten piperidinen
DE69525354D1 (de) Eine neuartige medizinische verwendung eines 5ht 3-antagonisten
ES515081A0 (es) "procedimiento para la preparacion de derivados de 6-metilprednisolona".
ES514625A0 (es) "procedimiento para la preparacion de sulfonilureas substituidas con heterociclos".
ES2140765T3 (es) Guanididas sustituidas del acido cinamico, procedimiento para su preparacion, su uso como medicamento o agente de diagnostico cardiovascular, asi como medicamento que las contiene.
DE60128800D1 (de) Hydrophobe iodverbindung enthaltende liposome
DE59108033D1 (de) Verwendung eines mikrobioziden Mittels bei der Herstellung von Betondachsteinen
NZ220772A (en) 1-hydroxypyrazole derivatives and microbicidal compositions
ES2049692T1 (es) Compuestos fluorados como agentes transportadores de oxigeno.
FI863565A0 (fi) Foerfarande foer framstaellning av nya pyrrobenzimidazoler, pyrrolbenzoxazoler och pyrrolbenztiazoler.
ATE92469T1 (de) Neue alpha-aminocarbonsaeure-derivate, ihre herstellung und verwendung.
ES2045235T3 (es) Fungicidas que contienen compuestos de guanidinio y procedimiento para la lucha contra los hongos.
DE59006295D1 (de) Verfahren zur Herstellung perfluorierter heterocyclischer Verbindungen und nach diesem Verfahren hergestellte Verbindungen.
ES2037135T3 (es) Procedimiento para la obtencion de 5-amino-pirazoles substituidos y los fungicidas que les contienen.
PT98268A (pt) Processo para a preparacao de indano-pirrolidino-carbamatos
DK0520372T3 (da) Inositol-phosphat-analoger som calciumantagonistiske stoffer
PT91576A (pt) Processo para a preparacao de de sulfonamidas contendo o radical tetrazolilo e de composicoes farmaceuticas que as contem
ATE375173T1 (de) Hydrophobe iodverbindung enthaltendes liposom und dieses enthaltendes röntgenkontrastmittel
ES2106866T3 (es) Nuevos derivados de 2h-benzo(b)pirano sustituidos en la posicion 4 por arilo o n-heteroarilo, procedimiento para su preparacion y su uso, asi como preparados que contienen los compuestos.
IT1113373B (it) Derivati del 1,5-dimetilbiciclo(3.2.1.)-ottano,preparazione di questi composti e loro impiego come composti per profumi
DE59204576D1 (de) Verfahren zur Herstellung von Fluor enthaltenden Ethanderivaten.