ES2164041T1 - Utilizacion de un gel absorbente para eliminar y purificar las biomoleculas. - Google Patents

Utilizacion de un gel absorbente para eliminar y purificar las biomoleculas.

Info

Publication number
ES2164041T1
ES2164041T1 ES99950867T ES99950867T ES2164041T1 ES 2164041 T1 ES2164041 T1 ES 2164041T1 ES 99950867 T ES99950867 T ES 99950867T ES 99950867 T ES99950867 T ES 99950867T ES 2164041 T1 ES2164041 T1 ES 2164041T1
Authority
ES
Spain
Prior art keywords
module
biomolecules
purify
eliminate
kda
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES99950867T
Other languages
English (en)
Other versions
ES2164041T3 (es
Inventor
Mookambeswaran Vijayalakshmi
Olivier Pitiot
Cecile Legallais
Philippe Moriniere
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Publication of ES2164041T1 publication Critical patent/ES2164041T1/es
Application granted granted Critical
Publication of ES2164041T3 publication Critical patent/ES2164041T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/3212—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3278—Polymers being grafted on the carrier
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0415—Plasma
    • A61M2202/0421—Beta-2-microglobulin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • External Artificial Organs (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

Dispositivo para eliminar moléculas biológicas que comprende un módulo de ultrafiltración eventualmente aguas arriba a y en serie con un módulo de diálisis, caracterizado porque este dispositivo comprende además una columna que contiene un gel adsorbente que une las propiedades de las cromatografías de exclusión estérica y de afinidad, estando constituido esencialmente el citado gel adsorbente por una matriz de polisacárido sobre la que está injertado un polímero acoplado a un ligando de afinidad y con un umbral de corte ajustable comprendido entre 2 kDa y 60 kDa, estando montada la citada columna en derivación del citado módulo de ultrafiltración.
ES99950867T 1998-10-30 1999-10-28 Utilizacion de un gel absorbente para eliminar y purificar las biomoleculas. Expired - Lifetime ES2164041T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9813655A FR2785200B1 (fr) 1998-10-30 1998-10-30 Utilisation d'un gel adsorbant pour eliminer et purifier les biomolecules

Publications (2)

Publication Number Publication Date
ES2164041T1 true ES2164041T1 (es) 2002-02-16
ES2164041T3 ES2164041T3 (es) 2003-08-16

Family

ID=9532195

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99950867T Expired - Lifetime ES2164041T3 (es) 1998-10-30 1999-10-28 Utilizacion de un gel absorbente para eliminar y purificar las biomoleculas.

Country Status (9)

Country Link
US (1) US6746607B1 (es)
EP (1) EP1124633B1 (es)
JP (1) JP2002528242A (es)
AT (1) ATE231411T1 (es)
AU (1) AU6347499A (es)
DE (2) DE1124633T1 (es)
ES (1) ES2164041T3 (es)
FR (1) FR2785200B1 (es)
WO (1) WO2000025911A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7241272B2 (en) 2001-11-13 2007-07-10 Baxter International Inc. Method and composition for removing uremic toxins in dialysis processes
EP1523350B1 (en) 2002-07-19 2011-04-13 Baxter International Inc. System for performing peritoneal dialysis
MXPA06012472A (es) 2004-04-27 2007-01-26 Vital Therapies Inc Sistema y metodo de desintoxicacion metabolica.
CN1830495B (zh) * 2005-03-11 2010-12-15 广东天普生化医药股份有限公司 基于亲和吸附的血液净化方法及系统
US8057679B2 (en) 2008-07-09 2011-11-15 Baxter International Inc. Dialysis system having trending and alert generation
US20100051552A1 (en) 2008-08-28 2010-03-04 Baxter International Inc. In-line sensors for dialysis applications
WO2011046504A1 (en) * 2009-10-18 2011-04-21 Glycorex Ab Method and product for blood treatment and purification
US20110097464A1 (en) * 2009-10-22 2011-04-28 Ge Healthcare Bio-Sciences Ab Method for liquid processing
WO2015133972A1 (en) * 2014-03-07 2015-09-11 Agency For Science, Technology And Research Apparatus and methods for fractionation of biological products
ES2987653T3 (es) 2015-06-25 2024-11-15 Gambro Lundia Ab Sistema y método de dispositivo médico que tiene una base de datos distribuida
WO2018114346A1 (en) 2016-12-21 2018-06-28 Gambro Lundia Ab Medical device system including information technology infrastructure having secure cluster domain supporting external domain
FR3109734B1 (fr) * 2020-05-04 2025-04-11 Univ Claude Bernard Lyon Système de dialyse pour le traitement du sepsis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2621974A1 (de) * 1976-05-18 1977-11-24 Max Planck Gesellschaft Verfahren zur herstellung eines zur kovalenten bindung mit biologisch aktivem material befaehigten traegermaterials
DE3687751T2 (de) * 1985-09-19 1993-05-27 Toray Industries Kolonne zum entfernen von beta-2-mikroglobulin.
EP0247592B1 (en) * 1986-05-30 1992-03-04 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Adsorbent for beta2-microglobulin and immunoglobulin l-chain
CA1320718C (en) * 1987-06-08 1993-07-27 Richard Frederick Hammen Chromatographic material
US5169936A (en) * 1989-04-14 1992-12-08 Biogen, Inc. Protein purification on immobilized metal affinity resins effected by elution using a weak ligand
US5403750A (en) * 1991-03-06 1995-04-04 W. R. Grace & Co.-Conn. Biocompatible, low protein adsorption affinity matrix

Also Published As

Publication number Publication date
EP1124633A1 (fr) 2001-08-22
AU6347499A (en) 2000-05-22
WO2000025911A1 (fr) 2000-05-11
EP1124633B1 (fr) 2003-01-22
DE69905066D1 (de) 2003-02-27
ATE231411T1 (de) 2003-02-15
JP2002528242A (ja) 2002-09-03
DE1124633T1 (de) 2002-02-07
FR2785200A1 (fr) 2000-05-05
FR2785200B1 (fr) 2001-03-30
DE69905066T2 (de) 2004-01-22
ES2164041T3 (es) 2003-08-16
US6746607B1 (en) 2004-06-08

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