ES2165105T3 - Procedimiento de isomerizacion. - Google Patents

Procedimiento de isomerizacion.

Info

Publication number
ES2165105T3
ES2165105T3 ES98102074T ES98102074T ES2165105T3 ES 2165105 T3 ES2165105 T3 ES 2165105T3 ES 98102074 T ES98102074 T ES 98102074T ES 98102074 T ES98102074 T ES 98102074T ES 2165105 T3 ES2165105 T3 ES 2165105T3
Authority
ES
Spain
Prior art keywords
vitamin
isomerization
nitrogen
isomeros
introduction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98102074T
Other languages
English (en)
Inventor
Angela Wildermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2165105T3 publication Critical patent/ES2165105T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/08—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B37/00—Reactions without formation or introduction of functional groups containing hetero atoms, involving either the formation of a carbon-to-carbon bond between two carbon atoms not directly linked already or the disconnection of two directly linked carbon atoms
    • C07B37/08—Isomerisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/10—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by etherified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/12—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/14—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

UN PROCESO PARA LA ISOMERIZACION CATALITICA DE UN ISOMERO Z DE UN COMPUESTO DE VITAMINA A O UNA MEZCLA DE ALGUNOS DE DICHOS ISOMEROS EN UNA MEZCLA DE LOS CORRESPONDIENTES ISOMEROS ALL-E Y 13-Z DE DICHO COMPUESTO DE VITAMINA A QUE CONSISTE EN UTILIZAR MONOXIDO DE NITROGENO O UNA MEZCLA GASEOSA CONTENIENDO MONOXIDO DE NITROGENO COMO CATALIZADOR DE ISOMERIZACION. POR OTRA PARTE, EL PROCESO DE ISOMERIZACION TRANSCURRE DEL MODO MAS CONVENIENTE EN UN MEDIO DISOLVENTE ORGANICO POLAR O NO POLAR, A TEMPERATURAS DE HASTA 200 C Y DE TAL MODO, QUE EL CONTACTO CATALITICO CON EL MONOXIDO DE NITROGENO TIENE LUGAR POR INTRODUCCION DEL OXIDO DE NITROGENO O DE UNA MEZCLA GASEOSA QUE LO CONTENGA, VGR. CON NITROGENO, EN EL COMPUESTO DE VITAMINA A OBJETO DE LA ISOMERIZACION (DILUIDO EN CASO NECESARIO) Y DISPERSION DEL MONOXIDO DE NITROGENO O DE LA MEZCLA GASEOSA CONTENIENDO MONOXIDO DE NITROGENO A PRESION ATMOSFERICA O BAJO LIGERA PRESION, VGR. HASTA 10 BAR. ES PREFERIBLE UTILIZAR ACETATO O ACIDO DE VITAMINA ACOMO COMPUESTO A ISOMERIZAR. LA VITAMINA ALL-E ASI PRODUCIDA Y SU ALCANOILESTER POSEEN CON DIFERENCIA LA MAYOR ACTIVIDAD BIOLOGICA DE TODOS LOS ISOMEROS Y POR ELLO SE UTILIZAN CASI EXCLUSIVAMENTE EN ALIMENTACION HUMANA Y ANIMAL. POR SU PARTE, LOS COMPUESTOS DE VITAMINA A 13-Z JUEGAN UN PAPEL IMPORTANTE COMO SUSTANCIAS ACTIVAS FARMACEUTICAS.
ES98102074T 1997-02-14 1998-02-06 Procedimiento de isomerizacion. Expired - Lifetime ES2165105T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97102394 1997-02-14

Publications (1)

Publication Number Publication Date
ES2165105T3 true ES2165105T3 (es) 2002-03-01

Family

ID=8226477

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98102074T Expired - Lifetime ES2165105T3 (es) 1997-02-14 1998-02-06 Procedimiento de isomerizacion.

Country Status (10)

Country Link
US (1) US5908957A (es)
EP (1) EP0858986B1 (es)
JP (1) JPH10226677A (es)
KR (1) KR19980071332A (es)
CN (1) CN1102579C (es)
BR (1) BR9800610A (es)
CA (1) CA2228990A1 (es)
DE (1) DE59801905D1 (es)
DK (1) DK0858986T3 (es)
ES (1) ES2165105T3 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2935186B1 (en) * 2012-12-18 2020-03-25 DSM IP Assets B.V. Polythiols as cis/trans isomerization catalysts for unsaturated compounds
EP2935189B1 (en) 2012-12-18 2019-06-12 DSM IP Assets B.V. Using mixtures of e/z isomers to obtain quantitatively specific products by combining asymmetric hydrogenation and isomerization
WO2014097172A1 (en) 2012-12-18 2014-06-26 Dsm Ip Assets B.V. Nitrogen monoxide as cis/trans isomerization catalysts for unsaturated compounds
CN113429326B (zh) * 2021-07-28 2022-08-05 万华化学集团股份有限公司 一种维生素a异构化的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1053574A (es) * 1964-04-24
DE2210800C2 (de) * 1972-03-07 1974-02-21 Basf Ag, 6700 Ludwigshafen Verfahren zur photochemischen Isomerisierung von cis-Isomeren von Vitamin-A-Verbindungen und deren Derivate
CH590222A5 (es) * 1973-08-21 1977-07-29 Hoffmann La Roche
US4051174A (en) * 1973-08-21 1977-09-27 Hoffmann-La Roche Inc. Isomerization process
CH605724A5 (es) * 1974-11-12 1978-10-13 Hoffmann La Roche
JP2955894B2 (ja) * 1991-07-05 1999-10-04 ミヨシ油脂株式会社 金属加工油

Also Published As

Publication number Publication date
JPH10226677A (ja) 1998-08-25
KR19980071332A (ko) 1998-10-26
EP0858986A1 (de) 1998-08-19
EP0858986B1 (de) 2001-10-31
CA2228990A1 (en) 1998-08-14
BR9800610A (pt) 1999-07-20
DK0858986T3 (da) 2002-02-18
CN1102579C (zh) 2003-03-05
DE59801905D1 (de) 2001-12-06
US5908957A (en) 1999-06-01
CN1201787A (zh) 1998-12-16

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