ES2172442A1 - Procedimiento para la produccion de un concentrado de licopeno libre de disolventes organicos, concentrado obtenido y composicion que comprende dicho concentrado. - Google Patents

Procedimiento para la produccion de un concentrado de licopeno libre de disolventes organicos, concentrado obtenido y composicion que comprende dicho concentrado.

Info

Publication number
ES2172442A1
ES2172442A1 ES200002739A ES200002739A ES2172442A1 ES 2172442 A1 ES2172442 A1 ES 2172442A1 ES 200002739 A ES200002739 A ES 200002739A ES 200002739 A ES200002739 A ES 200002739A ES 2172442 A1 ES2172442 A1 ES 2172442A1
Authority
ES
Spain
Prior art keywords
concentrate
lycopene
producing
composition
organic solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES200002739A
Other languages
English (en)
Other versions
ES2172442B2 (es
Inventor
Rey Eduardo Sabio
Gonzalez Antonio Ramiro
Gonzalez Juan Felix Gonzalez
Gomez Francisco J Castro
Garcia Maria Josefa Bernalte
Ruiz Mercedes Lozano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad de Extremadura
Original Assignee
Universidad de Extremadura
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad de Extremadura filed Critical Universidad de Extremadura
Priority to ES200002739A priority Critical patent/ES2172442B2/es
Priority to ARP010105291A priority patent/AR031749A1/es
Priority to TNTNSN01161A priority patent/TNSN01161A1/fr
Priority to JP2002542378A priority patent/JP2004513918A/ja
Priority to AT01996373T priority patent/ATE318134T1/de
Priority to ES01996373T priority patent/ES2259342T3/es
Priority to AU2002223690A priority patent/AU2002223690A1/en
Priority to PT01996373T priority patent/PT1384472E/pt
Priority to CNA018206883A priority patent/CN1481237A/zh
Priority to DE60117414T priority patent/DE60117414T2/de
Priority to HU0400563A priority patent/HUP0400563A3/hu
Priority to DK01996373T priority patent/DK1384472T3/da
Priority to US10/416,946 priority patent/US20040131733A1/en
Priority to EP01996373A priority patent/EP1384472B1/en
Priority to IL15529901A priority patent/IL155299A0/xx
Priority to BR0115661-6A priority patent/BR0115661A/pt
Priority to PCT/ES2001/000433 priority patent/WO2002040003A1/es
Publication of ES2172442A1 publication Critical patent/ES2172442A1/es
Priority to MA27134A priority patent/MA27460A1/fr
Priority to BG107809A priority patent/BG107809A/bg
Application granted granted Critical
Publication of ES2172442B2 publication Critical patent/ES2172442B2/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B61/00—Dyes of natural origin prepared from natural sources, e.g. vegetable sources
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Medicinal Preparation (AREA)
  • Processing Of Solid Wastes (AREA)

Abstract

Procedimiento para la producción de un concentrado de licopeno libre de disolventes orgánicos, concentrado obtenido y composición que comprende dicho concentrado. El procedimiento comprende poner en contacto una fuente de licopeno con un fluido supercrítico bajo condiciones que permiten la solubilización del licopeno en dicho fluido supercrítico, y separar el concentrado de licopeno mediante despresurización del fluido supercrítico cargado con licopeno. Cuando la despresurización se realiza hasta presiones inferiores a 10 MPa se obtiene una oleorresina y cuando se realiza a presiones superiores se obtiene un extracto, ambos ricos en licopeno libre de disolventes orgánicos. El concentrado y las composiciones que lo comprenden tienen propiedades antioxidantes y son útiles para elaborar productos alimenticios, cosméticos, farmacéuticos o nutracéuticos.
ES200002739A 2000-11-15 2000-11-15 Procedimiento para la produccion de un concentrado de licopeno libre de disolventes organicos, concentrado obtenido y composicion que comprende dicho concentrado. Expired - Fee Related ES2172442B2 (es)

Priority Applications (19)

Application Number Priority Date Filing Date Title
ES200002739A ES2172442B2 (es) 2000-11-15 2000-11-15 Procedimiento para la produccion de un concentrado de licopeno libre de disolventes organicos, concentrado obtenido y composicion que comprende dicho concentrado.
ARP010105291A AR031749A1 (es) 2000-11-15 2001-11-13 Procedimiento para la produccion de un concentrado de licopeno libre de disolventes organicos, concentrado obtenido y composicion que comprende dicho concentrado
EP01996373A EP1384472B1 (en) 2000-11-15 2001-11-14 Method for producing an organic solvent-free lycopene concentrate, the resulting concentrate and composition comprising said concentrate
AT01996373T ATE318134T1 (de) 2000-11-15 2001-11-14 Methode zur herstellung lycopen-konzentrats frei von organischen lösungsmitteln, das resultierende konzentrat und dieses konzentrat enthaltende zusammensetzungen
ES01996373T ES2259342T3 (es) 2000-11-15 2001-11-14 Procedimiento de produccion de un concentrado de licopeno sin disolventes organicos, el concentrado resultante y composiciones que comprenden dicho concentrado.
AU2002223690A AU2002223690A1 (en) 2000-11-15 2001-11-14 Method for producing an organic solvent-free lycopene concentrate, the resulting concentrate and composition comprising said concentrate
PT01996373T PT1384472E (pt) 2000-11-15 2001-11-14 Metodo para produzir um concentrado de licopeno sem solvente organico, o resultado concentrado e composicao ,compreende este concentrado
CNA018206883A CN1481237A (zh) 2000-11-15 2001-11-14 不含有机溶剂的番茄红素浓缩物的制备方法、所得浓缩物及含该浓缩物的组合物
DE60117414T DE60117414T2 (de) 2000-11-15 2001-11-14 Methode zur herstellung lycopen-konzentrats frei von organischen lösungsmitteln, das resultierende konzentrat und dieses konzentrat enthaltende zusammensetzungen
HU0400563A HUP0400563A3 (en) 2000-11-15 2001-11-14 Method for producing an organic solvent-free lycopene concentrate, the resulting concentrate and composition comprising said concentrate
TNTNSN01161A TNSN01161A1 (fr) 2000-11-15 2001-11-14 Procedure pour la production d'un concentre de lycopene libre de dissolvants organiques, concentre obtenu et composition qui comprend le dit concentre.
US10/416,946 US20040131733A1 (en) 2000-11-15 2001-11-14 Method for producing an organic solvent-free lycopene concentrate the resulting concentrate and composition comprising said concentrate
JP2002542378A JP2004513918A (ja) 2000-11-15 2001-11-14 有機溶媒不含リコペン濃縮物の製造方法、得られる濃縮物および該濃縮物を含む組成物
IL15529901A IL155299A0 (en) 2000-11-15 2001-11-14 Procedure for the production of a lycopene concentrate free of organic solvents, the concentrate obtained and the composition of this concentrate
BR0115661-6A BR0115661A (pt) 2000-11-15 2001-11-14 Procedimento para a produção de um concentrado de licopeno livre de solventes orgânicos, do concentrado obtido e da composição deste concentrado
PCT/ES2001/000433 WO2002040003A1 (es) 2000-11-15 2001-11-14 Procedimiento para la producción de un concentrado de licopeno libre de disolventes orgánicos, concentrado obtenido y composición que comprende dicho concentrado
DK01996373T DK1384472T3 (da) 2000-11-15 2001-11-14 Fremgangsmåde til fremstilling af et lycopenkoncentrat, som er frit for organisk oplösningsmiddel, det resulterende koncentrat og et præparat omfattende koncentratet
MA27134A MA27460A1 (fr) 2000-11-15 2003-04-30 Methode pour la production d'un concentre organique de lycopene sans solvant, le concentre resultant et composition comprenant ce concentre
BG107809A BG107809A (bg) 2000-11-15 2003-05-13 Метод за получаване на ликопенов концентрат, свободен от органични разтворители, полученият концентрат и състав, съдържащ този концентрат

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200002739A ES2172442B2 (es) 2000-11-15 2000-11-15 Procedimiento para la produccion de un concentrado de licopeno libre de disolventes organicos, concentrado obtenido y composicion que comprende dicho concentrado.

Publications (2)

Publication Number Publication Date
ES2172442A1 true ES2172442A1 (es) 2002-09-16
ES2172442B2 ES2172442B2 (es) 2003-12-01

Family

ID=8495645

Family Applications (2)

Application Number Title Priority Date Filing Date
ES200002739A Expired - Fee Related ES2172442B2 (es) 2000-11-15 2000-11-15 Procedimiento para la produccion de un concentrado de licopeno libre de disolventes organicos, concentrado obtenido y composicion que comprende dicho concentrado.
ES01996373T Expired - Lifetime ES2259342T3 (es) 2000-11-15 2001-11-14 Procedimiento de produccion de un concentrado de licopeno sin disolventes organicos, el concentrado resultante y composiciones que comprenden dicho concentrado.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES01996373T Expired - Lifetime ES2259342T3 (es) 2000-11-15 2001-11-14 Procedimiento de produccion de un concentrado de licopeno sin disolventes organicos, el concentrado resultante y composiciones que comprenden dicho concentrado.

Country Status (18)

Country Link
US (1) US20040131733A1 (es)
EP (1) EP1384472B1 (es)
JP (1) JP2004513918A (es)
CN (1) CN1481237A (es)
AR (1) AR031749A1 (es)
AT (1) ATE318134T1 (es)
AU (1) AU2002223690A1 (es)
BG (1) BG107809A (es)
BR (1) BR0115661A (es)
DE (1) DE60117414T2 (es)
DK (1) DK1384472T3 (es)
ES (2) ES2172442B2 (es)
HU (1) HUP0400563A3 (es)
IL (1) IL155299A0 (es)
MA (1) MA27460A1 (es)
PT (1) PT1384472E (es)
TN (1) TNSN01161A1 (es)
WO (1) WO2002040003A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2241503A1 (es) * 2005-04-19 2005-10-16 Eduardo Sabio Rey Procedimiento para preparar formulaciones enriquecidas en licopeno libres de disolventes organicos, formulaciones obtenidas, composiciones que comprenden dichas formulaciones y uso de las mismas.

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ES2197014B1 (es) * 2002-06-06 2005-03-01 Consejo Sup. Investig. Cientificas Extraccion fraccionada de carotenoides de fuentes naturales con alto contenido en licopeno mediante fluidos supercriticos.
EP1508325B1 (fr) * 2003-08-21 2009-03-11 Nestec S.A. Concentré naturel de Lycopène et procédé d'obtention
WO2006036125A1 (en) * 2004-09-28 2006-04-06 Gao Shen Sdn Bhd A process for producing lycopene extract
KR101081275B1 (ko) 2004-12-21 2011-11-08 (주)아모레퍼시픽 토마토에서 리코펜을 추출하는 방법 및 그 리코펜을함유하는 항산화용 화장료 조성물
US7572468B1 (en) 2004-12-28 2009-08-11 The United States Of America As Represented By The Secretary Of Agriculture Extraction of carotenoids from plant material
GB0515035D0 (en) * 2005-07-21 2005-08-31 Cambridge Theranostics Ltd Treatment of atherosclerotic conditions
JP2007046015A (ja) * 2005-08-12 2007-02-22 Tohoku Univ カロテノイド色素の製造方法
ES2285923B1 (es) * 2005-12-14 2008-10-16 Dieta Mediterranea Aceites Y Vinagres, S.A. Producto para su utilizacion en la prevencion y tratamiento de enfermedades cardiovasculares, cancer y enfermedades inflamatorias cronicas.
ITBA20060049A1 (it) * 2006-08-02 2008-02-03 Pierre S R L Integratore alimentare a base di licopene biologico e procedimento per l'ottenimento del licopene biologico.
KR100849156B1 (ko) 2007-01-23 2008-07-30 한국식품연구원 초임계 이산화탄소를 이용한 라이코펜 추출
US8557319B2 (en) * 2008-03-28 2013-10-15 Wild Flavors, Inc. Stable natural color process, products and use thereof
JP6047576B2 (ja) * 2011-09-19 2016-12-21 オムニアクティブ ヘルス テクノロジーズ リミテッド 食用のリコピン含有オレオレジンおよびリコピン結晶の調製のための効率的な方法
WO2013070682A1 (en) 2011-11-07 2013-05-16 Wild Flavors, Inc. Genipin-rich material and its use
US9750780B2 (en) 2012-06-25 2017-09-05 Dmitry DRUZHININ Aqueous-lipidic carotenoid-containing compositions
RU2512375C1 (ru) * 2012-11-13 2014-04-10 Дмитрий Лелич Дружинин Пищевая водно-липидная композиция, содержащая каротеноиды
KR102081489B1 (ko) * 2017-11-28 2020-02-26 신라대학교 산학협력단 알카리 가수분해 및 염석결정화를 이용한 토마토로부터 수용성 라이코펜 제조 및 라이코펜 분말 수득방법
CN109534944B (zh) * 2018-11-14 2021-09-28 北京联合大学 一种制备番茄红素纳米粉体的方法及装置
IT202000010291A1 (it) 2020-05-09 2021-11-09 Annamaria Cuccurullo Processo per l'estrazione e l'incapsulamento di principi attivi da prodotti naturali
CN113045377B (zh) * 2021-04-30 2023-02-28 中国药科大学 一种基于亚临界萃取与超临界制粒组合工艺的番茄红素微粒的制备方法
ES2932558B2 (es) * 2021-07-13 2024-02-16 Univ Cordoba Procedimiento para la obtencion de licopeno a partir de subproductos del tomate basado en el uso de biodisolventes supramoleculares

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2241503A1 (es) * 2005-04-19 2005-10-16 Eduardo Sabio Rey Procedimiento para preparar formulaciones enriquecidas en licopeno libres de disolventes organicos, formulaciones obtenidas, composiciones que comprenden dichas formulaciones y uso de las mismas.
WO2006111591A1 (es) * 2005-04-19 2006-10-26 Eduardo Sabio Rey Procedimiento para preparar formulaciones enriquecidas en licopeno libres de disolventes orgánicos, formulaciones obtenidas, composiciones que comprenden dichas formulaciones y uso de las mismas
ES2241503B2 (es) * 2005-04-19 2008-07-01 Eduardo Sabio Rey Procedimiento para preparar formulaciones enriquecidas en licopeno libres de disolventes organicos, formulaciones obtenidas, composiciones que comprenden dichas formulaciones y uso de las mismas.

Also Published As

Publication number Publication date
EP1384472B1 (en) 2006-02-22
DE60117414D1 (de) 2006-04-27
IL155299A0 (en) 2003-11-23
HUP0400563A2 (hu) 2004-08-30
BR0115661A (pt) 2005-02-01
ATE318134T1 (de) 2006-03-15
AU2002223690A1 (en) 2002-05-27
WO2002040003A1 (es) 2002-05-23
US20040131733A1 (en) 2004-07-08
PT1384472E (pt) 2006-07-31
ES2259342T3 (es) 2006-10-01
ES2172442B2 (es) 2003-12-01
HUP0400563A3 (en) 2005-11-28
DE60117414T2 (de) 2006-11-02
CN1481237A (zh) 2004-03-10
AR031749A1 (es) 2003-10-01
BG107809A (bg) 2004-06-30
EP1384472A1 (en) 2004-01-28
MA27460A1 (fr) 2005-08-01
JP2004513918A (ja) 2004-05-13
DK1384472T3 (da) 2006-06-12
TNSN01161A1 (fr) 2005-11-10

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