ES2180638T3 - Nuevos procedimientos e intermediarios para la preparacion de derivados de piperazina. - Google Patents

Nuevos procedimientos e intermediarios para la preparacion de derivados de piperazina.

Info

Publication number
ES2180638T3
ES2180638T3 ES95921010T ES95921010T ES2180638T3 ES 2180638 T3 ES2180638 T3 ES 2180638T3 ES 95921010 T ES95921010 T ES 95921010T ES 95921010 T ES95921010 T ES 95921010T ES 2180638 T3 ES2180638 T3 ES 2180638T3
Authority
ES
Spain
Prior art keywords
preparation
piperazine derivatives
compounds
intermediaries
new procedures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95921010T
Other languages
English (en)
Inventor
Christopher Ian Wye Brightwell
Robin Gerald Wyeth La Shepherd
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
John Wyeth and Brother Ltd
Original Assignee
John Wyeth and Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9411108A external-priority patent/GB9411108D0/en
Priority claimed from GBGB9510152.3A external-priority patent/GB9510152D0/en
Application filed by John Wyeth and Brother Ltd filed Critical John Wyeth and Brother Ltd
Application granted granted Critical
Publication of ES2180638T3 publication Critical patent/ES2180638T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D419/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

COMPUESTOS QUE TIENEN LA FORMULA R 5 O-A-NR 4 -R SUP,2} (V), DONDE R{SUP,2} ES UN GRUPO HETEROARILICO ENLAZADO AL RESIDUO DE LA MOLECULA MEDIANTE UN ATOMO DE CARBONO ADYACENTE A UN ATOMO DE NITROGENO Y R{SUP,4} Y R{SUP,5} SON ATOMOS DE HIDROGENO O JUNTOS REPRESENTAN -SO- O -SO{SUB,2}- Y A ES ALQUILENO C{SUB,2}C{SUB,4} OPCIONALMENTE SUSTITUIDO POR UNO O MAS GRUPOS DE ALQUILO BAJO SON NUEVOS INTERMEDIARIOS EN LA PREPARACION DE DERIVADOS DE PIPERAZINA FARMACEUTICAMENTE UTIL COMO COMPUESTOS FINALES. LOS COMPUESTOS QUE TIENEN LA FORMULA GENERAL (V) DONDE R{SUP,4} Y R{SUP,5} SON HIDROGENO PUEDEN SER PREPARADOS MEDIANTE UNA REDISPOSICION DE UN COMPUESTO QUE TIENE LA FORMULA R{SUP,2}-O-ANH{SUB,2} (VI).
ES95921010T 1994-06-03 1995-06-01 Nuevos procedimientos e intermediarios para la preparacion de derivados de piperazina. Expired - Lifetime ES2180638T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9411108A GB9411108D0 (en) 1994-06-03 1994-06-03 Novel processes and intermediates for the preparation of piperazine derivatives
GBGB9510152.3A GB9510152D0 (en) 1995-05-19 1995-05-19 Process for the preparation of piperazine intermediates

Publications (1)

Publication Number Publication Date
ES2180638T3 true ES2180638T3 (es) 2003-02-16

Family

ID=26304996

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95921010T Expired - Lifetime ES2180638T3 (es) 1994-06-03 1995-06-01 Nuevos procedimientos e intermediarios para la preparacion de derivados de piperazina.

Country Status (12)

Country Link
US (3) US6175012B1 (es)
EP (1) EP0763024B1 (es)
JP (1) JPH10504275A (es)
AT (1) ATE222238T1 (es)
AU (1) AU2622595A (es)
CA (1) CA2191874C (es)
DE (1) DE69527787T2 (es)
DK (1) DK0763024T3 (es)
ES (1) ES2180638T3 (es)
IL (1) IL113966A (es)
PT (1) PT763024E (es)
WO (1) WO1995033725A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0763024B1 (en) * 1994-06-03 2002-08-14 JOHN WYETH & BROTHER LIMITED Processes and intermediates for the preparation of piperazine derivatives
GB9514901D0 (en) * 1995-07-20 1995-09-20 American Home Prod Piperazine derivatives
CZ8197A3 (en) 1996-01-16 1997-10-15 American Home Prod (1h-indol-4-yl)-piperidine- or tetrahydropyridine ethyl amines and -ethyl carboxamides and pharmaceutical composition containing thereof
US6271234B1 (en) * 1997-08-01 2001-08-07 Recordati S.A., Chemical And Pharmaceutical Company 1,4-disubstituted piperazines
US20060223824A1 (en) 2000-11-28 2006-10-05 Wyeth Serotonergic agents
US20060287335A1 (en) 2000-11-28 2006-12-21 Wyeth Serotonergic agents for treating sexual dysfunction
EP1483256A2 (en) 2002-03-12 2004-12-08 Wyeth Process for making chiral 1,4-disubstituted piperazines
KR20040091720A (ko) * 2002-03-12 2004-10-28 와이어쓰 Ｎ1-(2'-피리딜)-1,2-프로판디아민 설팜산의 제조방법 및생물학적 활성 피페라진 합성시의 이의 용도
US7361773B2 (en) 2002-03-12 2008-04-22 Wyeth Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
US7091349B2 (en) 2002-03-12 2006-08-15 Wyeth Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution
CA2477892C (en) 2002-03-12 2010-11-23 Gregg Brian Feigelson Process for synthesizing chiral n-aryl piperazines
US20050209245A1 (en) * 2004-03-19 2005-09-22 Wyeth Process for preparing N-aryl-piperazine derivatives
JP2010503661A (ja) * 2006-09-12 2010-02-04 ジュビラント・オルガノシス・リミテッド ピリジンおよび／またはその誘導体の環境に優しい回収方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3405859A1 (de) * 1984-02-18 1985-08-22 Basf Ag, 6700 Ludwigshafen Sulfongruppenhaltige azoverbindungen
EP0200024B1 (de) * 1985-04-30 1992-07-01 ARZNEIMITTELWERK DRESDEN GmbH 3-Cyan-pyridine, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
GB8512163D0 (en) 1985-05-14 1985-06-19 Fujisawa Pharmaceutical Co Oxothiazolidine compound
US4741831A (en) * 1986-12-04 1988-05-03 The Dow Chemical Company Process and composition for removal of metal ions from aqueous solutions
CA2002199A1 (en) * 1988-11-05 1990-05-05 Takafumi Uemiya Method for producing organic crystal and crystal growth cell therefor
DE4042005A1 (de) 1990-12-22 1992-06-25 Schering Ag D-homo-(16-en)-11(beta)-aryl-4-estrene
US5342953A (en) 1991-01-31 1994-08-30 Syntex (U.S.A.) Inc. N-2-chlorobenzyl-2-oxo and N-2-chlorobenzyl-2,2-dioxo-1,2,3-oxathiazolidine derivatives, their preparation and synthesis of thieno[3,2-c]pyridine derivatives therefrom
MX9201991A (es) * 1991-05-02 1992-11-01 Jonh Wyeth & Brother Limited Derivados de piperazina y procedimiento para su preparacion.
US5271812A (en) * 1991-06-19 1993-12-21 Sepracor, Inc. Electrocatalytic oxidation method for the production of cyclic sulfates and sulfamidates
GB9314758D0 (en) * 1993-07-16 1993-08-25 Wyeth John & Brother Ltd Heterocyclic derivatives
GB9411099D0 (en) * 1994-06-03 1994-07-27 Wyeth John & Brother Ltd Piperazine derivatives
EP0763024B1 (en) * 1994-06-03 2002-08-14 JOHN WYETH & BROTHER LIMITED Processes and intermediates for the preparation of piperazine derivatives
US5439915A (en) * 1994-10-20 1995-08-08 American Home Products Corporation Pyrido[3,4-B]indole carboxamide derivatives as serotonergic agents
US5541179A (en) * 1995-05-02 1996-07-30 American Home Products Corporation Tropon-2-one piperazine carboxamides as serotonergic agents

Also Published As

Publication number Publication date
DE69527787D1 (de) 2002-09-19
EP0763024A1 (en) 1997-03-19
EP0763024B1 (en) 2002-08-14
DK0763024T3 (da) 2002-12-02
AU2622595A (en) 1996-01-04
IL113966A (en) 2000-08-13
PT763024E (pt) 2002-11-29
ATE222238T1 (de) 2002-08-15
IL113966A0 (en) 1995-10-31
US6395902B1 (en) 2002-05-28
WO1995033725A1 (en) 1995-12-14
US6175012B1 (en) 2001-01-16
CA2191874A1 (en) 1995-12-14
DE69527787T2 (de) 2003-01-02
CA2191874C (en) 2008-05-20
US6133449A (en) 2000-10-17
JPH10504275A (ja) 1998-04-28

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