ES257146A1 - Procedure for obtaining new basic indian labor derivatives (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for obtaining new basic indian labor derivatives (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES257146A1 ES257146A1 ES0257146A ES257146A ES257146A1 ES 257146 A1 ES257146 A1 ES 257146A1 ES 0257146 A ES0257146 A ES 0257146A ES 257146 A ES257146 A ES 257146A ES 257146 A1 ES257146 A1 ES 257146A1
- Authority
- ES
- Spain
- Prior art keywords
- aralkyl
- group
- translation
- procedure
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 150000007522 mineralic acids Chemical class 0.000 abstract 2
- 150000007524 organic acids Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- NLMQHXUGJIAKTH-UHFFFAOYSA-N 4-hydroxyindole Chemical compound OC1=CC=CC2=C1C=CN2 NLMQHXUGJIAKTH-UHFFFAOYSA-N 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
- 150000002475 indoles Chemical class 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedure for obtaining new basic indole derivatives, of the general formula I (see formula sheet) and their salts, with inorganic and organic acids, in which R1 is for a hydrogen atom or an aralkyl group and R2 for a hydrogen atom or a low alkyl group or an aralkyl group, R3 and R4 may be the same or different and each mean a hydrogen atom or a low alkyl group and A is for an alkylene group with a maximum of 3 carbon atoms, where A and R2 together must contain at least 2 atoms of carbon if R3 and R4 each means an alkyl group, characterized in that it starts from a 4-hydroxy-indole, optionally substituted alkyl or aralkyl in position 1, whose hydroxyl function is protected by an aralkyl group R1', preferably the benzyl moiety, in the indole it is gradually formed in position 3, according to methods two known, a carbon chain with a nitrogen function at the end, is modified by reduction to the desired side chain of the formula ** (see formula) ** or -CH2 -A-NH2, where A, R3 and R4 have the meaning above, optionally an alkyl or aralkyl substituent is introduced at position 1 and the hydroxy function is released from the aralkyl group or the benzyl moiety R1'and the compound obtained is transformed into a salt by reaction with an inorganic or organic acid. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH7167759A CH373381A (en) | 1959-07-13 | 1959-07-13 | Process for the preparation of new basic indole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES257146A1 true ES257146A1 (en) | 1960-12-01 |
Family
ID=4531186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0257146A Expired ES257146A1 (en) | 1959-07-13 | 1960-04-06 | Procedure for obtaining new basic indian labor derivatives (Machine-translation by Google Translate, not legally binding) |
Country Status (3)
| Country | Link |
|---|---|
| CH (4) | CH373381A (en) |
| ES (1) | ES257146A1 (en) |
| GB (1) | GB942548A (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003082271A2 (en) | 2002-04-03 | 2003-10-09 | Astrazeneca Ab | Indole derivatives having anti-angiogenetic activity |
| PH12022551981A1 (en) | 2020-02-04 | 2023-10-16 | Mindset Pharma Inc | Psilocin derivatives as serotonergic psychedelic agents for the treatment of cns disorders |
| CN115867533B (en) | 2020-06-30 | 2024-07-23 | 加拿大瑞安神经科学公司 | Tryptamine prodrugs |
| AU2021361987A1 (en) * | 2020-10-13 | 2023-05-11 | Caamtech, Inc. | Tryptamine derivatives and their therapeutic uses |
| CA3218596A1 (en) * | 2021-05-10 | 2022-11-17 | Collin CLARKE | Psilocybin and psilocin conjugates for treatment of mental illnesses |
| US12065404B2 (en) | 2022-03-18 | 2024-08-20 | Enveric Biosciences Canada Inc. | C4-carboxylic acid-substituted tryptamine derivatives and methods of using |
| WO2025049510A1 (en) * | 2023-08-29 | 2025-03-06 | Caamtech, Inc. | 4-hydroxy-n-ethyltryptamine |
-
1959
- 1959-07-13 CH CH7167759A patent/CH373381A/en unknown
- 1959-08-21 CH CH724264A patent/CH380130A/en unknown
- 1959-08-21 CH CH724364A patent/CH380131A/en unknown
-
1960
- 1960-02-24 CH CH204960A patent/CH383379A/en unknown
- 1960-03-22 GB GB1016660A patent/GB942548A/en not_active Expired
- 1960-04-06 ES ES0257146A patent/ES257146A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH373381A (en) | 1963-11-30 |
| CH380130A (en) | 1964-07-31 |
| GB942548A (en) | 1963-11-27 |
| CH380131A (en) | 1964-07-31 |
| CH383379A (en) | 1964-10-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR870006072A (en) | Method for preparing rapamycin precursor | |
| ES257146A1 (en) | Procedure for obtaining new basic indian labor derivatives (Machine-translation by Google Translate, not legally binding) | |
| ES311444A1 (en) | Procedure for the obtaining of pyridine compounds. (Machine-translation by Google Translate, not legally binding) | |
| ES321531A1 (en) | PROCEDURE FOR THE MANUFACTURE OF NEW 7- (PICOLYLAMINOALKYLTEOPHYLLINS). | |
| ES393934A2 (en) | Derivatives of theophylline | |
| ES451466A1 (en) | 5-thiazole-methane-amines, and their use as antilipolytics | |
| ES434405A1 (en) | Procedure for the preparation of imidazole derivatives. (Machine-translation by Google Translate, not legally binding) | |
| ES407519A1 (en) | 2-(5'-nitro-2'-furyl)-thieno(2,3-d)pyridines and salts thereof | |
| ES385774A1 (en) | Procedure for the preparation of new 2- (5-nitro-2- furil) -the (3,2-d) pyrimidines. (Machine-translation by Google Translate, not legally binding) | |
| ES274329A1 (en) | Procedure for the preparation of new compounds of 1,5-benzodioxepano (Machine-translation by Google Translate, not legally binding) | |
| ES418841A1 (en) | Derivatives of pyridine-3-acetic acid | |
| ES274909A1 (en) | Iminodibenzyl derivatives | |
| ES402639A1 (en) | Tropanol esters of alpha-phenyl-alpha-cyclopentyl-acetic acid | |
| ES364726A1 (en) | Procedure for the preparation of new derivatives of paminoalquil-bencensulfonamida. (Machine-translation by Google Translate, not legally binding) | |
| ES321808A1 (en) | Procedure for the synthesis of new derivatives of piperidine. (Machine-translation by Google Translate, not legally binding) | |
| ES393259A1 (en) | Amino-acid ester derivatives of 2h-chromen-5-ol | |
| ES294197A1 (en) | PROCEDURE FOR THE PREPARATION OF NEW AZEPINIC DERIVATIVES | |
| ES266945A1 (en) | Procedure for obtaining tiaxyanene derivatives (Machine-translation by Google Translate, not legally binding) | |
| ES415404A1 (en) | Procedure for preparing amino-2 benzoic acid derivatives. (Machine-translation by Google Translate, not legally binding) | |
| ES371234A1 (en) | Procedure for the preparation of new benzofuran derivatives. (Machine-translation by Google Translate, not legally binding) | |
| ES309826A1 (en) | Procedure for the obtaining of phosphoric esters. (Machine-translation by Google Translate, not legally binding) | |
| ES252657A1 (en) | Procedure for the obtaining of derivatives of difenilmetano replaced by basic radicals (Machine-translation by Google Translate, not legally binding) | |
| ES371235A1 (en) | Procedure for the preparation of new benzofuran derivatives. (Machine-translation by Google Translate, not legally binding) | |
| ES446532A1 (en) | Procedure for the obtaining of derivatives of the phenoxyactic acid. (Machine-translation by Google Translate, not legally binding) | |
| ES385906A1 (en) | Procedure for the obtaining of acid derivatives -7- cephaloesporanic amino. (Machine-translation by Google Translate, not legally binding) |