ES422932A1 - PROCEDURE FOR THE PREPARATION OF NEW ACID AMIDAS. - Google Patents
PROCEDURE FOR THE PREPARATION OF NEW ACID AMIDAS.Info
- Publication number
- ES422932A1 ES422932A1 ES422932A ES422932A ES422932A1 ES 422932 A1 ES422932 A1 ES 422932A1 ES 422932 A ES422932 A ES 422932A ES 422932 A ES422932 A ES 422932A ES 422932 A1 ES422932 A1 ES 422932A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- amidas
- procedure
- new acid
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- XVTAQSGZOGYIEY-UHFFFAOYSA-N 3,4-dihydroisocoumarin Chemical class C1=CC=C2C(=O)OCCC2=C1 XVTAQSGZOGYIEY-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 230000002082 anti-convulsion Effects 0.000 abstract 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000001991 dicarboxylic acids Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- -1 sedating Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/14—Monocyclic dicarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Process for the preparation of novel acid amides of the formula I < IMAGE > in which R1 to R3 which are identical or different, denote hydrogen or alkyl having 1 to 3 carbon atoms. The novel compounds are distinguished by useful pharmacological properties, in particular by muscle-relaxant, sedating, antiarrhythmic and anticonvulsive actions. They are prepared, starting from the corresponding isochromanones or the corresponding dicarboxylic acids, by reaction with suitably substituted glycinamides or their acid addition salts.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2237770A DE2237770A1 (en) | 1972-08-01 | 1972-08-01 | NEW ACID AMID |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES422932A1 true ES422932A1 (en) | 1976-06-16 |
Family
ID=5852334
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES417443A Expired ES417443A1 (en) | 1972-08-01 | 1973-07-31 | PROCEDURE FOR THE PREPARATION OF NEW ACID AMIDAS. |
| ES422932A Expired ES422932A1 (en) | 1972-08-01 | 1974-02-05 | PROCEDURE FOR THE PREPARATION OF NEW ACID AMIDAS. |
| ES422931A Expired ES422931A1 (en) | 1972-08-01 | 1974-02-05 | PROCEDURE FOR THE PREPARATION OF NEW ACID AMIDAS. |
| ES422930A Expired ES422930A1 (en) | 1972-08-01 | 1974-02-05 | PROCEDURE FOR THE PREPARATION OF NEW ACID AMIDAS. |
| ES422933A Expired ES422933A1 (en) | 1972-08-01 | 1974-02-05 | Pharmaceutical compositions containing dioxo-isoquinoline derivatives |
| ES422929A Expired ES422929A1 (en) | 1972-08-01 | 1974-02-05 | Pharmaceutical compositions containing dioxo-isoquinoline derivatives |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES417443A Expired ES417443A1 (en) | 1972-08-01 | 1973-07-31 | PROCEDURE FOR THE PREPARATION OF NEW ACID AMIDAS. |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES422931A Expired ES422931A1 (en) | 1972-08-01 | 1974-02-05 | PROCEDURE FOR THE PREPARATION OF NEW ACID AMIDAS. |
| ES422930A Expired ES422930A1 (en) | 1972-08-01 | 1974-02-05 | PROCEDURE FOR THE PREPARATION OF NEW ACID AMIDAS. |
| ES422933A Expired ES422933A1 (en) | 1972-08-01 | 1974-02-05 | Pharmaceutical compositions containing dioxo-isoquinoline derivatives |
| ES422929A Expired ES422929A1 (en) | 1972-08-01 | 1974-02-05 | Pharmaceutical compositions containing dioxo-isoquinoline derivatives |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS558973B2 (en) |
| AT (2) | AT329059B (en) |
| AU (1) | AU476552B2 (en) |
| BE (1) | BE803086A (en) |
| CH (6) | CH615918A5 (en) |
| DE (1) | DE2237770A1 (en) |
| DK (1) | DK137008C (en) |
| ES (6) | ES417443A1 (en) |
| FI (1) | FI52218C (en) |
| FR (1) | FR2194435A1 (en) |
| GB (1) | GB1450793A (en) |
| NL (1) | NL7310562A (en) |
-
1972
- 1972-08-01 DE DE2237770A patent/DE2237770A1/en active Pending
-
1973
- 1973-07-30 CH CH1106573A patent/CH615918A5/en not_active IP Right Cessation
- 1973-07-30 FR FR7327882A patent/FR2194435A1/fr not_active Withdrawn
- 1973-07-31 NL NL7310562A patent/NL7310562A/xx not_active Application Discontinuation
- 1973-07-31 BE BE134124A patent/BE803086A/en unknown
- 1973-07-31 AU AU58735/73A patent/AU476552B2/en not_active Expired
- 1973-07-31 DK DK420373A patent/DK137008C/en active
- 1973-07-31 ES ES417443A patent/ES417443A1/en not_active Expired
- 1973-07-31 JP JP8629773A patent/JPS558973B2/ja not_active Expired
- 1973-07-31 GB GB3638873A patent/GB1450793A/en not_active Expired
- 1973-07-31 FI FI732412A patent/FI52218C/en active
- 1973-08-01 AT AT673773A patent/AT329059B/en not_active IP Right Cessation
- 1973-09-01 AT AT225975*7A patent/AT329060B/en not_active IP Right Cessation
-
1974
- 1974-02-05 ES ES422932A patent/ES422932A1/en not_active Expired
- 1974-02-05 ES ES422931A patent/ES422931A1/en not_active Expired
- 1974-02-05 ES ES422930A patent/ES422930A1/en not_active Expired
- 1974-02-05 ES ES422933A patent/ES422933A1/en not_active Expired
- 1974-02-05 ES ES422929A patent/ES422929A1/en not_active Expired
-
1978
- 1978-05-07 CH CH498578A patent/CH611887A5/en not_active IP Right Cessation
- 1978-05-08 CH CH498678A patent/CH615423A5/en not_active IP Right Cessation
- 1978-06-12 CH CH638978A patent/CH611888A5/en not_active IP Right Cessation
- 1978-06-12 CH CH638878A patent/CH612184A5/en not_active IP Right Cessation
- 1978-06-12 CH CH639078A patent/CH611280A5/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CH615918A5 (en) | 1980-02-29 |
| ES422931A1 (en) | 1976-06-16 |
| CH611280A5 (en) | 1979-05-31 |
| ES422930A1 (en) | 1976-06-16 |
| CH612184A5 (en) | 1979-07-13 |
| ES417443A1 (en) | 1976-03-16 |
| ES422929A1 (en) | 1976-06-16 |
| DE2237770A1 (en) | 1974-02-14 |
| NL7310562A (en) | 1974-02-05 |
| DK137008B (en) | 1978-01-02 |
| AU476552B2 (en) | 1976-09-30 |
| FI52218C (en) | 1977-07-11 |
| AT329059B (en) | 1976-04-26 |
| FI52218B (en) | 1977-03-31 |
| ATA673773A (en) | 1975-07-15 |
| CH615423A5 (en) | 1980-01-31 |
| ATA225975A (en) | 1975-07-15 |
| JPS4980080A (en) | 1974-08-02 |
| CH611887A5 (en) | 1979-06-29 |
| DK137008C (en) | 1978-05-22 |
| JPS558973B2 (en) | 1980-03-07 |
| AT329060B (en) | 1976-04-26 |
| GB1450793A (en) | 1976-09-29 |
| CH611888A5 (en) | 1979-06-29 |
| BE803086A (en) | 1974-01-31 |
| AU5873573A (en) | 1975-02-06 |
| ES422933A1 (en) | 1976-06-16 |
| FR2194435A1 (en) | 1974-03-01 |
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