ES453263A1 - PROCEDURE FOR PREPARING GUANIDINE DERIVATIVES ANTAGONISTS OF HISTAMINE H2. - Google Patents

PROCEDURE FOR PREPARING GUANIDINE DERIVATIVES ANTAGONISTS OF HISTAMINE H2.

Info

Publication number
ES453263A1
ES453263A1 ES453263A ES453263A ES453263A1 ES 453263 A1 ES453263 A1 ES 453263A1 ES 453263 A ES453263 A ES 453263A ES 453263 A ES453263 A ES 453263A ES 453263 A1 ES453263 A1 ES 453263A1
Authority
ES
Spain
Prior art keywords
histamine
antagonists
compounds
useful
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES453263A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Publication of ES453263A1 publication Critical patent/ES453263A1/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedimiento para preparar compuestos farmalógicamente activos, útiles para emplearse en composiciones farmacéuticas. Los compuestos producidos por el proceso de esta invención tienen una útil actividad antagonista de histamina H2. Estos compuestos pueden existir como sales de adición de ácido. Los antagonistas de histamina H2 se pueden definir como compuestos que bloquean los receptores de histamina H2. Los receptores de histamina H2 no son bloqueados por mepiramina y "antihistaminas" típicas (antagonistas de receptores de histamina H1), pero son bloqueados por burimamida. Los antagonistas de histamina H2 son de utilidad como inhibidores de la secreción de ácidos gástricos, como agentes anti-inflamatorios y como agentes que actúan sobre el sistema cardiovascular. Los productos del procedimiento de esta invención están representados por la siguiente fórmula I: **(Fórmula)**.Process for preparing pharmacologically active compounds, useful for use in pharmaceutical compositions. The compounds produced by the process of this invention have useful histamine H2 antagonist activity. These compounds can exist as acid addition salts. Histamine H2 antagonists can be defined as compounds that block histamine H2 receptors. Histamine H2 receptors are not blocked by mepyramine and typical "antihistamines" (histamine H1 receptor antagonists), but are blocked by burimamide. Histamine H 2 antagonists are useful as inhibitors of gastric acid secretion, as anti-inflammatory agents, and as agents acting on the cardiovascular system. The products of the process of this invention are represented by the following formula I: **(Formula)**.

ES453263A 1975-11-12 1976-11-12 PROCEDURE FOR PREPARING GUANIDINE DERIVATIVES ANTAGONISTS OF HISTAMINE H2. Expired ES453263A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB46732/75A GB1573611A (en) 1975-11-12 1975-11-12 Heterocyclic thioalkyl-amines-guanidines and -thioureas

Publications (1)

Publication Number Publication Date
ES453263A1 true ES453263A1 (en) 1978-01-16

Family

ID=10442384

Family Applications (1)

Application Number Title Priority Date Filing Date
ES453263A Expired ES453263A1 (en) 1975-11-12 1976-11-12 PROCEDURE FOR PREPARING GUANIDINE DERIVATIVES ANTAGONISTS OF HISTAMINE H2.

Country Status (22)

Country Link
JP (1) JPS5262274A (en)
AT (1) AT350583B (en)
AU (1) AU508143B2 (en)
BE (1) BE848108A (en)
CA (1) CA1070316A (en)
DE (1) DE2649546A1 (en)
DK (1) DK503176A (en)
ES (1) ES453263A1 (en)
FI (1) FI763209A7 (en)
FR (1) FR2331342A1 (en)
GB (1) GB1573611A (en)
HU (1) HU175667B (en)
IE (1) IE44103B1 (en)
IL (1) IL50748A0 (en)
LU (1) LU76162A1 (en)
NL (1) NL7611590A (en)
NO (1) NO763812L (en)
NZ (1) NZ182309A (en)
PT (1) PT65759B (en)
SE (1) SE7611405L (en)
SU (1) SU634668A3 (en)
ZA (1) ZA766201B (en)

Also Published As

Publication number Publication date
FI763209A7 (en) 1977-05-13
AT350583B (en) 1979-06-11
NO763812L (en) 1977-05-13
HU175667B (en) 1980-09-28
SE7611405L (en) 1977-05-13
AU1890076A (en) 1978-04-27
BE848108A (en) 1977-05-09
FR2331342A1 (en) 1977-06-10
SU634668A3 (en) 1978-11-25
GB1573611A (en) 1980-08-28
IE44103L (en) 1977-05-12
FR2331342B1 (en) 1980-03-07
PT65759A (en) 1976-11-01
CA1070316A (en) 1980-01-22
DK503176A (en) 1977-05-13
JPS5262274A (en) 1977-05-23
IE44103B1 (en) 1981-08-12
ATA819776A (en) 1978-11-15
LU76162A1 (en) 1977-05-18
NL7611590A (en) 1977-05-16
IL50748A0 (en) 1976-12-31
PT65759B (en) 1978-04-27
ZA766201B (en) 1977-09-28
AU508143B2 (en) 1980-03-13
DE2649546A1 (en) 1977-05-26
NZ182309A (en) 1978-07-10

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