ES8405393A1 - Un procedimiento para la preparacion de nuevos benzopiranos. - Google Patents

Un procedimiento para la preparacion de nuevos benzopiranos.

Info

Publication number
ES8405393A1
ES8405393A1 ES521317A ES521317A ES8405393A1 ES 8405393 A1 ES8405393 A1 ES 8405393A1 ES 521317 A ES521317 A ES 521317A ES 521317 A ES521317 A ES 521317A ES 8405393 A1 ES8405393 A1 ES 8405393A1
Authority
ES
Spain
Prior art keywords
alkyl
benzopyranols
antihypertensive
hydrogen
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES521317A
Other languages
English (en)
Other versions
ES521317A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES521317A0 publication Critical patent/ES521317A0/es
Publication of ES8405393A1 publication Critical patent/ES8405393A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS BENZOPIRANOS.CONSISTE EN CICLAR UN COMPUESTO DE FORMULA (II) O UNA SAL METALICA DEL MISMO, TAL COMO SAL DE SODIO, PARA OBTENER UN COMPUESTO DE FORMULA (I), DONDE R1 Y R2 ES NITRO, CIANO O (ALQUIL C 1 A 3) CARBONILO, Y EL OTRO ES METOXI O AMINO; R3 Y R4 ES HIDROGENO O ALQUILO CON C 1 A 4 Y EL OTRO ES ALQUILO CON C 1 A 4, O ESPIROALQUILO CON C 3 A 6; R5 ES HIDROGENO, ALQUILO CON C 1 A 3 O ACILO CON C 1 A 8; N ES 1 O 2; SIENDO TRANS EL GRUPO LACTAMA AL GRUPO OR5; R1 Y R2 ES NITRO, CIANO O (ALQUILCON C 1 A 3) CARBONILO O UN GRUPO O ATOMO CONVERTIBLE EN ESTE Y EL OTRO ES METOXI O AMINO; X E Y ES CO Y EL OTRO ES (CH2)NB2; L1 ES UN GRUPO SALIENTE, Y EL GRUPO AMINO SUSTITUIDO ES TRANS AL GRUPO OR5.TIENE APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD REDUCTORA DE LA PRESION SANGUINEA.
ES521317A 1982-04-08 1983-04-07 Un procedimiento para la preparacion de nuevos benzopiranos. Expired ES8405393A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8210490 1982-04-08

Publications (2)

Publication Number Publication Date
ES521317A0 ES521317A0 (es) 1984-06-01
ES8405393A1 true ES8405393A1 (es) 1984-06-01

Family

ID=10529622

Family Applications (1)

Application Number Title Priority Date Filing Date
ES521317A Expired ES8405393A1 (es) 1982-04-08 1983-04-07 Un procedimiento para la preparacion de nuevos benzopiranos.

Country Status (7)

Country Link
US (2) US4542149A (es)
EP (1) EP0091748B1 (es)
JP (1) JPS58188880A (es)
AU (1) AU1320683A (es)
DE (1) DE3364145D1 (es)
ES (1) ES8405393A1 (es)
ZA (1) ZA832431B (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0139992B1 (en) * 1983-09-01 1988-12-28 Beecham Group Plc Chromanol derivatives
GB8409745D0 (en) * 1984-04-14 1984-05-23 Beecham Group Plc Active compounds
EP0172352B1 (en) * 1984-06-22 1990-08-29 Beecham Group Plc Active benzopyran compounds
GB8419516D0 (en) * 1984-07-31 1984-09-05 Beecham Group Plc Treatment
GB8419515D0 (en) * 1984-07-31 1984-09-05 Beecham Group Plc Treatment
GB8513369D0 (en) * 1985-05-28 1985-07-03 Beecham Group Plc Treatment
DE3682331D1 (de) 1985-06-08 1991-12-12 Beecham Group Plc Pyrano(3,2-c)pyridinderivate, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
GB8521857D0 (en) * 1985-09-03 1985-10-09 Beecham Group Plc Active compounds
DE3669317D1 (de) * 1985-09-11 1990-04-12 Beecham Group Plc Chromanderivate und aehnliche verbindungen mit blutdrucksenkender wirkung.
GB8625185D0 (en) * 1986-10-21 1986-11-26 Beecham Group Plc Active compounds
DE3703227A1 (de) * 1987-02-04 1988-08-18 Hoechst Ag Substituierte 3,4-dihydro-2h-benzopyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
CA1308108C (en) * 1987-10-27 1992-09-29 Dominick A. Quagliato Antihypertensive benzopyran derivatives
GB8800199D0 (en) * 1988-01-06 1988-02-10 Beecham Group Plc Pharmaceutical preparation
DE3811017A1 (de) * 1988-03-31 1989-10-19 Hoechst Ag Ungesaettigte n-benzopyranyllactame
DE3837809A1 (de) * 1988-11-08 1990-05-10 Merck Patent Gmbh Tetralinderivate
FR2639227A1 (fr) * 1988-11-23 1990-05-25 Sanofi Sa Utilisation de derives du chromane pour le traitement des etats depressifs
DE3918041A1 (de) * 1989-06-02 1990-12-06 Merck Patent Gmbh Chromanderivate
DE3926001A1 (de) * 1989-08-05 1991-02-07 Merck Patent Gmbh Chromanderivate
GB8924373D0 (en) * 1989-10-30 1989-12-20 Beecham Group Plc Novel compounds
US5254555A (en) * 1989-10-30 1993-10-19 Beecham Group P.L.C. Amino pyrimidin-7-yl substituted benzopyrans for treatment of hypertension
US5276168A (en) * 1990-06-18 1994-01-04 E. R. Squibb & Sons, Inc. Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents
JP3502403B2 (ja) * 1991-12-16 2004-03-02 アベンティス ファーマ株式会社 骨吸収抑制剤
US5540201A (en) * 1994-07-29 1996-07-30 Caterpillar Inc. Engine compression braking apparatus and method
US5629429A (en) * 1995-06-07 1997-05-13 Bristol-Myers Squibb Company Process for preparing 4-arylamino-benzopyran and related compounds
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
US5612323A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phosphinic ester substituted benzopyran derivatives
NZ333870A (en) * 1996-07-26 2000-08-25 Nissan Chemical Ind Ltd 4-amino substituted chroman derivatives
US6486178B1 (en) 1998-06-03 2002-11-26 Nissan Chemical Industries, Ltd. Indane derivatives
US6555574B1 (en) 1999-09-24 2003-04-29 Nissan Chemical Industries, Ltd. 4-oxybenzopyran derivative
WO2001025224A1 (en) 1999-10-05 2001-04-12 Nissan Chemical Industries, Ltd. 4-oxybenzopyran derivative
HUP0400362A3 (en) 2001-06-25 2007-05-29 Nissan Chemical Ind Ltd Substituted benzopyran derivetives against arrhythmia
KR101004133B1 (ko) * 2002-10-18 2010-12-27 닛산 가가쿠 고교 가부시키 가이샤 아세틸렌 화합물의 제조방법
AU2007225765B2 (en) 2006-03-10 2012-05-24 Nissan Chemical Industries, Ltd. Process for producing optically active chromene oxide compound

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1495526A (en) * 1974-05-31 1977-12-21 Beecham Group Ltd Chroman derivatives
GB1548221A (en) * 1976-01-27 1979-07-04 Beecham Group Ltd Trans-4-heterocycyl-3,4-dihydro-2h-benzo pyran-3-ol esters
US4391815A (en) * 1976-04-02 1983-07-05 Beecham Group Limited Cyanobenzano[b]pyrans
NZ183551A (en) * 1976-04-02 1978-09-20 Beecham Group Ltd Aminochromanols and pharmaceutical compositions containingthem
GB1511187A (en) * 1976-04-02 1978-05-17 Beecham Group Ltd Chromans
GB1548222A (en) * 1976-12-17 1979-07-04 Beecham Group Ltd Trans-4-heterocyclyl-3,4-dihydro-2h-benzo pyarn-3-ol derivatives
EP0009912B1 (en) * 1978-10-04 1983-06-22 Beecham Group Plc Chromanol derivatives, a process for their preparation and pharmaceutical compositions comprising them
EP0028064B1 (en) * 1979-09-28 1983-07-20 Beecham Group Plc Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them
DE3064285D1 (en) * 1979-09-28 1983-08-25 Beecham Group Plc Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them
DE2950479A1 (de) * 1979-12-14 1981-06-19 A. Nattermann & Cie GmbH, 5000 Köln N-(3-alkylamino-2-hydroxypropoxy-phenyl)-lactame, deren herstellungsverfahren und arzneimitttel auf deren basis
EP0046652B1 (en) * 1980-08-21 1985-05-22 Beecham Group Plc Chromanol derivatives, their production and pharmaceutical compositions containing them
EP0076075B1 (en) * 1981-09-25 1986-11-20 Beecham Group Plc Pharmaceutically active benzopyran compounds
DE3368629D1 (en) * 1982-04-28 1987-02-05 Beecham Group Plc Novel chromenes and chromans

Also Published As

Publication number Publication date
ES521317A0 (es) 1984-06-01
US4644070A (en) 1987-02-17
JPS58188880A (ja) 1983-11-04
DE3364145D1 (de) 1986-07-24
US4542149A (en) 1985-09-17
AU1320683A (en) 1983-10-13
EP0091748A1 (en) 1983-10-19
ZA832431B (en) 1984-03-28
EP0091748B1 (en) 1986-06-18

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