ES8600192A1 - Un procedimiento para sintetizar compuestos analogos de 13,14-dideshidro-15-oxo-prostaglandina - Google Patents

Un procedimiento para sintetizar compuestos analogos de 13,14-dideshidro-15-oxo-prostaglandina

Info

Publication number
ES8600192A1
ES8600192A1 ES527024A ES527024A ES8600192A1 ES 8600192 A1 ES8600192 A1 ES 8600192A1 ES 527024 A ES527024 A ES 527024A ES 527024 A ES527024 A ES 527024A ES 8600192 A1 ES8600192 A1 ES 8600192A1
Authority
ES
Spain
Prior art keywords
oxo
dideshidro
prostaglandina
procedure
analog compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES527024A
Other languages
English (en)
Other versions
ES527024A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of ES527024A0 publication Critical patent/ES527024A0/es
Publication of ES8600192A1 publication Critical patent/ES8600192A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/50—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C205/51—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA SINTETIZAR COMPUESTOS ANALOGOS DE 13,14-DIDESHIDRO-15-OXO-PROSTAGLANDINA.COMPRENDE: A) HACER REACCIONAR UN (A) DEL ACIDO 2-OXO-CICLOPENTANO-CARBOXILICO CON UN (A) DE 7-BROMO-HEPTANATO; B) OBTENER A (B) A PARTIR DEL PRODUCTO DE (A); C) HACER REACCIONAR A (B) CON CO3CA Y BR2 EN SOLUCION ACUOSA; D) PRODUCIR A (C) A PARTIR DEL PRODUCTO DE (C); E) OBTENER A (D) A PARTIR DE (C); F) CONVERTIR A (D) EN (E); G) OBTENER A (F) A PARTIR DE (E); H) DESBROMAR A (F) PARA OBTENER (G), E I) OXIDAR A (G) PARA OBTENER UN COMPUESTO DE FORMULA (I), SUS SALES Y SUS ESTERES. SIENDO: A, ESTER ALQUILICO INFERIOR; B, ENOL ACETATO; C, ENONA; D, NITRO-CETONA; E, DICETONA; F, BROMO-DICETO OLEFINA; G, INODIOL; R1, RADICAL DE FORMULA (II) Y (III); R2, CFO; R3, RK Y RL, H Y OTROS; R4, CH2 Y OTROS Y R5, C2H5 Y OTROS.SE UTILIZA PARA EL TRATAMIENTO Y PREVENCION DE ENFERMEDADES GASTRICAS.
ES527024A 1982-11-05 1983-11-04 Un procedimiento para sintetizar compuestos analogos de 13,14-dideshidro-15-oxo-prostaglandina Expired ES8600192A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43950482A 1982-11-05 1982-11-05
US54221083A 1983-10-19 1983-10-19

Publications (2)

Publication Number Publication Date
ES527024A0 ES527024A0 (es) 1985-09-16
ES8600192A1 true ES8600192A1 (es) 1985-09-16

Family

ID=27032069

Family Applications (3)

Application Number Title Priority Date Filing Date
ES527024A Expired ES8600192A1 (es) 1982-11-05 1983-11-04 Un procedimiento para sintetizar compuestos analogos de 13,14-dideshidro-15-oxo-prostaglandina
ES533466A Expired ES8603398A1 (es) 1982-11-05 1984-06-15 Un procedimiento para sintetizar la 13,14-dideshidro-15-oxo-pgf2
ES533467A Expired ES8603399A1 (es) 1982-11-05 1984-06-15 Un procedimiento para sintetizar compuestos analogos de 13,14-dideshidro-15-oxo de la serie e de prostaglandinas

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES533466A Expired ES8603398A1 (es) 1982-11-05 1984-06-15 Un procedimiento para sintetizar la 13,14-dideshidro-15-oxo-pgf2
ES533467A Expired ES8603399A1 (es) 1982-11-05 1984-06-15 Un procedimiento para sintetizar compuestos analogos de 13,14-dideshidro-15-oxo de la serie e de prostaglandinas

Country Status (7)

Country Link
EP (1) EP0108451A3 (es)
AU (1) AU2097283A (es)
CA (1) CA1255298A (es)
ES (3) ES8600192A1 (es)
GB (1) GB2131427B (es)
NZ (1) NZ206151A (es)
PH (1) PH23709A (es)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI71138C (fi) * 1976-12-31 1986-11-24 Erba Farmitalia Foerfarande foer framstaellning av terapeutiskt aktiva bisykliska prostaglandiner
GB2013661B (en) * 1978-01-26 1982-11-10 Erba Farmitalia 9-deoxy-9 -methylene isosteres of pgi2
US4180657A (en) * 1978-08-14 1979-12-25 The Upjohn Company Acyl-substituted phenyl esters of prostacyclin-type compounds
NL7810862A (nl) * 1978-11-01 1980-05-06 Upjohn Co 5 6-didehydroprostacycline-analoga, farmaceutische preparaten daarvan en werkwijzen voor het bereiden van een en ander.

Also Published As

Publication number Publication date
ES527024A0 (es) 1985-09-16
NZ206151A (en) 1986-11-12
ES533466A0 (es) 1985-12-16
ES533467A0 (es) 1985-12-16
CA1255298A (en) 1989-06-06
EP0108451A3 (en) 1985-04-10
PH23709A (en) 1989-09-27
AU2097283A (en) 1984-05-10
ES8603398A1 (es) 1985-12-16
GB2131427A (en) 1984-06-20
EP0108451A2 (en) 1984-05-16
GB2131427B (en) 1986-07-09
ES8603399A1 (es) 1985-12-16
GB8329392D0 (en) 1983-12-07

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