ES8604260A1 - Procedimiento para la preparacion de derivados de 17 a-halo-vinilestrano - Google Patents

Procedimiento para la preparacion de derivados de 17 a-halo-vinilestrano

Info

Publication number
ES8604260A1
ES8604260A1 ES545495A ES545495A ES8604260A1 ES 8604260 A1 ES8604260 A1 ES 8604260A1 ES 545495 A ES545495 A ES 545495A ES 545495 A ES545495 A ES 545495A ES 8604260 A1 ES8604260 A1 ES 8604260A1
Authority
ES
Spain
Prior art keywords
halovinyl
medicines
preparation
iodo
configuration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES545495A
Other languages
English (en)
Other versions
ES545495A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of ES545495A0 publication Critical patent/ES545495A0/es
Publication of ES8604260A1 publication Critical patent/ES8604260A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE 17A-HALOVINILESTRANO. COMPRENDE: A) HACER REACCIONAR UN DERIVADO 17A-ETINIL-ESTRANO DE FORMULA (II) CON UN HIDRURO DE TRIALQUILESTAÑO CON C 2 A 6 POR CADA RADICAL ALQUILO, EN UN DISOLVENTE INERTE POR EJEMPLO, ETERES TALES COMO DIETILETER, DIOXANO, ETC., EN PRESENCIA DE UN FORMADOR DE RADICALES TAL COMO A,A-AZOISO-BUTIRONITRILO COMO CATALIZADOR, PARA FORMAR EL 17A-(TRIALQUILESTANNILVINIL)-ESTRANO; Y B) INTERCAMBIAR EL RADICAL TRIALQUILESTANNILO POR BROMO O YODO, PARA OBTENER LOS DERIVADOS DE FORMULA (I). SIENDO: X, BROMO, YODO EN POSICION Z O E; R1, H, HIDROXI O ACILOXI; R2, H, ALQUILO DE C 3 Y AROILO DE C 7; R3, H O METILO; R4, H SITUADO EN POSICION A O B; R5, H, METILO O METOXI; R6, H, METILO; Y R7, H, ALCANOILO Y ARILCARBONILO. SE UTILIZA COMO AGENTES PARA DIAGNOSTICO.
ES545495A 1984-07-25 1985-07-23 Procedimiento para la preparacion de derivados de 17 a-halo-vinilestrano Expired ES8604260A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843427795 DE3427795A1 (de) 1984-07-25 1984-07-25 Neue 17(alpha)-halogenvinyl-estran-derivate, ihre herstellung und verwendung in der medizin

Publications (2)

Publication Number Publication Date
ES545495A0 ES545495A0 (es) 1986-02-01
ES8604260A1 true ES8604260A1 (es) 1986-02-01

Family

ID=6241772

Family Applications (1)

Application Number Title Priority Date Filing Date
ES545495A Expired ES8604260A1 (es) 1984-07-25 1985-07-23 Procedimiento para la preparacion de derivados de 17 a-halo-vinilestrano

Country Status (11)

Country Link
US (1) US4725426A (es)
EP (1) EP0169515B1 (es)
JP (1) JPH0755959B2 (es)
AT (1) ATE47143T1 (es)
AU (1) AU4528185A (es)
CA (1) CA1310631C (es)
DE (2) DE3427795A1 (es)
DK (1) DK327485A (es)
ES (1) ES8604260A1 (es)
GR (1) GR851824B (es)
IE (1) IE58386B1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3627154A1 (de) * 1986-08-11 1988-02-25 Schering Ag Verfahren zur herstellung von (z)-17(alpha)-halogenvinyl-steroiden und (z)-17(alpha)-chlorvinyl-steroide
WO1988001276A2 (en) * 1986-08-11 1988-02-25 Schering Aktiengesellschaft PROCESS FOR PRODUCING (Z)-17alpha-HALOGENVINYLSTEROIDS
FR2610933B1 (fr) * 1987-02-18 1989-06-09 Roussel Uclaf Nouveaux 19-nor steroides substitues en position 7, leur preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant
US5200169A (en) * 1987-04-16 1993-04-06 Neorx Corporation Vinyl substituted radiohalogen conjugates for protein labeling
US4876081A (en) * 1987-04-16 1989-10-24 Neorx Corporation Vinyl substituted radiohalogen and methods of use conjugates
US4870188A (en) * 1987-04-16 1989-09-26 Neorx Corporation Vinyl substituted radiohalogen conjugates for protein labeling
FR2613937B1 (fr) * 1987-04-17 1989-07-21 Ire Celltarg Sa Ligands specifiques de recepteurs d'hormones steroides utiles pour la therapie ciblee ou l'imagerie medicale notamment du cancer
FR2637803B1 (fr) * 1988-10-19 1993-07-09 Ire Celltarg Sa Ligands specifiques de recepteurs d'hormones steroides estrogenes et progestagenes, application et produits intermediaires de synthese
FR2690443B1 (fr) * 1992-04-10 1995-06-30 Wallone Region Marquage des hormones par le rhenium et le technetium.
US5427766A (en) * 1993-11-15 1995-06-27 The Dow Chemical Company Radiolabeled steroids for use in radiochemical-guided surgery
US7041839B2 (en) * 2000-06-22 2006-05-09 Northeastern University Steroidal antiestrogens and antiandrogens and uses thereof
US8173628B2 (en) * 2000-06-22 2012-05-08 Northeastern University Steroidal antiestrogens and antiandrogens and uses thereof
US7435757B2 (en) * 2004-07-02 2008-10-14 Schering Ag 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450149A (en) * 1981-06-15 1984-05-22 Research Corporation Radiohalogenation method
US4388504A (en) * 1981-06-24 1983-06-14 Westinghouse Electric Corp. Switch operating means including latching means maintaining switch contacts open or closed
US4541957A (en) * 1983-09-07 1985-09-17 The George Washington University Process for preparing iodovinyl-estradiol
DE3337179A1 (de) * 1983-10-10 1985-05-23 Schering AG, 1000 Berlin und 4709 Bergkamen Estran- und androstan-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende praeparate

Also Published As

Publication number Publication date
ES545495A0 (es) 1986-02-01
ATE47143T1 (de) 1989-10-15
EP0169515A3 (en) 1986-05-07
US4725426A (en) 1988-02-16
IE58386B1 (en) 1993-09-08
IE851849L (en) 1986-01-25
JPS61106595A (ja) 1986-05-24
EP0169515B1 (de) 1989-10-11
DE3573603D1 (en) 1989-11-16
JPH0755959B2 (ja) 1995-06-14
GR851824B (es) 1985-11-26
DK327485D0 (da) 1985-07-18
EP0169515A2 (de) 1986-01-29
DK327485A (da) 1986-01-26
DE3427795A1 (de) 1986-02-06
AU4528185A (en) 1986-01-30
CA1310631C (en) 1992-11-24

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