FI910853L - Vektorer och foereningar foer paovisande av zymogenformer av humanprotein-c. - Google Patents

Vektorer och foereningar foer paovisande av zymogenformer av humanprotein-c. Download PDF

Info

Publication number
FI910853L
FI910853L FI910853A FI910853A FI910853L FI 910853 L FI910853 L FI 910853L FI 910853 A FI910853 A FI 910853A FI 910853 A FI910853 A FI 910853A FI 910853 L FI910853 L FI 910853L
Authority
FI
Finland
Prior art keywords
zymogenformer
vektorer
humanprotein
foereningar
och
Prior art date
Application number
FI910853A
Other languages
English (en)
Finnish (fi)
Other versions
FI910853A0 (fi
FI910853A7 (fi
Inventor
Bruce Edward Gerlitz
Brian William Grinnell
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of FI910853A0 publication Critical patent/FI910853A0/fi
Publication of FI910853L publication Critical patent/FI910853L/fi
Publication of FI910853A7 publication Critical patent/FI910853A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
FI910853A 1990-02-23 1991-02-22 Vektoreita ja yhdisteitä humaaniproteiini-C:n tsymogeenimuotojen ilmentämiseksi FI910853A7 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/484,133 US5270178A (en) 1990-02-23 1990-02-23 Vectors and compounds for expression of zymogen forms of human protein C

Publications (3)

Publication Number Publication Date
FI910853A0 FI910853A0 (fi) 1991-02-22
FI910853L true FI910853L (fi) 1991-08-24
FI910853A7 FI910853A7 (fi) 1991-08-24

Family

ID=23922892

Family Applications (1)

Application Number Title Priority Date Filing Date
FI910853A FI910853A7 (fi) 1990-02-23 1991-02-22 Vektoreita ja yhdisteitä humaaniproteiini-C:n tsymogeenimuotojen ilmentämiseksi

Country Status (17)

Country Link
US (1) US5270178A (de)
EP (1) EP0443875A3 (de)
JP (1) JPH05103678A (de)
KR (1) KR910021476A (de)
CN (1) CN1054798A (de)
AU (1) AU7130891A (de)
CA (1) CA2036915A1 (de)
FI (1) FI910853A7 (de)
HU (1) HUT61592A (de)
IE (1) IE910610A1 (de)
IL (1) IL97310A0 (de)
MX (1) MX24652A (de)
NO (1) NO910720L (de)
NZ (1) NZ237198A (de)
PT (1) PT96854A (de)
YU (1) YU31791A (de)
ZA (1) ZA911330B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL97311A0 (en) * 1990-02-23 1992-05-25 Lilly Co Eli Vectors and compounds for expression of glycosylation mutants of human protein c
IL97312A (en) * 1990-02-23 1999-01-26 Lilly Co Eli A method of generating a polypeptide in an eukaryotic vector AND recombinant surrogate cell containing an enhanced transcriptional control unit based on the primary late adenovirus coefficient
MY110664A (en) * 1992-05-21 1999-01-30 Lilly Co Eli Protein c derivatives
DE4320294A1 (de) * 1993-06-18 1994-12-22 Immuno Ag Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen
US5585095A (en) * 1993-09-14 1996-12-17 Regents Of The University Of Minnesota Method to enhance thrombomodulin APC generation using cationic proteins
AU1477000A (en) * 1998-11-13 2000-06-05 Eli Lilly And Company Method of treating heparin-induced thrombocytopenia
US6485957B1 (en) * 1999-04-30 2002-11-26 Ortho-Mcneil Pharmaceutical, Inc. DNA encoding the human serine protease EOS
US6998122B1 (en) * 1999-04-30 2006-02-14 Eli Lilly And Company Protein C derivatives
US6420157B1 (en) * 1999-04-30 2002-07-16 Ortho-Mcneil Pharmaceutical, Inc. Zymogen activation system
US6426199B1 (en) 1999-08-31 2002-07-30 Ortho-Mcneil Pharmaceutical, Inc. Dna
US6458564B1 (en) 1999-08-31 2002-10-01 Ortho-Mcneil Pharmaceutical, Inc. DNA encoding the human serine protease T
CA2391651A1 (en) * 1999-11-19 2001-05-25 Eli Lilly And Company Protein c derivatives
WO2001057193A2 (en) 2000-02-02 2001-08-09 Eli Lilly And Company Protein c derivatives
CA2400187A1 (en) 2000-02-11 2001-08-16 Eli Lilly And Company Protein c derivatives
JP4071105B2 (ja) * 2000-10-18 2008-04-02 マキシゲン・エイピーエス プロテインｃまたは活性化プロテインｃ様分子
US6933367B2 (en) 2000-10-18 2005-08-23 Maxygen Aps Protein C or activated protein C-like molecules
US20070142272A1 (en) * 2003-01-24 2007-06-21 Zlokovic Berislav V Neuroprotective activity of activated protein c independent of its anticoagulant activity
JP2008507561A (ja) * 2004-07-23 2008-03-13 ザ ユニバーシティ オブ ロチェスター 活性化プロテインｃによる、脳内のプラスミノゲン活性化因子の不都合な作用の阻害
CA2654761A1 (en) * 2006-06-09 2007-12-13 The University Of British Columbia Interferon gamma polymorphisms as indicators of subject outcome in critically ill subjects
US20110171200A1 (en) * 2008-01-15 2011-07-14 Walley Keith R Protein c rs2069915 as a response predictor to survival and administration of activated protein c or protein c-like compound
WO2011106759A1 (en) * 2010-02-26 2011-09-01 The Children's Hospital Of Philadelphia Protein c zymogen and methods of use thereof to prevent cancer metastases
WO2012068519A2 (en) 2010-11-19 2012-05-24 Sirius Genomics Inc. Markers associated with response to activated protein c administration, and uses thereof
WO2023119230A1 (en) 2021-12-22 2023-06-29 L'oreal Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775624A (en) * 1985-02-08 1988-10-04 Eli Lilly And Company Vectors and compounds for expression of human protein C
CA1341228C (en) * 1985-06-27 2001-05-15 Mark J. Murray Expression of protein c
EP0245949B1 (de) * 1986-04-09 1997-10-29 Eli Lilly And Company Verfahren zur Anwendung von den BK-Virus-Verstärker enthaltenden eukaryotischen Expressionsvektoren
US4992373A (en) * 1987-12-04 1991-02-12 Eli Lilly And Company Vectors and compounds for direct expression of activated human protein C
ZA889497B (en) * 1987-12-28 1990-08-29 Lilly Co Eli Vectors and compounds for expression of zymogen forms of human protein c
CA1332049C (en) * 1988-10-07 1994-09-20 Eli Lilly And Company Eukaryotic expression

Also Published As

Publication number Publication date
FI910853A0 (fi) 1991-02-22
AU7130891A (en) 1991-08-29
MX24652A (es) 1994-01-31
CN1054798A (zh) 1991-09-25
YU31791A (sh) 1994-05-10
NO910720L (no) 1991-08-26
HU910605D0 (en) 1991-09-30
JPH05103678A (ja) 1993-04-27
EP0443875A2 (de) 1991-08-28
ZA911330B (en) 1992-10-28
PT96854A (pt) 1991-10-31
US5270178A (en) 1993-12-14
IE910610A1 (en) 1991-08-28
HUT61592A (en) 1993-01-28
EP0443875A3 (en) 1992-07-15
NZ237198A (en) 1993-07-27
CA2036915A1 (en) 1991-08-24
IL97310A0 (en) 1992-05-25
FI910853A7 (fi) 1991-08-24
NO910720D0 (no) 1991-02-22
KR910021476A (ko) 1991-12-20

Similar Documents

Publication Publication Date Title
FI902064A7 (fi) Foerfarande och anordning foer foertjockning av mesaslam.
FI902267L (fi) Foerfarande foer paofyllning och toemning av pipett och pipett.
FI910853L (fi) Vektorer och foereningar foer paovisande av zymogenformer av humanprotein-c.
FI901486A0 (fi) Foerfarande och anordning foer behandling av en mineralfiberbana.
FI902187A7 (fi) Foerfarande och anordning foer styrning av barkningsprocess.
FI900031A0 (fi) Foerfarande och anordning foer behandling av gaser fraon foergasnings- eller foerbraenningsanlaeggningar.
FI900915A7 (fi) Foerfarande och anordning foer rengoering av foeroreningar innehaollande gaser.
FI902269A7 (fi) Foerfarande foer laosning av pipettregleringsanordning och pipett.
FI902243A0 (fi) Foerfarande och anordning foer foerflyttning av betongplattor.
FI901558A7 (fi) Foerfarande och anlaeggning foer framstaellning av en mineralfiberbana.
FI900803L (fi) Kopplingsanordning foer foerening av rf-foerstaerkare och driftspaenningsfilter.
FI902463A0 (fi) Foerfarande och anordning foer framstaellning av kretskort.
FI900806A7 (fi) Foerfarande foer skjutoevning och analysering av skytteprocessen.
FI902183L (fi) Verktyg foer oeppning och staengning av ventilhatt foer luftfyllt daeck.
FI900168A0 (fi) Foerfarande och anordning foer borning av kanaloeppning.
FI900426A7 (fi) Foerpackningsaemne och foerfarande foer hopmontering av foerpackningen.
FI901931A7 (fi) Foerfarande och anordning foer vaermebehandling av en mjoelkprodukt.
FI900103A7 (fi) Dielektrisk keramikkomposition foer mikrovaogsomraodet och anvaendning daer av.
FI901117L (fi) Foerfarande och anordning foer framstaellning av en transportskruv.
FI901229A0 (fi) Golvkonstruktion och foerfarande foer bildande av densamma.
FI900692A7 (fi) Foerfarande och anordning foer bekaempning av oljeskador.
FI900583A7 (fi) Kontinuerligt foerfarande och anordning foer framstaellning av en foerspaend betongprodukt.
FI901287L (fi) Anordning foer bearbetning och utjaemning av jord.
FI901350A0 (fi) Foerfarande och anordning foer framstaellning av olika fibermaterial foer spaonplatta- fiberplatta- och traeindustrer.
FI900133A7 (fi) Foerfarande och anordning foer kompensering av oevertryck.

Legal Events

Date Code Title Description
FD Application lapsed