|
FR2686899B1
(en)
|
1992-01-31 |
1995-09-01 |
Rhone Poulenc Rorer Sa |
NOVEL BIOLOGICALLY ACTIVE POLYPEPTIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
|
|
US7183387B1
(en)
|
1999-01-15 |
2007-02-27 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
US7459540B1
(en)
|
1999-09-07 |
2008-12-02 |
Amgen Inc. |
Fibroblast growth factor-like polypeptides
|
|
EP2213743A1
(en)
|
2000-04-12 |
2010-08-04 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
CA2463879C
(en)
*
|
2001-10-25 |
2012-12-04 |
Genentech, Inc. |
Glycoprotein compositions
|
|
WO2003059934A2
(en)
|
2001-12-21 |
2003-07-24 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
WO2005003296A2
(en)
|
2003-01-22 |
2005-01-13 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
AU2002364586A1
(en)
|
2001-12-21 |
2003-07-30 |
Delta Biotechnology Limited |
Albumin fusion proteins
|
|
US20070161087A1
(en)
*
|
2003-05-29 |
2007-07-12 |
Wolfgang Glaesner |
Glp-1 fusion proteins
|
|
DK1641823T3
(en)
*
|
2003-06-12 |
2011-12-12 |
Lilly Co Eli |
GLP-1 analog fusion proteins
|
|
HUE027902T2
(en)
|
2004-02-09 |
2016-11-28 |
Human Genome Sciences Inc Corp Service Company |
Albumin fusion proteins
|
|
DK1831252T3
(en)
*
|
2004-12-22 |
2009-10-05 |
Lilly Co Eli |
GLP-1 analog fusion protein formulations
|
|
CA2608311C
(en)
*
|
2005-05-13 |
2012-11-27 |
Eli Lilly And Company |
Glp-1 pegylated compounds
|
|
US8658174B2
(en)
|
2005-07-27 |
2014-02-25 |
Qinghua Wang |
GLP/1/exendin 4 IgG Fc fusion constructs for treatment of diabetes
|
|
CA2658678A1
(en)
|
2005-08-06 |
2007-02-15 |
Gerald J. Prud'homme |
Composition and method for prevention and treatment of type i diabetes
|
|
DE602005017628D1
(en)
*
|
2005-09-22 |
2009-12-24 |
Biocompatibles Uk Ltd |
Fusion polypeptides of glp-1 (glucagon-like peptide-1) with increased peptidase resistance
|
|
EA200801174A1
(en)
*
|
2005-10-24 |
2009-02-27 |
Сентокор, Инк. |
GLP-2 MIMETIC ANTIBODIES, POLYPEPTIDES, COMPOSITIONS, METHODS AND APPLICATIONS
|
|
US8202837B2
(en)
*
|
2005-11-04 |
2012-06-19 |
Glaxosmithkline Llc |
Methods for administering hypoglycemic agents
|
|
CA2913805A1
(en)
|
2005-11-07 |
2007-05-18 |
Indiana University Research And Technology Corporation |
Glucagon analogs exhibiting physiological solubility and stability
|
|
US20130172274A1
(en)
|
2005-12-20 |
2013-07-04 |
Duke University |
Methods and compositions for delivering active agents with enhanced pharmacological properties
|
|
US8841255B2
(en)
|
2005-12-20 |
2014-09-23 |
Duke University |
Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
|
|
EP1816201A1
(en)
|
2006-02-06 |
2007-08-08 |
CSL Behring GmbH |
Modified coagulation factor VIIa with extended half-life
|
|
JP2009534423A
(en)
|
2006-04-20 |
2009-09-24 |
アムジェン インコーポレイテッド |
GLP-1 compounds
|
|
JP5290177B2
(en)
*
|
2006-08-31 |
2013-09-18 |
セントカー・インコーポレーテツド |
GLP-2 mimetibodies, polypeptides, compositions, methods and uses
|
|
CA2663047A1
(en)
*
|
2006-09-06 |
2008-03-13 |
Phase Bioscience, Inc. |
Therapeutic elastin-like polypeptide (elp) fusion proteins
|
|
US8338376B2
(en)
*
|
2006-10-20 |
2012-12-25 |
Biogen Idec Ma Inc. |
Compositions comprising variant LT-B-R-IG fusion proteins
|
|
CA2673459C
(en)
|
2006-12-22 |
2016-09-13 |
Stefan Schulte |
Modified coagulation factors with prolonged in vivo half-life
|
|
US20090098130A1
(en)
*
|
2007-01-05 |
2009-04-16 |
Bradshaw Curt W |
Glucagon-like protein-1 receptor (glp-1r) agonist compounds
|
|
AU2011254001B2
(en)
*
|
2007-01-05 |
2012-08-02 |
Covx Technologies Ireland Limited |
Glucagon-like protein-1 receptor (GLP-1R) agonist compounds
|
|
RU2477286C2
(en)
*
|
2007-01-05 |
2013-03-10 |
Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн |
GLUCAGON ANALOGUES, HAVING HIGH SOLUBILITY IN PHYSIOLOGICAL pH BUFFERS
|
|
JP2008169195A
(en)
*
|
2007-01-05 |
2008-07-24 |
Hanmi Pharmaceutical Co Ltd |
Insulin secretory peptide drug conjugates using carrier substances
|
|
CA2678001C
(en)
|
2007-02-12 |
2017-07-11 |
Stefan Schulte |
Therapeutic application of kazal-type serine protease inhibitors
|
|
CA2677932A1
(en)
|
2007-02-15 |
2008-08-21 |
Indiana University Research And Technology Corporation |
Glucagon/glp-1 receptor co-agonists
|
|
CA2680792A1
(en)
*
|
2007-03-15 |
2008-09-18 |
Biogen Idec Ma Inc. |
Treatment of autoimmune disorders
|
|
KR20100049032A
(en)
*
|
2007-06-19 |
2010-05-11 |
오츠카 가가쿠 가부시키가이샤 |
Glp-1 peptide having sugar chain attached thereto
|
|
US20110034373A1
(en)
*
|
2007-08-03 |
2011-02-10 |
Eli Lilly And Company |
Use of an fgf-21 compound and a glp-1 compound for the treatment of obesity
|
|
US7960336B2
(en)
*
|
2007-08-03 |
2011-06-14 |
Pharmain Corporation |
Composition for long-acting peptide analogs
|
|
US8563527B2
(en)
*
|
2007-08-20 |
2013-10-22 |
Pharmain Corporation |
Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same
|
|
EP2031064A1
(en)
*
|
2007-08-29 |
2009-03-04 |
Boehringer Ingelheim Pharma GmbH & Co. KG |
Method for increasing protein titres
|
|
MX2010004298A
(en)
*
|
2007-10-30 |
2010-05-03 |
Univ Indiana Res & Tech Corp |
Compounds exhibiting glucagon antagonist and glp-1 agonist activity.
|
|
ES2509883T3
(en)
|
2007-10-30 |
2014-10-20 |
Indiana University Research And Technology Corporation |
Glucagon antagonists
|
|
US20100317057A1
(en)
*
|
2007-12-28 |
2010-12-16 |
Novo Nordisk A/S |
Semi-recombinant preparation of glp-1 analogues
|
|
EP2249853A4
(en)
*
|
2008-01-30 |
2012-12-26 |
Univ Indiana Res & Tech Corp |
PEPTIDE PRODRUGS BASED ON ESTERS
|
|
US8034770B2
(en)
|
2008-06-04 |
2011-10-11 |
Amgen Inc. |
FGF21 polypeptides comprising two or more mutations
|
|
AR072160A1
(en)
|
2008-06-17 |
2010-08-11 |
Univ Indiana Res & Tech Corp |
GLUCAGON / GLP-1 RECEIVER CO-AGONISTS
|
|
US8450270B2
(en)
*
|
2008-06-17 |
2013-05-28 |
Indiana University Research And Technology Corporation |
Glucagon analogs exhibiting enhanced solubility and stability in physiological pH buffers
|
|
CN102105159B
(en)
*
|
2008-06-17 |
2015-07-08 |
印第安纳大学研究及科技有限公司 |
GIP-based mixed agonists for the treatment of metabolic disorders and obesity
|
|
PL2291523T3
(en)
|
2008-06-24 |
2015-05-29 |
Csl Behring Gmbh |
Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life
|
|
CN102131516B
(en)
|
2008-06-27 |
2016-03-16 |
杜克大学 |
Therapeutics comprising elastin-like peptides
|
|
CA2739615C
(en)
|
2008-10-10 |
2017-12-05 |
Amgen Inc. |
Fgf21 mutants comprising polyethylene glycol and uses thereof
|
|
PE20120332A1
(en)
|
2008-12-19 |
2012-04-14 |
Univ Indiana Res & Tech Corp |
PEPTIDE PROPHARS FROM THE GLUCAGON SUPERFAMILY BASED ON AMIDA
|
|
WO2010096394A2
(en)
|
2009-02-17 |
2010-08-26 |
Redwood Biosciences, Inc. |
Aldehyde-tagged protein-based drug carriers and methods of use
|
|
WO2010129503A1
(en)
*
|
2009-05-05 |
2010-11-11 |
Amgen Inc. |
Fgf21 mutants and uses thereof
|
|
WO2010129600A2
(en)
|
2009-05-05 |
2010-11-11 |
Amgen Inc. |
Fgf21 mutants and uses thereof
|
|
EP2443146B1
(en)
|
2009-06-16 |
2016-10-05 |
Indiana University Research And Technology Corporation |
Gip receptor-active glucagon compounds
|
|
MX2011013903A
(en)
*
|
2009-06-17 |
2012-05-08 |
Amgen Inc |
Chimeric fgf19 polypeptides and uses thereof.
|
|
CN101993485B
(en)
|
2009-08-20 |
2013-04-17 |
重庆富进生物医药有限公司 |
Peptide analog homologous dimer capable of accelerating insulin secretion and application thereof
|
|
WO2011043530A1
(en)
*
|
2009-10-09 |
2011-04-14 |
(주)알테오젠 |
Glp-1 analog fusions, and composition for preventing or treating diabetes containing the fusions as an active ingredient
|
|
EP2679234A3
(en)
*
|
2009-12-02 |
2014-04-23 |
Amgen Inc. |
Binding proteins that bind to human FGFR1C, human beta-klotho and both human FGFR1C and human beta-klotho
|
|
UA109888C2
(en)
*
|
2009-12-07 |
2015-10-26 |
|
ANTIBODY OR ANTIBODILITY ANTIBODY OR ITS BINDING TO THE β-CLOTE, FGF RECEPTORS AND THEIR COMPLEXES
|
|
US8703701B2
(en)
|
2009-12-18 |
2014-04-22 |
Indiana University Research And Technology Corporation |
Glucagon/GLP-1 receptor co-agonists
|
|
KR20120123443A
(en)
|
2010-01-27 |
2012-11-08 |
인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 |
Glucagon antagonist - gip agonist conjugates and composition for the treatment of metabolic disorders and obesity
|
|
EP2371857A1
(en)
|
2010-04-01 |
2011-10-05 |
CSL Behring GmbH |
Factor XII inhibitors for treating interstitial lung disease
|
|
CA2796055A1
(en)
|
2010-04-15 |
2011-10-20 |
Amgen Inc. |
Human fgf receptor and .beta.-klotho binding proteins
|
|
MX2012012383A
(en)
|
2010-04-30 |
2012-11-30 |
Sanwa Kagaku Kenkyusho Co |
Peptide for improving in vivo stability of physiologically active substance or the like and physiologically active substance with improved in vivo stability.
|
|
MX2012013001A
(en)
|
2010-05-13 |
2013-02-26 |
Univ Indiana Res & Tech Corp |
Glucagon superfamily peptides exhibiting nuclear hormone receptor activity.
|
|
JP6050746B2
(en)
|
2010-05-13 |
2016-12-21 |
インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation |
Glucagon superfamily of peptides exhibiting G protein-coupled receptor activity
|
|
CN101891823B
(en)
|
2010-06-11 |
2012-10-03 |
北京东方百泰生物科技有限公司 |
Exendin-4 and analog fusion protein thereof
|
|
EP2588126A4
(en)
|
2010-06-24 |
2015-07-08 |
Univ Indiana Res & Tech Corp |
GLUCAGON SUPERFAMILY AMIDE PEPTIDE PRODRUGS
|
|
CN103415300B
(en)
*
|
2010-07-20 |
2018-02-23 |
诺沃—诺迪斯克有限公司 |
FGF21 compounds end modified N
|
|
US8507428B2
(en)
|
2010-12-22 |
2013-08-13 |
Indiana University Research And Technology Corporation |
Glucagon analogs exhibiting GIP receptor activity
|
|
WO2012097333A2
(en)
|
2011-01-14 |
2012-07-19 |
Redwood Bioscience, Inc. |
Aldehyde-tagged immunoglobulin polypeptides and method of use thereof
|
|
US9352016B2
(en)
|
2011-03-09 |
2016-05-31 |
Csl Behring Gmbh |
Factor XII inhibitors for the administration with medical procedures comprising contact with artificial surfaces
|
|
EP2497489A1
(en)
|
2011-03-09 |
2012-09-12 |
CSL Behring GmbH |
Factor XII inhibitors for the treatment of silent brain ischemia and ischemia of other organs
|
|
ES2692268T5
(en)
|
2011-03-29 |
2025-02-26 |
Roche Glycart Ag |
Antibody fc variants
|
|
KR20140043793A
(en)
|
2011-06-22 |
2014-04-10 |
인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 |
Glucagon/glp-1 receptor co-agonists
|
|
RS56173B1
(en)
|
2011-06-22 |
2017-11-30 |
Univ Indiana Res & Tech Corp |
GLUCAGON / GLP-1 RECEPTOR RECEPTOR COAGONISTS
|
|
IL230564B2
(en)
|
2011-07-22 |
2023-09-01 |
Csl Ltd |
Inhibitory anti-factor xii/xiia monoclonal antibodies, methods of producing the same, pharmaceutical compositions containing the same and medical uses
|
|
UY34317A
(en)
|
2011-09-12 |
2013-02-28 |
Genzyme Corp |
T cell antireceptor antibody (alpha) / ß
|
|
KR20130049671A
(en)
|
2011-11-04 |
2013-05-14 |
한미사이언스 주식회사 |
Method for preparation of biological active polypeptide conjugate
|
|
JP6324315B2
(en)
|
2011-11-17 |
2018-05-16 |
インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation |
Glucagon superfamily of peptides exhibiting glucocorticoid receptor activity
|
|
EP2623110A1
(en)
|
2012-01-31 |
2013-08-07 |
CSL Behring GmbH |
Factor XII inhibitors for the treatment of neurological inflammatory disorders
|
|
WO2013120939A1
(en)
|
2012-02-15 |
2013-08-22 |
Csl Behring Gmbh |
Von willebrand factor variants having improved factor viii binding affinity
|
|
CN104583232B
(en)
|
2012-06-21 |
2018-04-13 |
印第安纳大学研究及科技有限公司 |
Show the glucagon analogs of GIP receptor actives
|
|
SG11201408538PA
(en)
|
2012-07-13 |
2015-02-27 |
Roche Glycart Ag |
Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases
|
|
PL3366705T3
(en)
*
|
2012-09-12 |
2023-09-18 |
Genzyme Corporation |
Fc containing polypeptides with altered glycosylation and reduced effector function
|
|
US9790268B2
(en)
|
2012-09-12 |
2017-10-17 |
Genzyme Corporation |
Fc containing polypeptides with altered glycosylation and reduced effector function
|
|
ES2729997T3
(en)
|
2012-11-27 |
2019-11-07 |
Biomarin Pharm Inc |
Targeted therapeutic lysosomal enzyme fusion proteins and uses thereof
|
|
CN104870019A
(en)
|
2012-11-27 |
2015-08-26 |
阿特根公司 |
Composition for stabilizing fusion protein in which protein and fc domain are fused
|
|
CN105188750A
(en)
|
2013-03-08 |
2015-12-23 |
德国杰特贝林生物制品有限公司 |
Treatment and prevention of remote ischemia-reperfusion injury
|
|
US9701753B2
(en)
|
2013-03-11 |
2017-07-11 |
Genzyme Corporation |
Hyperglycosylated binding polypeptides
|
|
US9580486B2
(en)
*
|
2013-03-14 |
2017-02-28 |
Amgen Inc. |
Interleukin-2 muteins for the expansion of T-regulatory cells
|
|
JP6538645B2
(en)
|
2013-03-14 |
2019-07-03 |
インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation |
Insulin-incretin complex
|
|
EP2796145B1
(en)
|
2013-04-22 |
2017-11-01 |
CSL Ltd. |
A covalent complex of von willebrand factor and faktor viii linked by a disulphide bridge
|
|
CA2916399C
(en)
|
2013-06-28 |
2022-08-02 |
Marc Nolte |
Combination therapy using a factor xii inhibitor and a c1-inhibitor
|
|
CN103408669B
(en)
*
|
2013-08-01 |
2016-01-20 |
江苏泰康生物医药有限公司 |
GLP-1 analog fusion, and its production and use
|
|
CN104592381A
(en)
*
|
2013-10-31 |
2015-05-06 |
江苏万邦生化医药股份有限公司 |
Preparation method of liraglutide intermediate polypeptide
|
|
US20170065678A1
(en)
|
2014-03-11 |
2017-03-09 |
Novartis Ag |
Methods of treating metabolic disorders associated with lipodystrophies and defects in insulin production or signaling
|
|
WO2015143091A1
(en)
|
2014-03-19 |
2015-09-24 |
Genzyme Corporation |
Site-specific glycoengineering of targeting moieties
|
|
MX387560B
(en)
*
|
2014-03-31 |
2025-03-18 |
Hanmi Pharmaceutical Co Ltd |
PROCEDURE FOR IMPROVING THE SOLUBILITY OF PROTEINS AND PEPTIDES USING AN IMMUNOGLOBULIN FC FRAGMENT LINKAGE.
|
|
JP7109160B2
(en)
|
2014-06-18 |
2022-07-29 |
ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー |
Therapy using factor XII inhibitors in neurotraumatic disorders
|
|
BR112016030950A2
(en)
|
2014-07-02 |
2018-03-27 |
Csl Ltd |
modified factor viii binding polypeptide, complex, pharmaceutical composition, methods for treating a coagulopathy, to produce a polypeptide comprising a modified vwf, and to increase vwf factor viii binding affinity and factor viii half-life, use of a modified polypeptide or complex, polynucleotide, plasmid or vector, and host cell.
|
|
PT3172227T
(en)
|
2014-07-21 |
2019-12-06 |
Delinia Inc |
Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases
|
|
AU2015301936B2
(en)
|
2014-08-11 |
2019-03-07 |
Delinia, Inc. |
Modified IL-2 variants that selectively activate regulatory T cells for the treatment of autoimmune diseases
|
|
CN108271356A
(en)
|
2014-09-24 |
2018-07-10 |
印第安纳大学研究及科技有限公司 |
incretin-insulin conjugate
|
|
CN104293834B
(en)
*
|
2014-10-11 |
2018-03-23 |
上海兴迪金生物技术有限公司 |
GLP 1 or its analog and antibody Fc fragment fusion protein preparation method
|
|
AR103246A1
(en)
|
2014-12-23 |
2017-04-26 |
Novo Nordiks As |
DERIVATIVES OF FGF21 AND ITS USES
|
|
KR101825048B1
(en)
*
|
2014-12-31 |
2018-02-05 |
주식회사 제넥신 |
Fusion Polypeptide Comprising GLP and Immunoglobulin Hybrid Fc and use thereof
|
|
CR20170510A
(en)
|
2015-04-10 |
2018-02-26 |
Amgen Inc |
INTERUQUINE MUTEINS 2 FOR THE EXPANSION OF REGULATORY T-CELLS
|
|
AR105616A1
(en)
*
|
2015-05-07 |
2017-10-25 |
Lilly Co Eli |
FUSION PROTEINS
|
|
EP3297656B1
(en)
|
2015-05-22 |
2020-01-08 |
CSL Behring Lengnau AG |
Truncated von willebrand factor polypeptides for treating hemophilia
|
|
JP6651548B2
(en)
|
2015-05-22 |
2020-02-19 |
ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト |
Method for producing a modified von Willebrand factor
|
|
TWI622596B
(en)
|
2015-10-26 |
2018-05-01 |
美國禮來大藥廠 |
Glucagon receptor agonist
|
|
KR102670157B1
(en)
|
2015-10-28 |
2024-05-29 |
주식회사유한양행 |
Dual function proteins and pharmaceutical composition comprising the same
|
|
KR102668200B1
(en)
|
2015-10-28 |
2024-05-23 |
주식회사유한양행 |
Long-acting fgf21 fusion proteins and pharmaceutical composition comprising the same
|
|
EP3184149A1
(en)
|
2015-12-23 |
2017-06-28 |
Julius-Maximilians-Universität Würzburg |
Soluble glycoprotein v for treating thrombotic diseases
|
|
UA127495C2
(en)
|
2015-12-23 |
2023-09-13 |
Амджен Інк. |
Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (gipr) in combination with glp-1 agonists
|
|
DK3400002T3
(en)
|
2016-01-07 |
2022-04-11 |
CSL Behring Lengnau AG |
MUTTERED, TRUNKED BY WILLEBRAND FACTOR
|
|
RU2018128613A
(en)
|
2016-01-07 |
2020-02-07 |
Цсл Беринг Ленгнау Аг |
MUTED FACTOR BACKGROUND VILLEBRAND
|
|
US20170204154A1
(en)
|
2016-01-20 |
2017-07-20 |
Delinia, Inc. |
Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases
|
|
US11174321B2
(en)
|
2016-04-06 |
2021-11-16 |
Csl Limited |
Method of treating atherosclerosis
|
|
JP2019515677A
(en)
|
2016-04-26 |
2019-06-13 |
アール.ピー.シェーラー テクノロジーズ エルエルシー |
Antibody conjugates and methods of making and using the same
|
|
US10336812B2
(en)
*
|
2016-05-10 |
2019-07-02 |
Janssen Biotech, Inc. |
GDF15 fusion proteins and uses thereof
|
|
CN106317226B
(en)
|
2016-08-19 |
2017-09-05 |
安源医药科技(上海)有限公司 |
Linker peptides for construction of fusion proteins
|
|
US11123438B2
(en)
|
2016-08-19 |
2021-09-21 |
Ampsource Biopharma Shanghai Inc. |
Linker peptide for constructing fusion protein
|
|
CN106279437B
(en)
|
2016-08-19 |
2017-10-31 |
安源医药科技(上海)有限公司 |
Hyperglycosylated human coagulation factor VIII fusion proteins and preparation method thereof and purposes
|
|
EP3538548A4
(en)
|
2016-11-08 |
2020-08-19 |
Delinia, Inc. |
IL-2 VARIANTS FOR THE TREATMENT OF AUTOIMMUNE DISEASES
|
|
MX2019005380A
(en)
|
2016-11-10 |
2019-08-12 |
Yuhan Corp |
Pharmaceutical composition for preventing or treating hepatitis, hepatic fibrosis, and hepatic cirrhosis comprising fusion proteins.
|
|
SG11201903954WA
(en)
|
2016-11-11 |
2019-05-30 |
CSL Behring Lengnau AG |
Truncated von willebrand factor polypeptides for extravascular administration in the treatment or prophylaxis of a blood coagulation disorder
|
|
US11814421B2
(en)
|
2016-11-11 |
2023-11-14 |
CSL Behring Lengnau AG |
Truncated von Willebrand Factor polypeptides for treating hemophilia
|
|
EP3351262A1
(en)
|
2016-12-30 |
2018-07-25 |
Istanbul Universitesi Rektorlugu |
Curaglutide for in treatment of prediabetes, diabetes, obesity and metabolic diseases associated thereto
|
|
IL313587A
(en)
|
2017-01-17 |
2024-08-01 |
Amgen Inc |
Method for treating or ameliorating metabolic disorders using GLP-1 receptor agonists conjugated to gastric inhibitory peptide receptor antagonists
|
|
WO2018166461A1
(en)
|
2017-03-14 |
2018-09-20 |
Sunshine Lake Pharma Co., Ltd. |
Dual-target fusion proteins comprising the fc portion of an immunoglobulin
|
|
US11560416B2
(en)
|
2017-04-21 |
2023-01-24 |
Yuhan Corporation |
Method for producing dual function proteins and its derivatives
|
|
CA3065295C
(en)
|
2017-06-01 |
2023-08-29 |
Eli Lilly And Company |
Dulaglutide for the treatment of chronic kidney disease
|
|
EA201992502A1
(en)
|
2017-06-20 |
2020-04-22 |
Эмджен Инк. |
METHOD FOR TREATING OR REDUCING THE INTENSITY OF METABOLIC DISORDERS WITH APPLICATION OF PROTEINS BINDING THE GASTROINhibitor PEPTIDE RECEPTOR (GIPR) IN COMBINATION WITH GL 1 AGONISTS
|
|
EP3642238A1
(en)
|
2017-06-21 |
2020-04-29 |
Amgen Inc. |
Method of treating or ameliorating metabolic disorders using antagonistic binding proteins for gastric inhibitory peptide receptor (gipr)/glp-1 receptor agonist fusion proteins
|
|
ES2966835T3
(en)
|
2017-06-22 |
2024-04-24 |
CSL Behring Lengnau AG |
Modulation of FVIII immunogenicity by truncated VWF
|
|
US12297272B2
(en)
|
2017-08-15 |
2025-05-13 |
Eianco US inc. |
IgG Fc variants for veterinary use
|
|
EP3684793A1
(en)
|
2017-09-22 |
2020-07-29 |
Regeneron Pharmaceuticals, Inc. |
Glucagon-like peptide 1 receptor agonists and uses thereof
|
|
KR102589234B1
(en)
|
2017-11-21 |
2023-10-16 |
일라이 릴리 앤드 캄파니 |
Compositions containing dulaglutide and methods of use
|
|
WO2019119673A1
(en)
|
2017-12-19 |
2019-06-27 |
北京吉源生物科技有限公司 |
Double gene-modified stem cell and use thereof
|
|
WO2019123427A1
(en)
|
2017-12-22 |
2019-06-27 |
Novartis Ag |
Methods of treating metabolic disorders with fgf21 variants
|
|
US11491235B2
(en)
|
2017-12-22 |
2022-11-08 |
Kb Biomed Inc. |
Oral gene carrier and use thereof
|
|
WO2019140021A1
(en)
|
2018-01-12 |
2019-07-18 |
Eli Lilly And Company |
Combination therapy
|
|
AU2019218147B2
(en)
|
2018-02-08 |
2023-06-08 |
Sunshine Lake Pharma Co., Ltd. |
FGF21 variant, fusion protein and application thereof
|
|
CN121591873A
(en)
|
2018-07-19 |
2026-03-03 |
D&D制药技术股份有限公司 |
Pharmaceutical compositions comprising polypeptides
|
|
KR20200135618A
(en)
|
2019-05-23 |
2020-12-03 |
㈜ 디앤디파마텍 |
Pharmaceutical composition for preventing or treating nonalcoholic fatty liver disease comprising a polypeptide
|
|
CN110878127B
(en)
|
2018-09-06 |
2022-06-28 |
浙江柏拉阿图医药科技有限公司 |
Long-acting recombinant GLP1-Fc-CD47 protein and preparation and application thereof
|
|
EA202191105A1
(en)
|
2018-10-22 |
2021-08-03 |
Янссен Фармацевтика Нв |
FUSION PROTEINS OBTAINED FROM GLUCAGON-LIKE PEPTIDE 1 (GLP1) AND GROWTH DIFFERENTIATION FACTOR 15 (GDF15) AND THEIR APPLICATION
|
|
MY195550A
(en)
|
2018-10-29 |
2023-01-31 |
Hoffmann La Roche |
Antibody Formulation
|
|
CN111234000B
(en)
*
|
2018-11-28 |
2023-05-26 |
鲁南制药集团股份有限公司 |
Ai Saina peptide analogues
|
|
CN111269312B
(en)
*
|
2018-12-04 |
2023-05-09 |
鲁南制药集团股份有限公司 |
Heterologous fusion protein
|
|
CN109836486B
(en)
*
|
2019-01-30 |
2020-09-08 |
北京双因生物科技有限公司 |
Fibroblast growth factor 21 variants, fusion proteins thereof, and uses thereof
|
|
EP3935075A4
(en)
|
2019-03-05 |
2023-01-18 |
Sunshine Lake Pharma Co., Ltd. |
POLYPEPTIDIC MOLECULE AND ITS APPLICATION
|
|
WO2020185533A1
(en)
|
2019-03-08 |
2020-09-17 |
Amgen Inc. |
Growth differentiation factor 15 combination therapy
|
|
WO2020190591A1
(en)
|
2019-03-15 |
2020-09-24 |
Eli Lilly And Company |
Preserved formulations
|
|
CN120192414A
(en)
|
2019-04-03 |
2025-06-24 |
建新公司 |
Anti-αβTCR binding polypeptides with reduced fragmentation
|
|
CA3177693A1
(en)
|
2019-04-05 |
2020-10-05 |
Eli Lilly And Company |
Therapeutic uses of dulaglutide
|
|
PE20220500A1
(en)
*
|
2019-04-23 |
2022-04-07 |
Lg Chemical Ltd |
FUSION POLYPEPTIDE COMPRISING THE Fc REGION OF IMMUNOGLOBULIN AND GDF15
|
|
KR20220009984A
(en)
|
2019-05-17 |
2022-01-25 |
유니베르시태트 취리히 |
Haptoglobin for use in the treatment of secondary neurological adverse events after hemorrhagic stroke
|
|
WO2021001522A1
(en)
|
2019-07-04 |
2021-01-07 |
CSL Behring Lengnau AG |
A truncated von willebrand factor (vwf) for increasing the in vitro stability of coagulation factor viii
|
|
PH12022550326A1
(en)
|
2019-08-13 |
2023-03-13 |
Amgen Inc |
Interleukin-2 muteins for the expansion of t-regulatory cells
|
|
CN114555792A
(en)
|
2019-10-15 |
2022-05-27 |
伊莱利利公司 |
Recombinant engineered, lipase/esterase deficient mammalian cell lines
|
|
US20220348637A1
(en)
|
2019-11-11 |
2022-11-03 |
CSL Behring Lengnau AG |
Polypeptides for inducing tolerance to factor viii
|
|
CN113728013B
(en)
|
2020-01-11 |
2022-06-14 |
北京质肽生物医药科技有限公司 |
Conjugates of fusion proteins of GLP-1 and FGF21
|
|
US11981718B2
(en)
|
2020-05-27 |
2024-05-14 |
Ampsource Biopharma Shanghai Inc. |
Dual-function protein for lipid and blood glucose regulation
|
|
CA3190399A1
(en)
|
2020-08-24 |
2022-03-03 |
James M. Wilson |
Viral vectors encoding glp-1 receptor agonist fusions and uses thereof in treating metabolic diseases
|
|
CN114106194B
(en)
*
|
2020-08-31 |
2024-01-16 |
中国科学院天津工业生物技术研究所 |
Fusion protein for treating diabetes and/or obesity
|
|
WO2022109124A1
(en)
|
2020-11-20 |
2022-05-27 |
Csl Behring Gmbh |
Method for treating antibody-mediated rejection
|
|
CN114685644A
(en)
*
|
2020-12-29 |
2022-07-01 |
苏州康宁杰瑞生物科技有限公司 |
Human GLP-1 polypeptide variant and application thereof
|
|
WO2022162218A1
(en)
|
2021-02-01 |
2022-08-04 |
Csl Behring Ag |
Method of treating or preventing an adverse secondary neurological outcome following a haemorrhagic stroke
|
|
KR20240005075A
(en)
|
2021-05-07 |
2024-01-11 |
체에스엘 베링 아게 |
Expression system for producing recombinant haptoglobin (HP) beta chain
|
|
TW202317607A
(en)
|
2021-07-06 |
2023-05-01 |
大陸商蘇州康寧杰瑞生物科技有限公司 |
Fusion protein and its applications thereof
|
|
WO2023284822A1
(en)
|
2021-07-14 |
2023-01-19 |
Beijing Ql Biopharmaceutical Co., Ltd. |
Fusion polypeptides for metabolic disorders
|
|
IL317049A
(en)
|
2022-05-18 |
2025-01-01 |
Protomer Tech Inc |
Aromatic boron-containing compounds and related insulin analogs
|
|
CN114774496B
(en)
*
|
2022-06-21 |
2022-10-04 |
北京惠之衡生物科技有限公司 |
Method for preparing GLP-1 analogue through high-density fermentation
|
|
JP2025530774A
(en)
|
2022-09-02 |
2025-09-17 |
ツェー・エス・エル・ベーリング・アクチエンゲゼルシャフト |
Haptoglobin for use in the treatment or prevention of hyper-erectile response or erectile dysfunction - Patent Application 20070122997
|
|
WO2024064842A1
(en)
|
2022-09-21 |
2024-03-28 |
Regeneron Pharmaceuticals, Inc. |
Methods of treating obesity, diabetes, and liver dysfunction
|
|
WO2024068848A1
(en)
|
2022-09-28 |
2024-04-04 |
Zealand Pharma A/S |
Methods for treating obesity
|
|
WO2024123812A1
(en)
|
2022-12-05 |
2024-06-13 |
Shattuck Labs, Inc. |
Fusion proteins for the treatment of cardiometabolic diseases
|
|
EP4638483A1
(en)
|
2022-12-22 |
2025-10-29 |
LifeArc |
Galanin-2 receptor agonists
|
|
CN120917038A
(en)
|
2023-03-23 |
2025-11-07 |
伊莱利利公司 |
Method for producing Fc-containing protein
|
|
WO2025069009A1
(en)
|
2023-09-29 |
2025-04-03 |
Graviton Bioscience Bv |
Rock2 inhibitors in the treatment of obesity
|
|
WO2025122835A2
(en)
|
2023-12-08 |
2025-06-12 |
Eli Lilly And Company |
Methods of producing fc-containing proteins
|
|
US20250270274A1
(en)
*
|
2024-02-26 |
2025-08-28 |
Serpentide Inc. |
Super long-lasting glp1 or glp1/gip analogue drug for type-2 diabetes and obesity
|
|
WO2025256577A1
(en)
*
|
2024-06-13 |
2025-12-18 |
上海银诺医药技术有限公司 |
Fusion protein containing improved glp-1 polypeptide and use
|
|
WO2025257801A1
(en)
|
2024-06-13 |
2025-12-18 |
CSL Innovation Pty Ltd |
Heme-binding protein for the treatment of ischemia-reperfusion injury (iri)
|
|
WO2026073030A1
(en)
|
2024-09-27 |
2026-04-02 |
Carmot Therapeutics Inc. |
Combination therapy of peptide tyrosine-tyrosine (pyy) analogues and glp-1r agonists
|