HK184996A - Crystalline r-h-gm-csf and method for its preparation - Google Patents

Crystalline r-h-gm-csf and method for its preparation

Info

Publication number
HK184996A
HK184996A HK184996A HK184996A HK184996A HK 184996 A HK184996 A HK 184996A HK 184996 A HK184996 A HK 184996A HK 184996 A HK184996 A HK 184996A HK 184996 A HK184996 A HK 184996A
Authority
HK
Hong Kong
Prior art keywords
csf
crystalline
crystals
preparation
protein
Prior art date
Application number
HK184996A
Other languages
German (de)
English (en)
Inventor
Reichert Paul
S Hammond Gerald
V Le Hung
L Nagabhushan Tattanahall
P Trotta Paul
Original Assignee
Schering Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corporation filed Critical Schering Corporation
Publication of HK184996A publication Critical patent/HK184996A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/145—Colony stimulating factor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Glass Compositions (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)

Claims (3)

  1. GM-CSF (facteur stimulant les colonies de granulocytes et macrophages) cristallin recombinant humain manquant d'une méthionine N-terminale et ayant inne méthionine à la position 80.
  2. GM-CSF cristallin de la revendication 1 qui a la séquence d'acides aminés :
  3. Composition pharmaceutique comprenant GM-CSF cristallin recombinant humain selon la revendication 1 ou la revendication 2 et un support acceptable en pharmacie.
HK184996A 1989-06-06 1996-10-03 Crystalline r-h-gm-csf and method for its preparation HK184996A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/362,187 US5109119A (en) 1989-06-06 1989-06-06 Crystalline r-h-gm-csf and method

Publications (1)

Publication Number Publication Date
HK184996A true HK184996A (en) 1996-10-11

Family

ID=23425041

Family Applications (1)

Application Number Title Priority Date Filing Date
HK184996A HK184996A (en) 1989-06-06 1996-10-03 Crystalline r-h-gm-csf and method for its preparation

Country Status (14)

Country Link
US (2) US5109119A (fr)
EP (3) EP0561429A1 (fr)
JP (1) JP2572160B2 (fr)
KR (1) KR960004454B1 (fr)
AT (1) ATE110113T1 (fr)
AU (1) AU644083B2 (fr)
CA (1) CA2058441C (fr)
DE (1) DE69011586T2 (fr)
DK (1) DK0402070T3 (fr)
FI (1) FI915709A7 (fr)
HK (1) HK184996A (fr)
HU (1) HU209871B (fr)
NO (1) NO914771L (fr)
WO (1) WO1990015151A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991002063A1 (fr) * 1989-08-11 1991-02-21 Amrad Corporation Limited Ameliorations relatives au recepteur de facteur stimulateur des colonies de granulocyte-macrophage
EP0955365A3 (fr) * 1992-06-09 2000-12-20 Chiron Corporation Cristallisation du M-CSF
US5581476A (en) * 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
US6004549A (en) * 1994-12-14 1999-12-21 Schering Corporation Crystalline protein controlled release compositions
US6555660B2 (en) * 2000-01-10 2003-04-29 Maxygen Holdings Ltd. G-CSF conjugates
US6646110B2 (en) * 2000-01-10 2003-11-11 Maxygen Holdings Ltd. G-CSF polypeptides and conjugates
US6831158B2 (en) * 2000-01-10 2004-12-14 Maxygen Holdings Ltd. G-CSF conjugates
PE20020394A1 (es) * 2000-08-18 2002-06-21 Agouron Pharma Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
PL371781A1 (en) * 2001-07-11 2005-06-27 Maxygen Holdings, Ltd. G-csf conjugates
US7765302B2 (en) * 2003-06-30 2010-07-27 Nortel Networks Limited Distributed call server supporting communication sessions in a communication system and method
CA2573262C (fr) * 2004-07-16 2015-02-10 Nektar Therapeutics Al, Corporation Conjugues de fraction gm-csf et polymere
EP1888119B1 (fr) 2005-06-01 2011-03-09 Maxygen, Inc. Polypeptides g-csf pegyles et procedes de production correspondants
US9012605B2 (en) * 2006-01-23 2015-04-21 Amgen Inc. Crystalline polypeptides
JP6564369B2 (ja) 2013-12-09 2019-08-21 デュレクト コーポレイション 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU588819B2 (en) * 1984-10-29 1989-09-28 Immunex Corporation Cloning of human granulocyte-macrophage colony stimulating factor gene
IL77080A (en) * 1984-11-20 1998-02-08 Schering Biotech Corp Polypeptides exhibiting human granulocyte macrophage and eosinophil cellular growth factor activity, vectors and transformed cells for their production and pharmaceutical compositions comprising them
JP2595216B2 (ja) * 1986-12-12 1997-04-02 日清製粉株式会社 α―アミラーゼインヒビターの結晶の製造方法
US4912200A (en) * 1987-05-11 1990-03-27 Schering Corporation Extraction of granulocyte macrophage colony stimulating factor from bacteria
DE68921186T2 (de) * 1988-05-31 1995-06-14 Cetus Oncology Corp Verfahren zur gewinnung von heterologe proteine enthaltenden refraktilkörpern aus mikrobiellen wirten.

Also Published As

Publication number Publication date
JPH04502014A (ja) 1992-04-09
HUT58822A (en) 1992-03-30
AU644083B2 (en) 1993-12-02
KR920700293A (ko) 1992-02-19
EP0402070B1 (fr) 1994-08-17
FI915709A0 (fi) 1991-12-04
EP0476022A1 (fr) 1992-03-25
DE69011586T2 (de) 1995-03-02
ATE110113T1 (de) 1994-09-15
KR960004454B1 (ko) 1996-04-06
HU209871B (en) 1994-11-28
DE69011586D1 (de) 1994-09-22
NO914771D0 (no) 1991-12-04
HU904835D0 (en) 1992-02-28
CA2058441C (fr) 1997-12-16
WO1990015151A1 (fr) 1990-12-13
EP0561429A1 (fr) 1993-09-22
US5109119A (en) 1992-04-28
JP2572160B2 (ja) 1997-01-16
AU5834890A (en) 1991-01-07
EP0402070A1 (fr) 1990-12-12
US5616555A (en) 1997-04-01
NO914771L (no) 1991-12-04
CA2058441A1 (fr) 1990-12-07
FI915709A7 (fi) 1991-12-04
DK0402070T3 (da) 1994-09-12

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)