HK62497A - Use of derivatives of human bile-salt stimulated lipase for the preparation of medicaments - Google Patents

Use of derivatives of human bile-salt stimulated lipase for the preparation of medicaments Download PDF

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Publication number
HK62497A
HK62497A HK62497A HK62497A HK62497A HK 62497 A HK62497 A HK 62497A HK 62497 A HK62497 A HK 62497A HK 62497 A HK62497 A HK 62497A HK 62497 A HK62497 A HK 62497A
Authority
HK
Hong Kong
Prior art keywords
bssl
protein
amino acid
sequence
human
Prior art date
Application number
HK62497A
Other languages
English (en)
French (fr)
Inventor
Bjursell Gunnar
Blaeckberg Lars
Carlsson Peter
Enerbaeck Sven
Hernell Olle
Nilsson Jeanette
Olivecrona Thomas
Original Assignee
Arexis Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arexis Ab filed Critical Arexis Ab
Publication of HK62497A publication Critical patent/HK62497A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/596—Mixtures of surface active compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Genetics & Genomics (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Claims (7)

  1. Verwendung eines rekombinanten Proteins, wie in Fig. VII von Position 1 bis Position 722 gezeigt, oder einer funktionell äquivalenten Variante desselben, zur Herstellung eines Medikaments zur Behandlung eines mit exokriner Pankreas-Insuffizienz verbundenen pathologischen Zustandes.
  2. Verwendung nach Anspruch 1 zur Herstellung eines Medikaments zur Behandlung zystischer Fibrose.
  3. Verwendung nach Anspruch 1 zur Herstellung eines Medikaments zur Behandlung chronischer Pankreatitis.
  4. Verwendung nach Anspruch 1 zur Herstellung eines Medikaments zur Behandlung der Malabsorption von Fett.
  5. Verwendung nach Anspruch 1 zur Herstellung eines Medikaments zur Behandlung der Malabsorption fettlöslicher Vitamine.
  6. Verwendung nach Anspruch 1 zur Herstellung eines Medikaments zur Behandlung der Malabsoption von Fett, welche auf physiologische Ursachen zurückzuführen ist.
  7. Verwendung nach einem der Ansprüche 1 bis 6, wobei das Protein in Verbindung mit einer Lipase oder mit Lipasen oder in Verbindung mit eine Lipase oder Lipasen enthaltenden Präparaten vorliegt.
HK62497A 1990-06-01 1997-05-08 Use of derivatives of human bile-salt stimulated lipase for the preparation of medicaments HK62497A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9001985A SE9001985D0 (sv) 1990-06-01 1990-06-01 New chemical products
PCT/SE1991/000381 WO1991018923A1 (en) 1990-06-01 1991-05-30 Derivatives of human bile-salt stimulated lipase, and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
HK62497A true HK62497A (en) 1997-05-16

Family

ID=20379662

Family Applications (1)

Application Number Title Priority Date Filing Date
HK62497A HK62497A (en) 1990-06-01 1997-05-08 Use of derivatives of human bile-salt stimulated lipase for the preparation of medicaments

Country Status (44)

Country Link
EP (1) EP0535048B1 (de)
JP (1) JPH05507201A (de)
KR (1) KR100212411B1 (de)
CN (2) CN1075113C (de)
AP (1) AP207A (de)
AT (1) ATE151077T1 (de)
AU (1) AU651979B2 (de)
BG (1) BG61165B1 (de)
CA (1) CA2083396C (de)
CZ (1) CZ287470B6 (de)
DE (1) DE69125489T2 (de)
DK (1) DK0535048T3 (de)
DZ (1) DZ1503A1 (de)
EG (1) EG19937A (de)
ES (1) ES2099159T3 (de)
FI (1) FI114639B (de)
GR (1) GR3023618T3 (de)
HK (1) HK62497A (de)
HR (1) HRP920771B1 (de)
HU (1) HU215258B (de)
IE (1) IE911844A1 (de)
IL (1) IL98273A (de)
IS (1) IS1751B (de)
JO (1) JO1694B1 (de)
LT (1) LT4020B (de)
LV (1) LV10292B (de)
MA (1) MA22166A1 (de)
MY (1) MY111245A (de)
NO (1) NO322962B1 (de)
NZ (1) NZ238223A (de)
PH (1) PH30761A (de)
PL (1) PL166534B1 (de)
PT (1) PT97836B (de)
RO (1) RO114793B1 (de)
RU (1) RU2140983C1 (de)
SE (1) SE9001985D0 (de)
SG (1) SG48078A1 (de)
SK (1) SK281089B6 (de)
TN (1) TNSN91041A1 (de)
TW (1) TW221712B (de)
UA (1) UA39165C2 (de)
WO (1) WO1991018923A1 (de)
YU (1) YU49138B (de)
ZA (1) ZA913778B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP930935A2 (en) * 1992-06-11 1994-12-31 Astra Ab New dna sequences
IS4130A (is) * 1993-03-01 1994-09-02 Ab Astra Ný fjölpeptíð
SE9300686D0 (sv) 1993-03-01 1993-03-01 Astra Ab Novel polypeptides
FR2754827B1 (fr) * 1996-10-17 1998-12-24 Biocem Lipases pancreatiques et/ou colipases recombinantes et polypeptides dervies produits par les plantes, leurs procedes d'obtention et leurs utilisations
JP2000026311A (ja) 1998-07-02 2000-01-25 Amano Pharmaceut Co Ltd 胃排出能亢進剤組成物
EP1963524A2 (de) * 2005-12-01 2008-09-03 University of Bergen Diagnose und behandlung von exokriner pankreasfehlfunktion und diabetes unter verwendung des menschlichen cel-gens
PT2561069T (pt) * 2010-04-23 2017-05-22 Alexion Pharma Inc Enzima de doença de armazenamento lisossomal
CA2810999C (en) 2010-09-09 2023-10-03 Anthony Quinn Use of lysosomal acid lipase for treating lysosomal acid lipase deficiency in patients
WO2012052060A1 (en) 2010-10-21 2012-04-26 Swedish Orphan Biovitrum Ab (Publ) Method to increase the growth velocity of human infants
RU2013123056A (ru) 2010-10-21 2014-11-27 Сведиш Орфан Биовитрум Аб (Пабл) Способ повышения всасывания ненасыщенных жирных кислот у грудных детей
KR20200018781A (ko) * 2017-06-19 2020-02-20 스위디쉬 오르펀 바이오비트럼 에이비 (피유비엘) 반감기 연장 폴리펩티드를 갖는 융합 단백질
EP4501403A3 (de) 2019-08-30 2025-05-14 Société des Produits Nestlé S.A. Manipulierte lipasevarianten

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60501758A (ja) * 1983-07-01 1985-10-17 セルテク　リミテツド タンパク質、医薬構成物、遺伝子、ベクタ−宿主生物及びそれらの生産方法

Also Published As

Publication number Publication date
TW221712B (de) 1994-03-11
CZ287470B6 (cs) 2000-12-13
RO114793B1 (ro) 1999-07-30
YU95191A (sh) 1994-06-10
RU2140983C1 (ru) 1999-11-10
CZ164491A3 (cs) 1999-07-14
KR100212411B1 (en) 1999-08-02
DK0535048T3 (da) 1997-09-29
PH30761A (en) 1997-10-17
CN1064313A (zh) 1992-09-09
AP207A (en) 1992-08-18
JPH05507201A (ja) 1993-10-21
FI925453L (fi) 1992-11-30
IE911844A1 (en) 1991-12-04
HRP920771B1 (en) 1999-10-31
EP0535048B1 (de) 1997-04-02
ES2099159T3 (es) 1997-05-16
NO924528L (no) 1992-11-24
DE69125489D1 (de) 1997-05-07
DE69125489T2 (de) 1997-08-14
LV10292B (en) 1995-08-20
SK164491A3 (en) 1995-07-11
CA2083396C (en) 2006-09-19
EP0535048A1 (de) 1993-04-07
WO1991018923A1 (en) 1991-12-12
IL98273A0 (en) 1992-06-21
PT97836B (pt) 1998-11-30
AU651979B2 (en) 1994-08-11
NO924528D0 (no) 1992-11-24
UA39165C2 (uk) 2001-06-15
FI925453A0 (fi) 1992-11-30
CA2083396A1 (en) 1991-12-02
IS1751B (is) 2000-07-21
SK281089B6 (sk) 2000-11-07
GR3023618T3 (en) 1997-08-29
AU7964591A (en) 1991-12-31
SG48078A1 (en) 1998-04-17
DZ1503A1 (fr) 2004-09-13
ZA913778B (en) 1992-02-26
SE9001985D0 (sv) 1990-06-01
PT97836A (pt) 1992-02-28
CN1075113C (zh) 2001-11-21
NO322962B1 (no) 2006-12-18
HU215258B (hu) 1998-11-30
FI114639B (fi) 2004-11-30
BG97123A (bg) 1993-12-24
LT4020B (en) 1996-08-26
HU9203774D0 (en) 1993-03-29
IS3710A7 (is) 1991-12-02
MA22166A1 (fr) 1991-12-31
LV10292A (lv) 1994-10-20
YU49138B (sh) 2004-03-12
AP9100270A0 (en) 1991-07-31
TNSN91041A1 (fr) 1992-10-25
PL166534B1 (pl) 1995-05-31
MY111245A (en) 1999-10-30
LTIP1736A (en) 1995-08-25
CN1326782A (zh) 2001-12-19
ATE151077T1 (de) 1997-04-15
EG19937A (en) 2000-12-31
BG61165B1 (bg) 1997-01-31
JO1694B1 (en) 1992-08-09
HRP920771A2 (en) 1997-04-30
HUT63184A (en) 1993-07-28
IL98273A (en) 2005-11-20
NZ238223A (en) 1993-05-26

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Effective date: 20110529