HRP20020910B1 - DERIVATI ß-KARBOLINA KORISNI KAO INHIBITORI FOSFODIESTERAZE - Google Patents

DERIVATI ß-KARBOLINA KORISNI KAO INHIBITORI FOSFODIESTERAZE

Info

Publication number
HRP20020910B1
HRP20020910B1 HR20020910A HRP20020910A HRP20020910B1 HR P20020910 B1 HRP20020910 B1 HR P20020910B1 HR 20020910 A HR20020910 A HR 20020910A HR P20020910 A HRP20020910 A HR P20020910A HR P20020910 B1 HRP20020910 B1 HR P20020910B1
Authority
HR
Croatia
Prior art keywords
c8alkyl
group
optionally substituted
nhra
heteroaryl
Prior art date
Application number
HR20020910A
Other languages
English (en)
Croatian (hr)
Inventor
Sui Zhihua
J. Macielag Mark
Original Assignee
Ortho-Mcneil Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho-Mcneil Pharmaceutical filed Critical Ortho-Mcneil Pharmaceutical
Publication of HRP20020910A2 publication Critical patent/HRP20020910A2/hr
Publication of HRP20020910B1 publication Critical patent/HRP20020910B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HR20020910A 2000-05-17 2001-05-03 DERIVATI ß-KARBOLINA KORISNI KAO INHIBITORI FOSFODIESTERAZE HRP20020910B1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20466700P 2000-05-17 2000-05-17
PCT/US2001/014357 WO2001087038A2 (en) 2000-05-17 2001-05-03 β-CARBOLINE DERIVATIVES USEFUL AS INHIBITORS OF PHOSPHODIESTERASE

Publications (2)

Publication Number Publication Date
HRP20020910A2 HRP20020910A2 (en) 2004-12-31
HRP20020910B1 true HRP20020910B1 (hr) 2011-02-28

Family

ID=22758909

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020910A HRP20020910B1 (hr) 2000-05-17 2001-05-03 DERIVATI ß-KARBOLINA KORISNI KAO INHIBITORI FOSFODIESTERAZE

Country Status (31)

Country Link
US (2) US6492358B2 (cs)
EP (1) EP1289985B1 (cs)
JP (1) JP5014551B2 (cs)
KR (1) KR20030031482A (cs)
CN (1) CN1255403C (cs)
AR (1) AR028576A1 (cs)
AT (1) ATE256127T1 (cs)
AU (2) AU2001261167B2 (cs)
BG (1) BG66141B1 (cs)
CA (1) CA2409715C (cs)
CZ (1) CZ20023934A3 (cs)
DE (1) DE60101479T2 (cs)
DK (1) DK1289985T3 (cs)
ES (1) ES2211806T3 (cs)
GE (1) GEP20053511B (cs)
HR (1) HRP20020910B1 (cs)
HU (1) HUP0302412A3 (cs)
IL (2) IL152873A0 (cs)
MX (1) MXPA02011426A (cs)
MY (1) MY128479A (cs)
NO (1) NO324251B1 (cs)
NZ (1) NZ522731A (cs)
PL (1) PL205507B1 (cs)
PT (1) PT1289985E (cs)
RU (1) RU2271358C2 (cs)
SK (1) SK16972002A3 (cs)
TR (1) TR200302309T4 (cs)
TW (1) TWI286553B (cs)
UA (1) UA74826C2 (cs)
WO (1) WO2001087038A2 (cs)
ZA (1) ZA200210111B (cs)

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JP4220779B2 (ja) * 2001-02-12 2009-02-04 リリー アイコス リミテッド ライアビリティ カンパニー 化学化合物
AU2002249890A1 (en) * 2001-02-12 2002-08-28 Lilly Icos Llc Carboline derivatives
EP1383765B1 (en) * 2001-04-25 2006-12-13 Lilly Icos LLC Carboline derivatives as inhibitors of phosphodiesterase 5 (PDE5) for the treatment of cardiovascular diseases and erectile dysfunction
WO2002098875A1 (en) * 2001-06-05 2002-12-12 Lilly Icos Llc Carboline derivatives as pde-5 inhibitors
WO2003000691A1 (en) * 2001-06-21 2003-01-03 Lilly Icos Llc Carboline derivatives as pdev inhibitors
PT1448562E (pt) 2001-11-14 2007-08-31 Ortho Mcneil Pharm Inc Derivados da pirroloquinolona tetracíclica substituídos, úteis como inibidores da fosfodiesterase
PT1480634E (pt) * 2002-02-07 2011-10-12 Univ Tennessee Res Foundation Moduladores selectivos do receptor do androgénio (sarms) para o tratamento da hiperplasia benigna da próstata
US6800625B2 (en) * 2002-06-19 2004-10-05 Janssen Pharmaceutica N.V. Substituted 2,4-dihydro-pyrrolo[3,4-b]quinolin-9-one derivatives useful as phosphodiesterase inhibitors
ES2427166T3 (es) * 2003-06-23 2013-10-29 Ono Pharmaceutical Co., Ltd. Compuesto heterocíclico tricíclico novedoso
CN1910183A (zh) 2004-01-23 2007-02-07 希龙公司 四氢咔啉化合物作为抗癌药
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
US7767689B2 (en) 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
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US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
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WO2006068164A1 (ja) * 2004-12-22 2006-06-29 Ono Pharmaceutical Co., Ltd. 三環式化合物およびその用途
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EP1928437A2 (en) 2005-08-26 2008-06-11 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
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US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
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AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
EP2068872A1 (en) * 2006-09-08 2009-06-17 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
EP2178537A4 (en) * 2007-07-19 2011-08-17 Merck Sharp & Dohme BETA-CARBOLIN DERIVATIVES AS ANTIDIBLE COMPOUNDS
EP2225250A2 (en) 2007-11-30 2010-09-08 Biota Scientific Management Pty Ltd Bicyclic ppat inhibitors as antibacterial agents
US8716308B2 (en) 2008-01-11 2014-05-06 Albany Molecular Research, Inc. (1-azinone)-substituted pyridoindoles
TWI443098B (zh) 2008-03-24 2014-07-01 Medivation Technologies Inc 吡啶并〔３，４－ｂ〕吲哚及使用方法
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US8629158B2 (en) 2009-07-01 2014-01-14 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
WO2011003012A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof
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Also Published As

Publication number Publication date
DK1289985T3 (da) 2004-04-05
RU2271358C2 (ru) 2006-03-10
ES2211806T3 (es) 2004-07-16
HUP0302412A2 (hu) 2003-11-28
UA74826C2 (en) 2006-02-15
TWI286553B (en) 2007-09-11
DE60101479D1 (en) 2004-01-22
PL205507B1 (pl) 2010-04-30
TR200302309T4 (tr) 2004-02-23
SK16972002A3 (sk) 2003-11-04
IL152873A0 (en) 2003-06-24
US6864253B2 (en) 2005-03-08
PT1289985E (pt) 2004-03-31
NZ522731A (en) 2004-09-24
IL152873A (en) 2012-01-31
NO20025527L (no) 2003-01-16
HRP20020910A2 (en) 2004-12-31
GEP20053511B (en) 2005-05-10
NO20025527D0 (no) 2002-11-18
ZA200210111B (en) 2004-03-12
KR20030031482A (ko) 2003-04-21
BG107285A (bg) 2003-07-31
JP2003533453A (ja) 2003-11-11
MY128479A (en) 2007-02-28
JP5014551B2 (ja) 2012-08-29
US20030166641A1 (en) 2003-09-04
BG66141B1 (bg) 2011-07-29
MXPA02011426A (es) 2004-09-06
US20020010189A1 (en) 2002-01-24
AU6116701A (en) 2001-11-26
CN1446217A (zh) 2003-10-01
CA2409715A1 (en) 2001-11-22
WO2001087038A2 (en) 2001-11-22
EP1289985A2 (en) 2003-03-12
PL365445A1 (en) 2005-01-10
AR028576A1 (es) 2003-05-14
AU2001261167B2 (en) 2006-10-05
HUP0302412A3 (en) 2007-02-28
CN1255403C (zh) 2006-05-10
CZ20023934A3 (cs) 2003-10-15
WO2001087038A3 (en) 2002-05-16
NO324251B1 (no) 2007-09-17
DE60101479T2 (de) 2005-04-28
EP1289985B1 (en) 2003-12-10
US6492358B2 (en) 2002-12-10
ATE256127T1 (de) 2003-12-15
HK1051368A1 (en) 2003-08-01
CA2409715C (en) 2010-09-14

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