HUP0101048A2 - Glicin transzport gátló hatású 4,4 bisz[(4-fluorfenil)butil]-1-(piperazinil és piperidinil)-származékok és gyógyászati alkalmazásuk - Google Patents

Glicin transzport gátló hatású 4,4 bisz[(4-fluorfenil)butil]-1-(piperazinil és piperidinil)-származékok és gyógyászati alkalmazásuk Download PDF

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Publication number
HUP0101048A2
HUP0101048A2 HU0101048A HUP0101048A HUP0101048A2 HU P0101048 A2 HUP0101048 A2 HU P0101048A2 HU 0101048 A HU0101048 A HU 0101048A HU P0101048 A HUP0101048 A HU P0101048A HU P0101048 A2 HUP0101048 A2 HU P0101048A2
Authority
HU
Hungary
Prior art keywords
group
formula
butyl
bis
fluorophenyl
Prior art date
Application number
HU0101048A
Other languages
English (en)
Hungarian (hu)
Inventor
Frans Eduard Janssens
Ludo Edmond Josephine Kennis
Walter Herman Maria Louis Luyten
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of HUP0101048A2 publication Critical patent/HUP0101048A2/hu

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HU0101048A 1998-03-06 1999-02-26 Glicin transzport gátló hatású 4,4 bisz[(4-fluorfenil)butil]-1-(piperazinil és piperidinil)-származékok és gyógyászati alkalmazásuk HUP0101048A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98200701 1998-03-06
PCT/EP1999/001309 WO1999044596A2 (en) 1998-03-06 1999-02-26 Glycine transport inhibitors

Publications (1)

Publication Number Publication Date
HUP0101048A2 true HUP0101048A2 (hu) 2001-10-28

Family

ID=8233444

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0101048A HUP0101048A2 (hu) 1998-03-06 1999-02-26 Glicin transzport gátló hatású 4,4 bisz[(4-fluorfenil)butil]-1-(piperazinil és piperidinil)-származékok és gyógyászati alkalmazásuk

Country Status (17)

Country Link
EP (1) EP1059922A2 (no)
JP (1) JP2002505277A (no)
KR (1) KR20010032968A (no)
CN (1) CN1292698A (no)
AU (1) AU3408999A (no)
BG (1) BG104685A (no)
BR (1) BR9907951A (no)
CA (1) CA2322164A1 (no)
EE (1) EE200000482A (no)
HR (1) HRP20000523A2 (no)
HU (1) HUP0101048A2 (no)
IL (1) IL138228A0 (no)
NO (1) NO20004431L (no)
PL (1) PL343435A1 (no)
SK (1) SK13082000A3 (no)
TR (1) TR200002567T2 (no)
WO (1) WO1999044596A2 (no)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EE04592B1 (et) * 1999-06-28 2006-02-15 Janssen Pharmaceutica N.V. Respiratoorse süntsütiaalviiruse replikatsiooni inhibiitorid, nende valmistamismeetod, kasutamine ja vaheühendid, farmatseutiline kompositsioon ja selle valmistamismeetod ning produkt
UA73749C2 (en) * 1999-11-01 2005-09-15 Diarylenines
AU2001254546A1 (en) * 2000-04-20 2001-11-07 Nps Allelix Corp. Aminopiperidines
DE10040016A1 (de) * 2000-08-16 2002-02-28 Boehringer Ingelheim Pharma Neue beta-Amyloid Inhibitoren, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
AU2001288896A1 (en) 2000-09-08 2002-03-22 Gliatech, Inc. Substituted hydrazine derivatives
US6946474B2 (en) 2000-09-14 2005-09-20 Merck & Co., Inc. Nitrogen-containing compounds and their use as glycine transport inhibitors
AR032653A1 (es) 2001-02-09 2003-11-19 Telik Inc Inhibidores heterociclicos del trasportador de glicina 2 composiciones farmaceuticas, uso y metodos.
US7030150B2 (en) 2001-05-11 2006-04-18 Trimeris, Inc. Benzimidazole compounds and antiviral uses thereof
DK1703909T3 (da) * 2003-09-09 2009-06-22 Hoffmann La Roche 1-benzoyl-piperazinderivater som glycinoptagelsesinhibitorer til behandling af psykoser
PT1663232E (pt) 2003-09-09 2007-12-12 Hoffmann La Roche Derivados de 1- (2-amino-benzol) -piperazina como inibidores de absorção de glicina para o tratamento de psicoses
WO2005058885A2 (en) * 2003-12-18 2005-06-30 Glaxo Group Limited Piperidine derivatives and their use as glycine transporter inhibitors
TW200630337A (en) 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
HRP20090264T1 (hr) * 2004-12-09 2009-06-30 F. Hoffmann - La Roche Ag Derivati fenil-piperazin metanona
WO2006063709A1 (en) * 2004-12-15 2006-06-22 F.Hoffmann-La Roche Ag Bi- and tricyclic substituted phenyl methanones as glycine transporter i (glyt-1) inhibitors for the treatment of alzheimer’s disease
GB0428233D0 (en) * 2004-12-23 2005-01-26 Glaxo Group Ltd Compounds
PE20061156A1 (es) 2004-12-23 2006-12-16 Glaxo Group Ltd Derivados de benzamida como agentes inhibidores del transportador de glicina
US7485637B2 (en) 2005-01-04 2009-02-03 Hoffmann-La Roche Inc. Benzoyl-tetrahydropiperidine derivatives
CA2593453A1 (en) * 2005-01-06 2006-07-13 F. Hoffmann-La Roche Ag Sulfanyl substituted phenyl methanones as glycine transporter 1 (glyt-1) inhibitors for the treatment of neurological and neuropsychiatric disorders
AU2005324024B2 (en) * 2005-01-07 2011-02-17 F. Hoffmann-La Roche Ag [4-(Heteroaryl) piperazin-1-yl]-(2,5-substituted -phenyl)methanone derivatives as glycine transporter 1 (GlyT-1) inhibitors for the treatment of neurological and neuropsychiatric disorders
AU2006207650B2 (en) 2005-01-18 2011-01-27 F. Hoffmann-La Roche Ag 2, 5-disubstituted phenyl methanone derivatives as glycine transporter 1 (GlyT-I) inhibitors for the treatment of neurological and neuropsychiatry disorders
BRPI0607241A2 (pt) 2005-01-26 2009-08-25 Hoffmann La Roche derivados de fenil metanona e o uso dos mesmos como inibidores do transportador de glicina 1
DE602006010665D1 (en) * 2005-02-07 2010-01-07 Hoffmann La Roche Heterocyclsche substituierte phenylmethanone als inhibitoren des glycintransporters 1
CN100341871C (zh) * 2005-06-03 2007-10-10 复旦大学 含哌啶结构的有机硫化合物，制备方法和应用
WO2007110449A1 (en) 2006-03-29 2007-10-04 Euro-Celtique S.A. Benzenesulfonamide compounds and their use
US8937181B2 (en) 2006-04-13 2015-01-20 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
TW200815353A (en) 2006-04-13 2008-04-01 Euro Celtique Sa Benzenesulfonamide compounds and their use
CN101553256B (zh) * 2006-11-01 2013-01-30 普渡制药公司 苯基丙酰胺化合物及其用途
FR2910320B1 (fr) * 2006-12-21 2009-02-13 Galderma Res & Dev S N C Snc Emulsion comprenant au moins un retinoide et du peroxyde de benzole
FR2910321B1 (fr) 2006-12-21 2009-07-10 Galderma Res & Dev S N C Snc Gel creme comprenant au moins un retinoide et du peroxyde de benzole
US8399486B2 (en) 2007-04-09 2013-03-19 Purdue Pharma L.P. Benzenesulfonyl compounds and the use thereof
US8765736B2 (en) 2007-09-28 2014-07-01 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
EP2231601B1 (en) * 2007-12-12 2014-06-18 Amgen Inc. Glycine transporter-1 inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4219559A (en) * 1979-01-10 1980-08-26 Janssen Pharmaceutica N.V. N-Heterocyclyl-4-piperidinamines
CA1140119A (en) * 1978-04-03 1983-01-25 Joseph Torremans N-heterocyclyl-4-piperidinamines
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
US4695575A (en) * 1984-11-13 1987-09-22 Janssen Pharmaceutica, N.V. 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines
AU1041599A (en) * 1997-11-13 1999-06-07 Jose Luis Castro Pineiro Therapeutic uses of triazolo-pyridazine derivatives

Also Published As

Publication number Publication date
HRP20000523A2 (en) 2001-02-28
BG104685A (en) 2001-04-30
AU3408999A (en) 1999-09-20
PL343435A1 (en) 2001-08-13
WO1999044596A3 (en) 2000-02-17
SK13082000A3 (sk) 2001-03-12
WO1999044596A2 (en) 1999-09-10
EP1059922A2 (en) 2000-12-20
EE200000482A (et) 2002-02-15
BR9907951A (pt) 2001-01-30
NO20004431D0 (no) 2000-09-05
JP2002505277A (ja) 2002-02-19
KR20010032968A (ko) 2001-04-25
CA2322164A1 (en) 1999-09-10
IL138228A0 (en) 2001-10-31
TR200002567T2 (tr) 2000-11-21
NO20004431L (no) 2000-10-30
CN1292698A (zh) 2001-04-25

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