IL96924A0 - Imidazole derivatives,process for the preparation thereof and pharmaceutical compositions containing the same - Google Patents

Imidazole derivatives,process for the preparation thereof and pharmaceutical compositions containing the same

Info

Publication number: IL96924A0
Authority: IL; Israel
Prior art keywords: imidazole derivatives; preparation; same; pharmaceutical compositions; compositions containing
Prior art date: 1990-01-12

Application number

IL96924A

Other languages

English (en)

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-01-12

Filing date

1991-01-10

Publication date

1992-03-29

1990-01-12 Priority claimed from GB909000696A external-priority patent/GB9000696D0/en

1990-12-21 Priority claimed from GB909027892A external-priority patent/GB9027892D0/en

1991-01-10 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1992-03-29 Publication of IL96924A0 publication Critical patent/IL96924A0/xx

Links

150000002460 imidazoles Chemical class 0.000 title abstract 2
229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
102000004357 Transferases Human genes 0.000 abstract 1
108090000992 Transferases Proteins 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
-1 acyl coenzyme-A Chemical compound 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
RGJOEKWQDUBAIZ-UHFFFAOYSA-N coenzime A Natural products OC1C(OP(O)(O)=O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-UHFFFAOYSA-N 0.000 abstract 1
239000005516 coenzyme A Substances 0.000 abstract 1
229940093530 coenzyme a Drugs 0.000 abstract 1
KDTSHFARGAKYJN-UHFFFAOYSA-N dephosphocoenzyme A Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 KDTSHFARGAKYJN-UHFFFAOYSA-N 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1
RZWIIPASKMUIAC-VQTJNVASSA-N thromboxane Chemical compound CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC RZWIIPASKMUIAC-VQTJNVASSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
- C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Inks, Pencil-Leads, Or Crayons (AREA)
Plural Heterocyclic Compounds (AREA)
Photoreceptors In Electrophotography (AREA)
Polyurethanes Or Polyureas (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Macromonomer-Based Addition Polymer (AREA)
Adhesives Or Adhesive Processes (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Luminescent Compositions (AREA)

IL96924A 1990-01-12 1991-01-10 Imidazole derivatives,process for the preparation thereof and pharmaceutical compositions containing the same IL96924A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB909000696A GB9000696D0 (en)	1990-01-12	1990-01-12	New compositions of matter
GB909027892A GB9027892D0 (en)	1990-12-21	1990-12-21	Imidazoles

Publications (1)

Publication Number	Publication Date
IL96924A0 true IL96924A0 (en)	1992-03-29

Family

ID=26296489

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL96924A IL96924A0 (en)	1990-01-12	1991-01-10	Imidazole derivatives,process for the preparation thereof and pharmaceutical compositions containing the same

Country Status (17)

Country	Link
EP (1)	EP0510036B1 (cs)
JP (1)	JPH05503095A (cs)
KR (1)	KR927003576A (cs)
AT (1)	ATE121401T1 (cs)
AU (1)	AU7066191A (cs)
CA (1)	CA2073443A1 (cs)
CS (1)	CS5291A3 (cs)
DE (1)	DE69109090T2 (cs)
FI (1)	FI923189A7 (cs)
HU (1)	HUT61540A (cs)
IE (1)	IE910098A1 (cs)
IL (1)	IL96924A0 (cs)
MX (1)	MX9203711A (cs)
NO (1)	NO922729L (cs)
NZ (1)	NZ236763A (cs)
PT (1)	PT96467A (cs)
WO (1)	WO1991010662A1 (cs)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9019838D0 (en) *	1990-09-11	1990-10-24	Smith Kline French Lab	Compounds
US5212318A (en) *	1991-03-04	1993-05-18	Eastman Kodak Company	Preparation of omega-substituted alkanamide
GB9115005D0 (en) *	1991-07-11	1991-08-28	Rhone Poulenc Rorer Ltd	Novel compositions of matter
GB9115190D0 (en) *	1991-07-12	1991-08-28	Rhone Poulenc Rorer Ltd	New compositions of matter
US5310748A (en) *	1992-05-11	1994-05-10	The Du Pont Merck Pharmaceutical Company	Imidazoles for the treatment of atherosclerosis
US5364875A (en) *	1992-05-11	1994-11-15	The Du Pont Merck Pharmaceutical Company	Imidazoles linked to bicyclic heterocyclic groups for the treatment of atherosclerosis
IT1265209B1 (it) *	1993-11-22	1996-10-31	Pierrel Spa	Difenilimidazoli utili nel trattamento di dislipidemia, arteriosclerosi e malattie coronariche procedimento per la loro
US5491152A (en) *	1994-03-23	1996-02-13	The Du Pont Merck Pharmaceutical Company	Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis
DE19645313A1 (de)	1996-11-04	1998-05-07	Basf Ag	Substituierte 3-Benzylpyrazole
DE10107683A1 (de)	2001-02-19	2002-08-29	Merckle Gmbh Chem Pharm Fabrik	2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie
DE10114775A1 (de) *	2001-03-26	2002-10-10	Gerhard Dannhardt	2-Mercapto-4,5-diarylimidazolderivate und ihre Verwendung in der Pharmazie
DE10238045A1 (de)	2002-08-20	2004-03-04	Merckle Gmbh Chem.-Pharm. Fabrik	2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie
MD4150C1 (ro) *	2011-10-11	2012-09-30	Институт Химии Академии Наук Молдовы	Procedeu de obţinere a compuşilor coordinativi ai Co(II), Ni(II) şi Zn(II) cu 2-nitro-4,5-difenilimidazol pornind de la 4,5-difenilimidazol şi nitraţii metalelor respective
MD4178C1 (ro) *	2012-02-27	2013-02-28	Институт Химии Академии Наук Молдовы	Procedeu de obţinere a 2-nitro-4,5-difenilimidazolului
CN106699738A (zh) *	2015-11-18	2017-05-24	南京大学	一类含甲硝唑吡唑类骨架的抗菌化合物的设计、合成及生物活性评价

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3323870A1 (de) *	1983-07-02	1985-01-03	A. Nattermann & Cie GmbH, 5000 Köln	Neue imidazol-2-ylthioalkansaeuren und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DK167187A (da) *	1986-04-02	1987-10-03	Otsuka Pharma Co Ltd	Carbostyrilderivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse
US4900744A (en) *	1988-09-14	1990-02-13	E. I. Du Pont De Nemours And Company	Antihypercholesterolemic 4,5-diaryl-2-substituted thioimidazoles

1991
- 1991-01-09 AU AU70661/91A patent/AU7066191A/en not_active Abandoned
- 1991-01-09 JP JP3502230A patent/JPH05503095A/ja active Pending
- 1991-01-09 MX MX9203711A patent/MX9203711A/es unknown
- 1991-01-09 HU HU9422A patent/HUT61540A/hu unknown
- 1991-01-09 WO PCT/EP1991/000023 patent/WO1991010662A1/en not_active Ceased
- 1991-01-09 AT AT91901788T patent/ATE121401T1/de not_active IP Right Cessation
- 1991-01-09 DE DE69109090T patent/DE69109090T2/de not_active Expired - Fee Related
- 1991-01-09 EP EP91901788A patent/EP0510036B1/en not_active Expired - Lifetime
- 1991-01-09 FI FI923189A patent/FI923189A7/fi not_active Application Discontinuation
- 1991-01-09 CA CA002073443A patent/CA2073443A1/en not_active Abandoned
- 1991-01-09 KR KR1019920701647A patent/KR927003576A/ko not_active Withdrawn
- 1991-01-10 IL IL96924A patent/IL96924A0/xx unknown
- 1991-01-11 PT PT96467A patent/PT96467A/pt not_active Application Discontinuation
- 1991-01-11 CS CS9152A patent/CS5291A3/cs unknown
- 1991-01-11 IE IE009891A patent/IE910098A1/en unknown
- 1991-01-14 NZ NZ236763A patent/NZ236763A/xx unknown
1992
- 1992-07-10 NO NO92922729A patent/NO922729L/no unknown

Also Published As

Publication number	Publication date
IE910098A1 (en)	1991-07-17
CS5291A3 (en)	1992-02-19
JPH05503095A (ja)	1993-05-27
NZ236763A (en)	1993-05-26
FI923189A0 (fi)	1992-07-10
DE69109090T2 (de)	1995-09-14
NO922729D0 (no)	1992-07-10
HUT61540A (en)	1993-01-28
EP0510036A1 (en)	1992-10-28
KR927003576A (ko)	1992-12-18
FI923189L (fi)	1992-07-10
PT96467A (pt)	1991-10-15
AU7066191A (en)	1991-08-05
WO1991010662A1 (en)	1991-07-25
CA2073443A1 (en)	1991-07-13
ATE121401T1 (de)	1995-05-15
MX9203711A (es)	1992-07-01
NO922729L (no)	1992-09-02
EP0510036B1 (en)	1995-04-19
HU9202294D0 (en)	1992-10-28
FI923189A7 (fi)	1992-07-10
DE69109090D1 (de)	1995-05-24

Publication	Publication Date	Title
IL96924A0 (en)	1992-03-29	Imidazole derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
TW349946B (en)	1999-01-11	Novel naphthyl compounds and their process for preparation and pharmaceutical compositions containing same
KR940002942B1 (en)	1994-04-09	Process for preparing antimycotic nail varnish
HUT37128A (en)	1985-11-28	Process for the production of dihydropyridazinone-derivatives, as well as of pharmaceutical preparations containing these derivatives as agent
MX9800946A (es)	1998-04-30	Derivados de 4-mercaptopirrolidina como inhibidores de farnesil trasnferasa.
AU589427B2 (en)	1989-10-12	Pyridonecarboxylic acid derivatives and process for their preparation
EG15921A (en)	1986-09-30	Method of preparation pyrrolidine derivatives
HU895226D0 (en)	1990-01-28	Process for the preparation of novel imidazoline derivatives and pharmaceutical compositions containing said compounds as active ingredients
GB1254332A (en)	1971-11-17	Amino acids and their derivatives and processes for preparing them
ES8609225A1 (es)	1986-07-16	Un procedimiento para preparar un derivado de semicarbazida
YU217181A (en)	1983-10-31	Process for preparing 2-(1,4-benzodioxane-2-ylalkyl)-imidazoles
DE3061125D1 (en)	1982-12-30	1-(naphthyl-n-propyl)imidazole derivatives, compositions containing them, methods of making them and their use for pharmaceuticals
ES484718A1 (es)	1980-09-01	Un procedimiento para la preparacion de benzopiranos.
HU906230D0 (en)	1991-03-28	Process for the preparation of benzanilide derivatives and medical preparations containing them
ES8609212A1 (es)	1986-09-01	Un procedimiento para la preparacion de derivados de etanolamina.
EP0123962A3 (en)	1987-10-07	Novel benzimidazole derivative, process for the preparation thereof and pharmaceutical composition
NO170974C (no)	1993-01-06	Analogifremgangsmaate for fremstilling av terapeutisk brukbare ((((3-pyridinyl)metylen)amino)oksy)alkansyrer og estere derav samt mellomprodukt for anvendelse ved fremgangsmaaten
DE3070768D1 (en)	1985-07-25	1-((substituted-naphthyl)ethyl)-imidazole derivatives, pharmaceutical compositions containing them and methods of making them
AP1518A (en)	2005-12-12	Novel octahydro-6, 10-dioxo-6h-pyridazino/1,2-a/ /1,2/diazepin-1-carboxylic acid derivatives, preparation method and use for preparing therapeutically active compounds.
DE3374005D1 (en)	1987-11-12	1-methyl-5-nitro-imidazoline derivatives and therapeutic compositions which contain them as active principle
DE3362876D1 (en)	1986-05-15	Dibenzocycloheptenylidene compounds for use in modulating the immune response
IL115085A0 (en)	1995-12-08	Bicyclic carboxamide derivatives their preparation and pharmaceutical compositions containing them
DE3475402D1 (en)	1989-01-05	Endo-8,8-dialkyl-8-azoniabicyclo (3.2.1) octane-6,7-exo-epoxy-3-alkyl-carboxylate salts, a process for their preparation, and therapeutic compositions which contain them as active principle
ATE29133T1 (de)	1987-09-15	Troponon-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung.
IL70552A (en)	1986-12-31	Aminoethoxybenzyl alcohol derivatives,their preparation and pharmaceutical compositions containing them