IN2014DN01992A - - Google Patents

Info

Publication number
IN2014DN01992A
IN2014DN01992A IN1992DEN2014A IN2014DN01992A IN 2014DN01992 A IN2014DN01992 A IN 2014DN01992A IN 1992DEN2014 A IN1992DEN2014 A IN 1992DEN2014A IN 2014DN01992 A IN2014DN01992 A IN 2014DN01992A
Authority
IN
India
Prior art keywords
methyl
aminosulfonyl
thiazol
pyridinyl
phenyl
Prior art date
Application number
Inventor
Wilfried Schwab
Alexander Birkmann
Kerstin Paulus
Kurt Vögtli
Dieter Haag
Stephan Maas
Kristian Ruepp
Original Assignee
Aicuris Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh & Co Kg filed Critical Aicuris Gmbh & Co Kg
Publication of IN2014DN01992A publication Critical patent/IN2014DN01992A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to the crystalline mesylate monohydrate salt of N [5 (aminosulfonyl) 4 methyl 1 3 thiazol 2 yl] N methyl 2 [4 (2 pyridinyl)phenyl]acet amide in a definite particle size distribution and a specific surface area range which has demonstrated increased long term stability and release kinetics from pharmaceutical compositions as well as to pharmaceutical compositions containing said N [5 (aminosulfonyl) 4 methyl 1 3 thiazol 2 yl] N methyl 2 [4 (2 pyridinyl)phenyl]acetamide mesylate monohydrate having the afore mentioned particle size distribution and specific surface area range.
IN1992DEN2014 2011-09-26 2012-09-26 IN2014DN01992A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11007803A EP2573085A1 (en) 2011-09-26 2011-09-26 N-[5-(aminosulfonyl)-4methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl] acetamide mesylate monohydrate having a specific particle size distribution range and a specific surface area range
PCT/EP2012/068958 WO2013045491A1 (en) 2011-09-26 2012-09-26 N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate having a specific particle size distribution range and a specific surface area range for use in pharmaceutical formulations.

Publications (1)

Publication Number Publication Date
IN2014DN01992A true IN2014DN01992A (en) 2015-05-15

Family

ID=46889071

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1992DEN2014 IN2014DN01992A (en) 2011-09-26 2012-09-26

Country Status (11)

Country Link
US (5) US9119786B2 (en)
EP (1) EP2573085A1 (en)
JP (1) JP6043356B2 (en)
KR (1) KR20140066705A (en)
CN (1) CN103842360B (en)
AU (1) AU2012314473B2 (en)
IN (1) IN2014DN01992A (en)
MX (1) MX364094B (en)
RU (1) RU2606628C2 (en)
WO (1) WO2013045491A1 (en)
ZA (1) ZA201401774B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2573085A1 (en) 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(aminosulfonyl)-4methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl] acetamide mesylate monohydrate having a specific particle size distribution range and a specific surface area range
EP2573086A1 (en) * 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate
JP2016507546A (en) 2013-02-12 2016-03-10 アイクリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト Helicase / primase inhibitors for use in a method of treating Alzheimer's disease
BR112017006287A2 (en) * 2014-09-26 2017-12-12 Millendo Therapeutics Inc n- (2,6-bis (1-methylethyl) phenyl) -N '- ((1- (4- (dimethylamino) phenyl) cyclopentyl) methyl) urea hydrochloride solid drug form and related compositions, methods and kits the same
EP3135275B1 (en) * 2015-08-27 2020-05-13 Grindeks, A Joint Stock Company Pharmaceutical composition capable of the incorporation of lenalidomide in various crystalline modifications
AR110251A1 (en) 2016-11-28 2019-03-13 Aicuris Anti Infective Cures Gmbh A MALEATE SALT OF THE FREE BASE OF N- [5- (AMINOSULFONIL) -4-METHYL-1,3-TIAZOL-2-IL] -N-METHYL-2- [4- (2-PIRIDINIL) -PENYL] ACETAMIDE, PHARMACEUTICAL FORMULATIONS, MANUFACTURING METHODS AND USES OF THE SAME
AR110250A1 (en) 2016-11-28 2019-03-13 Aicuris Anti Infective Cures Gmbh TOPICAL FORMULATION INCLUDING N- [5- (AMINOSULFONIL) -4-METHYL-1,3-TIAZOL-2-IL] -N-METHYL-2- [4- (2-PYRIDINYL) -PHENYL] -ACETAMIDE
LT3544976T (en) 2016-11-28 2021-08-10 Aicuris Gmbh & Co. Kg N- [5- (AMINOSULPHONYL) -4-METHYL-1,3-THIAZOL-2-YL] -N-METHYL-2- [4- (2-PYRIDINYL) -PHENYL] -ACETAMIDE FREE BASE HEMIHYDRATE AND MANUFACTURING METHODS AND USES
PT3644958T (en) 2017-06-28 2021-11-08 Aicuris Gmbh & Co Kg INTRAVAGINALLY APPLICABLE DEVICES INCLUDING ANTIVIRAL COMPOUNDS
TW202038947A (en) 2018-11-28 2020-11-01 德商創新分子有限責任公司 Helicase primase inhibitors for treating cancer in a combination therapy with oncolytic viruses
JP2025527942A (en) 2022-08-29 2025-08-25 アセンブリー・バイオサイエンシーズ・インコーポレイテッド Novel crystal morphology
WO2024047507A1 (en) 2022-08-29 2024-03-07 Assembly Biosciences, Inc. A novel crystalline form of pritelivir
IL319024A (en) 2022-08-29 2025-04-01 Assembly Biosciences Inc Pharmaceutical compositions for herpes virus

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US6355684B1 (en) * 1990-10-11 2002-03-12 Meryl J. Squires Antimicrobial treatment for herpes simplex virus and other infectious diseases
US9662360B2 (en) 2008-10-09 2017-05-30 Meritus Corporation Treatment of herpes, pseudomonas, staph, and hepatitis
DOP2000000109A (en) * 1999-12-23 2002-08-30 Gerald Kleymann THIAZOLILAMIDE DERIVATIVES
EP1319185A1 (en) * 2000-06-15 2003-06-18 Bayer Aktiengesellschaft Method for identifying compounds with anti-herpes activity
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DE10129714A1 (en) * 2001-06-22 2003-01-02 Bayer Ag Topical application of thiazolylamides
DE10129717A1 (en) 2001-06-22 2003-01-02 Bayer Ag Combination preparation containing nucleoside compound and 5-sulfonyl-2-phenylacetamido-thiazole derivative, useful as antiviral agent effective againts herpes viruses, especially herpes simplex
DE10131128A1 (en) * 2001-06-28 2003-01-16 Bayer Ag New 5-aminosulfonyl-2-phenylacetamido-thiazole derivatives, useful as antiviral medicaments effective against herpes viruses, especially herpes simplex
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EP2573086A1 (en) * 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate
EP2573085A1 (en) * 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(aminosulfonyl)-4methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl] acetamide mesylate monohydrate having a specific particle size distribution range and a specific surface area range
JP2016507546A (en) * 2013-02-12 2016-03-10 アイクリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト Helicase / primase inhibitors for use in a method of treating Alzheimer's disease
BR112017006287A2 (en) 2014-09-26 2017-12-12 Millendo Therapeutics Inc n- (2,6-bis (1-methylethyl) phenyl) -N '- ((1- (4- (dimethylamino) phenyl) cyclopentyl) methyl) urea hydrochloride solid drug form and related compositions, methods and kits the same
AR110251A1 (en) 2016-11-28 2019-03-13 Aicuris Anti Infective Cures Gmbh A MALEATE SALT OF THE FREE BASE OF N- [5- (AMINOSULFONIL) -4-METHYL-1,3-TIAZOL-2-IL] -N-METHYL-2- [4- (2-PIRIDINIL) -PENYL] ACETAMIDE, PHARMACEUTICAL FORMULATIONS, MANUFACTURING METHODS AND USES OF THE SAME
LT3544976T (en) 2016-11-28 2021-08-10 Aicuris Gmbh & Co. Kg N- [5- (AMINOSULPHONYL) -4-METHYL-1,3-THIAZOL-2-YL] -N-METHYL-2- [4- (2-PYRIDINYL) -PHENYL] -ACETAMIDE FREE BASE HEMIHYDRATE AND MANUFACTURING METHODS AND USES
KR102335327B1 (en) 2017-04-28 2021-12-03 현대자동차 주식회사 Water cooled egr cooler
PT3644958T (en) 2017-06-28 2021-11-08 Aicuris Gmbh & Co Kg INTRAVAGINALLY APPLICABLE DEVICES INCLUDING ANTIVIRAL COMPOUNDS

Also Published As

Publication number Publication date
US20140065224A1 (en) 2014-03-06
US9889124B2 (en) 2018-02-13
EP2573085A1 (en) 2013-03-27
WO2013045491A1 (en) 2013-04-04
US20170348297A1 (en) 2017-12-07
US9592225B2 (en) 2017-03-14
RU2014116621A (en) 2015-11-10
MX2014003623A (en) 2014-05-30
US20160008341A1 (en) 2016-01-14
CN103842360B (en) 2016-06-22
USRE49697E1 (en) 2023-10-17
US20150366849A1 (en) 2015-12-24
JP2014527995A (en) 2014-10-23
AU2012314473B2 (en) 2015-09-17
US10137117B2 (en) 2018-11-27
JP6043356B2 (en) 2016-12-14
US9119786B2 (en) 2015-09-01
KR20140066705A (en) 2014-06-02
RU2606628C2 (en) 2017-01-10
ZA201401774B (en) 2015-12-23
CN103842360A (en) 2014-06-04
MX364094B (en) 2019-04-12
AU2012314473A1 (en) 2014-02-06

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