JOP20200251A1 - نظائر glp-1 جديدة - Google Patents

نظائر glp-1 جديدة

Info

Publication number
JOP20200251A1
JOP20200251A1 JOP/2020/0251A JOP20200251A JOP20200251A1 JO P20200251 A1 JOP20200251 A1 JO P20200251A1 JO P20200251 A JOP20200251 A JO P20200251A JO P20200251 A1 JOP20200251 A1 JO P20200251A1
Authority
JO
Jordan
Prior art keywords
analogs
present disclosure
glp
action
new
Prior art date
Application number
JOP/2020/0251A
Other languages
English (en)
Inventor
Pradeep Dinesh Shahi
Krunal Harishbhai Soni
Ravishankara Madavati Nagaraja
Brijeshkumar Patel
Vinod Sampatrao Burade
Abhishek Tiwari
Dhiren Rameshchandra Joshi
Nishith Chaturvedi
Rishit Mansukhlal Zalawadia
Muthukumaran Natarajan
Kunal Pandya
Rajamannar Thennati
Vipulkumar Shankarbhai Patel
Original Assignee
Sun Pharmaceutical Ind Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sun Pharmaceutical Ind Ltd filed Critical Sun Pharmaceutical Ind Ltd
Publication of JOP20200251A1 publication Critical patent/JOP20200251A1/ar
Application granted granted Critical
Publication of JOP20200251B1 publication Critical patent/JOP20200251B1/ar

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Transmission And Conversion Of Sensor Element Output (AREA)

Abstract

يتعلق الكشف الحالي بنظائر ببتيد-1 جديدة شبيهة بالجلوكاجون (GLP-1) (7-37) لها متوالية حمض أميني حيث يكون Leu أو Ile عند الطرف C-. تكون النظائر الجديدة عبارةً عن مساعدات GLP-1 قوية لها تأثيرات عكسية منخفضة وفترة تأثير طويلة. كما يتعلق الكشف الحالي بمشتقات معالجة بأسيل من النظائر الجديدة ولها فاعلية وفترة تأثير محسنة ومناسبة لإعطائها عبر الفم. قد تكون نظائر الكشف الحالي مفيدةً في علاج مرض السكر والسِّمنة.
JOJO/P/2020/0251A 2018-04-05 2020-10-04 نظائر glp-1 جديدة JOP20200251B1 (ar)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN201821013109 2018-04-05
IN201821040474 2018-10-26
IN201821040468 2018-10-26
PCT/IB2019/052835 WO2019193576A1 (en) 2018-04-05 2019-04-05 Novel glp-1 analogues

Publications (2)

Publication Number Publication Date
JOP20200251A1 true JOP20200251A1 (ar) 2020-10-04
JOP20200251B1 JOP20200251B1 (ar) 2024-04-18

Family

ID=66589592

Family Applications (1)

Application Number Title Priority Date Filing Date
JOJO/P/2020/0251A JOP20200251B1 (ar) 2018-04-05 2020-10-04 نظائر glp-1 جديدة

Country Status (33)

Country Link
US (7) US11447535B2 (ar)
EP (3) EP4364751A3 (ar)
JP (2) JP7250814B2 (ar)
KR (2) KR20250065720A (ar)
CN (3) CN117964735A (ar)
AU (3) AU2019247936C1 (ar)
BR (1) BR112020020419A2 (ar)
CA (1) CA3095988A1 (ar)
CL (1) CL2020002574A1 (ar)
CO (1) CO2020012425A2 (ar)
CY (1) CY1125528T1 (ar)
DK (2) DK3774862T3 (ar)
EC (1) ECSP20070185A (ar)
ES (2) ES2925678T3 (ar)
FI (1) FI4122954T3 (ar)
HR (2) HRP20240749T1 (ar)
HU (2) HUE060135T2 (ar)
IL (1) IL277483B1 (ar)
JO (1) JOP20200251B1 (ar)
LT (2) LT3774862T (ar)
MX (2) MX2020010505A (ar)
MY (1) MY202560A (ar)
PE (1) PE20211417A1 (ar)
PH (1) PH12020551591A1 (ar)
PL (2) PL4122954T3 (ar)
PT (2) PT4122954T (ar)
RS (2) RS65639B1 (ar)
SG (1) SG11202009467YA (ar)
SI (2) SI3774862T1 (ar)
SM (2) SMT202400241T1 (ar)
UA (1) UA128210C2 (ar)
WO (1) WO2019193576A1 (ar)
ZA (1) ZA202306729B (ar)

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WO2020180534A1 (en) 2019-03-01 2020-09-10 President And Fellows Of Harvard College Methods and compositions for protein delivery
TW202216746A (zh) * 2020-06-22 2022-05-01 印度商太陽製藥工業有限公司 長效型ｇｌｐ－１／ｇｉｐ雙重促效劑
PE20231309A1 (es) * 2020-10-17 2023-08-24 Sun Pharmaceutical Ind Ltd Agonistas duales glp-1/gip
CN114685646B (zh) * 2020-12-31 2023-04-07 厦门赛诺邦格生物科技股份有限公司 一种多肽侧链类似物的制备方法及其应用
CA3204051A1 (en) 2021-01-20 2022-07-28 Brian Lian Compositions and methods for the treatment of metabolic and liver disorders
JP7642830B2 (ja) 2021-09-15 2025-03-10 バイキング・セラピューティクス・インコーポレイテッド 代謝及び肝臓障害の処置のための組成物及び方法
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EP4731244A1 (en) 2023-06-20 2026-04-29 Sun Pharmaceutical Industries Limited Glp-1 analog for use in the treatment of metabolic disorders
CN117756914B (zh) * 2023-12-15 2024-09-03 瀚晖制药有限公司 依柯胰岛素的制备方法
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RS65639B1 (sr) 2024-07-31
BR112020020419A2 (pt) 2021-01-19
CN112236444A (zh) 2021-01-15
EP3774862A1 (en) 2021-02-17
JP2023078367A (ja) 2023-06-06
PT3774862T (pt) 2022-09-05
SMT202200352T1 (it) 2022-09-14
EP4122954B1 (en) 2024-04-03
RS63523B1 (sr) 2022-09-30
PT4122954T (pt) 2024-06-05
CN120554480A (zh) 2025-08-29
US20220402992A1 (en) 2022-12-22
ZA202306729B (en) 2024-03-27
CL2020002574A1 (es) 2021-06-04
US20240199718A1 (en) 2024-06-20
US11866477B2 (en) 2024-01-09
AU2019247936B2 (en) 2023-03-02
MY202560A (en) 2024-05-08
SG11202009467YA (en) 2020-10-29
SI4122954T1 (sl) 2024-07-31
AU2023203430B2 (en) 2025-07-03
KR20200141469A (ko) 2020-12-18
JP2021520346A (ja) 2021-08-19
US20240376175A1 (en) 2024-11-14
US20200362007A1 (en) 2020-11-19
AU2019247936C1 (en) 2023-06-15
KR20250065720A (ko) 2025-05-13
EP4122954A1 (en) 2023-01-25
KR102801994B1 (ko) 2025-04-30
CN117964735A (zh) 2024-05-03
CN112236444B (zh) 2025-09-19
PH12020551591A1 (en) 2021-08-16
HUE067499T2 (hu) 2024-10-28
FI4122954T3 (fi) 2024-06-18
IL277483B1 (en) 2026-01-01
US11447535B2 (en) 2022-09-20
UA128210C2 (uk) 2024-05-08
WO2019193576A1 (en) 2019-10-10
PL4122954T3 (pl) 2024-08-12
MX2020010505A (es) 2021-01-15
CO2020012425A2 (es) 2020-12-21
JP7250814B2 (ja) 2023-04-03
ES2980707T3 (es) 2024-10-02
JOP20200251B1 (ar) 2024-04-18
IL277483A (en) 2020-11-30
HRP20240749T1 (hr) 2024-09-13
NZ768446A (en) 2025-10-31
AU2023203430A1 (en) 2023-06-29
EP3774862B1 (en) 2022-06-08
CA3095988A1 (en) 2019-10-10
LT3774862T (lt) 2022-09-12
DK4122954T3 (da) 2024-06-10
AU2019247936A1 (en) 2020-10-15
MX2024007688A (es) 2024-07-09
SI3774862T1 (sl) 2022-10-28
US11242373B2 (en) 2022-02-08
ES2925678T3 (es) 2022-10-19
PL3774862T3 (pl) 2022-10-03
PE20211417A1 (es) 2021-08-02
AU2025242190A1 (en) 2025-10-23
ECSP20070185A (es) 2021-01-29
CY1125528T1 (el) 2026-02-25
US11873328B2 (en) 2024-01-16
US12421289B2 (en) 2025-09-23
EP4364751A2 (en) 2024-05-08
LT4122954T (lt) 2024-06-25
US11485766B2 (en) 2022-11-01
US20190309040A1 (en) 2019-10-10
US20210206823A1 (en) 2021-07-08
SMT202400241T1 (it) 2024-07-09
HRP20221054T1 (hr) 2022-11-11
HUE060135T2 (hu) 2023-02-28
DK3774862T3 (da) 2022-09-05
US20220402991A1 (en) 2022-12-22
EP4364751A3 (en) 2024-06-26

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