JP2017514856A5 - - Google Patents
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- JP2017514856A5 JP2017514856A5 JP2016566651A JP2016566651A JP2017514856A5 JP 2017514856 A5 JP2017514856 A5 JP 2017514856A5 JP 2016566651 A JP2016566651 A JP 2016566651A JP 2016566651 A JP2016566651 A JP 2016566651A JP 2017514856 A5 JP2017514856 A5 JP 2017514856A5
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- JP
- Japan
- Prior art keywords
- substituted
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- alkoxy
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- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 C[C@@](C1)C2CC1*C2 Chemical compound C[C@@](C1)C2CC1*C2 0.000 description 9
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461989651P | 2014-05-07 | 2014-05-07 | |
| US61/989,651 | 2014-05-07 | ||
| PCT/US2015/029409 WO2015171722A1 (en) | 2014-05-07 | 2015-05-06 | Pyrrolidine gpr40 modulators for the treatment of diseases such as diabetes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017514856A JP2017514856A (ja) | 2017-06-08 |
| JP2017514856A5 true JP2017514856A5 (2) | 2018-04-19 |
| JP6483156B2 JP6483156B2 (ja) | 2019-03-13 |
Family
ID=53181359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016566651A Active JP6483156B2 (ja) | 2014-05-07 | 2015-05-06 | 糖尿病などの疾患の治療用のピロリジンｇｐｒ４０モジュレータ |
Country Status (33)
| Country | Link |
|---|---|
| US (4) | US9873679B2 (2) |
| EP (1) | EP3140296B1 (2) |
| JP (1) | JP6483156B2 (2) |
| KR (1) | KR102336370B1 (2) |
| CN (1) | CN106458976B (2) |
| AR (1) | AR100328A1 (2) |
| AU (1) | AU2015256120B2 (2) |
| BR (1) | BR112016024936A2 (2) |
| CA (1) | CA2948161C (2) |
| CL (1) | CL2016002809A1 (2) |
| CY (1) | CY1120340T1 (2) |
| DK (1) | DK3140296T3 (2) |
| EA (1) | EA033250B1 (2) |
| ES (1) | ES2674531T3 (2) |
| HR (1) | HRP20180641T1 (2) |
| HU (1) | HUE039288T2 (2) |
| IL (1) | IL248668B (2) |
| MA (1) | MA39427B1 (2) |
| MX (1) | MX378160B (2) |
| MY (1) | MY181959A (2) |
| NZ (1) | NZ727146A (2) |
| PE (1) | PE20161363A1 (2) |
| PH (1) | PH12016502034B1 (2) |
| PL (1) | PL3140296T3 (2) |
| PT (1) | PT3140296T (2) |
| RS (1) | RS57170B1 (2) |
| SG (1) | SG11201609170UA (2) |
| SI (1) | SI3140296T1 (2) |
| SM (1) | SMT201800342T1 (2) |
| TN (1) | TN2016000444A1 (2) |
| TR (1) | TR201809633T4 (2) |
| TW (1) | TWI659951B (2) |
| WO (1) | WO2015171722A1 (2) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015256038B2 (en) * | 2014-05-07 | 2019-07-11 | Bristol-Myers Squibb Company | Pyrrolidine GPR40 modulators for the treatment of diseases such as diabetes |
| DK3140296T3 (en) * | 2014-05-07 | 2018-07-23 | Bristol Myers Squibb Co | PYRROLIDIN GPR40 MODULATORS FOR TREATMENT OF DISEASES SUCH AS DIABETES |
| WO2018049324A1 (en) | 2016-09-12 | 2018-03-15 | Numerate, Inc. | Monocyclic compounds useful as gpr120 modulators |
| EP3509588B1 (en) | 2016-09-12 | 2023-06-07 | Integral Health,Inc. | Bicyclic compounds useful as gpr120 modulators |
| JPWO2018181847A1 (ja) * | 2017-03-31 | 2020-03-05 | 武田薬品工業株式会社 | 芳香環化合物 |
| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| CN110772636B (zh) * | 2017-08-21 | 2021-03-16 | 武汉大学 | Gpr31抑制剂在制备治疗心脏缺血再灌注损伤及相关疾病药物中的应用 |
| TWI707849B (zh) | 2018-02-13 | 2020-10-21 | 美商基利科學股份有限公司 | Pd‐1/pd‐l1抑制劑 |
| KR102591947B1 (ko) | 2018-04-19 | 2023-10-25 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| EP3820572B1 (en) | 2018-07-13 | 2023-08-16 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| US11236085B2 (en) | 2018-10-24 | 2022-02-01 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
| WO2020113094A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| US11919879B2 (en) | 2021-06-16 | 2024-03-05 | Celgene Corporation | Carboxylic acid containing azetidinyl compounds for the treatment of neurodegenerative diseases |
| CN116283699B (zh) * | 2023-03-02 | 2025-02-11 | 遵义医科大学 | 一种合成氟烷基取代的吡咯烷的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5614492A (en) | 1986-05-05 | 1997-03-25 | The General Hospital Corporation | Insulinotropic hormone GLP-1 (7-36) and uses thereof |
| KR20120104534A (ko) * | 2009-10-06 | 2012-09-21 | 브리스톨-마이어스 스큅 컴퍼니 | 피롤리딘 ｇｐｒ40 조절제 |
| US7939569B1 (en) * | 2009-12-01 | 2011-05-10 | Hoffmann-La Roche Inc. | Aniline analogs as glycogen synthase activators |
| GB2498976A (en) * | 2012-02-01 | 2013-08-07 | Prosidion Ltd | GPR119 agonists useful in the treatment of type II diabetes |
| EP2880034B1 (en) | 2012-08-01 | 2016-06-22 | Bristol-Myers Squibb Company | Amino-heteroaryl 7-hydroxy-spiropiperidine indolinyl antagonists of p2y1 receptor |
| CA2891535A1 (en) | 2012-11-16 | 2014-05-22 | Bristol-Myers Squibb Company | Dihydropyrazole gpr40 modulators |
| BR112015010649A2 (pt) * | 2012-11-16 | 2017-07-11 | Bristol Myers Squibb Co | moduladores de gpr40 à base de pirrolidina |
| WO2014078610A1 (en) | 2012-11-16 | 2014-05-22 | Bristol-Myers Squibb Company | Dihydropyrazole gpr40 modulators |
| JP6322204B2 (ja) | 2012-11-16 | 2018-05-09 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | ジヒドロピラゾールのｇｐｒ４０モジュレーター |
| DK3140296T3 (en) * | 2014-05-07 | 2018-07-23 | Bristol Myers Squibb Co | PYRROLIDIN GPR40 MODULATORS FOR TREATMENT OF DISEASES SUCH AS DIABETES |
| US10301260B2 (en) | 2014-05-07 | 2019-05-28 | Bristol-Myers Squibb Company | Pyrrolidine GPR40 modulators |
| CN106456536B (zh) | 2014-05-07 | 2020-05-12 | 克罗马药品股份有限公司 | 水性眼用溶液和治疗干眼综合征的方法 |
-
2015
- 2015-05-06 DK DK15723095.4T patent/DK3140296T3/en active
- 2015-05-06 CN CN201580022579.4A patent/CN106458976B/zh active Active
- 2015-05-06 AR ARP150101379A patent/AR100328A1/es unknown
- 2015-05-06 PL PL15723095T patent/PL3140296T3/pl unknown
- 2015-05-06 MA MA39427A patent/MA39427B1/fr unknown
- 2015-05-06 SG SG11201609170UA patent/SG11201609170UA/en unknown
- 2015-05-06 NZ NZ727146A patent/NZ727146A/en unknown
- 2015-05-06 TR TR2018/09633T patent/TR201809633T4/tr unknown
- 2015-05-06 HR HRP20180641TT patent/HRP20180641T1/hr unknown
- 2015-05-06 US US14/705,524 patent/US9873679B2/en active Active
- 2015-05-06 MY MYPI2016704054A patent/MY181959A/en unknown
- 2015-05-06 EA EA201692037A patent/EA033250B1/ru not_active IP Right Cessation
- 2015-05-06 SI SI201530232T patent/SI3140296T1/en unknown
- 2015-05-06 MX MX2016013801A patent/MX378160B/es unknown
- 2015-05-06 KR KR1020167033863A patent/KR102336370B1/ko active Active
- 2015-05-06 TW TW104114493A patent/TWI659951B/zh active
- 2015-05-06 CA CA2948161A patent/CA2948161C/en active Active
- 2015-05-06 HU HUE15723095A patent/HUE039288T2/hu unknown
- 2015-05-06 AU AU2015256120A patent/AU2015256120B2/en active Active
- 2015-05-06 PT PT157230954T patent/PT3140296T/pt unknown
- 2015-05-06 EP EP15723095.4A patent/EP3140296B1/en active Active
- 2015-05-06 SM SM20180342T patent/SMT201800342T1/it unknown
- 2015-05-06 JP JP2016566651A patent/JP6483156B2/ja active Active
- 2015-05-06 WO PCT/US2015/029409 patent/WO2015171722A1/en not_active Ceased
- 2015-05-06 PE PE2016002178A patent/PE20161363A1/es unknown
- 2015-05-06 TN TN2016000444A patent/TN2016000444A1/en unknown
- 2015-05-06 RS RS20180504A patent/RS57170B1/sr unknown
- 2015-05-06 BR BR112016024936A patent/BR112016024936A2/pt not_active Application Discontinuation
- 2015-05-06 ES ES15723095.4T patent/ES2674531T3/es active Active
-
2016
- 2016-10-12 PH PH12016502034A patent/PH12016502034B1/en unknown
- 2016-11-01 IL IL248668A patent/IL248668B/en active IP Right Grant
- 2016-11-07 CL CL2016002809A patent/CL2016002809A1/es unknown
-
2017
- 2017-12-13 US US15/840,198 patent/US20180099949A1/en not_active Abandoned
-
2018
- 2018-05-23 CY CY20181100547T patent/CY1120340T1/el unknown
- 2018-12-06 US US16/211,848 patent/US10717725B2/en active Active
-
2020
- 2020-06-08 US US16/895,058 patent/US20200299267A1/en not_active Abandoned
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