JP2017528734A5 - - Google Patents
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- Publication number
- JP2017528734A5 JP2017528734A5 JP2017527543A JP2017527543A JP2017528734A5 JP 2017528734 A5 JP2017528734 A5 JP 2017528734A5 JP 2017527543 A JP2017527543 A JP 2017527543A JP 2017527543 A JP2017527543 A JP 2017527543A JP 2017528734 A5 JP2017528734 A5 JP 2017528734A5
- Authority
- JP
- Japan
- Prior art keywords
- lymphocytes
- lymphocyte
- level
- individual
- blood sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000001744 T-lymphocyte Anatomy 0.000 claims 27
- 210000004369 blood Anatomy 0.000 claims 18
- 239000008280 blood Substances 0.000 claims 18
- 238000000034 method Methods 0.000 claims 17
- 210000004698 lymphocyte Anatomy 0.000 claims 15
- 239000003153 chemical reaction reagent Substances 0.000 claims 9
- 239000000090 biomarker Substances 0.000 claims 8
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 7
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 6
- 101100262440 Arabidopsis thaliana ECR1 gene Proteins 0.000 claims 5
- 231100000433 cytotoxic Toxicity 0.000 claims 5
- 230000001472 cytotoxic effect Effects 0.000 claims 5
- 210000000265 leukocyte Anatomy 0.000 claims 4
- 230000002159 abnormal effect Effects 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 238000000684 flow cytometry Methods 0.000 claims 2
- 239000003287 lymphocyte surface marker Substances 0.000 claims 2
- 102100037853 C-C chemokine receptor type 4 Human genes 0.000 claims 1
- 101710149863 C-C chemokine receptor type 4 Proteins 0.000 claims 1
- 102100025074 C-C chemokine receptor-like 2 Human genes 0.000 claims 1
- 102100028990 C-X-C chemokine receptor type 3 Human genes 0.000 claims 1
- 102100031658 C-X-C chemokine receptor type 5 Human genes 0.000 claims 1
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 1
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims 1
- -1 Crth2 Proteins 0.000 claims 1
- 101000716068 Homo sapiens C-C chemokine receptor type 6 Proteins 0.000 claims 1
- 101000916050 Homo sapiens C-X-C chemokine receptor type 3 Proteins 0.000 claims 1
- 101000922405 Homo sapiens C-X-C chemokine receptor type 5 Proteins 0.000 claims 1
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 1
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims 1
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims 1
- 102100027268 Interferon-stimulated gene 20 kDa protein Human genes 0.000 claims 1
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 1
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 1
- 230000005856 abnormality Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462035073P | 2014-08-08 | 2014-08-08 | |
| US62/035,073 | 2014-08-08 | ||
| PCT/US2015/044372 WO2016023006A1 (en) | 2014-08-08 | 2015-08-07 | Anti-lymphocyte autoantibodies as diagnostic biomarkers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017528734A JP2017528734A (ja) | 2017-09-28 |
| JP2017528734A5 true JP2017528734A5 (2) | 2018-08-09 |
Family
ID=55264686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017527543A Pending JP2017528734A (ja) | 2014-08-08 | 2015-08-07 | 診断用バイオマーカーとしての抗リンパ球自己抗体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9709564B2 (2) |
| EP (1) | EP3177930A1 (2) |
| JP (1) | JP2017528734A (2) |
| CN (1) | CN107110861A (2) |
| BR (1) | BR112017002575B1 (2) |
| RU (1) | RU2017107273A (2) |
| WO (1) | WO2016023006A1 (2) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2990722C (en) | 2015-07-31 | 2022-07-05 | Allegheny-Singer Research Institute | Cell-bound complement activation product assays as companion diagnostics for antibody-based drugs |
| KR101674018B1 (ko) * | 2016-05-16 | 2016-11-08 | (주)글로리바이오텍 | Cd4, cd8 세포 정보를 이용한 hiv 진단 방법 |
| US12130288B2 (en) | 2016-05-24 | 2024-10-29 | Allegheny Singer Research Institute | Methods and systems using C4 gene copy number and cell-bound complement activation products for identification of lupus and pre-lupus |
| EP4217744A4 (en) * | 2020-09-28 | 2024-11-06 | Allegheny Singer Research Institute | METHOD FOR DETERMINING A LEVEL OF A CELL FRAGMENT-BOUND COMPLEMENT ACTIVATION PRODUCT |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1756571B8 (en) * | 2004-04-09 | 2010-10-13 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Real time method of detecting acute inflammatory conditions |
| CA2564492C (en) * | 2004-05-11 | 2012-05-22 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Diagnosing and monitoring inflammatory diseases by measuring complement components on white blood cells |
| US20100233752A1 (en) * | 2008-10-16 | 2010-09-16 | Cypress Bioscience, Inc. | Method for diagnosis and monitoring of disease activity and response to treatment in systemic lupus erythematosus (sle) and other autoimmune diseases |
| WO2011099012A1 (en) * | 2010-02-12 | 2011-08-18 | Yeda Research And Development Co. Ltd. | Diagnosis of systemic lupus erythematosus (sle) |
| EP2673644B1 (en) * | 2011-02-11 | 2016-02-10 | Exagen Diagnostics, Inc. | Methods for diagnosing systemic lupus erythematosus |
| CN102818890A (zh) * | 2011-06-10 | 2012-12-12 | 苏州卫生职业技术学院 | 一种检测系统性红斑狼疮患者自身抗体的方法 |
| AU2012321074B2 (en) * | 2011-12-13 | 2015-12-03 | Takeda Pharmaceutical Company Limited | Measurement of autoantibodies at low conductivity conditions with increased sensitivity |
| US20150204866A1 (en) * | 2012-08-02 | 2015-07-23 | Sense Proteomic Limited | Auto-antigen biomarkers for lupus |
| WO2014093268A1 (en) * | 2012-12-10 | 2014-06-19 | Allegheny-Singer Research Institute | Methods and systems for using complement-tagged molecules as biomarkers of disease |
| RU2019103573A (ru) | 2013-02-08 | 2019-03-15 | Аллегени-Сингер Рисерч Инститьют | Клеточно-связанные продукты активации комплемента в качестве диагностических биомаркеров волчанки в доклинической стадии |
| CN103439517A (zh) * | 2013-09-11 | 2013-12-11 | 河北省健海生物芯片技术有限责任公司 | 一种系统性红斑狼疮自身抗体检测装置 |
-
2015
- 2015-08-07 JP JP2017527543A patent/JP2017528734A/ja active Pending
- 2015-08-07 RU RU2017107273A patent/RU2017107273A/ru not_active Application Discontinuation
- 2015-08-07 CN CN201580053913.2A patent/CN107110861A/zh active Pending
- 2015-08-07 WO PCT/US2015/044372 patent/WO2016023006A1/en not_active Ceased
- 2015-08-07 US US14/821,670 patent/US9709564B2/en active Active
- 2015-08-07 BR BR112017002575-2A patent/BR112017002575B1/pt active IP Right Grant
- 2015-08-07 EP EP15754066.7A patent/EP3177930A1/en not_active Withdrawn
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