JP2017536116A5 - - Google Patents
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- JP2017536116A5 JP2017536116A5 JP2017525107A JP2017525107A JP2017536116A5 JP 2017536116 A5 JP2017536116 A5 JP 2017536116A5 JP 2017525107 A JP2017525107 A JP 2017525107A JP 2017525107 A JP2017525107 A JP 2017525107A JP 2017536116 A5 JP2017536116 A5 JP 2017536116A5
- Authority
- JP
- Japan
- Prior art keywords
- aav
- nucleic acid
- capsid
- aav capsid
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021019477A JP2021097675A (ja) | 2014-11-21 | 2021-02-10 | 中枢神経系を標的化したａａｖベクター |
| JP2023108201A JP2023123765A (ja) | 2014-11-21 | 2023-06-30 | 中枢神経系を標的化したａａｖベクター |
| JP2025015920A JP2025072468A (ja) | 2014-11-21 | 2025-02-03 | 中枢神経系を標的化したａａｖベクター |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462082897P | 2014-11-21 | 2014-11-21 | |
| US62/082,897 | 2014-11-21 | ||
| US201562218857P | 2015-09-15 | 2015-09-15 | |
| US62/218,857 | 2015-09-15 | ||
| PCT/US2015/061788 WO2016081811A1 (fr) | 2014-11-21 | 2015-11-20 | Vecteurs aav ciblant le système nerveux central |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021019477A Division JP2021097675A (ja) | 2014-11-21 | 2021-02-10 | 中枢神経系を標的化したａａｖベクター |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017536116A JP2017536116A (ja) | 2017-12-07 |
| JP2017536116A5 true JP2017536116A5 (fr) | 2018-12-13 |
Family
ID=56014589
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017525107A Withdrawn JP2017536116A (ja) | 2014-11-21 | 2015-11-20 | 中枢神経系を標的化したａａｖベクター |
| JP2021019477A Pending JP2021097675A (ja) | 2014-11-21 | 2021-02-10 | 中枢神経系を標的化したａａｖベクター |
| JP2023108201A Pending JP2023123765A (ja) | 2014-11-21 | 2023-06-30 | 中枢神経系を標的化したａａｖベクター |
| JP2025015920A Pending JP2025072468A (ja) | 2014-11-21 | 2025-02-03 | 中枢神経系を標的化したａａｖベクター |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021019477A Pending JP2021097675A (ja) | 2014-11-21 | 2021-02-10 | 中枢神経系を標的化したａａｖベクター |
| JP2023108201A Pending JP2023123765A (ja) | 2014-11-21 | 2023-06-30 | 中枢神経系を標的化したａａｖベクター |
| JP2025015920A Pending JP2025072468A (ja) | 2014-11-21 | 2025-02-03 | 中枢神経系を標的化したａａｖベクター |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US10532110B2 (fr) |
| EP (2) | EP4344741A3 (fr) |
| JP (4) | JP2017536116A (fr) |
| KR (2) | KR20170086537A (fr) |
| CN (2) | CN107532173A (fr) |
| AU (2) | AU2015349759B2 (fr) |
| BR (1) | BR112017010447A2 (fr) |
| CA (1) | CA2967393A1 (fr) |
| IL (1) | IL252072B (fr) |
| MX (1) | MX2017006652A (fr) |
| RU (1) | RU2727015C2 (fr) |
| WO (1) | WO2016081811A1 (fr) |
Families Citing this family (69)
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|---|---|---|---|---|
| WO2015191508A1 (fr) | 2014-06-09 | 2015-12-17 | Voyager Therapeutics, Inc. | Capsides chimériques |
| SG11201703148TA (en) | 2014-11-05 | 2017-05-30 | Voyager Therapeutics Inc | Aadc polynucleotides for the treatment of parkinson's disease |
| CA3193811A1 (fr) | 2014-11-14 | 2016-05-19 | Voyager Therapeutics, Inc. | Compositions et methodes de traitement de la sclerose laterale amyotrophique (sla) |
| CN119876138A (zh) | 2014-11-14 | 2025-04-25 | 沃雅戈治疗公司 | 调节性多核苷酸 |
| WO2016081811A1 (fr) | 2014-11-21 | 2016-05-26 | The University Of North Carolina At Chapel Hill | Vecteurs aav ciblant le système nerveux central |
| HK1245326A1 (zh) | 2014-12-12 | 2018-08-24 | Voyager Therapeutics, Inc. | 用於生产scaav的组合物和方法 |
| CN107249646B (zh) | 2014-12-16 | 2021-06-29 | 内布拉斯加大学董事会 | 用于青少年巴滕病的基因疗法 |
| GB201508026D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Capsid |
| WO2016190780A1 (fr) | 2015-05-22 | 2016-12-01 | Dmitry Dmitrievich Genkin | Adn extracellulaire en tant que cible thérapeutique dans la neurodégénérescence |
| BR112018003665A2 (en) | 2015-09-28 | 2018-09-25 | The University Of North Carolina At Chapel Hill | methods and compositions for antibody evasion viral vectors |
| WO2017096162A1 (fr) | 2015-12-02 | 2017-06-08 | Voyager Therapeutics, Inc. | Dosages pour la détection d'anticorps neutralisants de vaa |
| EP3448987A4 (fr) | 2016-04-29 | 2020-05-27 | Voyager Therapeutics, Inc. | Compositions pour le traitement de maladies |
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| CA3024449A1 (fr) | 2016-05-18 | 2017-11-23 | Voyager Therapeutics, Inc. | Compositions et methodes de traitement de la maladie de huntington |
| CA3024448C (fr) | 2016-05-18 | 2025-09-09 | Voyager Therapeutics, Inc. | Polynucleotides modulateurs |
| RU2764919C2 (ru) | 2016-06-13 | 2022-01-24 | Дзе Юниверсити Оф Норт Каролина Эт Чепел Хилл | Оптимизированные гены и экспрессионные кассеты cln1, и их применение |
| MA44546B1 (fr) * | 2016-06-15 | 2021-03-31 | Univ California | Virus adéno-associés variants et procédés d'utilisation |
| US20190262373A1 (en) * | 2016-08-16 | 2019-08-29 | The University Of North Carolina At Chapel Hill | Methods and compositions for targeted gene transfer |
| WO2018044933A1 (fr) | 2016-08-30 | 2018-03-08 | The Regents Of The University Of California | Procédés de ciblage et d'administration biomédicaux, et dispositifs et systèmes pour la mise en œuvre de ceux-ci |
| JP2020518259A (ja) | 2017-05-05 | 2020-06-25 | ボイジャー セラピューティクス インコーポレイテッドＶｏｙａｇｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | ハンチントン病治療組成物および方法 |
| EP3618839A4 (fr) | 2017-05-05 | 2021-06-09 | Voyager Therapeutics, Inc. | Compositions et méthodes de traitement de la sclérose latérale amyotrophique (sla) |
| JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
| JP7229989B2 (ja) | 2017-07-17 | 2023-02-28 | ボイジャー セラピューティクス インコーポレイテッド | 軌道アレイガイドシステム |
| JP7221275B2 (ja) | 2017-08-03 | 2023-02-13 | ボイジャー セラピューティクス インコーポレイテッド | Ａａｖを送達するための組成物および方法 |
| US20200263199A1 (en) | 2017-09-29 | 2020-08-20 | Voyager Therapeutics, Inc. | Rescue of central and peripheral neurological phenotype of friedreich's ataxia by intravenous delivery |
| WO2019079242A1 (fr) | 2017-10-16 | 2019-04-25 | Voyager Therapeutics, Inc. | Traitement de la sclérose latérale amyotrophique (sla) |
| TW202413649A (zh) | 2017-10-16 | 2024-04-01 | 美商航海家醫療公司 | 肌萎縮性脊髓側索硬化症(als)之治療 |
| RU2020118342A (ru) | 2017-11-07 | 2021-12-08 | Дзе Юниверсити Оф Норт Каролина Эт Чепел Хилл | Оптимизированные гены aga и экспрессионные кластеры и их применение |
| CN111867595A (zh) * | 2017-12-20 | 2020-10-30 | 奥维德医疗公司 | hM4Di在治疗癫痫发作紊乱中的用途 |
| KR20200122320A (ko) | 2018-01-16 | 2020-10-27 | 씨엘에스 테라퓨틱스 리미티드 | 데옥시리보뉴클레아제 (dnase) 활성을 갖는 효소의 간 발현에 의한 질환의 치료 |
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| CN112543766A (zh) | 2018-04-03 | 2021-03-23 | 斯特里迪比奥公司 | 抗体逃避性病毒载体 |
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| SG11202011296VA (en) | 2018-05-15 | 2020-12-30 | Voyager Therapeutics Inc | Compositions and methods for the treatment of parkinson's disease |
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| CN112566923B (zh) * | 2018-06-12 | 2024-10-29 | 北卡罗来纳大学教堂山分校 | 合成嗜肝性腺相关病毒衣壳及其用途 |
| IL279131B2 (en) | 2018-06-28 | 2025-06-01 | Univ North Carolina Chapel Hill | Optimized cln5 genes and expression cassettes and their use |
| IL280300B2 (en) | 2018-08-10 | 2025-06-01 | Univ North Carolina Chapel Hill | Optimized cln7 genes and expression cassettes and their use |
| WO2020068990A1 (fr) | 2018-09-26 | 2020-04-02 | California Institute Of Technology | Compositions de virus adéno-associé pour une thérapie génique ciblée |
| US12281321B2 (en) | 2018-09-28 | 2025-04-22 | Voyager Therapeutics, Inc. | Frataxin expression constructs having engineered promoters and methods of use thereof |
| EP3861010A1 (fr) | 2018-10-02 | 2021-08-11 | Voyager Therapeutics, Inc. | Redirection de tropisme de capsides aav |
| BR112021006074A2 (pt) | 2018-11-05 | 2021-07-20 | The University Of North Carolina At Chapel Hill | genes e cassetes de expressão fig4 otimizados e seu uso |
| US12454701B2 (en) * | 2018-12-05 | 2025-10-28 | Abeona Therapeutics Inc. | Recombinant adeno-associated viral vector for gene delivery |
| EP3884057A4 (fr) | 2018-12-21 | 2022-09-07 | The University of North Carolina at Chapel Hill | Gènes galc optimisés et cassettes d'expression et leur utilisation |
| PE20220014A1 (es) * | 2019-04-29 | 2022-01-11 | Univ Pennsylvania | Nuevas capsides de aav y composiciones que las contienen |
| EP3963073A4 (fr) | 2019-04-29 | 2023-01-25 | The University of North Carolina at Chapel Hill | Gènes sumf1 optimisés et cassettes d'expression et leur utilisation |
| WO2020237130A1 (fr) | 2019-05-22 | 2020-11-26 | The University Of North Carolina At Chapel Hill | Gènes ube3a et cassettes d'expression et leur utilisation |
| CA3147034A1 (fr) * | 2019-07-12 | 2021-01-21 | Cls Therapeutics Limited | Traitement de maladies associees a un mauvais repliement de proteines par expression du systeme nerveux d'une enzyme ayant une activite desoxyribonuclease (dnase) |
| WO2021041489A1 (fr) * | 2019-08-29 | 2021-03-04 | The Board Of Trustees Of The Leland Stanford Junior University | Vecteurs viraux adéno-associés pour traverser la barrière hémato-encéphalique humaine |
| EP4025258A4 (fr) * | 2019-09-03 | 2023-09-06 | University of Cincinnati | Méthodes et compositions pour le traitement de la sclérose latérale amyotrophique |
| KR20220083714A (ko) | 2019-10-17 | 2022-06-20 | 스트라이드바이오 인코포레이티드 | 니만-피크 질환 c형의 치료를 위한 아데노-연관 바이러스 벡터 |
| US20230013145A1 (en) * | 2020-02-18 | 2023-01-19 | The University Of North Carolina At Chapel Hill | Aav capsid-promoter interactions and cell selective gene expression |
| AU2021264061A1 (en) * | 2020-05-01 | 2022-12-01 | Massachusetts Institute Of Technology | Engineered central nervous system compositions |
| US20230304033A1 (en) * | 2020-05-04 | 2023-09-28 | The University Of North Carolina At Chapel Hill | Modified adeno-associated virus vectors that evade neutralizing antibodies and uses thereof |
| US12209251B2 (en) * | 2020-05-05 | 2025-01-28 | The University Of North Carolina At Chapel Hill | Modified adeno-associated virus 5 capsids and uses thereof |
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| EP4591708A3 (fr) | 2020-07-08 | 2026-01-14 | Baylor College of Medicine | Thérapie génique pour encéphalopathie stxbp1 |
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| EP4185700B1 (fr) | 2020-07-23 | 2025-12-17 | The University of North Carolina at Chapel Hill | Gènes slc13a5 optimisés, cassettes d'expression et leur utilisation |
| TWI902867B (zh) * | 2020-08-12 | 2025-11-01 | 比利時商Ｕｃｂ生物製藥公司 | 基因療法 |
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| WO2025084951A1 (fr) * | 2023-10-16 | 2025-04-24 | Joint Stock Company "Axelgen" | Construction génétique recombinée, virus adéno-associé pour le traitement de la leucodystrophie métachromatique |
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| US7867484B2 (en) * | 2006-01-27 | 2011-01-11 | University Of North Carolina At Chapel Hill | Heparin and heparan sulfate binding chimeric vectors |
| KR101589259B1 (ko) * | 2006-06-21 | 2016-02-01 | 유니큐어 아이피 비.브이. | 곤충세포 내 ａａｖ의 생산에 유용한 ａａｖ-ｒｅｐ78의 번역을 위한 변형된 개시 코돈을 갖는 벡터 |
| EP2019143A1 (fr) | 2007-07-23 | 2009-01-28 | Genethon | Thérapie génique du CNS utilisant l'administration périphérique de vecteurs AAV |
| EP2058401A1 (fr) | 2007-10-05 | 2009-05-13 | Genethon | Fourniture généralisée de gènes à des motoneurones utilisant l'injection périphérique de vecteurs AAV |
| US8632764B2 (en) * | 2008-04-30 | 2014-01-21 | University Of North Carolina At Chapel Hill | Directed evolution and in vivo panning of virus vectors |
| US9415121B2 (en) * | 2008-12-19 | 2016-08-16 | Nationwide Children's Hospital | Delivery of MECP2 polynucleotide using recombinant AAV9 |
| EP2826860B1 (fr) | 2010-04-23 | 2018-08-22 | University of Massachusetts | Vecteurs AAV de ciblage du système nerveux central et leurs procédés d'utilisation |
| US8663624B2 (en) | 2010-10-06 | 2014-03-04 | The Regents Of The University Of California | Adeno-associated virus virions with variant capsid and methods of use thereof |
| EP2634253B1 (fr) * | 2010-10-27 | 2016-05-11 | Jichi Medical University | Virions de virus adéno-associé pour le transfert de gènes dans des cellules neuronales |
| KR101830651B1 (ko) | 2011-01-04 | 2018-02-21 | 엘지전자 주식회사 | 정보 표시 장치 및 그 방법 |
| US9636370B2 (en) | 2012-09-28 | 2017-05-02 | The University Of North Carolina At Chapel Hill | AAV vectors targeted to oligodendrocytes |
| WO2016081811A1 (fr) * | 2014-11-21 | 2016-05-26 | The University Of North Carolina At Chapel Hill | Vecteurs aav ciblant le système nerveux central |
-
2015
- 2015-11-20 WO PCT/US2015/061788 patent/WO2016081811A1/fr not_active Ceased
- 2015-11-20 KR KR1020177014680A patent/KR20170086537A/ko not_active Ceased
- 2015-11-20 AU AU2015349759A patent/AU2015349759B2/en active Active
- 2015-11-20 US US15/525,214 patent/US10532110B2/en active Active
- 2015-11-20 KR KR1020247013508A patent/KR20240063169A/ko active Pending
- 2015-11-20 CA CA2967393A patent/CA2967393A1/fr active Pending
- 2015-11-20 EP EP23199459.1A patent/EP4344741A3/fr active Pending
- 2015-11-20 CN CN201580074023.XA patent/CN107532173A/zh active Pending
- 2015-11-20 CN CN202210236316.5A patent/CN114480440A/zh active Pending
- 2015-11-20 BR BR112017010447-4A patent/BR112017010447A2/pt not_active Application Discontinuation
- 2015-11-20 JP JP2017525107A patent/JP2017536116A/ja not_active Withdrawn
- 2015-11-20 EP EP15861347.1A patent/EP3221453A4/fr not_active Ceased
- 2015-11-20 MX MX2017006652A patent/MX2017006652A/es unknown
- 2015-11-20 RU RU2017121593A patent/RU2727015C2/ru active
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2017
- 2017-05-03 IL IL252072A patent/IL252072B/en unknown
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2019
- 2019-06-13 US US16/440,638 patent/US10561743B2/en active Active
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2020
- 2020-01-13 US US16/741,324 patent/US11491242B2/en active Active
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2021
- 2021-02-10 JP JP2021019477A patent/JP2021097675A/ja active Pending
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2022
- 2022-03-04 AU AU2022201540A patent/AU2022201540B2/en active Active
- 2022-09-21 US US17/933,937 patent/US20230263910A1/en active Pending
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2023
- 2023-06-30 JP JP2023108201A patent/JP2023123765A/ja active Pending
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2025
- 2025-02-03 JP JP2025015920A patent/JP2025072468A/ja active Pending
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