|
US2699808A
(en)
|
1944-10-06 |
1955-01-18 |
Mark W Lowe |
Apparatus for peeling tomatoes
|
|
US2699508A
(en)
|
1951-12-21 |
1955-01-11 |
Selectronics Inc |
Method of mounting and construction of mounting for low frequency piezoelectric crystals
|
|
US3687808A
(en)
|
1969-08-14 |
1972-08-29 |
Univ Leland Stanford Junior |
Synthetic polynucleotides
|
|
US4880635B1
(en)
|
1984-08-08 |
1996-07-02 |
Liposome Company |
Dehydrated liposomes
|
|
US5367066A
(en)
|
1984-10-16 |
1994-11-22 |
Chiron Corporation |
Oligonucleotides with selectably cleavable and/or abasic sites
|
|
FR2575751B1
(fr)
|
1985-01-08 |
1987-04-03 |
Pasteur Institut |
Nouveaux nucleosides de derives de l'adenosine, leur preparation et leurs applications biologiques
|
|
US5506337A
(en)
|
1985-03-15 |
1996-04-09 |
Antivirals Inc. |
Morpholino-subunit combinatorial library and method
|
|
US5185444A
(en)
|
1985-03-15 |
1993-02-09 |
Anti-Gene Deveopment Group |
Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
|
|
US5034506A
(en)
|
1985-03-15 |
1991-07-23 |
Anti-Gene Development Group |
Uncharged morpholino-based polymers having achiral intersubunit linkages
|
|
US5166315A
(en)
|
1989-12-20 |
1992-11-24 |
Anti-Gene Development Group |
Sequence-specific binding polymers for duplex nucleic acids
|
|
US4921757A
(en)
|
1985-04-26 |
1990-05-01 |
Massachusetts Institute Of Technology |
System for delayed and pulsed release of biologically active substances
|
|
US4920016A
(en)
|
1986-12-24 |
1990-04-24 |
Linear Technology, Inc. |
Liposomes with enhanced circulation time
|
|
JPH0825869B2
(ja)
|
1987-02-09 |
1996-03-13 |
株式会社ビタミン研究所 |
抗腫瘍剤包埋リポソ−ム製剤
|
|
US4911928A
(en)
|
1987-03-13 |
1990-03-27 |
Micro-Pak, Inc. |
Paucilamellar lipid vesicles
|
|
US4917951A
(en)
|
1987-07-28 |
1990-04-17 |
Micro-Pak, Inc. |
Lipid vesicles formed of surfactants and steroids
|
|
AU598946B2
(en)
|
1987-06-24 |
1990-07-05 |
Howard Florey Institute Of Experimental Physiology And Medicine |
Nucleoside derivatives
|
|
US5175273A
(en)
|
1988-07-01 |
1992-12-29 |
Genentech, Inc. |
Nucleic acid intercalating agents
|
|
US5134066A
(en)
|
1989-08-29 |
1992-07-28 |
Monsanto Company |
Improved probes using nucleosides containing 3-dezauracil analogs
|
|
US5130302A
(en)
|
1989-12-20 |
1992-07-14 |
Boron Bilogicals, Inc. |
Boronated nucleoside, nucleotide and oligonucleotide compounds, compositions and methods for using same
|
|
US5587470A
(en)
|
1990-01-11 |
1996-12-24 |
Isis Pharmaceuticals, Inc. |
3-deazapurines
|
|
US5459255A
(en)
|
1990-01-11 |
1995-10-17 |
Isis Pharmaceuticals, Inc. |
N-2 substituted purines
|
|
US5681941A
(en)
|
1990-01-11 |
1997-10-28 |
Isis Pharmaceuticals, Inc. |
Substituted purines and oligonucleotide cross-linking
|
|
US5149797A
(en)
|
1990-02-15 |
1992-09-22 |
The Worcester Foundation For Experimental Biology |
Method of site-specific alteration of rna and production of encoded polypeptides
|
|
BR9106702A
(pt)
|
1990-07-27 |
1993-06-08 |
Isis Pharmaceuticals Inc |
Analogo de oligonucleotideos e processos para modular a producao de uma proteina por um organismo e para tratar um organismo
|
|
US5432272A
(en)
|
1990-10-09 |
1995-07-11 |
Benner; Steven A. |
Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases
|
|
US6582908B2
(en)
|
1990-12-06 |
2003-06-24 |
Affymetrix, Inc. |
Oligonucleotides
|
|
US5594121A
(en)
|
1991-11-07 |
1997-01-14 |
Gilead Sciences, Inc. |
Enhanced triple-helix and double-helix formation with oligomers containing modified purines
|
|
AU3222793A
(en)
|
1991-11-26 |
1993-06-28 |
Gilead Sciences, Inc. |
Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
|
|
TW393513B
(en)
|
1991-11-26 |
2000-06-11 |
Isis Pharmaceuticals Inc |
Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
|
|
US5484908A
(en)
|
1991-11-26 |
1996-01-16 |
Gilead Sciences, Inc. |
Oligonucleotides containing 5-propynyl pyrimidines
|
|
WO2002081494A1
(en)
|
2001-03-26 |
2002-10-17 |
Sirna Therapeutics, Inc. |
Oligonucleotide mediated inhibition of hepatitis b virus and hepatitis c virus replication
|
|
US20040054156A1
(en)
|
1992-05-14 |
2004-03-18 |
Kenneth Draper |
Method and reagent for inhibiting hepatitis B viral replication
|
|
EP0673559A1
(en)
|
1992-12-14 |
1995-09-27 |
Honeywell Inc. |
Motor system with individually controlled redundant windings
|
|
KR940021073A
(ko)
|
1993-03-02 |
1994-10-17 |
미야베 요시가즈 |
알쯔하이머병의 예방 또는 치료제, 그 스크리닝 방법 및 인간 유래의 타우 단백질 키나아제 i
|
|
US5502177A
(en)
|
1993-09-17 |
1996-03-26 |
Gilead Sciences, Inc. |
Pyrimidine derivatives for labeled binding partners
|
|
US5801154A
(en)
|
1993-10-18 |
1998-09-01 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of multidrug resistance-associated protein
|
|
US5457187A
(en)
|
1993-12-08 |
1995-10-10 |
Board Of Regents University Of Nebraska |
Oligonucleotides containing 5-fluorouracil
|
|
US5596091A
(en)
|
1994-03-18 |
1997-01-21 |
The Regents Of The University Of California |
Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides
|
|
US5525711A
(en)
|
1994-05-18 |
1996-06-11 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Pteridine nucleotide analogs as fluorescent DNA probes
|
|
US5656408A
(en)
|
1996-04-29 |
1997-08-12 |
Xerox Corporation |
Coated carrier particles
|
|
JP3756313B2
(ja)
|
1997-03-07 |
2006-03-15 |
武 今西 |
新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
|
|
US6770748B2
(en)
|
1997-03-07 |
2004-08-03 |
Takeshi Imanishi |
Bicyclonucleoside and oligonucleotide analogue
|
|
AU9063398A
(en)
|
1997-09-12 |
1999-04-05 |
Exiqon A/S |
Oligonucleotide analogues
|
|
US6794499B2
(en)
|
1997-09-12 |
2004-09-21 |
Exiqon A/S |
Oligonucleotide analogues
|
|
US20030228597A1
(en)
|
1998-04-13 |
2003-12-11 |
Cowsert Lex M. |
Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation
|
|
WO1999062548A1
(en)
|
1998-06-01 |
1999-12-09 |
Advanced Research And Technology Institute |
Methods and compositions for diagnosing tauopathies
|
|
CZ296576B6
(cs)
|
1999-02-12 |
2006-04-12 |
Sankyo Company Limited |
Nukleosidový analog a oligonukleotidový analog a farmaceutický prostredek, sonda a primer s jeho obsahem
|
|
US7084125B2
(en)
|
1999-03-18 |
2006-08-01 |
Exiqon A/S |
Xylo-LNA analogues
|
|
WO2000063364A2
(en)
|
1999-04-21 |
2000-10-26 |
American Home Products Corporation |
Methods and compositions for inhibiting the function of polynucleotide sequences
|
|
EP1178999B1
(en)
|
1999-05-04 |
2007-03-14 |
Santaris Pharma A/S |
L-ribo-lna analogues
|
|
US6525191B1
(en)
|
1999-05-11 |
2003-02-25 |
Kanda S. Ramasamy |
Conformationally constrained L-nucleosides
|
|
JP4151751B2
(ja)
|
1999-07-22 |
2008-09-17 |
第一三共株式会社 |
新規ビシクロヌクレオシド類縁体
|
|
EP1097941A1
(en)
|
1999-11-05 |
2001-05-09 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Substance capable of controlling the inclusion of exon 10 of the tau gene, and its therapeutic use against tauopathies
|
|
JP2004509604A
(ja)
*
|
2000-03-28 |
2004-04-02 |
アイシス・ファーマシューティカルス・インコーポレーテッド |
ｍＲＮＡプロセッシングのアンチセンスモジュレーションによる、細胞行動の改変
|
|
AU2001250572A1
(en)
*
|
2000-04-07 |
2001-10-23 |
Epigenomics Ag |
Detection of single nucleotide polymorphisms (snp's) and cytosine-methylations
|
|
US20050019915A1
(en)
|
2001-06-21 |
2005-01-27 |
Bennett C. Frank |
Antisense modulation of superoxide dismutase 1, soluble expression
|
|
JP2005504020A
(ja)
|
2001-07-03 |
2005-02-10 |
アイシス・ファーマシューティカルス・インコーポレーテッド |
ヌクレアーゼ耐性キメラオリゴヌクレオチド
|
|
EP1472335A4
(en)
|
2001-11-08 |
2005-12-28 |
Univ Johns Hopkins |
METHODS AND SYSTEMS FOR SEQUENCING NUCLEIC ACIDS
|
|
US20070203333A1
(en)
|
2001-11-30 |
2007-08-30 |
Mcswiggen James |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
|
US20050153336A1
(en)
|
2002-03-29 |
2005-07-14 |
Bennett C. F. |
Compositions and their uses directed to nucleic acid binding proteins
|
|
US7569575B2
(en)
|
2002-05-08 |
2009-08-04 |
Santaris Pharma A/S |
Synthesis of locked nucleic acid derivatives
|
|
AU2003268032A1
(en)
|
2002-07-29 |
2004-02-16 |
Epigenesis Pharmaceuticals, Inc. |
Composition and methods for treatment and screening
|
|
US20040241854A1
(en)
*
|
2002-08-05 |
2004-12-02 |
Davidson Beverly L. |
siRNA-mediated gene silencing
|
|
US20050106731A1
(en)
|
2002-08-05 |
2005-05-19 |
Davidson Beverly L. |
siRNA-mediated gene silencing with viral vectors
|
|
AU2003255435A1
(en)
|
2002-08-14 |
2004-03-03 |
Universitat Zurich |
A cellular assay system for neurofibrillary tangle formation
|
|
AU2003284323A1
(en)
|
2002-10-18 |
2004-05-04 |
Alnylam Pharmaceuticals Inc |
Double-stranded rna structures and constructs, and methods for generating and using the same
|
|
US8604183B2
(en)
|
2002-11-05 |
2013-12-10 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
|
|
CA2504694C
(en)
|
2002-11-05 |
2013-10-01 |
Isis Pharmaceuticals, Inc. |
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
|
EP2305812A3
(en)
|
2002-11-14 |
2012-06-06 |
Dharmacon, Inc. |
Fuctional and hyperfunctional sirna
|
|
US20080318210A1
(en)
|
2003-08-27 |
2008-12-25 |
Rosetta Genomics |
Bioinformatically detectable group of novel regulatory viral and viral associated oligonucleotides and uses thereof
|
|
US6673661B1
(en)
|
2002-12-20 |
2004-01-06 |
Taiwan Semiconductor Manufacturing Co., Ltd. |
Self-aligned method for forming dual gate thin film transistor (TFT) device
|
|
WO2004106356A1
(en)
|
2003-05-27 |
2004-12-09 |
Syddansk Universitet |
Functionalized nucleotide derivatives
|
|
AU2003904328A0
(en)
|
2003-08-13 |
2003-08-28 |
Garvan Institute Of Medical Research |
Diagnosis and treatment of neurodegenerative disorders
|
|
EP1661905B9
(en)
|
2003-08-28 |
2012-12-19 |
IMANISHI, Takeshi |
Novel artificial nucleic acids of n-o bond crosslinkage type
|
|
WO2005027962A1
(en)
|
2003-09-18 |
2005-03-31 |
Isis Pharmaceuticals, Inc. |
4’-thionucleosides and oligomeric compounds
|
|
WO2005030928A2
(en)
|
2003-09-23 |
2005-04-07 |
Chihiro Koike |
PORCINE INVARIANT CHAIN PROTEIN, FULL LENGTH cDNA, GENOMIC ORGANIZATION, AND REGULATORY REGION
|
|
US8012944B2
(en)
*
|
2003-10-30 |
2011-09-06 |
Pharmascience Inc. |
Method for treating cancer using IAP antisense oligomer and chemotherapeutic agent
|
|
US20050244851A1
(en)
|
2004-01-13 |
2005-11-03 |
Affymetrix, Inc. |
Methods of analysis of alternative splicing in human
|
|
CN100410383C
(zh)
|
2004-05-11 |
2008-08-13 |
中国农业科学院生物技术研究所 |
一种昆虫杆状病毒生物反应器的制备方法
|
|
EP1752536A4
(en)
|
2004-05-11 |
2008-04-16 |
Alphagen Co Ltd |
POLYNUCLEOTIDE CAUSING RNA INTERFERENCE AND METHOD OF REGULATING GENE EXPRESSION WITH THE USE OF THE SAME
|
|
DK1794313T3
(da)
|
2004-06-21 |
2013-07-22 |
Proteome Sciences Plc |
Fremgangsmåde til screeninger der anvender C-ABL, FYN og SYK i kombination med tau-protein
|
|
CA2585970A1
(en)
|
2004-10-27 |
2006-05-04 |
Vanderbilt University |
Mammalian genes involved in infection
|
|
US20080003570A1
(en)
|
2004-12-22 |
2008-01-03 |
The General Hospital Corporation |
Translation enhancer elements of genes encoding human Tau protein and human alpha-synuclein protein
|
|
US20060216722A1
(en)
|
2005-03-25 |
2006-09-28 |
Christer Betsholtz |
Glomerular expression profiling
|
|
US20090176725A1
(en)
|
2005-08-17 |
2009-07-09 |
Sirna Therapeutics Inc. |
Chemically modified short interfering nucleic acid molecules that mediate rna interference
|
|
CA2620856C
(en)
|
2005-08-29 |
2017-11-28 |
Isis Pharmaceuticals, Inc. |
Methods for use in modulating mir-122a
|
|
WO2007025987A1
(en)
|
2005-08-30 |
2007-03-08 |
Novo Nordisk A/S |
Expression of proteins in e.coli
|
|
JP5342881B2
(ja)
|
2006-01-27 |
2013-11-13 |
アイシス ファーマシューティカルズ， インコーポレーテッド |
６−修飾された二環式核酸類似体
|
|
US8178503B2
(en)
|
2006-03-03 |
2012-05-15 |
International Business Machines Corporation |
Ribonucleic acid interference molecules and binding sites derived by analyzing intergenic and intronic regions of genomes
|
|
GB0605337D0
(en)
*
|
2006-03-17 |
2006-04-26 |
Genomica Sau |
Treatment of CNS conditions
|
|
EP2023940B1
(en)
|
2006-05-05 |
2011-06-22 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating expression of sglt2
|
|
AU2007249349B2
(en)
|
2006-05-11 |
2012-03-08 |
Isis Pharmaceuticals, Inc. |
5'-Modified bicyclic nucleic acid analogs
|
|
JP4798093B2
(ja)
|
2006-08-04 |
2011-10-19 |
日産自動車株式会社 |
流体改質装置及びこれを用いた流体改質方法
|
|
JP2010505897A
(ja)
|
2006-10-11 |
2010-02-25 |
マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ |
インフルエンザターゲット
|
|
JP2010507387A
(ja)
|
2006-10-25 |
2010-03-11 |
クアーク・ファーマスーティカルス、インコーポレイテッド |
新規のｓｉＲＮＡおよびその使用方法
|
|
US20100190837A1
(en)
|
2007-02-15 |
2010-07-29 |
Isis Pharmaceuticals, Inc. |
5'-Substituted-2-F' Modified Nucleosides and Oligomeric Compounds Prepared Therefrom
|
|
WO2008124066A1
(en)
|
2007-04-05 |
2008-10-16 |
The J. David Gladstone Institutes |
Agents that reduce neuronal overexcitation
|
|
EP2170917B1
(en)
|
2007-05-30 |
2012-06-27 |
Isis Pharmaceuticals, Inc. |
N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
|
|
EP2173760B2
(en)
|
2007-06-08 |
2015-11-04 |
Isis Pharmaceuticals, Inc. |
Carbocyclic bicyclic nucleic acid analogs
|
|
WO2008151631A2
(en)
|
2007-06-15 |
2008-12-18 |
Exiqon A/S |
Use of short oligonucleotides for reagent redundancy experiments in rna functional analysis
|
|
CA2692579C
(en)
|
2007-07-05 |
2016-05-03 |
Isis Pharmaceuticals, Inc. |
6-disubstituted bicyclic nucleic acid analogs
|
|
US20090076725A1
(en)
|
2007-09-14 |
2009-03-19 |
Kulvir Singh Bhogal |
Conveyance mode aware navigation device
|
|
US8546556B2
(en)
|
2007-11-21 |
2013-10-01 |
Isis Pharmaceuticals, Inc |
Carbocyclic alpha-L-bicyclic nucleic acid analogs
|
|
WO2009100320A2
(en)
|
2008-02-07 |
2009-08-13 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexitol nucleic acid analogs
|
|
WO2009124341A1
(en)
|
2008-04-07 |
2009-10-15 |
The University Of Queensland |
Rna molecules and uses thereof
|
|
WO2010036698A1
(en)
|
2008-09-24 |
2010-04-01 |
Isis Pharmaceuticals, Inc. |
Substituted alpha-l-bicyclic nucleosides
|
|
PT3305302T
(pt)
|
2009-06-17 |
2018-12-14 |
Biogen Ma Inc |
Composições e métodos de modulação de excisões de smn2 em um sujeito
|
|
EP2451476A4
(en)
|
2009-07-06 |
2013-07-03 |
Alnylam Pharmaceuticals Inc |
BIOTRAITEMENT BASED ON CELLS
|
|
JP2014501097A
(ja)
|
2009-07-06 |
2014-01-20 |
アルナイラム ファーマシューティカルズ， インコーポレイテッド |
生物由来物質の産生を高めるための組成物及び方法
|
|
EP2462153B1
(en)
|
2009-08-06 |
2015-07-29 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexose nucleic acid analogs
|
|
WO2011097643A1
(en)
*
|
2010-02-08 |
2011-08-11 |
Isis Pharmaceuticals, Inc. |
Selective reduction of allelic variants
|
|
RU2664452C2
(ru)
|
2010-04-19 |
2018-08-17 |
Нлифе Терапеутикс, С.Л. |
Конъюгат, медицинское средство и способы лечения и/или профилактики депрессии и болезни, связанной с отложением телец Леви
|
|
KR101869570B1
(ko)
|
2010-04-28 |
2018-06-20 |
아이오니스 파마수티컬즈, 인코포레이티드 |
변형된 뉴클레오사이드 및 그로부터 제조된 올리고머 화합물
|
|
WO2012005898A2
(en)
|
2010-06-15 |
2012-01-12 |
Alnylam Pharmaceuticals, Inc. |
Chinese hamster ovary (cho) cell transcriptome, corresponding sirnas and uses thereof
|
|
WO2012018881A2
(en)
|
2010-08-03 |
2012-02-09 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for the regulation of rna
|
|
US20140155462A1
(en)
*
|
2011-04-22 |
2014-06-05 |
Dicerna Pharmaceuticals, Inc. |
Methods and compositions for the specific inhibitions of egfr by double-stranded rna
|
|
WO2012177639A2
(en)
|
2011-06-22 |
2012-12-27 |
Alnylam Pharmaceuticals, Inc. |
Bioprocessing and bioproduction using avian cell lines
|
|
US9670488B2
(en)
*
|
2011-11-04 |
2017-06-06 |
Dicerna Pharmaceuticals, Inc. |
Methods and compositions for the specific inhibition of met by double stranded RNA
|
|
US9070158B1
(en)
|
2012-02-24 |
2015-06-30 |
Amazon Technologies, Inc. |
Adaptive information regions displaying content associated with an electronic commerce system
|
|
US9778706B2
(en)
|
2012-02-24 |
2017-10-03 |
Blackberry Limited |
Peekable user interface on a portable electronic device
|
|
AU2013203395A1
(en)
|
2012-03-30 |
2013-10-17 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulating TAU expression for reducing seizure and modifying a neurodegenerative syndrome
|
|
EA201492119A1
(ru)
|
2012-05-16 |
2015-05-29 |
Рана Терапьютикс, Инк. |
Композиции и способы для модулирования экспрессии apoa1 и abca1
|
|
JP6453212B2
(ja)
|
2012-07-13 |
2019-01-16 |
ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． |
キラル制御
|
|
GB201301233D0
(en)
|
2013-01-24 |
2013-03-06 |
Queen Mary & Westfield College |
Method
|
|
ES2807379T3
(es)
|
2013-03-14 |
2021-02-22 |
Ionis Pharmaceuticals Inc |
Composiciones y métodos para regular la expresión de Tau
|
|
TWI772856B
(zh)
|
2013-07-19 |
2022-08-01 |
美商百健Ｍａ公司 |
用於調節τ蛋白表現之組合物
|
|
WO2016019063A1
(en)
|
2014-07-29 |
2016-02-04 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulating tau expression
|
|
EP3274456B1
(en)
|
2015-03-25 |
2020-06-24 |
Università Degli Studi Di Trento |
Rna interference mediated therapy for neurodegenerative diseases
|
|
ES2963428T3
(es)
|
2016-09-29 |
2024-03-27 |
Biogen Ma Inc |
Compuestos y métodos para reducir la expresión de Tau
|
|
AR109750A1
(es)
|
2016-09-29 |
2019-01-23 |
Ionis Pharmaceuticals Inc |
Compuestos y métodos para reducir la expresión de tau
|