JP2726320B2 - ペプチド誘導体 - Google Patents

ペプチド誘導体

Info

Publication number
JP2726320B2
JP2726320B2 JP1315124A JP31512489A JP2726320B2 JP 2726320 B2 JP2726320 B2 JP 2726320B2 JP 1315124 A JP1315124 A JP 1315124A JP 31512489 A JP31512489 A JP 31512489A JP 2726320 B2 JP2726320 B2 JP 2726320B2
Authority
JP
Japan
Prior art keywords
group
hydrogen
acid
formula
residue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP1315124A
Other languages
English (en)
Japanese (ja)
Other versions
JPH02184698A (ja
Inventor
ライナー・アルベルト
エリック・ペー・クレニング
ステファン・ヴェー・イェー・ランベルツ
ヤノス・プレス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888828364A external-priority patent/GB8828364D0/en
Priority claimed from GB898916115A external-priority patent/GB8916115D0/en
Priority claimed from GB898916761A external-priority patent/GB8916761D0/en
Application filed by Novartis AG filed Critical Novartis AG
Publication of JPH02184698A publication Critical patent/JPH02184698A/ja
Application granted granted Critical
Publication of JP2726320B2 publication Critical patent/JP2726320B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP1315124A 1988-12-05 1989-12-04 ペプチド誘導体 Expired - Lifetime JP2726320B2 (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB8828364 1988-12-05
GB888828364A GB8828364D0 (en) 1988-12-05 1988-12-05 Improvements in/relating to organic compounds
GB8916115 1989-07-13
GB898916115A GB8916115D0 (en) 1989-07-13 1989-07-13 Improvements in or relating to organic compounds
GB898916761A GB8916761D0 (en) 1989-07-21 1989-07-21 Improvements in or relating to organic compounds
GB8916761 1989-07-21

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP20891597A Division JP3686503B2 (ja) 1988-12-05 1997-08-04 ペプチド誘導体

Publications (2)

Publication Number Publication Date
JPH02184698A JPH02184698A (ja) 1990-07-19
JP2726320B2 true JP2726320B2 (ja) 1998-03-11

Family

ID=27264222

Family Applications (2)

Application Number Title Priority Date Filing Date
JP1315124A Expired - Lifetime JP2726320B2 (ja) 1988-12-05 1989-12-04 ペプチド誘導体
JP20891597A Expired - Lifetime JP3686503B2 (ja) 1988-12-05 1997-08-04 ペプチド誘導体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP20891597A Expired - Lifetime JP3686503B2 (ja) 1988-12-05 1997-08-04 ペプチド誘導体

Country Status (24)

Country Link
JP (2) JP2726320B2 (de)
KR (1) KR0156541B1 (de)
AT (1) AT403476B (de)
AU (1) AU633859B2 (de)
BE (1) BE1002296A5 (de)
CA (1) CA2004532C (de)
CH (1) CH678329A5 (de)
DE (1) DE3991505B4 (de)
DK (1) DK175338B1 (de)
ES (1) ES2023533A6 (de)
FI (1) FI102540B1 (de)
FR (1) FR2639947B1 (de)
GB (1) GB2225579B (de)
HK (1) HK189995A (de)
HU (2) HUT53375A (de)
IE (1) IE62091B1 (de)
IL (1) IL92534A (de)
LU (1) LU87633A1 (de)
MY (1) MY106120A (de)
NL (1) NL194828C (de)
PT (1) PT92487B (de)
SA (1) SA96160495B1 (de)
SE (1) SE508799C2 (de)
WO (1) WO1990006949A2 (de)

Families Citing this family (52)

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AU639371B2 (en) * 1987-07-10 1993-07-22 Novartis Ag Method of treating breast cancer
DE3845000C2 (de) * 1987-07-10 1998-11-19 Novartis Ag Anwendung von Octreotid zur Behandlung von Brustkrebs
GB9111199D0 (en) * 1991-05-23 1991-07-17 Sandoz Ltd Improvements in or relating to organic compounds
US5460785A (en) * 1989-08-09 1995-10-24 Rhomed Incorporated Direct labeling of antibodies and other protein with metal ions
US5700444A (en) * 1992-02-20 1997-12-23 Rhomed Incorporated Chemotactic peptide pharmaceutical applications
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5985240A (en) * 1989-08-09 1999-11-16 Rhomed Incorporated Peptide radiopharmaceutical applications
GB9004017D0 (en) * 1990-02-22 1990-04-18 Krenning Eric P Improvements in or relating to organic compounds
US5382654A (en) * 1992-02-05 1995-01-17 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US7238340B1 (en) 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
JPH05506254A (ja) * 1991-02-08 1993-09-16 バイオメジャー，インコーポレイテッド 良性および悪性増殖性皮膚病の治療方法
WO1992021383A1 (en) * 1991-06-03 1992-12-10 Mallinckrodt Medical, Inc. Radiolabelled somatostatin derivatives, their preparation and use
DK0600992T3 (da) * 1991-08-29 2000-10-09 Mallinckrodt Medical Inc Anvendelse af gentissyre eller gentisylalkohol til stabilisering af radiomærkede peptider og proteiner
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
DE69231586T2 (de) * 1992-01-03 2001-07-19 Rhomed, Inc. Pharmazeutische anwendungen auf der basis von peptid-metall-ionen
US5556609A (en) * 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
US5738838A (en) * 1992-02-20 1998-04-14 Rhomed Incorporated IKVAV peptide radiopharmaceutical applications
US5371184A (en) * 1992-02-05 1994-12-06 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
JPH08504166A (ja) * 1992-02-05 1996-05-07 マリンクロッド・メディカル・インコーポレイテッド 放射標識ペプチド化合物
US5643549A (en) * 1992-02-20 1997-07-01 Rhomed Incorporated Leukostimulatory agent for in vivo leukocyte tagging
WO1993018797A1 (en) * 1992-03-25 1993-09-30 Mallinckrodt Medical, Inc. Method of intraoperatively detecting and locating tumoral tissues
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5620675A (en) * 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US5871711A (en) * 1992-06-23 1999-02-16 Diatide, Inc. Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US5650134A (en) * 1993-01-12 1997-07-22 Novartis Ag (Formerly Sandoz Ltd.) Peptides
NZ250653A (en) * 1993-01-12 1995-12-21 Sandoz Ltd Somatostatin derivatives and pharmaceutical or diagnostic imaging compositions
CA2154667A1 (en) * 1993-02-02 1994-08-18 Linda M. Gustavson Directed biodistribution of small molecules
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
ATE337338T1 (de) * 1993-06-23 2006-09-15 Diatide Inc Radioaktiv-markierte peptidderivate des somatostatins zur bildformenden und therapeutischen verwendung
US5932189A (en) * 1994-07-29 1999-08-03 Diatech, Inc. Cyclic peptide somatostatin analogs
CA2190727C (en) * 1994-05-19 2006-07-18 Sudhakar Kasina Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
GB9417873D0 (en) * 1994-09-06 1994-10-26 Sandoz Ltd Organic compounds
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
US5830431A (en) * 1995-06-07 1998-11-03 Mallinckrodt Medical, Inc. Radiolabeled peptide compositions for site-specific targeting
GB9708265D0 (en) 1997-04-24 1997-06-18 Nycomed Imaging As Contrast agents
FI965181A7 (fi) * 1996-12-20 1998-06-21 Map Medical Tech Oy Polyalkoholi-peptidijohdannaiset
US6630570B1 (en) 1999-04-09 2003-10-07 Insitut für Diagnostikforschung GmbH Short-chain peptide-dye conjugates as contrast media for optical diagnosis
US7175953B2 (en) 1999-04-09 2007-02-13 Institute Fuer Diagnostik Forschung Short-warp peptide-dye conjugate as contrast agent for optical diagnostic
DE19917713A1 (de) * 1999-04-09 2000-10-19 Diagnostikforschung Inst Kurzkettige Peptid-Farbstoffkonjugate als Konstrastmittel für die optische Diagnostik
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
HU228811B1 (hu) * 2001-04-23 2013-05-28 Mallinckrodt Llc Technéciummal és réniummal radioaktívan jelölt, glikozilált oktreotidszármazékok
US7968080B2 (en) 2003-08-20 2011-06-28 The Regents Of The University Of California Somatostatin analogs with inhibitory activity to growth hormone release
WO2005027981A1 (en) * 2003-09-17 2005-03-31 Board Of Regents, The University Of Texas System Mechanism-based targeted pancreatic beta cell imaging and therapy
EP2067786A1 (de) 2007-12-07 2009-06-10 ITALFARMACO S.p.A. Neue nichtselektive Analoga von Somatostatin
EP2922578B1 (de) 2012-11-21 2018-12-12 Serene, Llc Tin-117m-somatostatinrezeptor-bindende verbindungen
CN119708199A (zh) 2023-09-27 2025-03-28 钱杭江医药科技(嘉兴)有限公司 生长抑素肽类类似物、螯合物及其应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1222691A (en) * 1981-12-29 1987-06-09 Wilhelmus T. Goedemans Method of preparing radionuclide-labelled proteins, in particular antibodies or antibody fragments
US4652519A (en) * 1983-02-03 1987-03-24 Yeda Research And Development Company Limited Bifunctional chelating agents and process for their production
US4707352A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
HUT42101A (en) * 1985-01-07 1987-06-29 Sandoz Ag Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds
DE3511206A1 (de) * 1985-03-28 1986-10-09 Sandoz-Patent-GmbH, 7850 Lörrach Neue polypeptidderivate, ihre herstellung und pharmazeutische praeparate, welche diese polypeptidderivate enthalten
DE3522638A1 (de) * 1985-06-25 1987-01-08 Diamalt Ag Neue somatostatin-derivate
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents
CA1266344A (en) * 1986-02-14 1990-02-27 Miki Kurami High molecular compounds having amino groups, and their utilization
US4732974A (en) * 1986-03-05 1988-03-22 Mallinckrodt, Inc. Metal ion labeling of carrier molecules
US4861869A (en) * 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
NL194729C (nl) * 1986-10-13 2003-01-07 Novartis Ag Werkwijze voor de bereiding van peptidealcoholen via vaste fase.
CH679045A5 (de) * 1987-06-29 1991-12-13 Sandoz Ag
US5073541A (en) * 1987-11-18 1991-12-17 Administrators Of The Tulane Educational Fund Treatment of small cell lung cancer with somatostatin analogs
BE1003762A3 (fr) * 1988-11-11 1992-06-09 Sandoz Sa Nouvelle utilisation therapeutique de la somatostatine et de ses analogues et derives.

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Ｂｒａｉｎ Ｒｅｓｅａｒｃｈ，４０６，３９１〜３９６ （１９８７）
Ｎｅｕｒｏｅｎｄｏｃｒｉｎｏｌｏｇｙ，４５，４２９−４３６ （１９８７）

Also Published As

Publication number Publication date
PT92487B (pt) 1996-01-31
IE893866L (en) 1990-06-05
GB2225579A (en) 1990-06-06
SE508799C2 (sv) 1998-11-09
KR0156541B1 (ko) 1998-10-15
IE62091B1 (en) 1994-12-14
DK175338B1 (da) 2004-08-30
FI102540B (fi) 1998-12-31
JPH1095737A (ja) 1998-04-14
FI102540B1 (fi) 1998-12-31
ATA901789A (de) 1997-07-15
JPH02184698A (ja) 1990-07-19
AU633859B2 (en) 1993-02-11
DK612689D0 (da) 1989-12-05
FR2639947B1 (fr) 1995-04-21
FI895809A0 (fi) 1989-12-04
CA2004532C (en) 2000-02-22
MY106120A (en) 1995-03-31
SE8904087D0 (sv) 1989-12-04
HK189995A (en) 1995-12-29
KR900009697A (ko) 1990-07-05
GB2225579B (en) 1993-03-17
ES2023533A6 (es) 1992-01-16
WO1990006949A2 (en) 1990-06-28
BE1002296A5 (fr) 1990-11-20
FR2639947A1 (fr) 1990-06-08
CH678329A5 (de) 1991-08-30
AT403476B (de) 1998-02-25
DE3991505B4 (de) 2006-04-20
GB8927255D0 (en) 1990-01-31
JP3686503B2 (ja) 2005-08-24
DK612689A (da) 1990-06-06
HUT53375A (en) 1990-10-28
SA96160495B1 (ar) 2006-08-23
HU211468A9 (en) 1995-11-28
PT92487A (pt) 1990-06-29
IL92534A (en) 1994-06-24
NL194828B (nl) 2002-12-02
CA2004532A1 (en) 1990-06-05
LU87633A1 (fr) 1991-09-18
NL194828C (nl) 2003-04-03
NL8902981A (nl) 1990-07-02
SE8904087L (sv) 1991-06-05
WO1990006949A3 (en) 1990-07-26
AU4587189A (en) 1990-06-14
HU896359D0 (en) 1990-02-28

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