JP4460764B2 - アルデヒドで固定化した生体補綴物質のカルシウム沈着を阻害するための方法 - Google Patents

アルデヒドで固定化した生体補綴物質のカルシウム沈着を阻害するための方法 Download PDF

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Publication number: JP4460764B2
Authority: JP; Japan
Prior art keywords: tissue; contacting; aldehyde; polyglycidyl ether; biological tissue
Prior art date: 1997-12-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

JP2000522960A

Other languages

English (en)

Japanese (ja)

Other versions

JP2001524358A (ja

Inventor

キャサリンティンリー，

ジュンヤン，

タンザンディン，

アーネストエイチ．プファデンハウアー，

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Edwards Lifesciences Corp

Original Assignee

Edwards Lifesciences Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-02

Filing date

1998-11-23

Publication date

2010-05-12

1998-11-23 Application filed by Edwards Lifesciences Corp filed Critical Edwards Lifesciences Corp

2001-12-04 Publication of JP2001524358A publication Critical patent/JP2001524358A/ja

2010-05-12 Application granted granted Critical

2010-05-12 Publication of JP4460764B2 publication Critical patent/JP4460764B2/ja

2018-11-23 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

238000000034 method Methods 0.000 title claims abstract description 38
239000000463 material Substances 0.000 title claims abstract description 15
230000002308 calcification Effects 0.000 title abstract description 16
230000002401 inhibitory effect Effects 0.000 title 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 74
210000001519 tissue Anatomy 0.000 claims abstract description 73
210000002808 connective tissue Anatomy 0.000 claims abstract description 16
102000004169 proteins and genes Human genes 0.000 claims abstract description 14
108090000623 proteins and genes Proteins 0.000 claims abstract description 14
238000004132 cross linking Methods 0.000 claims abstract description 13
239000000834 fixative Substances 0.000 claims abstract description 8
230000000694 effects Effects 0.000 claims abstract description 5
SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 34
150000001299 aldehydes Chemical class 0.000 claims description 27
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 18
239000000203 mixture Substances 0.000 claims description 14
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 13
UWFRVQVNYNPBEF-UHFFFAOYSA-N 1-(2,4-dimethylphenyl)propan-1-one Chemical compound CCC(=O)C1=CC=C(C)C=C1C UWFRVQVNYNPBEF-UHFFFAOYSA-N 0.000 claims description 8
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 7
102000008186 Collagen Human genes 0.000 claims description 7
108010035532 Collagen Proteins 0.000 claims description 7
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210000000988 bone and bone Anatomy 0.000 claims description 3
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WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
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238000004809 thin layer chromatography Methods 0.000 description 3
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AOBIOSPNXBMOAT-UHFFFAOYSA-N 2-[2-(oxiran-2-ylmethoxy)ethoxymethyl]oxirane Chemical compound C1OC1COCCOCC1CO1 AOBIOSPNXBMOAT-UHFFFAOYSA-N 0.000 description 2
241000283690 Bos taurus Species 0.000 description 2
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
102000016942 Elastin Human genes 0.000 description 2
108010014258 Elastin Proteins 0.000 description 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
238000007792 addition Methods 0.000 description 2
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238000006731 degradation reaction Methods 0.000 description 2
229920002549 elastin Polymers 0.000 description 2
230000003100 immobilizing effect Effects 0.000 description 2
239000007943 implant Substances 0.000 description 2
208000015181 infectious disease Diseases 0.000 description 2
230000000116 mitigating effect Effects 0.000 description 2
230000004048 modification Effects 0.000 description 2
238000012986 modification Methods 0.000 description 2
GYHFUZHODSMOHU-UHFFFAOYSA-N nonanal Chemical compound CCCCCCCCC=O GYHFUZHODSMOHU-UHFFFAOYSA-N 0.000 description 2
229920001184 polypeptide Polymers 0.000 description 2
102000004196 processed proteins & peptides Human genes 0.000 description 2
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XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
KATAXDCYPGGJNJ-UHFFFAOYSA-N 1,3-bis(oxiran-2-ylmethoxy)propan-2-ol Chemical compound C1OC1COCC(O)COCC1CO1 KATAXDCYPGGJNJ-UHFFFAOYSA-N 0.000 description 1
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
239000004971 Cross linker Substances 0.000 description 1
208000035448 Device deposit issue Diseases 0.000 description 1
229920002085 Dialdehyde starch Polymers 0.000 description 1
208000032843 Hemorrhage Diseases 0.000 description 1
239000005057 Hexamethylene diisocyanate Substances 0.000 description 1
208000037147 Hypercalcaemia Diseases 0.000 description 1
DTERQYGMUDWYAZ-ZETCQYMHSA-N N(6)-acetyl-L-lysine Chemical compound CC(=O)NCCCC[C@H]([NH3+])C([O-])=O DTERQYGMUDWYAZ-ZETCQYMHSA-N 0.000 description 1
GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
239000007997 Tricine buffer Substances 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
239000003146 anticoagulant agent Substances 0.000 description 1
229940127219 anticoagulant drug Drugs 0.000 description 1
230000010100 anticoagulation Effects 0.000 description 1
239000012620 biological material Substances 0.000 description 1
208000034158 bleeding Diseases 0.000 description 1
230000000740 bleeding effect Effects 0.000 description 1
239000001110 calcium chloride Substances 0.000 description 1
229910001628 calcium chloride Inorganic materials 0.000 description 1
230000000747 cardiac effect Effects 0.000 description 1
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238000010382 chemical cross-linking Methods 0.000 description 1
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238000006297 dehydration reaction Methods 0.000 description 1
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238000000921 elemental analysis Methods 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical compound O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 description 1
229920001519 homopolymer Polymers 0.000 description 1
230000000148 hypercalcaemia Effects 0.000 description 1
208000030915 hypercalcemia disease Diseases 0.000 description 1
238000011065 in-situ storage Methods 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
229910052740 iodine Inorganic materials 0.000 description 1
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238000000968 medical method and process Methods 0.000 description 1
230000005499 meniscus Effects 0.000 description 1
208000030159 metabolic disease Diseases 0.000 description 1
WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
229910017604 nitric acid Inorganic materials 0.000 description 1
244000052769 pathogen Species 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3695—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the function or physical properties of the final product, where no specific conditions are defined to achieve this
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/02—Treatment of implants to prevent calcification or mineralisation in vivo
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Dermatology (AREA)
Medicinal Chemistry (AREA)
Oral & Maxillofacial Surgery (AREA)
Transplantation (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Botany (AREA)
Zoology (AREA)
Urology & Nephrology (AREA)
General Chemical & Material Sciences (AREA)
Biophysics (AREA)
Materials For Medical Uses (AREA)
Prostheses (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

JP2000522960A 1997-12-02 1998-11-23 アルデヒドで固定化した生体補綴物質のカルシウム沈着を阻害するための方法 Expired - Lifetime JP4460764B2 (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/982,846 US6008292A (en)	1997-12-02	1997-12-02	Method for inhibiting calcification of aldehyde-fixed bioprosthetic materials
US08/982,846		1997-12-02
PCT/US1998/024900 WO1999027979A1 (fr)	1997-12-02	1998-11-23	Procede empechant la calcification des materiaux de bioprothese fixes par l'aldehyde

Publications (2)

Publication Number	Publication Date
JP2001524358A JP2001524358A (ja)	2001-12-04
JP4460764B2 true JP4460764B2 (ja)	2010-05-12

Family

ID=25529556

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2000522960A Expired - Lifetime JP4460764B2 (ja)	1997-12-02	1998-11-23	アルデヒドで固定化した生体補綴物質のカルシウム沈着を阻害するための方法

Country Status (11)

Country	Link
US (1)	US6008292A (fr)
EP (1)	EP1035877B1 (fr)
JP (1)	JP4460764B2 (fr)
AT (1)	ATE204767T1 (fr)
AU (1)	AU1466799A (fr)
CA (1)	CA2312376C (fr)
DE (1)	DE69801517T2 (fr)
DK (1)	DK1035877T3 (fr)
ES (1)	ES2163898T3 (fr)
PT (1)	PT1035877E (fr)
WO (1)	WO1999027979A1 (fr)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69523074T2 (de) *	1994-07-29	2002-06-06	Edwards Lifesciences Corp., Irvine	Verfahren zur behandlung von implantierbaren biologischen geweben zur verringerung von verkalkung
US6214054B1 (en) *	1998-09-21	2001-04-10	Edwards Lifesciences Corporation	Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby
US6391538B1 (en) *	2000-02-09	2002-05-21	The Children's Hospital Of Philadelphia	Stabilization of implantable bioprosthetic tissue
US20030050276A1 (en) *	2001-08-15	2003-03-13	Cunanan Crystal M.	Treatment of tissue, instruments and work surfaces to remove infectious agents
CA2427165A1 (fr) *	2000-11-01	2002-06-06	Edwards Lifesciences Corporation	Methodes de preparation de tissu de bioprothese et dispositifs implantables comprenant un tel tissu de bioprothese
EP1404390B1 (fr) *	2001-06-29	2012-08-01	Cook Biotech, Inc.	Dispositifs medicaux a matrice d'eponge poreuse et procedes
US6878168B2 (en)	2002-01-03	2005-04-12	Edwards Lifesciences Corporation	Treatment of bioprosthetic tissues to mitigate post implantation calcification
RU2234217C1 (ru) *	2003-12-31	2004-08-20	Государственное образовательное учреждение Санкт-Петербургский государственный медицинский университет им. акад. И.П.Павлова	Способ структурной стабилизации биотканей
CN1903143A (zh) *	2005-07-29	2007-01-31	广东冠昊生物科技有限公司	生物型人工血管及其制备方法
CN1903144A (zh) *	2005-07-29	2007-01-31	广东冠昊生物科技有限公司	生物型人工韧带及其制备方法
CN100482178C (zh) *	2005-08-04	2009-04-29	广东冠昊生物科技有限公司	带生物膜的血管瘤夹
CN1986007B (zh) *	2005-12-20	2011-09-14	广东冠昊生物科技股份有限公司	生物型外科补片
CN1986001B (zh) *	2005-12-20	2011-09-14	广东冠昊生物科技股份有限公司	生物护创膜
CN1986006A (zh)	2005-12-20	2007-06-27	广州知光生物科技有限公司	生物型神经导管
CN1985778B (zh) *	2005-12-20	2010-10-13	广东冠昊生物科技股份有限公司	生物型人工角膜
US20070237802A1 (en) *	2006-04-11	2007-10-11	Medtronic Vascular, Inc.	Inhibition of Calcification on an Endovascular Device
CN101332316B (zh) *	2008-07-22	2012-12-26	广东冠昊生物科技股份有限公司	生物型鼻梁植入体
CN101332314B (zh) *	2008-07-22	2012-11-14	广东冠昊生物科技股份有限公司	生物型关节软骨修补件
US20100023129A1 (en) *	2008-07-22	2010-01-28	Guo-Feng Xu	Jawbone prosthesis and method of manufacture
WO2008073582A2 (fr)	2006-10-27	2008-06-19	Edwards Lifesciences Corporation	Tissu biologique pour implantation chirurgicale
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1997
- 1997-12-02 US US08/982,846 patent/US6008292A/en not_active Expired - Lifetime
1998
- 1998-11-23 AU AU14667/99A patent/AU1466799A/en not_active Abandoned
- 1998-11-23 DE DE69801517T patent/DE69801517T2/de not_active Expired - Lifetime
- 1998-11-23 ES ES98958678T patent/ES2163898T3/es not_active Expired - Lifetime
- 1998-11-23 AT AT98958678T patent/ATE204767T1/de not_active IP Right Cessation
- 1998-11-23 WO PCT/US1998/024900 patent/WO1999027979A1/fr not_active Ceased
- 1998-11-23 CA CA002312376A patent/CA2312376C/fr not_active Expired - Lifetime
- 1998-11-23 JP JP2000522960A patent/JP4460764B2/ja not_active Expired - Lifetime
- 1998-11-23 PT PT81300920T patent/PT1035877E/pt unknown
- 1998-11-23 DK DK98958678T patent/DK1035877T3/da active
- 1998-11-23 EP EP98958678A patent/EP1035877B1/fr not_active Expired - Lifetime

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DE69801517D1 (de)	2001-10-04
DE69801517T2 (de)	2002-04-11
EP1035877A1 (fr)	2000-09-20
ATE204767T1 (de)	2001-09-15
CA2312376A1 (fr)	1999-06-10
US6008292A (en)	1999-12-28
AU1466799A (en)	1999-06-16
CA2312376C (fr)	2007-02-20
DK1035877T3 (da)	2001-12-03
WO1999027979A1 (fr)	1999-06-10
ES2163898T3 (es)	2002-02-01
PT1035877E (pt)	2001-12-28
EP1035877B1 (fr)	2001-08-29
JP2001524358A (ja)	2001-12-04

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