JPH03255018A - Hair nourishing cosmetic - Google Patents

Abstract

PURPOSE:To obtain a hair nourishing cosmetic having excellent hair nourishing effect, hair producing effect, inhibitory effects on removal of hair, suppressing effects on itch and dandruff, containing a soluble egg shell film and a vitamin E. CONSTITUTION:Cosmetic raw materials (e.g. oil, water, surfactant, humectant, alcohols, chelating agent, antiseptic, colorant and perfume) are blended with a soluble egg shell film and at least one selected from vitamin Es and derivatives thereof and prepared by a conventional procedure to give the objec tive substance. The amount of the soluble egg shell film blended is 0.01-10wt.% calculated as dried substance and that of the vitamin Es is 0.01-5wt.%. The objective substance can he processed into a hair tonic, scalp agent, hair dressing agent, hair washing agent, etc. The soluble egg shell film is obtained by solubilizing membrane attached to the inside of egg shell of fowl egg with an organic solvent, etc., and DL-alpha-tocopherol may be cited as the vitamin Es.

Description

DETAILED DESCRIPTION OF THE INVENTION <Industrial Application Field> The present invention relates to a hair nourishing cosmetic with excellent hair nourishing and hair growing effects.

<Prior Art> When the eggshell membrane of a bird's egg is used to cover a wound caused by a burn or the like, the eggshell membrane adheres to the wound and promotes epithelial formation of the skin. As is clear from this, eggshell membrane has a good wound healing effect.

The mechanism for this is not yet clear, but it is not only due to the passive effects of the eggshell membrane, such as suppressing exudate from the wound and preventing bacterial infection, but also due to the leaching of unknown active ingredients from the eggshell membrane, direct or It is speculated that this may be due to an active action such as indirectly promoting the proliferation of fibroblasts, for example.

For this reason, it is known that eggshell membranes are blended with ordinary hair-growth cosmetic ingredients to create a hair-growth agent (Japanese Patent Application Laid-Open No. 1983-1998-1).
4094.4).

<Problem to be solved by the invention> Needless to say, hair is formed by keratinization as the hair matrix cells move upward, but the growth and
Differentiation requires various nutrients and oxygen supplied from the capillaries in the dermal papilla, interaction with fibroblasts is also an important factor, and there are various other factors. In other words, hair growth is the result of a complex interplay of these factors, so for example, only ingredients that activate hair matrix cells or ingredients that promote blood circulation are added to hair nourishing products. However, a good hair growth effect cannot be expected.

Therefore, since the hair growth agent proposed above simply contains eggshell membrane, it does not exhibit the expected hair growth effect.

Therefore, in order to obtain an effective hair nourishing agent, it is important to know how to combine multiple effective hair nourishing ingredients with different physiological activities, and how to create a synergistic effect. seems to be important.

Therefore, for example, as seen in JP-A-63-146806, studies have begun to consider the combination of multiple hair-nourishing ingredients, but perhaps because the activity of the hair-nourishing ingredients is weak, there is no one that can be expected to have sufficient effects. T! I haven't gotten it.

In view of these circumstances, an object of the present invention is to provide a hair nourishing cosmetic that is excellent in hair nourishing and hair growing effects.

Means for Solving the Problems> In order to achieve the above object, the present inventor has conducted extensive research and found that a hair-growth cosmetic that uses a combination of soluble eggshell membrane and vitamin E or a derivative thereof has a hair-growth effect. The present invention was completed based on the discovery that the present invention is excellent.

The cosmetic of the present invention is characterized by containing soluble eggshell membrane and at least one selected from vitamin E and its derivatives.

In the present invention, soluble eggshell membrane refers to the membrane (eggshell membrane) attached to the inside of the eggshell of bird eggs such as chicken eggs and quail eggs, which is solubilized in fresh water or alcohol. Refers to membranes that have been solubilized with acids, alkalines, organic solvents, oxidizing/reducing agents, enzymes, etc. Since such soluble eggshell membranes are generally not commercially available, an example of a method for obtaining soluble eggshell membranes by treating eggshell membranes with acids, alkalis, etc. in a conventional manner will be described.

First, eggshell membranes are decomposed in an alkaline water-containing organic solvent. Here, the alkaline water-containing organic solvents include caustic soda,
Add an alkaline agent such as caustic potash to reduce the alkaline concentration to 0.
．． 2-3.0N aqueous solution 70-40% (wt% i Jl, (same below), methanol, ethanol,
It refers to a mixture of 30 to 60% of a water-soluble organic solvent such as acetone. The conditions for decomposition treatment are 30-60℃ and 1-8
The time is appropriate.

Next, the obtained decomposition liquid is neutralized and filtered to obtain a solution of soluble eggshell membranes. Incidentally, if this solution is dried by a conventional method, a powdery soluble eggshell membrane can be obtained.

On the other hand, vitamin E is classified according to the number and position of the methyl group in the chroman nucleus, such as α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, α-tocoriere, β-tocoriere, and γ-tocopherol. There are 8[t isomers of tocoriere and δ-tocoriere, as well as their optical isomers, and any of them can be used in the present invention.

In addition, as derivatives of vitamin E, tocopherol monophosphate, tocopherol monophosphate, tocopherol calcium succinate, tocopherol nicotinate, etc. are well known, but in the present invention, other derivatives similar to these and known Any derivative that can be produced by the art can be used.

In the present invention, one or more of these vitamin E and derivatives thereof (hereinafter both referred to as vitamin E) may be selected and used.

In addition, the present invention also provides hair nourishing cosmetics and 1. f, hair nourishing material, scalp material,
It includes all products similar to hair cosmetics such as hair styling products and hair washing products.

To obtain the hair nourishing cosmetic of the present invention, the above-mentioned soluble eggshell membrane,
At least one selected from vitamin E may be added to ordinary cosmetic raw materials to prepare a hair nourishing cosmetic by a conventional method.

Here, the usual cosmetic ingredients differ depending on the type of hair nourishing cosmetic, but include oil, water, surfactants, moisturizing agents, alcohols, cleaning agents, coloring agents, preservatives, and coloring agents. fee,
There are fragrances, etc.

The amount of soluble eggshell membrane blended is preferably 0,0 to 10% based on the total cosmetic raw materials on a dry matter basis, and the blended amount of pitamine E is preferably 0.01 to 5%.

In either case, if the amount is too small, the resulting hair-growth cosmetic tends to have no effect on hair growth.
On the other hand, if the amount is too large, the hair nourishing cosmetic obtained tends to be sticky, which is both undesirable.

The hair-growth cosmetic of the present invention is thought to have excellent hair-growth and hair-growth effects because it improves blood flow to the scalp, retains various ingredients, and provides stimulation at the same time through the combination of eggshell membrane and vitamin E. It will be done.

Examples (1) Adjustment of soluble eggshell membrane After cracking chicken eggs with shells and removing the egg fluid, the resulting eggshells with eggshell membranes are placed in clean water, the eggshells are manually removed, and the eggshells are removed. A membrane was obtained. Next, the obtained eggshell membranes were immersed in a 1% aqueous hydrochloric acid solution for 1 hour to dissolve minute eggshells adhering to the eggshell membranes, washed with water, and dried in the sun to obtain dried eggshell membranes.

Add 1200 ml of 2N sodium hydroxide aqueous solution and 80 ml of absolute ethanol to 100 g of dried eggshell membrane obtained as described above.
0 ml was added and treated at 40°C for 5 hours with stirring to solubilize the eggshell membranes.

Next, the obtained liquid was filtered through a cloth filter, neutralized,
After desalting and freeze-drying, 53 g of powdered soluble eggshell membranes were obtained.

(2) Production of hair atonic The following raw materials were prepared.

Soluble eggshell membrane powder (obtained in (1)) x, 0 (X
) D L -a-) Copherol 0.5 Methylparaben 0.1 Olive oil 5.0 Glycerin
3.0 ethanol
55.0 fragrance
0.1 A hair tonic was produced using these raw materials in a conventional manner.

7- (3) Manufacture of hair cream The following raw materials were prepared.

Soluble eggshell membrane powder (obtained in (1)) DL-〇-
Tocopherol White petrolatum Liquid paraffin Lanolin Beeswax Sesquioleate Sorbitan Monolaurate Sorbitan Monolaurate Polyoxyethylene Sorbitan powder Sand Methyl paraben Fragrance 0.5 0.5 0 75 3.0 12.0 3.0 2.0 2.0 ( %) 0.5 0.1 0.1 Total 100 Using these raw materials, a hair cream was produced by a conventional method.

Example of exam Test example 1 (hair growth/hair growth test) The following four types of samples were prepared.

Test group: Hair tonic obtained in Example (2) Control group 1: In the hair tonic formulation of Example (2), soluble eggshell membrane was not used and replaced with the same amount of purified water, and other raw materials were not used. Hair tonic control group 2 obtained by using the same product as in Example (2) at the same mixing ratio: In the hair tonic formulation of Example (2), DL-〇-tocopherol was not used and the same amount of purified Hair tonic control group 3 obtained by replacing water with water and using the same ingredients as in Example (2) at the same blending ratio: In the hair tonic formulation of Example (2), soluble eggshell Hair tonic was prepared by using the same amount of purified water as in Example (2) and using the same ingredients as in Example (2). (Male, 1 & 50 days old) Hair was pricked on the backs of 40 mice, divided into 4 groups of 10 mice each, and each group was treated with hair tonic from the test group and control group 1 to 3 twice daily in the morning and evening.
．． It was applied at 1 mR for 20 days. Thereafter, the weight of hair regenerated in the test area was measured, and the average hair weight of each group was calculated, and the results shown in Table 1 were obtained.

Table-1 In comparison, it was recognized that the hair nourishing and hair growth effects were high.

Test Example 2 (Practical Test) Three types of hair 1-nick were prepared: the test group used in Test Example J, and control groups 1 and 2.

The 30 subjects with male alopecia were divided into 3 groups of 10 people each, and each group was divided into a two-leg test group, a control group, one group, and a control group.
Atonic was continuously applied to the same area twice in the morning and evening for two months.

After that, the number of people who answered ``Yes'' for ``hair growth effect'', ``hair loss prevention effect'', and ``dandruff and itch prevention effect'' was counted, and the results shown in Table 2 were obtained.

The results shown in Table 1 show that when soluble eggshell membrane and vitamin E are used in combination (test group), when each is used alone (control group), and when they are not used at all (control group 3). ) and the results shown in Table 2, when soluble eggshell membrane and vinyl 1-tamin EM were used together (test group), compared to when each was used alone (control group 1, control group 2), It was clearly recognized that the hair growth effect, hair loss prevention effect, and dandruff/itch prevention effect were high.

<Effects of the Invention> As explained above, since the hair nourishing cosmetic of the present invention contains soluble eggshell membrane and vitamin E, it has excellent hair nourishing and hair growth effects, hair loss prevention effects, and dandruff and itch prevention effects. It has a preventive effect.

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Claims (1)

[Claims] A hair nourishing cosmetic comprising a soluble eggshell membrane and at least one selected from vitamin E and its derivatives.