JPH06293637A - Cataplasm - Google Patents
CataplasmInfo
- Publication number
- JPH06293637A JPH06293637A JP3302654A JP30265491A JPH06293637A JP H06293637 A JPH06293637 A JP H06293637A JP 3302654 A JP3302654 A JP 3302654A JP 30265491 A JP30265491 A JP 30265491A JP H06293637 A JPH06293637 A JP H06293637A
- Authority
- JP
- Japan
- Prior art keywords
- sake lees
- gelatin
- sake
- poultice
- plaster
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 25
- 108010010803 Gelatin Proteins 0.000 claims abstract description 24
- 229920000159 gelatin Polymers 0.000 claims abstract description 23
- 239000008273 gelatin Substances 0.000 claims abstract description 23
- 235000019322 gelatine Nutrition 0.000 claims abstract description 23
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 23
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 19
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims abstract description 19
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 19
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims abstract description 19
- 239000011505 plaster Substances 0.000 claims abstract description 17
- 235000011187 glycerol Nutrition 0.000 claims abstract description 12
- 238000002156 mixing Methods 0.000 claims abstract description 12
- 239000005995 Aluminium silicate Substances 0.000 claims abstract description 10
- 235000012211 aluminium silicate Nutrition 0.000 claims abstract description 10
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims abstract description 10
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 9
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims abstract description 8
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 239000003795 chemical substances by application Substances 0.000 claims description 13
- 238000004898 kneading Methods 0.000 claims description 8
- 239000008213 purified water Substances 0.000 claims description 6
- 229920003169 water-soluble polymer Polymers 0.000 claims description 2
- 239000002440 industrial waste Substances 0.000 abstract description 7
- 208000017520 skin disease Diseases 0.000 abstract description 5
- 239000004480 active ingredient Substances 0.000 abstract description 3
- 230000002500 effect on skin Effects 0.000 abstract 1
- 230000001976 improved effect Effects 0.000 abstract 1
- 235000019991 rice wine Nutrition 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 16
- 230000003020 moisturizing effect Effects 0.000 description 16
- 210000003491 skin Anatomy 0.000 description 14
- 239000000203 mixture Substances 0.000 description 11
- 235000019271 petrolatum Nutrition 0.000 description 10
- 239000003871 white petrolatum Substances 0.000 description 10
- 102000004169 proteins and genes Human genes 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 9
- 108010076876 Keratins Proteins 0.000 description 8
- 102000011782 Keratins Human genes 0.000 description 8
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 8
- 230000003110 anti-inflammatory effect Effects 0.000 description 8
- 239000004202 carbamide Substances 0.000 description 8
- 239000002674 ointment Substances 0.000 description 8
- 230000002087 whitening effect Effects 0.000 description 8
- 208000003351 Melanosis Diseases 0.000 description 6
- 241000700159 Rattus Species 0.000 description 6
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 description 6
- 229960004705 kojic acid Drugs 0.000 description 6
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 235000019441 ethanol Nutrition 0.000 description 5
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 4
- 206010008570 Chloasma Diseases 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 4
- 206010042496 Sunburn Diseases 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 210000005056 cell body Anatomy 0.000 description 4
- 238000013329 compounding Methods 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- 230000002757 inflammatory effect Effects 0.000 description 4
- 210000003141 lower extremity Anatomy 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 210000000434 stratum corneum Anatomy 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 235000019156 vitamin B Nutrition 0.000 description 4
- 239000011720 vitamin B Substances 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 235000016709 nutrition Nutrition 0.000 description 3
- 230000000699 topical effect Effects 0.000 description 3
- PQUXFUBNSYCQAL-UHFFFAOYSA-N 1-(2,3-difluorophenyl)ethanone Chemical compound CC(=O)C1=CC=CC(F)=C1F PQUXFUBNSYCQAL-UHFFFAOYSA-N 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 2
- 240000006439 Aspergillus oryzae Species 0.000 description 2
- 235000002247 Aspergillus oryzae Nutrition 0.000 description 2
- 208000008035 Back Pain Diseases 0.000 description 2
- 108010077805 Bacterial Proteins Proteins 0.000 description 2
- 208000017667 Chronic Disease Diseases 0.000 description 2
- 206010014970 Ephelides Diseases 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 2
- 208000008930 Low Back Pain Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 208000012641 Pigmentation disease Diseases 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 229930003270 Vitamin B Natural products 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 2
- 229940105329 carboxymethylcellulose Drugs 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 229920001525 carrageenan Polymers 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 231100000321 erythema Toxicity 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- 210000000245 forearm Anatomy 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 235000020778 linoleic acid Nutrition 0.000 description 2
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 2
- 239000002075 main ingredient Substances 0.000 description 2
- 230000007721 medicinal effect Effects 0.000 description 2
- 239000004745 nonwoven fabric Substances 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 230000002085 persistent effect Effects 0.000 description 2
- 230000019612 pigmentation Effects 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000004064 recycling Methods 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 235000020083 shōchū Nutrition 0.000 description 2
- 229940047670 sodium acrylate Drugs 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 239000000052 vinegar Substances 0.000 description 2
- 235000021419 vinegar Nutrition 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 239000002759 woven fabric Substances 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- 210000005253 yeast cell Anatomy 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 description 1
- 229940063834 carboxymethylcellulose sodium Drugs 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920000131 polyvinylidene Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
Description
【産業上の利用分野】本発明は産業廃棄物としての酒粕
を有効利用したパップ剤に関するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a poultice which effectively uses sake lees as industrial waste.
【０００２】[0002]
【従来の技術】酒粕は従来合成清酒の香味付与剤、焼酎
原料、酢の原料として使用されるほか、香味の面から漬
物材料（粕漬の材料）又は甘酒の材料とし、或はそのま
ま食用に供されてきた。然しながら年間３５万トンも清
酒生産の副産物として生産される酒粕の有効利用にも限
度があり、産業廃棄物としての処理に苦慮しているのが
現状である。2. Description of the Related Art Sake lees are conventionally used as a flavoring agent for synthetic sake, a raw material for shochu, and a raw material for vinegar. It has been. However, there is a limit to the effective use of sake lees produced as a by-product of sake production by 350,000 tons per year, and it is currently difficult to treat it as industrial waste.
【０００３】又外用剤としてのパップ剤は、従来その基
剤として保湿性に富む水溶性高分子であるゼラチン、ポ
リビニ−ルアルコ−ル、ポリアクリル酸ナトリウム等々
を単体として、又は複数剤を使用しているが多くの栄養
を含有することは勿論のこと薬用効果、化粧効果等を有
する多種の成分に富む酒粕が外用剤特にパップ剤として
利用されることはなかった。Further, as a topical poultice, a poultice is conventionally prepared by using, as its base, gelatin, polyvinyl alcohol, sodium polyacrylate, etc., which are water-soluble polymers rich in moisture retention, as a single substance or by using a plurality of agents. However, the sake lees rich in various ingredients having a medicinal effect, a cosmetic effect, etc. as well as containing a lot of nutrition have not been used as an external preparation, particularly as a poultice.
【０００４】[0004]
【発明の解決しようとする課題】酒粕は酒精酵母の細胞
体つまり酵素のかたまりともいえ、麹菌体（コウジ酸）
及びリノ−ル酸が多く含まれていると共に、ビタミンＢ
1、Ｂ2、Ｂ6、も含まれ、蛋白質にも富んでいる。然も酒
粕は従来の外用剤特にパップ剤の主剤であるゼラチン、
ポリビニ−ルアルコ−ル及びポリアクリル酸ナトリウム
と練合性も優れている等の性質を有するので従来のパッ
プ剤の基剤に酒粕を配合してパップ剤としての効果を一
層向上させると共に酒粕に含まれる有効成分による皮膚
疾患の治療に寄与せしめ更に産業廃棄物としての酒粕の
リサイクルにも寄与せんとするものである。Sake lees can be said to be the cell bodies of liquor yeast, that is, a group of enzymes, and koji cells (kojic acid).
And a lot of linoleic acid, vitamin B
It also contains 1 , B 2 , and B 6 , and is rich in protein. Naturally, sake lees are gelatin, which is the main ingredient of conventional external preparations, especially poultices,
Since it has properties such as excellent kneadability with polyvinyl alcohol and sodium polyacrylate, it is possible to further improve the effect as a poultice by adding sake lees to the base of conventional poultices and also included in sake lees. It is intended to contribute to the treatment of skin diseases caused by the active ingredients and also to the recycling of sake lees as industrial waste.
【０００５】[0005]
【課題を解決するための手段】本発明は、ゼラチン、ポ
リビニ−ルアルコ−ル、ポリアクリル酸ナトリウム等を
パップ剤の基剤とし、これにカルボキシメチルセルロ−
スナトリウム、グリセリン、カオリン等を配合してなる
膏体の中に更に酒粕を添加練合することを特徴とする構
成を有するが、膏体剤料中ポリビニ−ルアルコ−ル、カ
オリン、ゼラチンを精製水で加熱溶融し、これに酒粕を
添加して混合撹拌したものに、アクリル酸ナトリウム、
カルボキシメチルセルロ−スナトリウム、グリセリンを
混合撹拌したものを加えて練合したのち支持体に圧延し
てパップ剤とする。この際膏体に対する酒粕の添加量
は、１ｗ/ｗ％〜５ｗ/ｗ％好ましくは２ｗ/ｗ％〜３０
ｗ/ｗ％、より好ましくは５ｗ/ｗ％〜２０ｗ/ｗ％を添
加練合し、又膏体剤料中、ゼラチンに対してポリビニ−
ルアルコ−ルを２５:１量比〜１:５０量比、好ましくは
１５:１量比〜１:３０量比、より好ましくは５:１量比
〜１:５量比の配合比からなり、又ゼラチンに対してポ
リアクリル酸ナトリウムは、２５:１量比〜１:２５量
比、好ましくは１５:１量比〜１:１５量比、より好まし
くは５:１量比〜１:５量比の配合比として混合撹拌した
膏体であると酒粕との練合がより良好である。The present invention uses gelatin, polyvinyl alcohol, sodium polyacrylate, etc. as a base for poultices, and carboxymethylcellulose
It has a constitution characterized by further adding and kneading sake lees into a paste prepared by blending sodium hydroxide, glycerin, kaolin, etc., but purifying polyvinyl alcohol, kaolin, gelatin in the paste preparation. Heat and melt with water, add sake lees to this, mix and stir, sodium acrylate,
A mixture prepared by mixing and stirring sodium carboxymethylcellulose and glycerin is added and kneaded, and then rolled on a support to obtain a poultice. At this time, the amount of sake lees added to the plaster is 1 w / w% to 5 w / w%, preferably 2 w / w% to 30.
w / w%, more preferably 5 w / w% to 20 w / w% are added and kneaded, and polyvinylidene is added to gelatin in the plaster material.
Lualcohol has a compounding ratio of 25: 1 to 1:50, preferably 15: 1 to 1:30, and more preferably 5: 1 to 1: 5. Further, sodium polyacrylate to gelatin is in a ratio of 25: 1 to 1:25, preferably 15: 1 to 1:15, and more preferably 5: 1 to 1: 5. When the paste is mixed and stirred as a mixing ratio of the ratio, the kneading with the sake lees is better.
【０００６】[0006]
実施例１ Example 1
【０００７】[0007]
実施例２ Example 2
【０００８】[0008]
【実施例】 実施例３ 但し(酒粕を除く対比膏体) Example 3 Example 3 (comparative plaster excluding sake lees)
【０００９】上記の実施例１及び２において、ポリビニ
−ルアルコ−ルとカオリン及びゼラチンを精製水でもっ
て加熱溶解し、これに酒粕を加えて混合撹拌したもの
に、ポリアクリル酸ナトリウムとカルボキシメチルセル
ロ−スナトリウム及びグリセリンを混合撹拌したものを
加えて約１０分間練合した後１０００ｇ／ｍ2の割合で
支持体（不織布又は織布）上にロ−ルにより圧延し、一
定面積にカットしてパップ剤とする。In the above-mentioned Examples 1 and 2, polyvinyl alcohol, kaolin and gelatin were dissolved by heating with purified water, to which sake lees were added and mixed and stirred, and sodium polyacrylate and carboxymethylcellulose were added. -Adding a mixture of sodium and glycerin and mixing and kneading for about 10 minutes, then rolling on a support (nonwoven fabric or woven fabric) at a rate of 1000 g / m 2 with a roll and cutting into a certain area Use as a poultice.
【００１０】実施例３は従来のパップ剤における膏体配
合剤料を本願実施例と同じくして本願実施例のパップ剤
とその効果ついて対比するための例であるが、混合撹拌
等の製造手順は実施例１、２と酒粕を除いて全く同一で
ある。Example 3 is an example for comparing the effect of the plaster compounding agent in the conventional poultice with the poultice of the present example in the same manner as in the present application, but the manufacturing procedure such as mixing and stirring. Is exactly the same as Examples 1 and 2 except for the sake lees.
【００１１】[0011]
【作用と効果について】酒粕の一般成分は、揮発性成分
（水分、アルコ−ル分）と固形分とがほぼ等しく、主な
成分としてはアルコ−ル分８％、蛋白質１５％、澱粉２
０％、酵母１５％〜２０％を占めている。蛋白質には、
アミノ酸が含まれているが、特に蛋白質としては、アル
カリ可溶区分（グリテリン）、菌体蛋白及び水溶性区分
（アルブミン、ペプチッド、アミノ酸）が主である。又
酒粕中には約２０％の酵母菌体が在ることから核酸物質
及びビタミンも多く含まれ酒粕（米の未分解物と酒精酵
母の細胞体…酵素のかたまり。）は栄養価も高く蛋白質
を初めビタミンＢ1、Ｂ2、Ｂ6も含まれている。[Regarding action and effect] As for the general components of sake lees, the volatile components (water content, alcohol content) and solid content are almost equal, and the main components are alcohol content 8%, protein 15%, starch 2
It accounts for 0% and yeast 15% to 20%. For proteins,
Amino acids are contained, but especially proteins are mainly alkali-soluble (glycerin), bacterial protein and water-soluble (albumin, peptide, amino acid). In addition, since about 20% of yeast cells are contained in sake lees, nucleic acid substances and vitamins are also contained in a large amount, and sake lees (undecomposed rice products and cell bodies of sake-yeast ... a group of enzymes.) Have a high nutritional value and protein. It also contains vitamins B 1 , B 2 and B 6 .
【００１２】又酒粕中には麹菌体（コウジ酸）及びリノ
−ル酸が含まれており、コウジ酸やリノ−ル酸は日やけ
によるシミ、ソバカスの予防に優れた効果即ち美白効果
があると報告されている。又日本酒を使った酒風呂が疲
労回復によく、肌にもよいとか、シミとり、しわの防止
には清酒が良いなどの報告もなされている。そこで出願
人は酒粕の持つこれらの性質に着目して酒粕を外用療法
に応用することを考え、外用剤の中でも特にパップ剤に
利用すべく研究した結果、酒粕はパップ剤を構成する水
溶性高分子であるゼラチン、ポリビニ−ルアルコ−ル及
びポリアクリル酸ナトリウムと極めて練合性も良く、従
来のパップ剤に比較して高い皮膚の保湿性に加えて皮膚
への高い粘着力を付与することが可能であることを発見
した。又酒粕の含有量に相関して肌の美白、皮膚保湿性
と肩こり、腰痛等の慢性疾患にも効果のあることがわか
った。The sake lees also contain koji mold (kojic acid) and linoleic acid, and kojic acid and linoleic acid have an excellent effect on the prevention of spots and freckles caused by sunburn, that is, a whitening effect. Is reported. It has also been reported that a sake bath using sake is good for fatigue recovery, good for the skin, and good for preventing stains and wrinkles. Therefore, the applicant considered focusing on these properties of the sake lees and applying the lees to the topical therapy, and as a result of researching to apply the lees to the poultices, as a result, the sake lees were highly soluble in the poultices. It has extremely good kneading properties with the molecules gelatin, polyvinyl alcohol and sodium polyacrylate, and in addition to having a higher moisturizing effect on the skin than conventional poultices, it can impart high adhesive strength to the skin. I found it possible. Further, it was found that it is also effective for the skin whitening, the skin moisturizing property and the chronic diseases such as stiff shoulders and low back pain in correlation with the content of sake lees.
【００１３】そこで実施例１、２に示す膏体基剤中ポリ
ビニ−ルアルコ−ルとカオリン、ゼラチンを同時に精製
水で加熱溶解し、これに酒粕を加えて混合撹拌し、この
混合撹拌したものに更にポリアクリル酸ナトリウム、カ
ルボキシメチルセルロ−スナトリウム及びグリセリンを
混合撹拌したものを加えて練合（約１０分間）すると練
合状態が極めて良好で支持体に圧延した場合でも均一な
品質のパップ剤が得られる。Therefore, polyvinyl alcohol, kaolin, and gelatin in the plaster base as shown in Examples 1 and 2 were dissolved by heating in purified water at the same time, and sake lees were added thereto, and the mixture was mixed and stirred. Furthermore, when a mixture of sodium polyacrylate, sodium carboxymethylcellulose and glycerin is added and kneaded and kneaded (for about 10 minutes), the kneaded state is extremely good and a poultice of uniform quality even when rolled on a support. Is obtained.
【００１４】[0014]
【発明の効果】次に本発明パップ剤の効果について説明
する。先ず皮膚への美白作用効果であるが前記実施例
１、２、３のパップ剤サンプルを用いて着色性皮膚疾患
に対する治驗を実施した。その結果は次の表１に示すよ
うに酒粕を含有した実施例１及び実施例２のサンプルで
は、酒サ、女子顔面黒皮症、肝斑、雀卵斑、日焦、二次
性色素沈着などに対して美白作用が認められた。The effects of the poultice of the present invention will be described below. First, for the whitening effect on the skin, using the poultice samples of Examples 1, 2, and 3 described above, the treatment for pigmented skin diseases was carried out. The results are shown in Table 1 below. In the samples of Example 1 and Example 2 containing sake lees, the sake liquor, female facial melasma, melasma, erythema speciosa, sunburn, secondary pigmentation A whitening effect was recognized against the above.
【００１５】[0015]
【表１】 [Table 1]
【００１６】次に抗炎症作用効果であるが、実施例１、
２、３のパップ剤サンプルを用いてラットの炎症動物モ
デルを使用してその抗炎症作用を実験した。Ｗｉｓｔａ
ｒ系雄ラット(体重１８０ｇ〜２００ｇ)の右後肢にサン
プル(２.５ｃｍ×３.０ｃｍ，０.７５ｇ）を貼付し、４
時間後に各サンプルを剥離除去した後、起炎剤１％カラ
ゲニン懸濁液０．１ｍｌを右後肢足蹠皮下に注射した。
その後経時的に５時間までラットの足容積を測定し、起
炎剤注射前の足容積から浮腫率を算出し、無処置対照群
に対する抑制効果を求めた。なお各サンプルは前処置に
限定し、動物数は一群ｎ＝１０とした。その抗炎症効果
は図１に示す通りである。Next, regarding the anti-inflammatory effect, Example 1
Its anti-inflammatory effect was tested using a rat animal model of inflammation with a few poultice samples. Wista
A sample (2.5 cm × 3.0 cm, 0.75 g) was attached to the right hind limb of an r strain male rat (body weight 180 g to 200 g), and 4
Each sample was peeled off after a lapse of time, and 0.1 ml of a carrageenin suspension containing 1% of the inflammatory agent was subcutaneously injected into the footpad of the right hind leg.
After that, the rat paw volume was measured for 5 hours, and the edema rate was calculated from the paw volume before injection of the inflammatory agent, and the inhibitory effect on the untreated control group was determined. Each sample was limited to pretreatment, and the number of animals was n = 10 per group. The anti-inflammatory effect is shown in FIG.
【００１７】保湿能検定試験効果について述べる。上記
実施例１のサンプルについて尿素軟膏、白色ワセリンを
対照薬剤としてその保湿能の評価試験を実施した。２５
才の女性被験者の前腕屈側に(５cm×５cm)ｃｍ2の被験
部位を試料の数に加え、コントロ−ルの分も設定した。
それぞれの部位の角層水分含有量を測定した。実施例１
のサンプルは(５cm×５cm)ｃｍ2にカットしたものを被
験部位に貼付し、又軟膏群（尿素軟膏、白色ワセリン）
は、１．２５μｌ／ｃｍ2の塗布密度で均一に塗布し、
コントロ−ル部は、無処置とした。被験薬剤投与直後、
３０分、６０分、９０分、１２０分後に角質水分含有を
測定した、それぞれの被験部位での角質水分含有量は５
回ずつ行いその平均をとった。結果は図２に示したよう
に実施例１、２のサンプル及び尿素クリ−ムは塗布直
後、角質水分含有量を増加させたが特に前者は後者に比
較してその増加度も高くかつ持続性が認められた。又逆
に白色ワセリンは塗布部位の角質水分含有量が塗布直後
に低下したがこれは、水を含まない白色ワセリンの皮膜
が角層の伝導性を妨げたものと考えられた。 以上の結
果から実施例１、２のサンプルは、皮膚の保湿性に優れ
た効果をもつ薬剤(パップ剤)であり、化粧用保湿パック
剤としても評価されるものと判定した。 実施例１、２
の処方によるパップ剤及び１０％尿素、軟膏並びに白色
ワセリンとの保湿能比較は図２に示す通りである。The effect of the moisturizing ability test will be described. With respect to the sample of Example 1 above, an evaluation test of its moisturizing ability was carried out using urea ointment and white petrolatum as control agents. 25
A test site of (5 cm × 5 cm) cm 2 was added to the number of samples on the flexion side of the forearm of an old female subject, and the control part was also set.
The water content of the stratum corneum of each site was measured. Example 1
The sample of (5 cm x 5 cm) cm 2 was cut and attached to the test site, and the ointment group (urea ointment, white petrolatum)
Is uniformly applied at a coating density of 1.25 μl / cm 2 ,
The control part was untreated. Immediately after administration of the test drug,
The keratin water content was measured after 30, 60, 90 and 120 minutes, and the keratin water content at each test site was 5
We did it each time and took the average. As shown in FIG. 2, the samples of Examples 1 and 2 and urea cream increased the keratin water content immediately after application, but the former has a higher degree of increase than the latter and is persistent. Was recognized. On the contrary, white petrolatum reduced the water content of keratin at the application site immediately after application, which is considered to be because the white petrolatum film containing no water hindered the conductivity of the stratum corneum. From the above results, it was determined that the samples of Examples 1 and 2 are agents (puppies) having an excellent effect on moisturizing the skin, and are also evaluated as a cosmetic moisturizing pack agent. Examples 1, 2
A comparison of the moisturizing ability with the poultice, 10% urea, ointment and white petrolatum according to the above formula is shown in FIG.
─────────────────────────────────────────────────────
─────────────────────────────────────────────────── ───
【手続補正書】[Procedure amendment]
【提出日】平成３年１１月２９日[Submission date] November 29, 1991
【手続補正１】[Procedure Amendment 1]
【補正対象書類名】明細書[Document name to be amended] Statement
【補正対象項目名】全文[Correction target item name] Full text
【補正方法】変更[Correction method] Change
【補正内容】[Correction content]
【書類名】 明細書[Document name] Statement
【発明の名称】 パップ剤[Title of Invention] Patch
【特許請求の範囲】[Claims]
【発明の詳細な説明】Detailed Description of the Invention
【０００１】[0001]
【産業上の利用分野】本発明は産業廃棄物としての酒粕
を有効利用したパップ剤に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a poultice which effectively uses sake lees as industrial waste.
【０００２】[0002]
【従来の技術】酒粕は従来合成清酒の香味付与剤、焼酎
原料、酢の原料として使用されるほか、香味の面から漬
物材料（粕漬の材料）又は甘酒の材料とし、或はそのま
ま食用に供されてきた。然しながら年間３５万トンも清
酒生産の副産物として生産される酒粕の有効利用にも限
度があり、産業廃棄物としての処理に苦慮しているのが
現状である。2. Description of the Related Art Sake lees are conventionally used as a flavoring agent for synthetic sake, a raw material for shochu, and a raw material for vinegar. It has been. However, there is a limit to the effective use of sake lees produced as a by-product of sake production by 350,000 tons per year, and it is currently difficult to treat it as industrial waste.
【０００３】又外用剤としてのパップ剤は、従来その基
剤として保湿性に富む水溶性高分子であるゼラチン、ポ
リビニールアルコール、ポリアクリル酸ナトリウム等々
を単体として、又は複数剤を使用しているが多くの栄養
を含有することは勿論のこと薬用効果、化粧効果等を有
する多種の成分に富む酒粕が外用剤特にパップ剤として
利用されることはなかった。In addition, as a base for the poultice as an external preparation, gelatin, polyvinyl alcohol, sodium polyacrylate, etc., which are water-soluble high-moisture-containing polymers, have been conventionally used as a single substance or as a plurality of agents. However, the sake lees rich in various ingredients having a medicinal effect, a cosmetic effect, etc. as well as containing a lot of nutrients have never been used as an external preparation, particularly as a poultice.
【０００４】[0004]
【発明の解決しようとする課題】酒粕は酒精酵母の細胞
体つまり酵素のかたまりともいえ、麹菌体（コウジ酸）
及びリノール酸が多く含まれていると共に、ビタミンＢ
１，Ｂ２、Ｂ６，も含まれ、蛋白質にも富んでいる。然
も酒粕は従来の外用剤特にパップ剤の主剤であるゼラチ
ン、ポリピニールアルコール及びポリアクリル酸ナトリ
ウムと練合性も優れている等の性質を有するので従来の
パップ剤の基剤に酒粕を配合してパップ剤としての効果
を一層向上させると共に酒粕に含まれる有効成分による
皮膚疾患の治療に寄与せしめ更に産業廃棄物としての酒
粕のリサイクルにも寄与せんとするものである。Sake lees can be said to be the cell bodies of liquor yeast, that is, a group of enzymes, and koji cells (kojic acid).
And a lot of linoleic acid, vitamin B
It also contains 1 , B 2 , and B 6 , and is rich in protein. Of course, sake lees have properties such as excellent kneadability with gelatin, polypinyl alcohol and sodium polyacrylate, which are the main ingredients of conventional external preparations, especially poultices, so sake lees are blended with the base of conventional poultices. It further improves the effect as a poultice and contributes to the treatment of skin diseases caused by the active ingredient contained in sake lees, and also contributes to the recycling of sake lees as industrial waste.
【０００５】[0005]
【課題を解決するための手段】本発明は、ゼラチン、ポ
リビニールアルコール、ポリアクリル酸ナトリウム等を
パップ剤の基剤とし、これにカルボキシメチルセルロー
スナトリウム、グリセリン、カオリン等を配合してなる
膏体の中に更に酒粕を添加練合することを特徴とする構
成を有するが、膏体剤料中ポリビニールアルコール、カ
オリン、ゼラチンを精製水で加熱溶融し、これに酒粕を
添加して混合撹拌したものに、ポリアクリル酸ナトリウ
ム、カルボキシメチルセルロースナトリウム、グリセリ
ンを混合撹拌したものを加えて練合したのち支持体に圧
延してパップ剤とする。この際膏体に対する酒粕の添加
量は、１ｗ／ｗ％〜５０ｗ／ｗ％好ましくは２ｗ／ｗ〜
３０ｗ／ｗ％、より好ましくは５ｗ／ｗ％〜２０ｗ／ｗ
％を添加練合し、又膏体剤料中、ゼラチンに対してポリ
ビニールアルコールを２５：１量比〜１：５０量比、好
ましくは１５：１量比〜１：３０量比、より好ましくは
５：１量比〜１：５量比の配合比からなり、又ゼラチン
に対してポリアクリル酸ナトリウムは、２５：１量比〜
１：２５量比、好ましくは１５：１量比〜１：１５量
比、より好ましくは５：１量比〜１：５量比の配合比と
して混合撹拌した膏体であると酒粕との練合がより良好
である。Means for Solving the Problems The present invention provides a plaster prepared by using gelatin, polyvinyl alcohol, sodium polyacrylate, etc. as a base for poultices and adding carboxymethyl cellulose sodium, glycerin, kaolin, etc. It has a constitution characterized by further adding and kneading sake lees inside, but polyvinyl alcohol, kaolin, and gelatin in the plaster material are heated and melted with purified water, to which sake lees are added and mixed and stirred. Then, a mixture of sodium polyacrylate, sodium carboxymethyl cellulose, and glycerin mixed and stirred is added and kneaded, and then rolled on a support to obtain a poultice. At this time, the amount of sake lees added to the plaster is 1 w / w% to 50 w / w%, preferably 2 w / w to
30 w / w%, more preferably 5 w / w% to 20 w / w
%, And kneaded, and in the plaster material, polyvinyl alcohol to gelatin in the ratio of 25: 1 to 1:50, preferably 15: 1 to 1:30, more preferably Is a compounding ratio of 5: 1 to 1: 5, and the ratio of sodium polyacrylate to gelatin is 25: 1.
Mixing and stirring the paste with the sake lees as a mixing ratio of 1:25 volume ratio, preferably 15: 1 volume ratio to 1:15 volume ratio, more preferably 5: 1 volume ratio to 1: 5 volume ratio. Is better.
【０００６】[0006]
【実施例】 実施例１ Example 1
【０００７】[0007]
【実施例】 実施例２ Example 2
【０００８】[0008]
【実施例】 実施例３ 但し（酒粕を除く対比膏体） Example 3 Example 3 (comparative plaster excluding sake lees)
【０００９】上記の実施例１及び２において、ポリビニ
ールアルコールとカオリン及びゼラチンを精製水でもっ
て加熱溶解し、これに酒粕を加えて混合撹拌したもの
に、ポリアクリル酸ナトリウムとカルボキシメチルセル
ロースナトリウム及びグリセリンを混合撹拌したものを
加えて約１０分間練合した後１０００ｇ／ｍ２の割合で
支持体（不織布又は織布）上にロールにより圧延し、一
定面積にカットしてパップ剤とする。In the above-mentioned Examples 1 and 2, polyvinyl alcohol, kaolin and gelatin were heated and dissolved in purified water, to which sake lees were added and mixed and stirred, and sodium polyacrylate, sodium carboxymethyl cellulose and glycerin were added. Is mixed and stirred, and the mixture is kneaded for about 10 minutes, then rolled on a support (nonwoven fabric or woven fabric) at a rate of 1000 g / m 2 by a roll and cut into a certain area to give a poultice.
【００１０】実施例３は従来のパップ剤における膏体配
合剤料を本願実施例と同じくして本願実施例のパップ剤
とその効果ついて対比するための例であるが、混合撹拌
等の製造手順は実施例１、２と酒粕を除いて全く同一で
ある。Example 3 is an example for comparing the effect of the plaster compounding agent in the conventional poultice with the poultice of the present example in the same manner as in the present application, but the manufacturing procedure such as mixing and stirring. Is exactly the same as Examples 1 and 2 except for the sake lees.
【００１１】[0011]
【作用と効果について】酒粕の一般成分は、揮発性成分
（水分、アルコール分）と固形分とがほぼ等しく、主な
成分としてはアルコール分８％、蛋白質１５％、澱粉２
０％、酵母１５％〜２０％を占めている。酒粕には、ア
ミノ酸が含まれているが、特に蛋白質としては、アルカ
リ可溶区分（グリテリン），菌体蛋白及び水溶性区分
（アルブミン、ペプチッド、アミノ酸）が主である。又
酒粕中には約２０％の酵母菌体が在ることから核酸物質
及びビタミンも多く含まれ酒粕（米の未分解物と酒精酵
母の細胞体…酵素のかたまり。）は栄養価も高く蛋白質
を初めビタミンＢ１，Ｂ２、Ｂ６も含まれてる。[About action and effect] As for the general components of sake lees, the volatile components (water content, alcohol content) and the solid content are almost equal, and the main components are alcohol content 8%, protein 15%, starch 2
It accounts for 0% and yeast 15% to 20%. Sake lees contain amino acids, but in particular, the proteins are mainly alkali-soluble (glycerin), bacterial protein and water-soluble (albumin, peptide, amino acid). In addition, since about 20% of yeast cells are contained in sake lees, nucleic acid substances and vitamins are also contained in a large amount, and sake lees (undecomposed rice products and cell bodies of sake-yeast ... a group of enzymes.) Have a high nutritional value and protein. It also contains vitamins B 1 , B 2 and B 6 .
【００１２】又酒粕中には麹菌体（コウジ酸）及びリノ
ール酸が含まれており、コウジ酸やリノール酸は日やけ
によるシミ、ソバカスの予防に優れた効果即ち美白効果
があると報告されている。又日本酒を使った酒風呂が疲
労回復によく、肌にもよいとか、シミとり、しわの防止
には清酒が良いなどの報告もなされている。そこで出願
人は酒粕の持つこれらの性質に着目して酒粕を外用療法
に応用することを考え、外用剤の中でも特にパップ剤に
利用すべく研究した結果、酒粕はパップ剤を構成する水
溶性高分子であるゼラチン、ポリビニールアルコール及
びポリアクリル酸ナトリウムと極めて練合性も良く、従
来のパップ剤に比較して高い皮膚の保湿性に加えて皮膚
への高い粘着力を付与することが可能であることを発見
した。又酒粕の含有量に相関して肌の美白、皮膚保湿性
と肩こり、腰痛等の慢性疾患にも効果のあることがわか
った。It is reported that sake lees contain koji mold cells (kojic acid) and linoleic acid, and that kojic acid and linoleic acid have an excellent effect of preventing dark spots and freckles caused by sunburn, that is, a whitening effect. There is. It has also been reported that a sake bath using sake is good for fatigue recovery, good for the skin, and good for preventing stains and wrinkles. Therefore, the applicant considered focusing on these properties of the sake lees and applying the lees to the topical therapy, and as a result of researching to apply the lees to the poultices, as a result, the sake lees were highly soluble in the poultices. It has very good kneading properties with the molecules gelatin, polyvinyl alcohol and sodium polyacrylate, and in addition to having a higher moisturizing effect on the skin than conventional poultices, it is possible to give a high adhesive force to the skin. I found that. Further, it was found that it is also effective for the skin whitening, the skin moisturizing property and the chronic diseases such as stiff shoulders and low back pain in correlation with the content of sake lees.
【００１３】そこで実施例１、２に示す膏体基剤中ポリ
ビニールアルコールとカオリン、ゼラチンを同時に精製
水で加熱溶解し、これに酒粕を加えて混合撹拌し、この
混合撹拌したものに更にポリアクリル酸ナトリウム、カ
ルボキシメチルセルロースナトリウム及びグリセリンを
混合撹拌したものを加えて練合（約１０分間）すると練
合状態が極めて良好で支持体に圧延した場合でも均一な
品質のパップ剤が得られる。Therefore, polyvinyl alcohol, kaolin and gelatin in the plaster base as shown in Examples 1 and 2 were dissolved by heating in purified water at the same time, sake lees were added to the mixture, and the mixture was agitated. When a mixture obtained by mixing and stirring sodium acrylate, sodium carboxymethyl cellulose and glycerin is added and kneaded (for about 10 minutes), the kneaded state is very good and a poultice of uniform quality can be obtained even when rolled on a support.
【００１４】[0014]
【発明の効果】次に本発明パップ剤の効果について説明
する。先ず皮膚への美白作用効果であるが前記実施例
１、２、３のパップ剤サンプルを用いて着色性皮膚疾患
に対する治驗を実施した。その結果は次の表１に示すよ
うに酒粕を含有した実施例１及び実施例２のサンプルで
は、酒サ、女子顔面黒皮症、肝斑、雀卵斑、日焦、二次
性色素沈着などに対して美白作用が認められた。The effects of the poultice of the present invention will be described below. First, for the whitening effect on the skin, using the poultice samples of Examples 1, 2, and 3 described above, the treatment for pigmented skin diseases was carried out. The results are shown in Table 1 below. In the samples of Example 1 and Example 2 containing sake lees, the sake liquor, female facial melasma, melasma, erythema speciosa, sunburn, secondary pigmentation A whitening effect was recognized against the above.
【００１５】[0015]
【表１】 [Table 1]
【００１６】次に抗炎症作用効果であるが、実施例１、
２、３のパップ剤サンプルを用いてラットの炎症動物モ
デルを使用してその抗炎症作用を実験した。Ｗｉｓｔａ
ｒ系雄ラット（体重１８０ｇ〜２００ｇ）の右後肢にサ
ンプル（２．５ｃｍ×３．０ｃｍ，０．７５ｇ）を貼付
し、４時間後に各サンプルを剥離除去した後、起炎剤１
％カラゲニン懸濁液０．１ｍｌを右後肢足蹠皮下に注射
した。その後経時的に５時間までラットの足容積を測定
し、起炎剤注射前の足容積から浮腫率を算出し、無処置
対照群に対する抑制効果を求めた。なお各サンプルは前
処置に限定し、動物数は一群ｎ＝１０とした。その抗炎
症効果は図１に示す通りである。Next, regarding the anti-inflammatory effect, Example 1
Its anti-inflammatory effect was tested using a rat animal model of inflammation with a few poultice samples. Wista
A sample (2.5 cm × 3.0 cm, 0.75 g) was attached to the right hind limb of an r-type male rat (body weight: 180 g to 200 g), and each sample was peeled off after 4 hours, and then the inflammatory agent 1
0.1 ml of a% carrageenin suspension was injected subcutaneously in the footpad of the right hind leg. After that, the rat paw volume was measured for 5 hours, and the edema rate was calculated from the paw volume before injection of the inflammatory agent, and the inhibitory effect on the untreated control group was determined. Each sample was limited to pretreatment, and the number of animals was n = 10 per group. The anti-inflammatory effect is shown in FIG.
【００１７】保湿能検定試験効果について述べる。上記
実施例１のサンプルについて尿素軟膏、白色ワセリンを
対照薬剤としてその保湿能の評価試験を実施した。２５
才の女性被験者の前腕屈側に（５ｃｍ×５ｃｍ）ｃｍ２
の被験部位を試料の数に加え、コントロールの分も設定
した。それぞれの部位の角層水分含有量を測定した。実
施例１のサンプルは（５ｃｍ×５ｃｍ）ｃｍ２にカット
したものを被験部位に貼付し、又軟膏群（尿素軟膏、白
色ワセリン）は、１．２５μｌ／ｃｍ２の塗布密度とで
均一に塗布し、コントロール部は、無処置とした。被験
薬剤投与直後、３０分、６０分、１２０分後に角質水分
含有を測定した、それぞれの被験部位での角質水分含有
量は５回ずつ行いその平均をとった。結果は図２に示し
たように実施例１、２のサンプル及び尿素クリームは塗
布直後、角質水分含有量を増加させたが特に前者は後者
に比較してその増加度も高くかつ持続性が認められた。
又逆に白色ワセリンは塗布部位の角質水分含有量が塗布
直後に低下したがこれは、水を含まない白色ワセリンの
皮膜が角層の伝導性を妨げたものと考えられた。以上の
結果から実施例１、２のサンプルは、皮膚の保湿性に優
れた効果をもつ薬剤（パップ剤）であり、化粧用保湿パ
ック剤としても評価されるものと判定した。実施例１、
２の処方によるパップ剤及び１０％尿素、軟膏並びに白
色ワセリンとの保湿能比較は図２に示す通りである。The effect of the moisturizing ability test will be described. With respect to the sample of Example 1 above, an evaluation test of its moisturizing ability was carried out using urea ointment and white petrolatum as control agents. 25
-Year-old female subject (5 cm x 5 cm) cm 2 on the forearm flexion side
The test site of was added to the number of samples, and a control part was also set. The water content of the stratum corneum of each site was measured. The sample of Example 1 was cut to (5 cm × 5 cm) cm 2 and attached to the test site, and the ointment group (urea ointment, white petrolatum) was applied uniformly with an application density of 1.25 μl / cm 2. However, the control part was left untreated. Immediately after administration of the test drug, 30 minutes, 60 minutes, and 120 minutes later, the keratin water content was measured. The keratin water content at each test site was measured 5 times and the average was taken. As shown in FIG. 2, the samples of Examples 1 and 2 and the urea cream increased the keratin water content immediately after the application, but the former has a higher degree of increase and is more persistent than the latter. Was given.
On the contrary, white petrolatum reduced the water content of keratin at the application site immediately after application, which is considered to be because the white petrolatum film containing no water hindered the conductivity of the stratum corneum. From the above results, it was determined that the samples of Examples 1 and 2 are drugs (puppies) having an excellent effect on the skin moisturizing property and are evaluated as a moisturizing pack for cosmetics. Example 1,
A comparison of the moisturizing ability with the poultice, 10% urea, ointment and white petrolatum according to the formulation of No. 2 is shown in FIG.
【図面の簡単な説明】[Brief description of drawings]
【図１】酒粕使用パップ剤の抗炎症効果を示す説明図
（グラフ）FIG. 1 is an explanatory diagram (graph) showing the anti-inflammatory effect of a poultice using sake lees.
【図２】酒粕使用パップ剤の保湿能試験結果を示す説明
図（グラフ） ─────────────────────────────────────────────────────
[Fig. 2] Explanatory drawing (graph) showing the results of the moisturizing ability test of the poultices using sake lees ─────────────────────────────── ───────────────────────
【手続補正書】[Procedure amendment]
【提出日】平成４年１１月１６日[Submission date] November 16, 1992
【手続補正１】[Procedure Amendment 1]
【補正対象書類名】明細書[Document name to be amended] Statement
【補正対象項目名】図面の簡単な説明[Name of item to be corrected] Brief description of the drawing
【補正方法】追加[Correction method] Added
【補正内容】[Correction content]
【図面の簡単な説明】[Brief description of drawings]
【図１】酒粕使用パップ剤と酒粕を使用しないパップ剤
との抗炎症効果の比較を線グラフで表示した図である。FIG. 1 is a line graph showing a comparison of the anti-inflammatory effect of a poultice using sake lees and a poultice not using sake lees.
【図２】酒粕使用パップ剤の保湿能試験結果を線グラフ
で表示した図である。FIG. 2 is a line graph showing the results of the moisturizing ability test of a poultice using sake lees.
Claims (3)
リアクリル酸ナトリウム等を基剤とした膏体と酒粕とを
練合してなることを特徴とするパップ剤。1. A poultice characterized by kneading a paste based on gelatin, polyvinyl alcohol, sodium polyacrylate or the like and sake lees.
リアクリル酸ナトリウム等水溶性高分子剤を基剤とし、
他にカルボキシメチルセルロ−スナトリウム、グリセリ
ン、カオリン等を適宜加えてなる膏体と酒粕とを精製水
を媒介として練合した構成を有し、前記膏体に対する酒
粕の添加量は、１ｗ/ｗ％〜５ｗ/ｗ％好ましくは２ｗ/
ｗ〜３０ｗ/ｗ％、より好ましくは５ｗ/ｗ％〜２０ｗ/
ｗ％を添加練合してなる前記請求項１記載のパップ剤。2. A water-soluble polymer agent such as gelatin, polyvinyl alcohol, sodium polyacrylate, etc. as a base,
Other sodium carboxymethyl cellulose, glycerin, having a configuration of kneading paste and sake lees made by appropriately adding kaolin and the like with purified water as a medium, the amount of sake lees added to the plaster is 1 w / w % To 5 w / w%, preferably 2 w /
w-30 w / w%, more preferably 5 w / w% -20 w /
The poultice according to claim 1, wherein w% is added and kneaded.
ルを２５:１量比〜１:５０量比、好ましくは１５:１量
比〜１:３０量比、より好ましくは５:１量比〜１:５量
比の配合比からなり、 又ゼラチンに対してポリアクリル酸ナトリウムは、２
５:１量比〜１:２５量比、好ましくは１５:１量比〜１:
１５量比、より好ましくは５:１量比〜１:５量比の配合
比となしたことを特徴とする前記請求項１又は２記載の
パップ剤。 【０００１】3. Polyvinyl alcohol for gelatin
Gelatin in a ratio of 25: 1 to 1:50, preferably 15: 1 to 1:30, and more preferably 5: 1 to 1: 5. Whereas sodium polyacrylate is 2
5: 1 volume ratio to 1:25 volume ratio, preferably 15: 1 volume ratio to 1:
The poultice according to claim 1 or 2, wherein the blending ratio is 15 parts by weight, more preferably 5: 1 to 1: 5. [0001]
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3302654A JPH0772132B2 (en) | 1991-10-23 | 1991-10-23 | Poultice |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3302654A JPH0772132B2 (en) | 1991-10-23 | 1991-10-23 | Poultice |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH06293637A true JPH06293637A (en) | 1994-10-21 |
| JPH0772132B2 JPH0772132B2 (en) | 1995-08-02 |
Family
ID=17911589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3302654A Expired - Fee Related JPH0772132B2 (en) | 1991-10-23 | 1991-10-23 | Poultice |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0772132B2 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991019035A1 (en) * | 1990-05-28 | 1991-12-12 | Kanebo, Ltd. | Method of inspecting cleanliness of top and device used therefor |
| JPH1192357A (en) * | 1997-09-25 | 1999-04-06 | Chieko Kabashima | Basic cosmetic for adjusting skin |
| CN1084184C (en) * | 1998-06-04 | 2002-05-08 | 天津大学 | Substrate of medical health-care plaster for external use and its preparation method |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03161433A (en) * | 1989-11-20 | 1991-07-11 | Lion Corp | patch |
| JPH03232811A (en) * | 1990-02-07 | 1991-10-16 | Toshie Tokuyama | Cosmetic |
-
1991
- 1991-10-23 JP JP3302654A patent/JPH0772132B2/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03161433A (en) * | 1989-11-20 | 1991-07-11 | Lion Corp | patch |
| JPH03232811A (en) * | 1990-02-07 | 1991-10-16 | Toshie Tokuyama | Cosmetic |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991019035A1 (en) * | 1990-05-28 | 1991-12-12 | Kanebo, Ltd. | Method of inspecting cleanliness of top and device used therefor |
| JPH1192357A (en) * | 1997-09-25 | 1999-04-06 | Chieko Kabashima | Basic cosmetic for adjusting skin |
| CN1084184C (en) * | 1998-06-04 | 2002-05-08 | 天津大学 | Substrate of medical health-care plaster for external use and its preparation method |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0772132B2 (en) | 1995-08-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69023574T2 (en) | Amphoteric compositions and polymer forms of alpha-hydroxy acids, and their therapeutic use. | |
| DE69802005T2 (en) | COMBINATION OF PROLAMINES AND POLAR VEGETABLE LIPIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE | |
| DE69715049T2 (en) | EXTERNAL CONTAINING TRANILAST AND METHOD FOR THE PRODUCTION THEREOF | |
| CA2309688C (en) | Penetration enhancing and irritation reducing systems | |
| US4416873A (en) | Combined allantoin-hydrolyzed animal protein skin preparation | |
| KR20070072482A (en) | Organogel Formulations for Therapeutic Applications | |
| JPS611623A (en) | Permeation promoting composition and method through skin andmembrane by local drug and general drug | |
| EP0127840A1 (en) | Antiinflammatory analgesic gelled ointments | |
| WO2001085156A1 (en) | Dermal compositions containing coenzyme q as the active ingredient | |
| US5098717A (en) | Method of treatment for pruritus | |
| DE1795067A1 (en) | Collagen hydrolyzate and depolymerized product and process for its production | |
| JP4681132B2 (en) | Nitric oxide synthase production promoter and cosmetic or pharmaceutical composition | |
| JP2001302690A (en) | Skin-permeable tripeptide, skin-permeable collagen peptide, skin-permeable care preparation and highly absorbable food | |
| JPH07194375A (en) | Promoter for synthesizing collagen and collagen metabolism activator | |
| CN102688483A (en) | Composition for treating skin diseases, preparation containing composition and preparation method of preparation | |
| JPH06293637A (en) | Cataplasm | |
| CN107519236A (en) | A kind of topical agent for treating onychomycosis | |
| JPS617209A (en) | Hair tonic composition | |
| EP0428352A1 (en) | Anti-inflammatory compositions for external use | |
| JP4851046B2 (en) | Cellular amino acid uptake promoter and pharmaceutical composition for cells | |
| CN101618030A (en) | Triptolide transdermal patch and preparation method thereof | |
| CN110448518A (en) | A kind of preparation method of whitening body lotion | |
| US20040072789A1 (en) | Veterinary composition for the topical treatment of traumatized or inflamed skin | |
| CN113134075B (en) | Antibacterial peptide cream and preparation method thereof | |
| DE212022000135U1 (en) | Topical composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| S531 | Written request for registration of change of domicile |
Free format text: JAPANESE INTERMEDIATE CODE: R313532 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| LAPS | Cancellation because of no payment of annual fees |