JPS5446836A - Antibacterial composition - Google Patents
Antibacterial compositionInfo
- Publication number
- JPS5446836A JPS5446836A JP11402177A JP11402177A JPS5446836A JP S5446836 A JPS5446836 A JP S5446836A JP 11402177 A JP11402177 A JP 11402177A JP 11402177 A JP11402177 A JP 11402177A JP S5446836 A JPS5446836 A JP S5446836A
- Authority
- JP
- Japan
- Prior art keywords
- gram
- antibacterial
- penicillin
- antibacterial composition
- aminoglycoside
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 3
- 239000002647 aminoglycoside antibiotic agent Substances 0.000 abstract 2
- CFOGIGZVKWLSHG-UHFFFAOYSA-N 2-(aminomethyl)-6-[4,6-diamino-3-(4-amino-3,5-dihydroxy-6-methyloxan-2-yl)oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol Chemical compound OC1C(N)C(O)C(C)OC1OC1C(O)C(OC2C(C(O)C(O)C(CN)O2)O)C(N)CC1N CFOGIGZVKWLSHG-UHFFFAOYSA-N 0.000 abstract 1
- 241000192125 Firmicutes Species 0.000 abstract 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229940126574 aminoglycoside antibiotic Drugs 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229960000318 kanamycin Drugs 0.000 abstract 1
- 229930027917 kanamycin Natural products 0.000 abstract 1
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 abstract 1
- 229930182823 kanamycin A Natural products 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- RBKMMJSQKNKNEV-RITPCOANSA-N penicillanic acid Chemical compound OC(=O)[C@H]1C(C)(C)S[C@@H]2CC(=O)N21 RBKMMJSQKNKNEV-RITPCOANSA-N 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: To provide an antibacterial agent having strong synergistic effect, a braod antibacterial spectrum to gram-negative- and gram-positive bacteria including Pseudomonas aeruginosa, and low side effects; containing specific D(-)-penicillin analogs and aminoglycoside antibiotics.
CONSTITUTION: An antibacterial composition containing (A) a D(-)-penicillin analog of formula (R1 is H, hydroxy, lower alkyxycarbonyloxy, acyloxy; R2 is H, halogen, nitro; R3 is lower alkyl; n is 1, 2), e.g. 6-[D-(-)-α-(4-ethyl-2, 3-dioxo-1- piperazinocarbonylamino)-p-(ethoxycarbonyloxy)phenylacetamido]penicillanic acid, and (B) an aminoglycoside antibiotic such as kanamycin, deoxykanamycin, etc. The ratio of (A) to (B) is 200:1-1:2, usually 100:1-1:1, and pref. 50:1;30:1.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11402177A JPS5446836A (en) | 1977-09-22 | 1977-09-22 | Antibacterial composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11402177A JPS5446836A (en) | 1977-09-22 | 1977-09-22 | Antibacterial composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5446836A true JPS5446836A (en) | 1979-04-13 |
Family
ID=14627051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11402177A Pending JPS5446836A (en) | 1977-09-22 | 1977-09-22 | Antibacterial composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5446836A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04362934A (en) * | 1990-10-11 | 1992-12-15 | Fuji Photo Film Co Ltd | Silver halide photographic sensitive material |
| JPH06130613A (en) * | 1992-10-16 | 1994-05-13 | Fuji Photo Film Co Ltd | Stabilizing solution and rinse solution for silver halide color photographic sensitive material and processing method using them |
| WO2000020009A1 (en) * | 1998-10-05 | 2000-04-13 | Kabushiki Kaisha Yakult Honsha | Antibacterial agents and process for producing the same |
| AU2007200916B2 (en) * | 1998-10-05 | 2009-09-17 | Kabushiki Kaisha Yakult Honsha | Antibacterial agents and process for producing the same |
| US20100063273A1 (en) * | 2007-01-31 | 2010-03-11 | Toyama Chemical Co., Ltd | Novel crystal of piperacillin sodium |
-
1977
- 1977-09-22 JP JP11402177A patent/JPS5446836A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04362934A (en) * | 1990-10-11 | 1992-12-15 | Fuji Photo Film Co Ltd | Silver halide photographic sensitive material |
| JPH06130613A (en) * | 1992-10-16 | 1994-05-13 | Fuji Photo Film Co Ltd | Stabilizing solution and rinse solution for silver halide color photographic sensitive material and processing method using them |
| WO2000020009A1 (en) * | 1998-10-05 | 2000-04-13 | Kabushiki Kaisha Yakult Honsha | Antibacterial agents and process for producing the same |
| US7498317B2 (en) | 1998-10-05 | 2009-03-03 | Kabushiki Kaisha Yakult Honsha | Antibacterial agents and process for producing the same |
| AU2007200916B2 (en) * | 1998-10-05 | 2009-09-17 | Kabushiki Kaisha Yakult Honsha | Antibacterial agents and process for producing the same |
| US20100063273A1 (en) * | 2007-01-31 | 2010-03-11 | Toyama Chemical Co., Ltd | Novel crystal of piperacillin sodium |
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