JPS5498793A - Deacylated antibiotic and its preparation - Google Patents
Deacylated antibiotic and its preparationInfo
- Publication number
- JPS5498793A JPS5498793A JP807877A JP807877A JPS5498793A JP S5498793 A JPS5498793 A JP S5498793A JP 807877 A JP807877 A JP 807877A JP 807877 A JP807877 A JP 807877A JP S5498793 A JPS5498793 A JP S5498793A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- deacylated
- antibiotic
- antibiotics
- acyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000003115 biocidal effect Effects 0.000 title abstract 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 2
- 229940088710 antibiotic agent Drugs 0.000 abstract 2
- 150000001875 compounds Chemical group 0.000 abstract 2
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 108090000371 Esterases Proteins 0.000 abstract 1
- 241000187654 Nocardia Species 0.000 abstract 1
- 241000187681 Nocardia sp. Species 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 235000019658 bitter taste Nutrition 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- -1 isovaleryl Chemical group 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
NEW MATERIAL:A deacylated antibiotic of formula I: (R1 is H, acetyl, or propionyl group) and its salt.
EXAMPLE: Isoleucomycin V(R1 is H in the formula I).
USE: A starting material for 13-acyl antibiotics, capable of giving the 13-acyl antibiotics having a good antibacterial spectrum and concentration in the blood free from bitterness by acylating OH groups at the 13- and 4"-positions of the compound of formula I.
PROCESS: Esterase-producing bacteria, e.g. Nocardia sp., FERM-P No. 2019, which fall under the genus Nocardia or Stuphylotrichum, are cultured in a liquid medium at 27W32°C for 2W5 days, and the cultured or treated product is reacted with an autibiotic of formula II: (R2 is acetyl, propionyl, butyryl, or isovaleryl group) in an aqueous solution at pH7W10, preferably 9, at 37°C for 30 min W 3 days to decompose the ester group at the 4"-position, and the fittrate is extracted with benzene to give the compound of formula I.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP807877A JPS5498793A (en) | 1977-01-27 | 1977-01-27 | Deacylated antibiotic and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP807877A JPS5498793A (en) | 1977-01-27 | 1977-01-27 | Deacylated antibiotic and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5498793A true JPS5498793A (en) | 1979-08-03 |
Family
ID=11683292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP807877A Pending JPS5498793A (en) | 1977-01-27 | 1977-01-27 | Deacylated antibiotic and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5498793A (en) |
-
1977
- 1977-01-27 JP JP807877A patent/JPS5498793A/en active Pending
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