JPS5519249A - Optically active 1,5-benzothiazepine derivative - Google Patents

Optically active 1,5-benzothiazepine derivative

Info

Publication number
JPS5519249A
JPS5519249A JP9299878A JP9299878A JPS5519249A JP S5519249 A JPS5519249 A JP S5519249A JP 9299878 A JP9299878 A JP 9299878A JP 9299878 A JP9299878 A JP 9299878A JP S5519249 A JPS5519249 A JP S5519249A
Authority
JP
Japan
Prior art keywords
optically active
cis
methylpiperadinyl
benzothiazepin
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9299878A
Other languages
Japanese (ja)
Inventor
Kihachiro Izumi
Mikio Hori
Sachio Ono
Seishi Mizukoshi
Kazuo Kato
Hajime Yamamoto
Mitsuaki Nagasaka
Yoshiki Nakamura
Makoto Mori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Maruko Pharmaceutical Co Ltd
Original Assignee
Maruko Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maruko Pharmaceutical Co Ltd filed Critical Maruko Pharmaceutical Co Ltd
Priority to JP9299878A priority Critical patent/JPS5519249A/en
Priority to GB7904882A priority patent/GB2017080B/en
Priority to CA321,396A priority patent/CA1114818A/en
Priority to DE19792905637 priority patent/DE2905637C3/en
Priority to US06/012,091 priority patent/US4264497A/en
Priority to ES477709A priority patent/ES477709A1/en
Priority to CH142479A priority patent/CH639660A5/en
Priority to FR7903753A priority patent/FR2416890A1/en
Publication of JPS5519249A publication Critical patent/JPS5519249A/en
Pending legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

NEW MATERIAL:A cis-form optically active 1,5-benzothiazepine dervative of the formula and its salts.
EXAMPLE: cis-(-)-2,3-Dihydro-3-[(4-methylpiperadinyl) methyl]-2-phenyl-1,5- benzothiazepin-4(5H)-one.
USE: Anti-acetylcholine and antitumor agents, having a greater action than the racemic isomer, and with weak side effects and low toxicity.
PROCESS: cis (±)-2,3-Dihydro-3-[(4-methylpiperadinyl) methyl]-2-phenyl-1,5- benzothiazepin-4(5H)-one is reacted with an optically active acid, e.g. (+) or (-)- tartaric acid in a solvent, e.g. CH3OH, to dissolve the (+) and (-) optically active salts which deposit due to the solubility difference in water. The solution is neutralized with Na2CO3, etc. to give the compound of the formula.
COPYRIGHT: (C)1980,JPO&Japio
JP9299878A 1978-02-14 1978-07-29 Optically active 1,5-benzothiazepine derivative Pending JPS5519249A (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP9299878A JPS5519249A (en) 1978-07-29 1978-07-29 Optically active 1,5-benzothiazepine derivative
GB7904882A GB2017080B (en) 1978-02-14 1979-02-12 Benzothiazepines
CA321,396A CA1114818A (en) 1978-02-14 1979-02-13 1,5-benzothiazepine compounds and process for preparing the same
DE19792905637 DE2905637C3 (en) 1978-02-14 1979-02-14 1,5-benzothiazepine derivatives
US06/012,091 US4264497A (en) 1978-02-14 1979-02-14 1,5-Benzothiazepine compounds
ES477709A ES477709A1 (en) 1978-02-14 1979-02-14 Benzothiazepines
CH142479A CH639660A5 (en) 1978-02-14 1979-02-14 1,5-benzothiazepine COMPOUNDS AND PROCESS FOR PRODUCING.
FR7903753A FR2416890A1 (en) 1978-02-14 1979-02-14 1,5-BENZOTHIAZEPINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9299878A JPS5519249A (en) 1978-07-29 1978-07-29 Optically active 1,5-benzothiazepine derivative

Publications (1)

Publication Number Publication Date
JPS5519249A true JPS5519249A (en) 1980-02-09

Family

ID=14070022

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9299878A Pending JPS5519249A (en) 1978-02-14 1978-07-29 Optically active 1,5-benzothiazepine derivative

Country Status (1)

Country Link
JP (1) JPS5519249A (en)

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