JPS56147765A - Preparation of active vitamin d3 - Google Patents

Preparation of active vitamin d3

Info

Publication number
JPS56147765A
JPS56147765A JP5025880A JP5025880A JPS56147765A JP S56147765 A JPS56147765 A JP S56147765A JP 5025880 A JP5025880 A JP 5025880A JP 5025880 A JP5025880 A JP 5025880A JP S56147765 A JPS56147765 A JP S56147765A
Authority
JP
Japan
Prior art keywords
formula
compound
hydroxycholesta
diene
unreacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5025880A
Other languages
Japanese (ja)
Other versions
JPS6034949B2 (en
Inventor
Osamu Nishikawa
Kenji Ishimaru
Toru Takeshita
Hideki Tsuruta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP55050258A priority Critical patent/JPS6034949B2/en
Priority to EP80303732A priority patent/EP0028484B1/en
Priority to DK447380A priority patent/DK160817C/en
Priority to DE8080303732T priority patent/DE3070985D1/en
Priority to CA000362937A priority patent/CA1160217A/en
Publication of JPS56147765A publication Critical patent/JPS56147765A/en
Priority to US06/371,870 priority patent/US4388243A/en
Publication of JPS6034949B2 publication Critical patent/JPS6034949B2/en
Expired legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain the titled compound useful as a calcium metabolic adjustor, by isomerizing a hydroxycholesta-5,7-diene protected by a lower alkoxy group thermally under irradiation of ultraviolet light.
CONSTITUTION: A hydroxycholesta-5,7-diene of formula I (R1 and R2 are lower alkoxycarbonyl R3 and R4 are H or lower alkoxycarbonyloxy) is isomerized thermally under irradiation of ultraviolet light to give a mixture of an active vitamin D3 derivative of formula II in which the hydroxyl groups are protected with the unreacted hydroxycholesta-5, 7-diene of formula I. The unreacted compound of formula I and the compound of formula II are then separated from the resultant mixture, and the unreacted compound of formula I is circulated for reuse. The protecting groups in the compound of formula II are then removed to afford the titled compound of formula III (R3' and R4' are H or OH).
COPYRIGHT: (C)1981,JPO&Japio
JP55050258A 1979-10-23 1980-04-18 Production method of active vitamin D↓3 types Expired JPS6034949B2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP55050258A JPS6034949B2 (en) 1980-04-18 1980-04-18 Production method of active vitamin D↓3 types
EP80303732A EP0028484B1 (en) 1979-10-23 1980-10-22 Process for the preparation of active-type vitamin d3 compounds and of the cholesta-5,7-diene precursors, and products so obtained
DK447380A DK160817C (en) 1979-10-23 1980-10-22 PROCEDURE FOR THE PREPARATION OF VITAMIN D3 COMPOUNDS
DE8080303732T DE3070985D1 (en) 1979-10-23 1980-10-22 Process for the preparation of active-type vitamin d3 compounds and of the cholesta-5,7-diene precursors, and products so obtained
CA000362937A CA1160217A (en) 1979-10-23 1980-10-22 Process for the preparation of active-type vitamin d.sub.3 compounds
US06/371,870 US4388243A (en) 1979-10-23 1982-04-26 Process for the preparation of active-type vitamin D3 compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55050258A JPS6034949B2 (en) 1980-04-18 1980-04-18 Production method of active vitamin D↓3 types

Publications (2)

Publication Number Publication Date
JPS56147765A true JPS56147765A (en) 1981-11-16
JPS6034949B2 JPS6034949B2 (en) 1985-08-12

Family

ID=12853948

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55050258A Expired JPS6034949B2 (en) 1979-10-23 1980-04-18 Production method of active vitamin D↓3 types

Country Status (1)

Country Link
JP (1) JPS6034949B2 (en)

Also Published As

Publication number Publication date
JPS6034949B2 (en) 1985-08-12

Similar Documents

Publication Publication Date Title
JPS56147765A (en) Preparation of active vitamin d3
JPS5441856A (en) 1 hydroxyy244oxoovitamin d3 and its preparation
JPS56145946A (en) Stabilized polyurethane composition
JPS5622763A (en) 25-hydroxy-24-oxovitamin d3, or its hydroxyl-protecting derivative and its preparation
JPS5740414A (en) Novel active type vitamin d3 derivative composition
JPS5626847A (en) Preparation of substituted salicylic acid derivative
JPS5692267A (en) Preparation of active vitamin d3
JPS5692266A (en) Preparation of active vitamin d3
JPS56138189A (en) 4-piperidone ketal derivative
JPS55108898A (en) 25-hydroxy-24-oxocholesterol derivative and its preparation
JPS55111461A (en) 24,25,26-trihydroxyvitamin d3 or its derivative having protected hydroxyl group and its preparation
JPS56122348A (en) 25-hydroxy-26,26,26-trifluorovitamin d3, its oh-protected derivative, and its preparation
JPS5283524A (en) Novel dicarbonyl compounds
JPS5414951A (en) Preparation of vitamin d derivatives
JPS5610173A (en) Analgesic
JPS5576858A (en) 24-fluoro-25-hydroxyvitamin d3 or its oh-protected derivative, and their preparation
JPS5740415A (en) Novel active type vitamin d3 derivative composition
JPS56122349A (en) 25-hydroxy-26,26,26-trifluoro-27-norvitamin d3, its hydroxylprotected derivative, and their preparation
JPS5772913A (en) Remedy for cardiac infraction
JPS5432487A (en) Preparation of 1-carbamoyluracils
JPS5368777A (en) Preparation of phenyathridine
JPS52111923A (en) Production of quinozolone derivative
JPS53101308A (en) Derivative of 5,6-dihydro-2h-pyran and its preparation
JPS5661351A (en) 1alpha,25-dihydroxy-24-oxocholecalciferols and their preparation
JPS574936A (en) 2-n-amyl-3-hydroxy-3-methyl-4-cyclopentenone and its preparation