JPS5840924B2 - hair nourishing composition - Google Patents

Description

[Detailed description of the invention] The present invention relates to a hair-growth composition having excellent hair-growth effects.

Conventionally, various hair growth compositions have been used for the prevention and treatment of alopecia.

There are various symptoms of alopecia, and the causes and hair loss mechanisms are as follows:
Although it is still largely unknown, when looking at alopecia comprehensively, some kind of abnormality occurs in various parts of the skin, including the capillary system, the epidermal system, and the epidermal system.

Therefore, hair growth compositions contain various medicinal agents that have the effect of preventing or suppressing these abnormalities, such as various fungicides, keratolytic agents such as salicylic acid and resorcin, female hormones, and vitamins such as vitamin E and biotin. Amino acids such as serine and methionine, vasodilators such as nicotinic acid derivatives and acetylcholine derivatives, and skin function enhancers such as cephalanthine and photosensitive pigments are included.

However, when applied externally, hair nourishing compositions exert their effectiveness by preventing or suppressing dandruff, itching, and dead hair, and by promoting hair growth and hair growth, but no product has yet been found that is fully satisfactory. .

While carrying out various studies on medicinal agents that have a hair-growth effect, the present inventors discovered that certain compounds that have an α-adrenergic blocking effect exhibit an excellent hair-growth effect, and this led to the completion of the present invention. Ta.

That is, the present invention provides a hair nourishing composition containing a compound selected from tolazoline, phentolamine, thymoxamine, phenoxybenzamine, and azapetine as an essential component.

All of these compounds have α-adrenergic blocking effects, are thought to exert excellent hair growth effects through dilation of peripheral blood vessels and activation of epidermal cells, and have good transdermal absorption (
The hair growth composition of the present invention has extremely excellent performance because of its low systemic effects and toxicity.

Next, the results of testing the hair growth effects of these compounds are shown.

Samples were prepared by adding each compound to 70% ethanol at a concentration of 1% (W/
V).

The test was conducted using a newly developed mouse hair growth measurement method.

That is, 9 to 10 5-week-old ddY male mice were
The left and right buttocks of each mouse were removed as a group, and 70% ethanol was applied to the right side as a control side, and a sample was applied to the left side as a test side, each at 0.1 mA! After applying each sample twice a day for 10 days, the hair on both sides was removed and the difference in average hair length between the control side and the test side was examined to examine the effect of the sample on mouse hair growth.

The results are shown in Table 1 below.

As shown in Table 1, the compounds used in the present invention have excellent hair growth effects.

In the present invention, these compounds can be used in free form or in the form of their pharmaceutically acceptable salts, and the amount to be added can be selected as appropriate, but usually the amount is 0.001-10% (weight%, same below)
It is preferable to mix them.

The hair growth composition of the present invention can be made into conventional dosage forms such as hair tonics, hair lotions, hair creams, shampoos, and conditioners according to conventional methods.

Other ingredients may be those that are normally used in the production of these products, such as distilled water, alcohols, polyhydric alcohols, oils and fats, surfactants, etc. as a base,
In addition, as medicinal ingredients, resorcinol, hormones,
Vitamins, nicotinic acid derivatives, photosensitive pigments, amino acids, etc., fungicides, menthol, other fragrances, etc. may be added.

Next, the present invention will be explained in more detail with reference to Examples, but the present invention is not limited thereto.

Example 1 A hair tonic with excellent hair growth effects was produced by a conventional method according to the following recipe.

Ingredients 95% ethanol % 0 Growth minutes Solubilizer [polyoxyethylene hardened castor Sea oil (60EO)] fragrance Tolazoline Distilled water 0.5 Adjust the total amount to 100% Example 2 According to the following prescription, by the usual method, produced a hair tonic.

Excellent ingredient for hair growth effect 95% Ethanol 0 Solubilizer [polyoxyethylene hydrogenated castor oil (60EO)] 1 Fragrance 0.5 Azapetine 1 Distilled water
Adjusting the total amount to 100% Example 3 A hair lotion was prepared by a conventional method according to the following recipe.

Predominant ingredient for hair growth effect Stearic acid (63℃) Ingredient cetanol 0.5 Emulsifier [polyoxyethylene (20EO) sorbitan sesquioleate] 0.8 Preservative and fragrance triethanolamine 0.4 Glyceryntimoxamine 0.05 95 % Ethanol Total amount of distilled water Adjusted to ioo% Example 4 A hair cream was prepared by a conventional method according to the following formulation.

Ingredients for hair growth: Beesuro lanolin (anhydrous) Vaseline Liquid paraffin 3 Emulsifier [polyoxyethylene (20EO) sorbitan monostearate] Ingredients Preservative and fragrance Phentolamine Borax propylene glycol Distilled water Example 5 According to the following recipe, use the conventional method A shampoo with excellent hair growth effects was produced.

share sodium lauryl sulfate Magnesium stearate polyvinyl alcohol cetyl alcohol lanolin glycerin laurate Phenoxypenzamine Distilled water % 5 ■ 0.01 Adjust the total amount to 100%

Claims (1)

[Scope of Claims] 1. A hair nourishing composition comprising a compound selected from tolazoline, phentolamine, thymoxamine, phenoxybenzamine, and azapetine as an essential component. 2. The composition according to item 1 above, containing 0.001 to 10% by weight of the compound.