JPS5864953A - Instantaneously opened vessel - Google Patents

Abstract

An easy-open container for the storage of blood components is a bag of flexible material having a body (10) provided with frangible seams (20) which join at an apex (22) of the body; a closure seam (24) transversely intersects the apex (22) and is designed to be ruptured at the apex (22) so that the body (10) can be torn open along the frangible seams (20) to separate it from its contents, when the bag is gripped to either side of the apex (22) and pulled apart.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to the field of blood component therapy, and more particularly to an apparatus for collecting, storing and dispensing plasma for processing blood components such as albumin and globulins.

A relatively modern medical technique known as blood component therapy involves providing the most appropriate blood to the patient's actual needs. Doctors determine which parts of blood or which components of blood are needed by a patient and give only those blood components to the patient, rather than the whole blood. Physicians therefore avoid many of the risks associated with using whole blood. This procedure is not only better for the patient in reducing certain risks associated with whole blood transfusions, but also allows one unit of blood supply to be used for a patient over 1 Å. For example, from one whole unit of blood that is separated, blood cells, platelets, fresh plasma,
Frozen or stored plasma, albumin, globulin, etc. come out.

Furthermore, in modern medical technology, cell separators separate blood into its components while leaving the donor to undergo the donation process. Modern medical technology allows blood banks to take specific components of the supplier needed by the patient and simultaneously return other components to the supplier.

In a treatment technique known as plasmapheresis, plasma is separated from the cellular components of the blood and the cells are returned to the supplier. The plasma is then later used to expand blood volume in the form of stored plasma or fresh frozen blood. This plasma can also be processed into any number of useful products such as albumin, globulins, and antihaemostatic factors. The present invention is provided for this purpose.

Blood is collected from a donor into a connected and sealed collection system, then centrifuged and separated into cells and plasma. The cells are returned to the donor and the plasma is then frozen in a collection bag. In a frozen state, plasma can be stored for many months before being extracted for production of plasma components.

As a result, large quantities of plasma, ie plasma from multiple donors, are processed in a batch process.

Contamination through this batch process is clearly a risk. The entire blood sputum is first collected into a collection channel that remains sealed while it is later centrifuged and frozen. However, the collection bag must eventually be cut open and the plasma must be removed either manually or by automatic operation. During this cutting and extraction operation, the plasma becomes contaminated.

Current procedures collect blood from a donor into a collection line and centrifuge it so that the plasma is collected into one of the collection bags in the collection line. The bag containing the plasma is then frozen and stored away from the rest of the collection line, all prioritizing processing weeks or injuries later. Continue.

A number of collection bags were opened and the plasma was collected in batches.
Put it in container j. The present invention provides an easy-to-open plasma bag that does not require cutting to remove plasma.

The easy-to-open collection bag for storing plasma is a sealable container made of flexible material. The collection bag has an easy-to-separate seam (hereinafter referred to as a "separable seam") that joins at the apex, and a motsu body.1. ,-, (J':' 6゜mcgq+yo.

By applying manual force directly to the apex, the closure seam ruptures at the apex and the body is torn along the dissociation seam without the need to cut the collection bag with a knife or any other means to remove frozen plasma. configured to leave. In certain embodiments, the collection bag is provided with means for manually applying a breaking force without cutting or otherwise puncturing it. According to a more particular aspect of the invention, the collection bag is made of a material that remains flexible at temperatures from -25°C to -80°C. The collector can be made in a number of ways, such as heat sealing or spray molding, without departing from the spirit of the invention.

Other features of the invention will be described in detail below with reference to the drawings. The particular section container embodying the invention is illustrated for illustrative purposes only and is not intended to limit the invention. The principles and features of the invention apply to many embodiments within the scope of the invention.

FIG. 1 shows a collection bag embodying the present invention. The collection bag was part of a multi-bag collection system and contained frozen plasma in an overturned position ready to be opened at any time. The main body IO of the collection bag communicates with a blood donation bag (not shown) through a flexible tube 12. This flexible tube is closed by a conventional seal 14. The collection bag has a hook hole 16 that is used when the blood donation bag is full.

The collection bag is made of a sealable container of flexible plastic material, such as polyolefin, with a thickness of 6 mils. The 6 mil thickness is such that it maintains flexibility at temperatures from -25°C to -180°C, the temperature range at which plasma is frozen and stored.

The body 10 of the container includes a pair of release seams 2o extending from the top to the bottom (as viewed in FIG. 1).

These release seams meet at apex 22.

As shown in Figures 2 and 3 (at the open end of the collection bag (only somewhat based on perspective), the IL seam 20
are on both sides of the body lO and on the plane that bisects the body. The closing seam 24, which laterally intersects the apex 22 of the release seam 200, has a width that is wider than the width of the release seam. Figure 1,
In the structure shown in FIGS. 2 and 3, a pair of ears 26 flank the apex 22 on opposite sides of the closing seam 240 (16 in this example) facing the release seam 20. The -\ end of the ear 26 is rounded and extends toward the apex 22. The closing seam 24 is essentially a straight line that seals the top of the collection bag and separates the interior portion of the body from the ear 26.

As shown again in FIGS. 1 and 2, rib 28 (third
(hidden in the figure) is formed on the main body and extends from the closing seam from the apex 22 to the end edge of the main body 1o in the direction of divergence. The lip 28 forms a portion 3o of the body lateral to the apex 22.

This portion is sealed from the inner portion of the body and therefore does not contain plasma.

To open the body, force is directed toward the apex 22 by pinching the ears 26 alone, or the ears and the closing seam 24 and/or the portion 3o, and pulling them apart as shown in either FIG. 2 or FIG. The collection bag is pulled apart at the apex 22, tearing the body 10 along the release seam 20, thereby stripping the flexible polyolefin from the frozen plasma within the collection bag and dislodging the plasma with a knife or other tearing tool or It can be dropped into a collection container without touching it. The collection bag is then turned over from the position shown in FIGS. 1, 2 and 3. Although Figures 2 and 3 show a readable bag torn with bare hands, gloves may be worn to provide insulation from the cooled contents.

In some known constructions, the bag is opened by cutting open the bag with a knife to expose the plasma, or by heating the bag from the outside inward to release the frozen plasma from the inside of the bag. That was needed.

According to the configuration of the present invention, there is no need to cut the bag.

Since the bag is inherently peeled from the frozen plasma, there is no need to warm the bag with the skin prior to opening it.

FIG. 4 shows another structure of the open part of the collection bag.

The closing seam 24 in the structure of FIG. 1 is essentially a straight line passing through the top of the collection bag, intersecting the apex 22 of the release seam 200. Closed seam 24 has a notch 34 that aligns with apex 22 to concentrate the breaking force at apex 22 . The body has no ears, but is optionally provided with ribs 28 that define sealed pockets 30 that do not contain plasma.

Another structure of the main body is shown in FIG. In this structure, the closing seam 24 has a V-shape consisting of seam portions 24α and 24b converging toward the apex 22. rib 2
8 forms the same region as the portion with the same reference numeral in the structure of FIG. 1, that is, a small portion 30. The provision of ribs 28 and this unfilled portion 30 is also optional. However, since there are no ears here, it is the small portion 30 and the seam portions 24α, 24b that are pinched and pulled apart, concentrating the breaking force at the apex and initiating tearing of the release seam 20.

Yet another structure is shown in FIGS. 6 and 7. A seam 24, similar to that shown in Figure 5, is V-shaped and converges at the apex of the release seam 200. Rib 28α, 28
b also converges at vertex 22 to form an unfilled region or sub-portion 30 as in the previously described structure.

To simplify the structure, the ribs 28α, 28b are converged at the apex. The closed seam portion 24α and the rib 28α are mutually aligned linear extensions, similar to the case of the closed seam portion 24a and the rib 28b.

This shape places the approximately triangular section 40 on the opposite side of the closing seam section 24α, 2.1b facing the subsection 30, indicated by 42, consisting of a folded corner of a portion of the bag. These corners are secured together by connecting seams 44.

The triangular portion 40 remains attached to the collection bag until it can be opened at any time. As is clear from Figure 6,
A straight punching 46 extends along the closed seam portions 24α, 246. The presence of the triangular portion 40 provides additional strength to the collection bag and prevents premature breakage at the apex 22.

To enable the collection bag to be opened at any time, the triangular portion 40 is torn from the collection bag along straight cutouts 46 to form the collection bag shown in FIG.

Then the small portion 30 and or the closed eye portion 24α,
24b and pull apart to concentrate the breaking force at the apex 22 as in the structure described above.

Various structures can be created in various ways.

The bag structure is made by cutting polyolefin material from a continuous long tube and heat-sealing it with a release seam 20, a bottom part 36,
A closing seam 24 and ribs are formed.

Another method is to start with folded sheets and heat seal them to create various ribs and seams.

Another possibility is to form the entire bag by blow molding.

Various ribs and seams can also be created in mold cavities and attached to the bag by blow molding.

[Brief explanation of the drawing]

FIG. 1 is a perspective view of a sealable container or bag between sections of flexible material embodying the invention; FIGS. 2 and 3 show the bag of FIG. 1 opened; Figures 1 and 5 are
FIGS. 6 and 7 are views showing still another structure of the bag shown in the first figure. lO...Main body, 20...Dissociation seam, 22.
... Vertex, 24 ... Closed seam, 26 ... Ear,
28...Rib, 30...Small part □ Leather, 4 Figure ''' is also 5 figure

Claims (1)

[Claims] 1. A partial container made of a flexible material, comprising a main body, a release seam on the main body joined at the apex, and a closing seam that seals the main body and crosses the apex laterally. wherein the container is configured such that by applying a manually applied force to the apex, the closing seam is separated at the apex and the body is torn and the body is removed from its contents along the release seam. Interpartial container. 2. A sealable container of flexible material comprising a body, a release seam on the body joined at the apex, and a closing seam sealing the body and laterally crossing the apex, the body A sealable container, wherein a portion of the material is disposed lateral to the apex to form a gripping means for applying a breaking force to the closing seam at the apex of the release seam. 3. A main body, a release seam on the main body joined at the apex, a closing seam that seals the main body and intersects the apex in the transverse direction, and a rib extending from the closing seam and extending from the apex in a direction widening toward the end. A sealable container made of a flexible material, the lip forming an unfilled area of the body which is gripped at the apex of the release seam to apply a breaking force to the closing seam. 4. A container according to claim 1, 2 or 3, wherein the closing seam is substantially straight. 5. The container according to claim 1, 2 or 3, wherein the closing seam converges into a V-shape at the apex. 6. The container according to claim 1, wherein the closing seam has a notch provided in a direction converging toward the apex. 7. A claim in which a portion of the flexible material is lateral to the apex opposite the closing seam facing the release seam and is configured to direct the breaking force toward the apex when the lateral portions are pulled apart. The container according to item 1, item 2, or item 3. 80. A container according to claim 1, 2 or 3, wherein the body is made from sheet and the body seams are formed by heat sealing. 9. The container according to claim 1, 2 or 3, wherein the main body is formed by blow molding. 10. Claim 1, wherein the plastic material maintains readability in a temperature range of 125°C to 180'C;
The container according to item 2 or 3. 4. A container according to claim 1, 2 or 3, wherein the 115T flexible material is a polyolefin. 12. Claims 1, 2 or 3 in which the closing seam has a separable material on its opposite side facing the release seam to prevent premature rupture.
Containers listed in section. 13. a body and a release seam on the body joined at the apex;
A sealable container of flexible material comprising a V-shaped closing seam sealing the body and laterally intersecting the apex, the closing seam tearing when the V-shaped body material is severed. A container forming a V-shaped breakaway portion of body material on the side opposite the breakaway seam so that the body can be removed from its contents. 14. The container of claim 13, wherein the punch separates the cutaway portion from the remainder of the body. 15, wherein the lip extends from the closing seam and diverges in a direction away from the apex to form an unfilled area of the body which is gripped to apply a breaking force to the closing seam at the apex of the release seam. container. 16. The container of claim 15, wherein the ribs converge at the apex of the release seam. 17. The container of claim 15, wherein the ribs are aligned linear extensions of the V-shaped closing seam.