JPS6064909A - Cosmetic - Google Patents

Abstract

PURPOSE:To provide a cosmetic having excellent effect to cure the wound, and containing an aqueous extract of the liver or spleen of mammals and a skin extract. CONSTITUTION:The objective cosmetic having synergistically improved wound- curing effect can be produced by compounding (A) an aqueous extract of the liver or spleen of mammals such as cattle, pig, etc. and (B) a skin extract such as mucopolysaccharide (e.g. hyaluronic acid, dermatan sulfate, chondroitinsulfuric acid, or their salts), collagen, elastin, etc. to a skin cosmetic such as beauty lotion, cream, milky lotion, pack, etc. The amount of the components A and B are generally 0.001-2wt% (in terms of dried residue) and 0.005-2wt% (in terms of solid component), based on the whole cosmetic composition. Since the excellent wound-curing effect can be maintained even by adding a component having suppressing effect against the curing of wound to the above cosmetic, the components used generally in cosmetics can be added to the above cosmetic in addition to the above components, according to the use.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a cosmetic product containing an aqueous extract from the liver or spleen of a mammal and a skin + i1 extract of mucopolysaccharide, collagen, elastin, etc., and which has an excellent wound healing effect. .

BACKGROUND ART Conventionally, extracts from organs such as the liver, spleen, or placenta of mammals have been commonly incorporated into cosmetics for the purpose of skin whitening and wound healing effects.

On the other hand, the above skin extract is known to have a wound healing effect.

However, the wound healing effects of the above extracts and skin extracts were still unsatisfactory when used alone.

In view of the above circumstances, the present inventors conducted intensive research and found that among the above extracts, if water extracts from mammalian livers or spleens are used in combination with skin extracts, they will have a complementary effect. The present inventors have discovered that the present invention has been completed based on the discovery that the present invention has an excellent wound healing effect that has not been seen in conventional wound healing agents.

That is, the present invention is a cosmetic material containing an aqueous extract from the liver or spleen of a mammal and a skin and kidney extract.

Below, the configuration of the present invention will be explained in detail.

The following is an example.

Fresh frozen beef spleen is crushed, extracted with hot water over 60°C for over 1 hour, further heated at over 10°C for over 10 minutes, passed through the mouth and concentrated. Add alcohol and pass through the mouth to dissolve the deproteinized protein.The molecular weight of the low-molecular effective components of the aqueous forest contained in the aqueous extract thus obtained is within the range of about 100 to 10,000. It is in.

The aqueous extract is stable against heat and can be incorporated into cosmetics such as lotion, Ri1nome, and milky lotion as it is without any special treatment.

Generally, the amount of dry residue is 0.001 to 0.001 of the total amount of makeup.
It is 2% by weight.

The skin extract used in the present invention includes mucopolysaccharides such as hyaluronic acid, dermatan sulfate, chondroitin sulfate and salts thereof, collagen, elastin, etc., and one or more of these may be arbitrarily selected and used.

The blending amount is generally 0.005 to 2% by weight (solid content).

(Hereinafter, blank spaces) The cosmetic of the present invention has an excellent wound healing effect even if it contains ingredients that generally act to suppress wound healing when added to a cosmetic.

Therefore, in addition to the essential constituents, other ingredients commonly incorporated into cosmetics may be optionally blended depending on the desired product.

For example, surfactants, water, oils, alcohols, preservatives, colorants, fragrances, etc. An example of an unexploded wound healing test will be specifically explained.

[Test Example 1] 5 6-week-old Wistar (SPF) 1
They were divided into groups and subjected to the test after being shaved.

Rats were anesthetized with Nembutal and were approximately 2
A centimeter dorsal skin incision was made, and the incision was immediately sutured using a Minohel suture device. After suturing, 0.1 m7 of the sample was applied to the incision site once a day for 3 weeks. Three weeks later, the horse was bludgeoned to death, and a 1 cm skin section was prepared after removing the sword. Tensilon (Ten5il) is used for tension measurement.
on) Using UTM-4 (manufactured by Toyo Sokki Co., Ltd.),
The cutting tension of the skin sections was measured.

The results are not shown in Table 1.0 Table 1 (Left below) From the results in Table 1, the tension at the site where 02% hyaluronic acid was applied increased compared to the control, and a wound healing effect was observed. An increase in tension was also observed at 0.01% application. On the other hand, in the case of the product of the present invention in which a water extract of bovine viscera and hyaluronic acid were used in combination, a significant increase in tension was observed compared to a comparative product in which each product was applied alone, and a remarkable wound healing effect was observed. In addition to the above animal tests, the product of the present invention also showed similar effects in human panel tests.

[Test Example 2] In the same manner as Test Example 1, the wound healing effect when elastin was used instead of hyaluronic acid was evaluated. Table 2 shows the results.
Shown below. It can be seen that the product of the present invention containing aqueous extract of bovine viscera and elastin has a complementary wound healing effect compared to a comparative product containing each ingredient alone.

(Leaving space below) Table 2 Sample (wt%) Average tension (Li/cJ) Water extract of bovine viscera 01 40 items Elastin Ol Light Water extract of medium viscera 01 46 items Elastin 05 Ratio of beef viscera Water extract 0.1 423 Comparison Hyaluronic acid 0.2 375 Product Control -285 (Sample: physiological saline solution, control: physiological saline) Next, the present invention will be explained in more detail with reference to Examples. The present invention is not limited thereby.

The blending amount is in weight%.

(Margin below) Example 1 Cream Propylene glycol 5.0 Cetyl alcohol 4.0 Beeswax 5゜ Squalane 35.0 U/Rin 50 Stearic acid glycerol 4 hydride z.

Polyoxyethylene (20 mol) Sorbitan monolaurate z○ Methylparaben o1 Ethylparaben 0.15 Water extract of bovine viscera 0.001 Sodium hyaluronate 0.005 Fragrance 01 Ion-exchanged water Residual (hereinafter referred to as the margin) Example 2 Packed polyvinyl alcohol 15.0 Polyethylene glycol 30 Propylene glycol 70 Ethanol 10.0 Methylparaben 02 Water extract of bovine viscera 2-0 Collagen 20 Fragrance 0.1 Ion exchange water Remainder (blank below) Example 3 Lotion glycerin 3゜Propylene glycol 4゜Ethanol 8゜Polyoxyethylene (20 mol) Oleyl alcohol
o5 Bovine spleen water extract o1 Sodium hyaluronate o1 Elastin o1 Methyl, paraben o1 Sodium citrate o1 Fragrance 005 Ion exchange water Remaining patent applicant Shiseido Co., Ltd.

Claims (1)

[Claims] (1) A cosmetic characterized by containing a daffodil extract from the liver or spleen of a mammal and a skin extract.