JPS607974B2 - 肝硬変の予防及び治療剤 - Google Patents

肝硬変の予防及び治療剤

Info

Publication number: JPS607974B2
Authority: JP; Japan
Prior art keywords: therapeutic agent; liver cirrhosis; alcohol; prophylactic; liver
Prior art date: 1979-05-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP54058119A

Other languages

English (en)

Japanese (ja)

Other versions

JPS55151517A (en

Inventor

甫勝田

湊関

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

DOTSUKYO GAKUEN

Original Assignee

DOTSUKYO GAKUEN

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-05-14

Filing date

1979-05-14

Publication date

1985-02-28

1979-05-14 Application filed by DOTSUKYO GAKUEN filed Critical DOTSUKYO GAKUEN

1979-05-14 Priority to JP54058119A priority Critical patent/JPS607974B2/ja

1979-12-17 Priority to CA342,048A priority patent/CA1116090A/en

1980-01-16 Priority to IT19228/80A priority patent/IT1140511B/it

1980-02-19 Priority to GB8100470A priority patent/GB2060384B/en

1980-02-19 Priority to NL8020059A priority patent/NL8020059A/nl

1980-02-19 Priority to PCT/JP1980/000022 priority patent/WO1980002503A1/ja

1980-02-19 Priority to CH22981A priority patent/CH644761A5/de

1980-02-19 Priority to DE19803045276 priority patent/DE3045276A1/de

1980-11-26 Publication of JPS55151517A publication Critical patent/JPS55151517A/ja

1980-12-01 Priority to EP80900424A priority patent/EP0030977B1/en

1981-01-13 Priority to SE8100149A priority patent/SE8100149L/

1985-02-28 Publication of JPS607974B2 publication Critical patent/JPS607974B2/ja

Status Expired legal-status Critical Current

Links

208000019425 cirrhosis of liver Diseases 0.000 title claims description 19
239000003814 drug Substances 0.000 title claims description 19
229940124597 therapeutic agent Drugs 0.000 title claims description 15
230000003449 preventive effect Effects 0.000 title 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 24
235000017190 Vitis vinifera subsp sylvestris Nutrition 0.000 claims description 22
244000237969 Vitis vulpina Species 0.000 claims description 22
235000017242 Vitis vulpina Nutrition 0.000 claims description 22
235000019441 ethanol Nutrition 0.000 claims description 19
235000013399 edible fruits Nutrition 0.000 claims description 16
230000000069 prophylactic effect Effects 0.000 claims description 14
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
238000002386 leaching Methods 0.000 claims description 4
239000003795 chemical substances by application Substances 0.000 claims description 3
239000000203 mixture Substances 0.000 claims description 3
210000002615 epidermis Anatomy 0.000 claims description 2
239000003978 infusion fluid Substances 0.000 claims description 2
238000012360 testing method Methods 0.000 description 21
238000011084 recovery Methods 0.000 description 16
238000001802 infusion Methods 0.000 description 15
241000700159 Rattus Species 0.000 description 13
210000004027 cell Anatomy 0.000 description 12
210000004185 liver Anatomy 0.000 description 12
241001465754 Metazoa Species 0.000 description 11
231100000456 subacute toxicity Toxicity 0.000 description 7
238000001000 micrograph Methods 0.000 description 6
239000000243 solution Substances 0.000 description 6
238000002474 experimental method Methods 0.000 description 5
241000219094 Vitaceae Species 0.000 description 4
230000037396 body weight Effects 0.000 description 4
229940079593 drug Drugs 0.000 description 4
229940038487 grape extract Drugs 0.000 description 4
239000008399 tap water Substances 0.000 description 4
235000020679 tap water Nutrition 0.000 description 4
241000228212 Aspergillus Species 0.000 description 3
206010067125 Liver injury Diseases 0.000 description 3
230000005856 abnormality Effects 0.000 description 3
238000010521 absorption reaction Methods 0.000 description 3
230000001476 alcoholic effect Effects 0.000 description 3
210000000416 exudates and transudate Anatomy 0.000 description 3
235000021021 grapes Nutrition 0.000 description 3
231100000234 hepatic damage Toxicity 0.000 description 3
239000007788 liquid Substances 0.000 description 3
230000008818 liver damage Effects 0.000 description 3
238000000034 method Methods 0.000 description 3
210000000056 organ Anatomy 0.000 description 3
210000003491 skin Anatomy 0.000 description 3
240000000560 Citrus x paradisi Species 0.000 description 2
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
GGLZPLKKBSSKCX-YFKPBYRVSA-N L-ethionine Chemical compound CCSCC[C@H](N)C(O)=O GGLZPLKKBSSKCX-YFKPBYRVSA-N 0.000 description 2
240000002853 Nelumbo nucifera Species 0.000 description 2
235000006508 Nelumbo nucifera Nutrition 0.000 description 2
235000006510 Nelumbo pentapetala Nutrition 0.000 description 2
235000009754 Vitis X bourquina Nutrition 0.000 description 2
235000012333 Vitis X labruscana Nutrition 0.000 description 2
240000006365 Vitis vinifera Species 0.000 description 2
235000014787 Vitis vinifera Nutrition 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
238000010586 diagram Methods 0.000 description 2
239000012153 distilled water Substances 0.000 description 2
238000002329 infrared spectrum Methods 0.000 description 2
201000007270 liver cancer Diseases 0.000 description 2
210000005229 liver cell Anatomy 0.000 description 2
208000014018 liver neoplasm Diseases 0.000 description 2
150000007524 organic acids Chemical class 0.000 description 2
235000005985 organic acids Nutrition 0.000 description 2
102000004196 processed proteins & peptides Human genes 0.000 description 2
108090000765 processed proteins & peptides Proteins 0.000 description 2
239000000047 product Substances 0.000 description 2
230000007863 steatosis Effects 0.000 description 2
231100000240 steatosis hepatitis Toxicity 0.000 description 2
MSWZFWKMSRAUBD-GASJEMHNSA-N 2-amino-2-deoxy-D-galactopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O MSWZFWKMSRAUBD-GASJEMHNSA-N 0.000 description 1
JCYPECIVGRXBMO-UHFFFAOYSA-N 4-(dimethylamino)azobenzene Chemical compound C1=CC(N(C)C)=CC=C1N=NC1=CC=CC=C1 JCYPECIVGRXBMO-UHFFFAOYSA-N 0.000 description 1
241000563984 Ampelopsis Species 0.000 description 1
241000776115 Ampelopsis glandulosa var. brevipedunculata Species 0.000 description 1
241000196324 Embryophyta Species 0.000 description 1
208000004930 Fatty Liver Diseases 0.000 description 1
206010016654 Fibrosis Diseases 0.000 description 1
206010019708 Hepatic steatosis Diseases 0.000 description 1
238000004566 IR spectroscopy Methods 0.000 description 1
241000218922 Magnoliophyta Species 0.000 description 1
238000011887 Necropsy Methods 0.000 description 1
235000009388 Parthenocissus quinquefolia Nutrition 0.000 description 1
244000184734 Pyrus japonica Species 0.000 description 1
BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
238000000692 Student's t-test Methods 0.000 description 1
241000700605 Viruses Species 0.000 description 1
230000002159 abnormal effect Effects 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
210000000702 aorta abdominal Anatomy 0.000 description 1
230000005784 autoimmunity Effects 0.000 description 1
235000021028 berry Nutrition 0.000 description 1
MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000008280 blood Substances 0.000 description 1
238000009395 breeding Methods 0.000 description 1
230000001488 breeding effect Effects 0.000 description 1
235000014121 butter Nutrition 0.000 description 1
230000003915 cell function Effects 0.000 description 1
230000007882 cirrhosis Effects 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
239000006059 cover glass Substances 0.000 description 1
238000005520 cutting process Methods 0.000 description 1
210000000805 cytoplasm Anatomy 0.000 description 1
230000006378 damage Effects 0.000 description 1
230000034994 death Effects 0.000 description 1
231100000517 death Toxicity 0.000 description 1
230000007850 degeneration Effects 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
241001233957 eudicotyledons Species 0.000 description 1
208000010706 fatty liver disease Diseases 0.000 description 1
239000000835 fiber Substances 0.000 description 1
235000011389 fruit/vegetable juice Nutrition 0.000 description 1
230000006870 function Effects 0.000 description 1
210000003494 hepatocyte Anatomy 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
230000008595 infiltration Effects 0.000 description 1
238000001764 infiltration Methods 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
239000007924 injection Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
238000007913 intrathecal administration Methods 0.000 description 1
238000002350 laparotomy Methods 0.000 description 1
239000012263 liquid product Substances 0.000 description 1
210000005228 liver tissue Anatomy 0.000 description 1
210000004698 lymphocyte Anatomy 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
238000002156 mixing Methods 0.000 description 1
230000035772 mutation Effects 0.000 description 1
230000017074 necrotic cell death Effects 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
239000002245 particle Substances 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
239000000843 powder Substances 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
238000012545 processing Methods 0.000 description 1
239000008213 purified water Substances 0.000 description 1
230000000384 rearing effect Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
230000028327 secretion Effects 0.000 description 1
229910052709 silver Inorganic materials 0.000 description 1
239000004332 silver Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
239000000126 substance Substances 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
238000012353 t test Methods 0.000 description 1
238000010998 test method Methods 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
238000005292 vacuum distillation Methods 0.000 description 1
230000017260 vegetative to reproductive phase transition of meristem Effects 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Landscapes

Health & Medical Sciences (AREA)
Natural Medicines & Medicinal Plants (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Alternative & Traditional Medicine (AREA)
Organic Chemistry (AREA)
Botany (AREA)
Medical Informatics (AREA)
Microbiology (AREA)
Mycology (AREA)
Epidemiology (AREA)
Medicines Containing Plant Substances (AREA)

JP54058119A 1979-05-14 1979-05-14 肝硬変の予防及び治療剤 Expired JPS607974B2 (ja)

Priority Applications (10)

Application Number	Priority Date	Filing Date	Title
JP54058119A JPS607974B2 (ja)	1979-05-14	1979-05-14	肝硬変の予防及び治療剤
CA342,048A CA1116090A (en)	1979-05-14	1979-12-17	Medicament for prevention and treatment of the liver cirrhosis
IT19228/80A IT1140511B (it)	1979-05-14	1980-01-16	Medicamento per la prevenzione ed il trattamento della cirrosi epatica
PCT/JP1980/000022 WO1980002503A1 (fr)	1979-05-14	1980-02-19	Medicament prophylactique et curatif de la cirrhose du foie
NL8020059A NL8020059A (nl)	1979-05-14	1980-02-19	Geneesmiddel ter voorkoming en behandeling van levercirrhose.
GB8100470A GB2060384B (en)	1979-05-14	1980-02-19	Prophylactic and curative medicine for cirrhotic liver
CH22981A CH644761A5 (de)	1979-05-14	1980-02-19	Verfahren zur herstellung eines medikaments fuer die verhuetung und zur behandlung von leberzirrhose.
DE19803045276 DE3045276A1 (de)	1979-05-14	1980-02-19	Prophylactic and curative medicine for cirrhotic liver
EP80900424A EP0030977B1 (en)	1979-05-14	1980-12-01	Prophylactic and curative medicine for cirrhotic liver
SE8100149A SE8100149L (sv)	1979-05-14	1981-01-13	Medikament for profylaktisk och kurativ behandling av leverskrumpning

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP54058119A JPS607974B2 (ja)	1979-05-14	1979-05-14	肝硬変の予防及び治療剤

Publications (2)

Publication Number	Publication Date
JPS55151517A JPS55151517A (en)	1980-11-26
JPS607974B2 true JPS607974B2 (ja)	1985-02-28

Family

ID=13075080

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP54058119A Expired JPS607974B2 (ja)	1979-05-14	1979-05-14	肝硬変の予防及び治療剤

Country Status (9)

Country	Link
EP (1)	EP0030977B1 ( )
JP (1)	JPS607974B2 ( )
CA (1)	CA1116090A ( )
CH (1)	CH644761A5 ( )
GB (1)	GB2060384B ( )
IT (1)	IT1140511B ( )
NL (1)	NL8020059A ( )
SE (1)	SE8100149L ( )
WO (1)	WO1980002503A1 ( )

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2003026584A (ja) *	2001-07-09	2003-01-29	Maruzen Pharmaceut Co Ltd	肝臓疾患治療剤
JP2010095529A (ja) *	2009-12-22	2010-04-30	Maruzen Pharmaceut Co Ltd	脂質代謝改善用組成物
JP2010120946A (ja) *	2009-12-22	2010-06-03	Maruzen Pharmaceut Co Ltd	抗炎症組成物

1979
- 1979-05-14 JP JP54058119A patent/JPS607974B2/ja not_active Expired
- 1979-12-17 CA CA342,048A patent/CA1116090A/en not_active Expired
1980
- 1980-01-16 IT IT19228/80A patent/IT1140511B/it active
- 1980-02-19 NL NL8020059A patent/NL8020059A/nl not_active Application Discontinuation
- 1980-02-19 GB GB8100470A patent/GB2060384B/en not_active Expired
- 1980-02-19 WO PCT/JP1980/000022 patent/WO1980002503A1/ja not_active Ceased
- 1980-02-19 CH CH22981A patent/CH644761A5/de not_active IP Right Cessation
- 1980-12-01 EP EP80900424A patent/EP0030977B1/en not_active Expired
1981
- 1981-01-13 SE SE8100149A patent/SE8100149L/ not_active Application Discontinuation

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2003026584A (ja) *	2001-07-09	2003-01-29	Maruzen Pharmaceut Co Ltd	肝臓疾患治療剤
JP2010095529A (ja) *	2009-12-22	2010-04-30	Maruzen Pharmaceut Co Ltd	脂質代謝改善用組成物
JP2010120946A (ja) *	2009-12-22	2010-06-03	Maruzen Pharmaceut Co Ltd	抗炎症組成物

Also Published As

Publication number	Publication date
EP0030977A4 (en)	1981-09-21
EP0030977B1 (en)	1984-07-25
WO1980002503A1 (fr)	1980-11-27
IT1140511B (it)	1986-10-01
JPS55151517A (en)	1980-11-26
GB2060384A (en)	1981-05-07
IT8019228A0 (it)	1980-01-16
SE8100149L (sv)	1981-01-13
GB2060384B (en)	1983-06-02
CH644761A5 (de)	1984-08-31
EP0030977A1 (en)	1981-07-01
CA1116090A (en)	1982-01-12
NL8020059A (nl)	1981-03-31

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JPS607974B2 - 肝硬変の予防及び治療剤 - Google Patents

Info

Links

Classifications

Landscapes

Priority Applications (10)

Applications Claiming Priority (1)

Publications (2)

Family

ID=13075080

Family Applications (1)

Country Status (9)

Cited By (3)

Cited By (3)

Also Published As

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