JPS6257555A - Medical bag - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a medical bag for containing blood, medical solutions, etc., which is excellent in hygiene, flexibility, transparency, and heat resistance. More specifically, it relates to a medical bag made of a copolymer of ethylene and 1-olefin that has a density of 0.935 g/cm' or less, and has excellent hygiene, flexibility, transparency,
#The purpose is to provide a medical bag that can hold blood, medical solutions, etc. that have excellent heat resistance.

At present, hard containers made of glass, polyethylene, polypropylene, etc., and soft bags made of polyvinyl chloride containing a softening agent are known as medical containers. but,
In the former case, air must be introduced using a ventilation needle or an infusion set with a ventilation hole when dropping the contents. Furthermore, contamination of the liquid content may occur. On the other hand, the latter is highly flexible and drips naturally due to external pressure, so there is no need to introduce air holes. However, there are problems such as the plasticizer contained in polyvinyl chloride and the toxicity of residual additives.

In order to solve these problems, a laminated medical bag using a flexible material for the middle layer and polyethylene, polypropylene, etc. for the inner and outer layers was proposed. decrease.

The present invention does not have these drawbacks (problems), namely, it not only has good hygiene, but also has extremely good flexibility and transparency, and has excellent heat resistance. You can also get a good medical bag.

According to the present invention, these problems are solved when the density is 0.935 g.
/ cm' or less, a medical bag made of a copolymer of ethylene and 1-olefin can solve the problem. The present invention will be explained in detail below.

(A) Copolymer of ethylene and 1-olefin The copolymer of ethylene and 1-olefin used in the present invention (hereinafter referred to as "ethylene copolymer") has a density of 0.935 g / c tn' or less,
0.930 g/cm" or less is preferable,
Particularly suitable is one having a weight of 0.925 g/cm' or less. 1 used in the production of this ethylene copolymer
-Olefins usually have at most 12 carbon atoms.
It is an olefin, typical examples of which are propylene and butene.
1, hexene-1, 4-methylpentene-1 and octene-1. In this copolymer, como/
The density of the 1-olefin copolymerized as a monomer decreases as the copolymerization ratio of the comonomer increases.

That is, the density not only decreases with an increase in the short chain branching of low-density polyethylene as the short chain branching increases, but it also becomes more flexible and transparent. However, in low-density polyethylene, the melting point also decreases as the density decreases, whereas in the case of the copolymer of ethylene and 1-olefin, the melting point is saturated at around 120°C, This deviates from the conventional relationship between density and melting point. By making use of this characteristic, it has been found that by applying it as an intermediate layer material that has excellent flexibility, transparency and heat resistance, it is not only flexible but also has good heat resistance, and the present invention. reached. The above-mentioned "short chain branched chain" refers to a branch that is sufficiently short compared to the main chain and has less than 15 carbon atoms, and the density of the copolymer is 0.915 g /
cm” or less (especially 0.910 g/cm
``The following are not only highly transparent, but also
It is especially advantageous because it is highly flexible.

The melt flow index of the copolymer of ethylene and 1-olefin (JIS K7210, but l
Measured under condition 4, hereafter referred to as MFRJ) is usually 0.1 to 20 g from the viewpoint of formability, strength, etc.
/10 minutes, preferably 0.1-15 g/10 minutes, particularly preferably 0.1-10 g/710 minutes.

(B) Production of film, production of medical bag In producing the medical bag of the present invention, first, the above-mentioned copolymer of ethylene and 1-olefin is prepared in the field of general polyethylene, polypropylene, etc. It can be obtained by employing an inflation method, a T-die method, etc. in the same manner as the film manufacturing method, but from the viewpoint of transparency, a water-cooled inflation method and a quenching T-die method are preferable. The obtained film is usually in the form of a tube or sheet, and the medical bag of the present invention can be manufactured by heat-sealing the bag into a suitably predetermined shape and size and attaching a pouring port.

The thickness of the obtained film is preferably 0.15 to 0.6
If it is less than 0.15 mm, the feeling of mass will be impaired, while if it exceeds 0.8 mm, the flexibility will be insufficient.

If necessary, the medical bag thus obtained is preferably washed with distilled water, sterilized water, etc. at a predetermined temperature on the inner and outer surfaces of the bag before being filled with the liquid content, dried, and then filled with the liquid content. Next, sterilization is performed, and this method includes a method using high-pressure steam, and the sterilization conditions are not particularly limited, but usually at a temperature of 115 ° C. for 30 minutes.
For example, 20 minutes at a temperature of 21°C. After sterilization, 40°
The transparency of the medical bag is improved by heat treatment for about 10 minutes at a temperature of C or higher.

- The present invention will be explained in more detail below with reference to Examples.

In addition, in the examples and comparative examples, the density is JIS
K? 112 (7) D method Nishitagai, 23℃ + 0.1℃
Measured at a temperature of Furthermore, the melting point was determined according to the DSC method by increasing the temperature at a rate of 10° C. per minute and determining the peak temperature. In addition, the flexibility is ASTM D-88
2, the tensile modulus was measured, and the natural drainage method was evaluated by observing with the naked eye. Furthermore, transparency was visually observed after filling with the contents, autoclaving at 115°C for 30 minutes, and heat-treating at 40°C for 40 minutes. Transparency is determined by filling with physiological saline and observing the transparency with the naked eye after sterilization, and by AST.
Evaluation was made by haze determined by measurement according to MD-1003 method. Furthermore, hygiene was evaluated based on the results of a test based on the Japanese Pharmacopoeia Test Method for Plastic Containers for Infusions. In addition, the appearance of the obtained medical bag was visually observed. Among the above, heat resistance and appearance were determined by observing wrinkles, deformation, and bag breakage, respectively. Heat resistance, flexibility (natural drainage), visual observation (transparency), hygiene, appearance, and overall evaluation were given in the following four ranks.

■: Very good O: Good Δ: Slightly poor ×: Bad Examples 1 to 3, Comparative Examples 1.2 In the Examples and Comparative Examples, the polymer had a density of 0.915 g/cm' using a high pressure method. Manufactured low density polyethylene (MFR2, Og/10 min, hereinafter r
PE(1) J], the density is 0.814 g/
c m' Copolymer of 1/ethyene and 1-butene (MFRl, 1 g/10 min, average number of carbon atoms in short chain branched alkyl group approximately 2, average number of short chain branches per 1000 carbons) about 23, hereinafter referred to as rPE(2)J), a copolymer of ethylene and butene-1 with a density of 0, HEi g/cm' (MFR 1.5 g/10 min, short chain branched alkyl Average number of carbon atoms in group: about 2, 10
The average number of short chain branches per 00 carbons is approximately 35, hereinafter referred to as rPE(3)J], and the density is 0.905 g.
Copolymer of ethylene and hexene-1 (MFR 1,5 g/10 min, average carbon number of short chain branched alkyl group 4, average number of short chain branches per 1000 carbons) 29, hereinafter referred to as rPE(4)J] and an ethylene-butene-1 copolymer with a density of 0J50 g/e m' (MFR 1.5 g/10 min, average carbon number of short chain branched alkyl groups) 2, the average number of short chain branches for 1000 carbons is about 4, hereafter rPE
(5) J) was used.

The above polymer was made to a thickness of 2 by the inflation method.
A film was produced that was 5 microns and had a 1401 fold.

Medical bags (inner volume: 500 m) were manufactured from each of the films thus obtained. Various characteristics of the medical bag thus obtained were measured. The results are shown in Table 1.

(Left below) From the results of the above Examples and Comparative Examples, the medical bag of the present invention not only has good flexibility, but also excellent transparency, as well as good heat resistance and hygiene. It is clear that there is.

Immunity 1 The medical bag of the present invention exhibits the following effects (features).

(1) Due to its excellent heat resistance, the bag hardly wrinkles or deforms during sterilization and has a good appearance.

(2) Due to its excellent flexibility, the liquid content will not be discharged.

(3) Good transparency makes it easy to judge the state of the liquid content.

(4) The outside is in good condition (wrinkles, deformation, etc.) and there is almost no tearing of the bag.

Claims (1)

[Claims] Ethylene with a density of 0.935g/cm^3 or less and 1
-Medical bags made of copolymers with olefins.