JPS6447793A - Phospholipid compound having alpha-methylene group - Google Patents
Phospholipid compound having alpha-methylene groupInfo
- Publication number
- JPS6447793A JPS6447793A JP20445687A JP20445687A JPS6447793A JP S6447793 A JPS6447793 A JP S6447793A JP 20445687 A JP20445687 A JP 20445687A JP 20445687 A JP20445687 A JP 20445687A JP S6447793 A JPS6447793 A JP S6447793A
- Authority
- JP
- Japan
- Prior art keywords
- alpha
- glycerophosphocholine
- compound
- formula
- methylene group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 Phospholipid compound Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229960004956 glycerylphosphorylcholine Drugs 0.000 abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- SUHOQUVVVLNYQR-MRVPVSSYSA-N choline alfoscerate Chemical compound C[N+](C)(C)CCOP([O-])(=O)OC[C@H](O)CO SUHOQUVVVLNYQR-MRVPVSSYSA-N 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 239000012528 membrane Substances 0.000 abstract 2
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 abstract 1
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000000010 aprotic solvent Substances 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 239000002502 liposome Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 238000007789 sealing Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Abstract
NEW MATERIAL:The compound of formula I (n is 9-17). EXAMPLE:1,2-Bis(alpha-methylenehexadecanoyl)-3-glycerophosphocholine. USE:Raw material for polymerized liposome, bimolecular membrane of lipid forming a material of separation membrane usable in industrial and medical fields and its built-up film. It can be easily synthesized and used as a transfer carrier by sealing a drug or enzyme, etc., in the compound. PREPARATION:The objective compound can be produced by (1) dissolving an alpha-methylenealkanoic acid of formula II and glycerophosphocholine of formula III or glycerophosphocholine.cadminum chloride complex in an aprotic solvent such as dichloroethane or chloroform and (2) reacting the components at room temperature in the presence of 4-(N,N-dimethylamino)pyridine as a catalyst and N,N-dicyclohexylcarbodiimide as a condensation agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20445687A JPS6447793A (en) | 1987-08-18 | 1987-08-18 | Phospholipid compound having alpha-methylene group |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20445687A JPS6447793A (en) | 1987-08-18 | 1987-08-18 | Phospholipid compound having alpha-methylene group |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6447793A true JPS6447793A (en) | 1989-02-22 |
Family
ID=16490834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP20445687A Pending JPS6447793A (en) | 1987-08-18 | 1987-08-18 | Phospholipid compound having alpha-methylene group |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6447793A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010235554A (en) * | 2009-03-31 | 2010-10-21 | Kuraray Medical Inc | Phosphate ester compound, and polymerizable composition containing the same |
-
1987
- 1987-08-18 JP JP20445687A patent/JPS6447793A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010235554A (en) * | 2009-03-31 | 2010-10-21 | Kuraray Medical Inc | Phosphate ester compound, and polymerizable composition containing the same |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US3369025A (en) | 3-pyridylmethyl phenoxy (phenylthio and anilino) alkanoates | |
| NO177004C (en) | Analogous Process for Preparation of 7-Substituted Derivatives of 3,5-Dihydroxyhept-6-ynoic Acid | |
| EP0268377A3 (en) | Glutamic acid derivatives, processes and intermediates for their preparation and pharmaceutical formulations containing them | |
| JPS5690031A (en) | Preparation of aromatic aldehyde | |
| RU1774941C (en) | Method of obtaining succinoyl amide | |
| SE8406138L (en) | NEW RETINOIDS | |
| JPS56166180A (en) | Dibenzoxazepine derivative and its preparation | |
| GB1458049A (en) | Process for preparing aryl-substituted pyridones | |
| FR2422405A1 (en) | NEW MEDICINES CONTAINED BY P-AMINOBENZOIC ACID DERIVATIVES | |
| JPS6447793A (en) | Phospholipid compound having alpha-methylene group | |
| EP0027597B1 (en) | Mono(2-ammonium-2-hydroxymethyl-1,3-propanediol)(2r-cis)-(3-methyloxiranyl)phosphonate, its preparation and pharmaceutical compositions containing it | |
| MX9604338A (en) | Substituted benzoylguanidines, process for their preparation, its utilization as medicament or diagnosis agent, as well as medicament containing them. | |
| Patel et al. | The conversion of phosphatidylethanolamine into phosphatidylcholine labeled in the choline group using methyl lodide, 18‐crown‐6 and potassium carbonate | |
| CN105985379B (en) | A kind of Mitochondrially targeted superoxide anion probe and preparation method thereof | |
| JPS57183777A (en) | Preparation of mycophenolic acid derivative | |
| IL134192A0 (en) | Thiazolobenzoheterocycles, their preparation and medicines containing same | |
| GB1334693A (en) | Acenaphthene derivatives | |
| ES8602581A1 (en) | A PROCEDURE FOR THE PREPARATION OF 2-CHLORINE-3-TRIFLUORME-TILBENZALDEHYDE | |
| ES461971A1 (en) | Benzoic acids and process for their preparation | |
| ATE40118T1 (en) | BENZAZEPINE DERIVATIVES, THEIR PRODUCTION AND USE AS MEDICINAL PRODUCTS. | |
| JPS6185396A (en) | Preparation of phosphatidylcholine | |
| EP0268267A3 (en) | Guanidinomethylbenzoic acid derivatives, compositions containing the same, processes for preparing the same, and the use of the same in the manufacture of medicaments of therapeutic value | |
| RU1824404C (en) | 3-(-thienyl) -5,6,7,8-tetrahydroimidazo(1,2-alpha) pyridine hydrochloride exhibiting antivirus activity relative to vesicular stomatitis virus | |
| WO1987004435A3 (en) | Xanthine compounds | |
| JP2972860B2 (en) | Sterol derivatives, vesicles using the same, and methods for their production |