MEP0808A - Karbonilamino pirolopirayoli, snažni inhibitori kinaza - Google Patents

Karbonilamino pirolopirayoli, snažni inhibitori kinaza

Info

Publication number: MEP0808A
Authority: ME; Montenegro
Prior art keywords: carbonylamino; kinase inhibitors; pyrrolopyrazoles; potent kinase; compounds
Prior art date: 2005-12-21

Application number

MEP-08/08A

Other languages

Bosnian (bs)

English (en)

Inventor

Liming Dong

Chuangxing Guo

Yufeng Hong

Mary Catherine Johnson

Susan Elizabeth Kephart

Haitao Li

Indrawan James Mcalpine

Jayashree Girish Tikhe

Anle Yang

Junhu Zhang

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-12-21

Filing date

2006-12-12

Publication date

2010-02-10

2006-12-12 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2010-02-10 Publication of ME00006B publication Critical patent/ME00006B/me

2010-02-10 Publication of MEP0808A publication Critical patent/MEP0808A/xx

Links

XPBFIMLMVNXIIB-UHFFFAOYSA-N 3-isocyanatopyrrolo[3,2-c]pyrazole Chemical class N1=CC=C2N=NC(N=C=O)=C21 XPBFIMLMVNXIIB-UHFFFAOYSA-N 0.000 title abstract 2
229940043355 kinase inhibitor Drugs 0.000 title 1
239000003757 phosphotransferase inhibitor Substances 0.000 title 1
230000003389 potentiating effect Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
101000987297 Homo sapiens Serine/threonine-protein kinase PAK 4 Proteins 0.000 abstract 1
102100027940 Serine/threonine-protein kinase PAK 4 Human genes 0.000 abstract 1
229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000003909 protein kinase inhibitor Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Oncology (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

MEP-08/08A 2005-12-21 2006-12-12 Karbonilamino pirolopirayoli, snažni inhibitori kinaza MEP0808A (xx)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US75334905P	2005-12-21	2005-12-21
US86493206P	2006-11-08	2006-11-08
PCT/IB2006/003646 WO2007072153A2 (en)	2005-12-21	2006-12-12	Carbonylamino pyrrolopyrazoles, potent kinase inhibitors

Publications (2)

Publication Number	Publication Date
ME00006B ME00006B (me)	2010-02-10
MEP0808A true MEP0808A (xx)	2010-02-10

Family

ID=38189022

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MEP-08/08A MEP0808A (xx)	2005-12-21	2006-12-12	Karbonilamino pirolopirayoli, snažni inhibitori kinaza

Country Status (26)

Country	Link
US (1)	US7884117B2 (es)
EP (1)	EP1979356B1 (es)
JP (1)	JP4635089B2 (es)
KR (1)	KR101029167B1 (es)
AP (1)	AP2369A (es)
AU (1)	AU2006327866B2 (es)
BR (1)	BRPI0620354A2 (es)
CA (1)	CA2634381C (es)
CR (1)	CR10094A (es)
CU (1)	CU23751B7 (es)
DK (1)	DK1979356T3 (es)
EA (1)	EA015513B1 (es)
EC (1)	ECSP088558A (es)
ES (1)	ES2435405T3 (es)
GE (1)	GEP20104974B (es)
HR (1)	HRP20130976T1 (es)
IL (1)	IL191776A (es)
MA (1)	MA30076B1 (es)
ME (1)	MEP0808A (es)
MY (1)	MY151455A (es)
NO (1)	NO20082482L (es)
NZ (1)	NZ568692A (es)
PL (1)	PL1979356T3 (es)
PT (1)	PT1979356E (es)
RS (2)	RS20080281A (es)
WO (1)	WO2007072153A2 (es)

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PL385265A1 (pl) *	2008-05-23	2009-12-07	Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna	Sposób wytwarzania solifenacyny i/lub jej soli o wysokiej czystości farmaceutycznej
CN102282155B (zh)	2008-12-02	2017-06-09	日本波涛生命科学公司	磷原子修饰的核酸的合成方法
RU2612521C2 (ru)	2009-07-06	2017-03-09	Онтории, Инк.	Новые пролекарства нуклеиновых кислот и способы их применения
WO2011090738A2 (en)	2009-12-29	2011-07-28	Dana-Farber Cancer Institute, Inc.	Type ii raf kinase inhibitors
JP5868324B2 (ja) *	2010-09-24	2016-02-24	株式会社Wave Life Sciences Japan	不斉補助基
WO2012065935A1 (en)	2010-11-17	2012-05-24	F. Hoffmann-La Roche Ag	Methods of treating tumors
US8771682B2 (en)	2011-04-26	2014-07-08	Technische Universtität Dresden	Methods and compositions for reducing interleukin-4 or interleukin-13 signaling
CN103796657B (zh)	2011-07-19	2017-07-11	波涛生命科学有限公司	合成官能化核酸的方法
US9382239B2 (en)	2011-11-17	2016-07-05	Dana-Farber Cancer Institute, Inc.	Inhibitors of c-Jun-N-terminal kinase (JNK)
JP2015511598A (ja)	2012-03-16	2015-04-20	エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト	Ｐａｋ１阻害剤を用いて黒色腫を治療する方法
PL2872485T3 (pl)	2012-07-13	2021-05-31	Wave Life Sciences Ltd.	Asymetryczna grupa pomocnicza
CA2879066C (en)	2012-07-13	2019-08-13	Shin Nippon Biomedical Laboratories, Ltd.	Chiral nucleic acid adjuvant
KR102213609B1 (ko)	2012-07-13	2021-02-08	웨이브 라이프 사이언시스 리미티드	키랄 제어
EP2909194A1 (en)	2012-10-18	2015-08-26	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinase 7 (cdk7)
USRE48175E1 (en)	2012-10-19	2020-08-25	Dana-Farber Cancer Institute, Inc.	Hydrophobically tagged small molecules as inducers of protein degradation
WO2014063054A1 (en)	2012-10-19	2014-04-24	Dana-Farber Cancer Institute, Inc.	Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof
WO2015058126A1 (en)	2013-10-18	2015-04-23	Syros Pharmaceuticals, Inc.	Heteroaromatic compounds useful for the treatment of prolferative diseases
EP3057956B1 (en)	2013-10-18	2021-05-05	Dana-Farber Cancer Institute, Inc.	Polycyclic inhibitors of cyclin-dependent kinase 7 (cdk7)
US10322173B2 (en)	2014-01-15	2019-06-18	Shin Nippon Biomedical Laboratories, Ltd.	Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
JPWO2015108047A1 (ja)	2014-01-15	2017-03-23	株式会社新日本科学	免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
JPWO2015108048A1 (ja)	2014-01-15	2017-03-23	株式会社新日本科学	抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
BR112016016400A2 (pt)	2014-01-16	2017-10-03	Wave Life Sciences Ltd	Composições de oligonucleotídeos quiralmente controlados, seu uso, sua composição farmacêutica, e métodos
US9862688B2 (en)	2014-04-23	2018-01-09	Dana-Farber Cancer Institute, Inc.	Hydrophobically tagged janus kinase inhibitors and uses thereof
WO2015164614A1 (en)	2014-04-23	2015-10-29	Dana-Farber Cancer Institute, Inc.	Janus kinase inhibitors and uses thereof
CA2966164C (en)	2014-10-31	2023-10-17	Ube Industries, Ltd.	Substituted dihydropyrrolopyrazole compound
JP6854762B2 (ja) *	2014-12-23	2021-04-07	ダナ−ファーバーキャンサーインスティテュート，インコーポレイテッド	サイクリン依存性キナーゼ７（ｃｄｋ７）の阻害剤
USRE50776E1 (en)	2015-03-27	2026-02-03	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinases
WO2016201370A1 (en)	2015-06-12	2016-12-15	Dana-Farber Cancer Institute, Inc.	Combination therapy of transcription inhibitors and kinase inhibitors
MX394157B (es)	2015-06-15	2025-03-24	Ube Corp	Derivado de dihidropirrolopirazol sustituido.
AU2016319125B2 (en)	2015-09-09	2021-04-08	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinases
WO2017144546A1 (en)	2016-02-23	2017-08-31	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and pharmaceutical compositions for the treatment of nasopharyngeal carcinoma
EP3810132A4 (en)	2018-06-25	2022-06-22	Dana-Farber Cancer Institute, Inc.	TAIRE FAMILY KINASE INHIBITORS AND RELATED USES
EP3885347B1 (en)	2018-11-14	2023-11-22	UBE Corporation	Dihydropyrrolopyrazole derivative
US12281126B2 (en)	2018-12-28	2025-04-22	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinase 7 and uses thereof
EP3956446A1 (en)	2019-04-17	2022-02-23	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and compositions for treatment of nlrp3 inflammasome mediated il-1beta dependent disorders
CN118767143A (zh)	2019-12-12	2024-10-15	听治疗有限责任公司	用于预防和治疗听力损失的组合物和方法
WO2021198511A1 (en)	2020-04-03	2021-10-07	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and compositions for treatment of sars-cov-2 infection
WO2022008597A1 (en)	2020-07-08	2022-01-13	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and pharmaceutical composition for the treatment of infectious diseases
WO2024261302A1 (en)	2023-06-22	2024-12-26	Institut National de la Santé et de la Recherche Médicale	Nlrp3 inhibitors, pak1/2 inhibitors and/or caspase 1 inhibitors for use in the treatment of rac2 monogenic disorders
WO2025078334A1 (en)	2023-10-09	2025-04-17	Institut National de la Santé et de la Recherche Médicale	Combination of pak1 inhibitors and clk inhibitors for preventing resistance to chemotherapy in patients suffering from acute myeloid leukemia

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DK1320531T3 (da) *	2000-08-10	2011-01-03	Pfizer Italia Srl	Bicyclo-pyrazoler, der er aktive som kinase inhibitorer, fremgangsmåde til fremstilling deraf og farmaceutiske sammensætninger, der indeholder disse
CA2493637A1 (en)	2002-07-25	2004-02-12	Manuela Villa	Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
GB0229526D0 (en)	2002-12-19	2003-01-22	Astrazeneca Ab	Chemical compounds
UA81790C2 (uk) *	2002-12-19	2008-02-11	Фармация Италия С.П.А.	Заміщені піролопіразольні похідні як інгібітори кінази
JP2007506787A (ja) *	2003-09-23	2007-03-22	バーテックス　ファーマシューティカルズ　インコーポレイテッド	プロテインキナーゼインヒビターとしてのピラゾロピロール誘導体
AU2005323797B2 (en)	2005-01-10	2009-07-09	Pfizer Inc.	Pyrrolopyrazoles, potent kinase inhibitors

2006
- 2006-12-12 NZ NZ568692A patent/NZ568692A/en not_active IP Right Cessation
- 2006-12-12 RS RSP-2008/0281A patent/RS20080281A/sr unknown
- 2006-12-12 MY MYPI20082267 patent/MY151455A/en unknown
- 2006-12-12 KR KR1020087014963A patent/KR101029167B1/ko not_active Expired - Fee Related
- 2006-12-12 CA CA2634381A patent/CA2634381C/en not_active Expired - Fee Related
- 2006-12-12 EA EA200801291A patent/EA015513B1/ru not_active IP Right Cessation
- 2006-12-12 ME MEP-08/08A patent/MEP0808A/xx unknown
- 2006-12-12 BR BRPI0620354-0A patent/BRPI0620354A2/pt not_active IP Right Cessation
- 2006-12-12 AP AP2008004506A patent/AP2369A/xx active
- 2006-12-12 DK DK06831731.2T patent/DK1979356T3/da active
- 2006-12-12 ES ES06831731T patent/ES2435405T3/es active Active
- 2006-12-12 HR HRP20130976TT patent/HRP20130976T1/hr unknown
- 2006-12-12 GE GEAP200610777A patent/GEP20104974B/en unknown
- 2006-12-12 PL PL06831731T patent/PL1979356T3/pl unknown
- 2006-12-12 AU AU2006327866A patent/AU2006327866B2/en not_active Ceased
- 2006-12-12 PT PT68317312T patent/PT1979356E/pt unknown
- 2006-12-12 EP EP06831731.2A patent/EP1979356B1/en active Active
- 2006-12-12 RS RS20130498A patent/RS53029B/sr unknown
- 2006-12-12 JP JP2008546667A patent/JP4635089B2/ja not_active Expired - Fee Related
- 2006-12-12 WO PCT/IB2006/003646 patent/WO2007072153A2/en not_active Ceased
- 2006-12-12 US US12/158,241 patent/US7884117B2/en not_active Expired - Fee Related
2008
- 2008-05-27 IL IL191776A patent/IL191776A/en not_active IP Right Cessation
- 2008-06-02 NO NO20082482A patent/NO20082482L/no not_active Application Discontinuation
- 2008-06-18 EC EC2008008558A patent/ECSP088558A/es unknown
- 2008-06-19 CU CU20080115A patent/CU23751B7/es active IP Right Grant
- 2008-06-20 MA MA31060A patent/MA30076B1/fr unknown
- 2008-06-20 CR CR10094A patent/CR10094A/es unknown

Also Published As

Publication number	Publication date
PL1979356T3 (pl)	2014-01-31
US7884117B2 (en)	2011-02-08
AP2369A (en)	2012-02-29
RS53029B (sr)	2014-04-30
WO2007072153A2 (en)	2007-06-28
IL191776A (en)	2013-03-24
MA30076B1 (fr)	2008-12-01
ME00006B (me)	2010-02-10
AU2006327866B2 (en)	2012-06-14
CR10094A (es)	2008-08-01
EP1979356A2 (en)	2008-10-15
NZ568692A (en)	2011-07-29
ES2435405T3 (es)	2013-12-19
HK1128290A1 (en)	2009-10-23
WO2007072153A3 (en)	2007-10-25
AU2006327866A1 (en)	2007-06-28
WO2007072153A8 (en)	2008-08-14
PT1979356E (pt)	2013-11-21
JP4635089B2 (ja)	2011-02-16
RS20080281A (sr)	2009-09-08
IL191776A0 (en)	2008-12-29
EA200801291A1 (ru)	2008-12-30
AP2008004506A0 (en)	2008-06-30
ECSP088558A (es)	2008-07-30
BRPI0620354A2 (pt)	2011-11-08
KR101029167B1 (ko)	2011-04-12
GEP20104974B (en)	2010-04-26
EP1979356B1 (en)	2013-09-18
KR20080080567A (ko)	2008-09-04
CA2634381C (en)	2011-03-08
MY151455A (en)	2014-05-30
NO20082482L (no)	2008-07-02
CU23751B7 (es)	2012-01-31
HRP20130976T1 (hr)	2013-11-22
CU20080115A7 (es)	2010-08-30
JP2009520805A (ja)	2009-05-28
DK1979356T3 (da)	2013-11-18
EA015513B1 (ru)	2011-08-30
CA2634381A1 (en)	2007-06-28
US20090318440A1 (en)	2009-12-24

Publication	Publication Date	Title
MY151455A (en)	2014-05-30	Carbonylamino pyrrolopyrazoles, potent kinase inhibitors
EA200701257A1 (ru)	2007-12-28	Пирролопиразолы в качестве сильнодействующих ингибиторов киназы
MXPA05012026A (es)	2006-02-03	Compuestos de azaindol como inhibidores de cinasa.
MXPA05012025A (es)	2006-02-03	Imidazo y tiazolopiridinas como inhibidores de cinasa jak3.
MX360970B (es)	2018-11-23	Compuestos de heteroarilo y usos de los mismos.
WO2007079164A3 (en)	2007-09-27	Protein kinase inhibitors
MXPA06011327A (es)	2006-12-15	Azaindoles utiles como inhibidores de jak y otras proteinas cinasas.
MY148634A (en)	2013-05-15	Pyridazinone derivatives
JO3181B1 (ar)	2018-03-08	مشتقات كمحول ثاني الكيل البايردينيل - أحادي الفينيل كأنزيم ثنائي استرات الفوسفود
SG154433A1 (en)	2009-08-28	Phthalazine derivatives as parp inhibitors
MX340714B (es)	2016-07-22	Inhibidores de hsp90.
TW200801003A (en)	2008-01-01	Novel compounds
GB0400895D0 (en)	2004-02-18	Chemical compounds
MX2008001538A (es)	2008-04-04	Aril piridinas y metodos para su uso.
TW200638930A (en)	2006-11-16	Acetylene derivatives
GB0508314D0 (en)	2005-06-01	Organic compounds
EA200800357A1 (ru)	2008-06-30	Новые фармацевтические соединения
TW200628153A (en)	2006-08-16	Novel compounds
UA87494C2 (en)	2009-07-27	Azaindoles useful as inhibitors of jak and other protein kinases
MX2009012079A (es)	2009-11-19	Compuestos heterociclicos condensados como inhibidores de proteina cinasas.
TW200624429A (en)	2006-07-16	Novel cysteine protease inhibitors
UA92047C2 (uk)	2010-09-27	Карбоніламінопіролпіразоли - потужні інгібітори кінази
WO2006097809A3 (en)	2007-04-26	Novel tyrosine derivatives
UA88794C2 (en)	2009-11-25	Pyrrolopyrazoles, potent kinase inhibitors
DE602006016430D1 (de)	2010-10-07	Phosphodiesteraseinhibitoren auf azolbasis