MX2012008657A - Peptidos melk modificados y vacunas que contienen los mismos. - Google Patents
Peptidos melk modificados y vacunas que contienen los mismos.Info
- Publication number
- MX2012008657A MX2012008657A MX2012008657A MX2012008657A MX2012008657A MX 2012008657 A MX2012008657 A MX 2012008657A MX 2012008657 A MX2012008657 A MX 2012008657A MX 2012008657 A MX2012008657 A MX 2012008657A MX 2012008657 A MX2012008657 A MX 2012008657A
- Authority
- MX
- Mexico
- Prior art keywords
- peptides
- endometriosis
- nucleic acids
- amino acid
- aforementioned
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 9
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 7
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 101150054634 melk gene Proteins 0.000 title 1
- 201000009273 Endometriosis Diseases 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 abstract 3
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 102100024299 Maternal embryonic leucine zipper kinase Human genes 0.000 abstract 2
- 101710154611 Maternal embryonic leucine zipper kinase Proteins 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 238000007792 addition Methods 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000002619 cancer immunotherapy Methods 0.000 abstract 1
- 238000009169 immunotherapy Methods 0.000 abstract 1
- 238000003780 insertion Methods 0.000 abstract 1
- 230000037431 insertion Effects 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/11—Protein-serine/threonine kinases (2.7.11)
- C12Y207/11025—Mitogen-activated protein kinase kinase kinase (2.7.11.25), i.e. MAPKKK or MAP3K
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001154—Enzymes
- A61K39/001162—Kinases, e.g. Raf or Src
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Reproductive Health (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Péptidos aislados compuestos de la secuencia de aminoácidos del péptido de epitope MELK modificado o fragmentos del mismo inmunológicamente activos que se unen a antígenos HLA y tienen mayor inducibilidad de linfocito T citotóxico (CTL) que aquélla del péptido de epitope de MELK de tipo silvestre y así son adecuados para uso en el contexto de inmunoterapia de cáncer o inmunoterapia de endometriosis, más particularmente se describen en la presente vacunas para cáncer o endometriosis. La presente invención proporciona además péptidos que incluyen una, dos o varias inserciones, sustituciones o adiciones de aminoácidos, a los péptidos o fragmentos antes mencionados, pero que retienen aun la inducibilidad requerida de célula T citotóxica. Se proporcionan además ácidos nucleicos que codifican cualquiera de estos péptidos antes mencionados así como también sustancias y composiciones farmacéuticas que incluyen cualquiera de los péptidos o ácidos nucleicos antes mencionados. Los péptidos, ácidos nucleicos, sustancias y composiciones farmacéuticas de esta invención encuentran utilidad particular en el tratamiento de cánceres, tumores y endometriosis.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29799610P | 2010-01-25 | 2010-01-25 | |
| PCT/JP2011/000352 WO2011089921A1 (en) | 2010-01-25 | 2011-01-24 | Modified melk peptides and vaccines containing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2012008657A true MX2012008657A (es) | 2013-05-30 |
Family
ID=44306725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012008657A MX2012008657A (es) | 2010-01-25 | 2011-01-24 | Peptidos melk modificados y vacunas que contienen los mismos. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8871719B2 (es) |
| EP (1) | EP2528937B1 (es) |
| JP (1) | JP5884104B2 (es) |
| KR (1) | KR101841475B1 (es) |
| CN (1) | CN102822193B (es) |
| AU (1) | AU2011208271B2 (es) |
| BR (1) | BR112012018457A2 (es) |
| CA (1) | CA2787369A1 (es) |
| MX (1) | MX2012008657A (es) |
| RU (1) | RU2580035C2 (es) |
| SG (1) | SG182580A1 (es) |
| TW (1) | TWI485245B (es) |
| WO (1) | WO2011089921A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012306258A1 (en) * | 2011-09-07 | 2014-04-17 | Immunotope, Inc. | Nanoparticle tumour vaccines |
| IN2014MN00433A (es) | 2011-09-07 | 2015-06-19 | Midatech Ltd | |
| SG11201405578TA (en) | 2012-03-09 | 2014-11-27 | Oncotherapy Science Inc | Pharmaceutical composition containing peptide |
| TWI775117B (zh) * | 2013-08-05 | 2022-08-21 | 德商伊瑪提克斯生物科技有限公司 | 新穎肽類，細胞及其用於治療多種腫瘤的用途，其製造方法及包含其等之醫藥組成物（二） |
| PL3456339T3 (pl) | 2013-08-05 | 2022-03-21 | Immatics Biotechnologies Gmbh | Nowa immunoterapia przeciwko szeregu nowotworom, takim jak rak płuc, w tym nsclc |
| KR102579047B1 (ko) * | 2016-08-31 | 2023-09-14 | 온코세라피 사이언스 가부시키가이샤 | MELK에 대한 단클론 항체(monoclonal antibody) 및 그 사용 |
| EP3883588A4 (en) * | 2018-11-21 | 2022-10-19 | Endomet Biosciences, Inc. | COMPOSITIONS AND METHODS FOR TREATING ENDOMETRIOSIS |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4722848A (en) | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| ATE300615T1 (de) | 1990-08-29 | 2005-08-15 | Genpharm Int | Transgene mäuse fähig zur produktion heterologer antikörper |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| KR100209784B1 (ko) | 1996-10-08 | 1999-07-15 | 박원훈 | 인간 단백질 변이인산화효소 유전자(hpk 38), 그의 염기 서열, 효소 단백질 및 그의 아미노산 서열 |
| US6229001B1 (en) | 1997-01-03 | 2001-05-08 | Southern Research Institute | Mycobacterium fol a gene that encodes for the enzyme dihydrofolate reductase |
| US6605709B1 (en) | 1999-04-09 | 2003-08-12 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to Proteus mirabilis for diagnostics and therapeutics |
| ES2299493T3 (es) | 2000-05-31 | 2008-06-01 | Novartis Vaccines And Diagnostics, Inc. | Composiciones y metodos para tratar la enfermedad neoplasica usando sensibilizadores a la radiacion y a la quimioterapia. |
| US6833447B1 (en) | 2000-07-10 | 2004-12-21 | Monsanto Technology, Llc | Myxococcus xanthus genome sequences and uses thereof |
| US20020156263A1 (en) | 2000-10-05 | 2002-10-24 | Huei-Mei Chen | Genes expressed in breast cancer |
| GB0103424D0 (en) | 2001-02-12 | 2001-03-28 | Chiron Spa | Gonococcus proteins |
| US20030157082A1 (en) | 2002-01-31 | 2003-08-21 | Millennium Pharmaceuticals, Inc. | Methods and compositions for treating cancer using 140, 1470, 1686, 2089, 2427, 3702, 5891, 6428, 7181, 7660, 25641, 69583, 49863, 8897, 1682, 17667, 9235, 3703, 14171, 10359, 1660, 1450, 18894, 2088, 32427, 2160, 9252, 9389, 1642, 85269, 10297, 1584, 9525, 14124, 4469, 8990, 2100, 9288, 64698, 10480,20893, 33230,1586, 9943, 16334, 68862, 9011, 14031, 6178, 21225, 1420, 32236, 2099, 2150, 26583, 2784, 8941, 9811, 27444, 50566 or 66428 molecules |
| US7547534B2 (en) | 2002-06-14 | 2009-06-16 | Verenium Corporation | Methods for making a composition to treat a wood, a pulp or a paper |
| TW200413725A (en) | 2002-09-30 | 2004-08-01 | Oncotherapy Science Inc | Method for diagnosing non-small cell lung cancers |
| WO2004070062A2 (en) * | 2003-02-04 | 2004-08-19 | Wyeth | Compositions and methods for diagnosing and treating cancers |
| ES2609234T3 (es) | 2003-06-24 | 2017-04-19 | Genomic Health, Inc. | Predicción de la probabilidad de recidiva de cáncer |
| WO2005016279A2 (en) | 2003-08-14 | 2005-02-24 | Exelixis, Inc. | Melks as modifiers of the rac pathway and methods of use |
| JP4721903B2 (ja) * | 2004-01-29 | 2011-07-13 | 大日本住友製薬株式会社 | 新規腫瘍抗原蛋白質及びその利用 |
| DE602005025231D1 (de) | 2004-08-10 | 2011-01-20 | Oncotherapy Science Inc | Gene und polypeptide in verbindung mit brustkrebserkrankungen |
| EP1856278A2 (en) | 2005-02-10 | 2007-11-21 | Oncotherapy Science, Inc. | Method of diagnosing bladder cancer |
| US20090075832A1 (en) | 2005-02-24 | 2009-03-19 | Cemines, Inc | Compositions and Methods for Classifying Biological Samples |
| US8088976B2 (en) | 2005-02-24 | 2012-01-03 | Monsanto Technology Llc | Methods for genetic control of plant pest infestation and compositions thereof |
| CN101283106A (zh) | 2005-07-27 | 2008-10-08 | 肿瘤疗法科学股份有限公司 | 小细胞肺癌的诊断方法 |
| ES2584247T3 (es) * | 2005-07-27 | 2016-09-26 | Oncotherapy Science, Inc. | Gen TOM34 relacionado con el cáncer de colon |
| CN101287831B (zh) | 2005-09-13 | 2013-05-15 | 国立大学法人三重大学 | T细胞受体和编码该受体的核酸 |
| WO2008023841A1 (en) | 2006-08-25 | 2008-02-28 | Oncotherapy Science, Inc. | Breast cancer-associated gene, melk, and its interactions with bcl-g |
| TWI466680B (zh) * | 2008-08-01 | 2015-01-01 | Oncotherapy Science Inc | Ｍｅｌｋ抗原決定位胜肽及含此胜肽的疫苗 |
-
2011
- 2011-01-21 TW TW100102242A patent/TWI485245B/zh not_active IP Right Cessation
- 2011-01-24 CA CA2787369A patent/CA2787369A1/en not_active Abandoned
- 2011-01-24 KR KR1020127021961A patent/KR101841475B1/ko not_active Expired - Fee Related
- 2011-01-24 AU AU2011208271A patent/AU2011208271B2/en not_active Ceased
- 2011-01-24 EP EP11734528.0A patent/EP2528937B1/en active Active
- 2011-01-24 MX MX2012008657A patent/MX2012008657A/es active IP Right Grant
- 2011-01-24 SG SG2012052999A patent/SG182580A1/en unknown
- 2011-01-24 BR BR112012018457A patent/BR112012018457A2/pt active Search and Examination
- 2011-01-24 CN CN201180015963.3A patent/CN102822193B/zh active Active
- 2011-01-24 WO PCT/JP2011/000352 patent/WO2011089921A1/en not_active Ceased
- 2011-01-24 RU RU2012136464/10A patent/RU2580035C2/ru not_active IP Right Cessation
- 2011-01-24 US US13/574,774 patent/US8871719B2/en active Active
- 2011-01-24 JP JP2012549592A patent/JP5884104B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011208271B2 (en) | 2015-04-09 |
| CN102822193B (zh) | 2016-03-30 |
| TWI485245B (zh) | 2015-05-21 |
| US20130034574A1 (en) | 2013-02-07 |
| EP2528937B1 (en) | 2019-05-08 |
| KR20120127467A (ko) | 2012-11-21 |
| KR101841475B1 (ko) | 2018-03-23 |
| CN102822193A (zh) | 2012-12-12 |
| RU2580035C2 (ru) | 2016-04-10 |
| CA2787369A1 (en) | 2011-07-28 |
| SG182580A1 (en) | 2012-08-30 |
| WO2011089921A1 (en) | 2011-07-28 |
| EP2528937A1 (en) | 2012-12-05 |
| EP2528937A4 (en) | 2013-07-03 |
| RU2012136464A (ru) | 2014-03-10 |
| AU2011208271A1 (en) | 2012-08-16 |
| US8871719B2 (en) | 2014-10-28 |
| JP2013517764A (ja) | 2013-05-20 |
| BR112012018457A2 (pt) | 2017-01-10 |
| TW201130972A (en) | 2011-09-16 |
| JP5884104B2 (ja) | 2016-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |