MX2013013465A - Polimorfo de rifaximina y proceso para la preparacion del mismo. - Google Patents

Polimorfo de rifaximina y proceso para la preparacion del mismo.

Info

Publication number
MX2013013465A
MX2013013465A MX2013013465A MX2013013465A MX2013013465A MX 2013013465 A MX2013013465 A MX 2013013465A MX 2013013465 A MX2013013465 A MX 2013013465A MX 2013013465 A MX2013013465 A MX 2013013465A MX 2013013465 A MX2013013465 A MX 2013013465A
Authority
MX
Mexico
Prior art keywords
rifaximin
preparation
polymorph
relates
designated
Prior art date
Application number
MX2013013465A
Other languages
English (en)
Other versions
MX348393B (es
Inventor
Enrico Vigano'
Renato Molteni
Simona Lanfranconi
Massimiliano Arrighi
Fabio Gatti
Original Assignee
Clarochem Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clarochem Ireland Ltd filed Critical Clarochem Ireland Ltd
Publication of MX2013013465A publication Critical patent/MX2013013465A/es
Publication of MX348393B publication Critical patent/MX348393B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se relaciona con un nuevo polimorfo de rifaximina, designado ?, y con un proceso para la preparación del mismo; bajo ciertos aspectos, la invención además se relaciona con composiciones farmacéuticas que comprenden una cantidad efectiva de la forma polimórfica ? de rifaximina y un vehículo farmacéuticamente aceptable y sus usos en el tratamiento de condiciones gastrointestinales.
MX2013013465A 2011-05-19 2012-05-18 Polimorfo de rifaximina y proceso para la preparacion del mismo. MX348393B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000890A ITMI20110890A1 (it) 2011-05-19 2011-05-19 Polimorfo di rifaximina e processo per la sua preparazione
PCT/IB2012/052506 WO2012156951A1 (en) 2011-05-19 2012-05-18 Polymorph of rifaximin and process for the preparation thereof

Publications (2)

Publication Number Publication Date
MX2013013465A true MX2013013465A (es) 2014-05-27
MX348393B MX348393B (es) 2017-06-08

Family

ID=44533008

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013013465A MX348393B (es) 2011-05-19 2012-05-18 Polimorfo de rifaximina y proceso para la preparacion del mismo.

Country Status (15)

Country Link
US (1) US8877770B2 (es)
EP (1) EP2710015B1 (es)
KR (2) KR20180032677A (es)
CN (1) CN103619852B (es)
AU (1) AU2012257360B2 (es)
BR (1) BR112013029804A2 (es)
CA (1) CA2844765C (es)
ES (1) ES2586124T3 (es)
IT (1) ITMI20110890A1 (es)
MX (1) MX348393B (es)
PL (1) PL2710015T3 (es)
PT (1) PT2710015T (es)
RU (1) RU2593750C2 (es)
SI (1) SI2710015T1 (es)
WO (1) WO2012156951A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1698630E (pt) 2005-03-03 2014-09-15 Alfa Wassermann Spa Novas formas polimorfas de rifaximina, processos para a sua produção e a sua utilização nas preparações medicinais
US9018684B2 (en) 2009-11-23 2015-04-28 California Institute Of Technology Chemical sensing and/or measuring devices and methods
IT1398550B1 (it) 2010-03-05 2013-03-01 Alfa Wassermann Spa Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo
ITBO20120368A1 (it) 2012-07-06 2014-01-07 Alfa Wassermann Spa Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso.
EP2983647B1 (en) 2013-04-12 2020-09-09 Alfasigma S.p.A. Nsaid administration and related compositions, methods and systems
US9419667B2 (en) 2013-04-16 2016-08-16 Skyworks Solutions, Inc. Apparatus and methods related to conformal coating implemented with surface mount devices
ITMI20131307A1 (it) * 2013-08-02 2015-02-02 A M S A Anonima Materie Sint & Affini S P A Processo per la preparazione di refaximina k
ES2621557T3 (es) 2014-03-31 2017-07-04 Euticals S.P.A. Mezcla polimórfica de rifaximina y su uso para la preparación de formulaciones sólidas
NZ723571A (en) 2014-05-12 2020-02-28 Alfasigma Spa New solvated crystal form of rifaximin, production, compositions and uses thereof
CN106632396B (zh) * 2017-01-06 2019-01-11 成都樵枫科技发展有限公司 γ晶型利福昔明的制备方法和用途
CN117447487A (zh) * 2022-07-19 2024-01-26 重庆圣华曦药业股份有限公司 一种利福昔明的纯化方法及其在利福昔明片剂中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1154655B (it) * 1980-05-22 1987-01-21 Alfa Farmaceutici Spa Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica
ITMI20032144A1 (it) * 2003-11-07 2005-05-08 Alfa Wassermann Spa Forme polimorfe di rifaximina, processi per ottenerle e
PT1698630E (pt) * 2005-03-03 2014-09-15 Alfa Wassermann Spa Novas formas polimorfas de rifaximina, processos para a sua produção e a sua utilização nas preparações medicinais
US7709634B2 (en) * 2007-09-20 2010-05-04 Apotex Pharmachem Inc. Amorphous form of rifaximin and processes for its preparation
US8486956B2 (en) * 2008-02-25 2013-07-16 Salix Pharmaceuticals, Ltd Forms of rifaximin and uses thereof
UA113275C2 (xx) * 2008-02-25 2017-01-10 ζ-ФОРМА РИФАКСИМІНУ І ЇЇ ЗАСТОСУВАННЯ

Also Published As

Publication number Publication date
ES2586124T3 (es) 2016-10-11
AU2012257360B2 (en) 2016-12-01
RU2013156344A (ru) 2015-06-27
EP2710015A1 (en) 2014-03-26
BR112013029804A2 (pt) 2016-09-06
RU2593750C2 (ru) 2016-08-10
CA2844765A1 (en) 2012-11-22
WO2012156951A1 (en) 2012-11-22
KR20180032677A (ko) 2018-03-30
EP2710015B1 (en) 2016-05-18
BR112013029706A2 (pt) 2021-07-27
KR20140045413A (ko) 2014-04-16
CN103619852A (zh) 2014-03-05
CN103619852B (zh) 2016-08-24
ITMI20110890A1 (it) 2012-11-20
US20140107144A1 (en) 2014-04-17
SI2710015T1 (sl) 2016-09-30
MX348393B (es) 2017-06-08
PT2710015T (pt) 2016-08-25
US8877770B2 (en) 2014-11-04
CA2844765C (en) 2019-07-16
PL2710015T3 (pl) 2017-08-31

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