MX336760B - Formas solidas de moduladores selectivos de receptor de androgenos. - Google Patents

Formas solidas de moduladores selectivos de receptor de androgenos.

Info

Publication number
MX336760B
MX336760B MX2012013653A MX2012013653A MX336760B MX 336760 B MX336760 B MX 336760B MX 2012013653 A MX2012013653 A MX 2012013653A MX 2012013653 A MX2012013653 A MX 2012013653A MX 336760 B MX336760 B MX 336760B
Authority
MX
Mexico
Prior art keywords
solid forms
androgen receptor
receptor modulators
selective androgen
selective
Prior art date
Application number
MX2012013653A
Other languages
English (en)
Inventor
James T Dalton
Dave Dickason
Seoung-Soo Hong
Tai Ahn
Thomas G Bird
Original Assignee
Univ Tennessee Res Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Tennessee Res Foundation filed Critical Univ Tennessee Res Foundation
Publication of MX336760B publication Critical patent/MX336760B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a formas sólidas de (S)-N(4-cian0-3-(trifluorometil)feniI)-3-(4-cianofenoxi)-2-hidrox i-2-metilpropanamida y los procesos para producir las mismas.
MX2012013653A 2007-09-11 2008-09-11 Formas solidas de moduladores selectivos de receptor de androgenos. MX336760B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96001207P 2007-09-11 2007-09-11
PCT/US2008/076066 WO2009036206A1 (en) 2007-09-11 2008-09-11 Solid forms of selective androgen receptor modulators

Publications (1)

Publication Number Publication Date
MX336760B true MX336760B (es) 2016-01-29

Family

ID=40452483

Family Applications (6)

Application Number Title Priority Date Filing Date
MX2016010097A MX351941B (es) 2007-09-11 2008-09-11 Formas sólidas de moduladores selectivos de receptor de andrógenos.
MX2010002784A MX2010002784A (es) 2007-09-11 2008-09-11 Formas solidas de moduladores selectivos del receptor de androgenos.
MX2012013650A MX341090B (es) 2007-09-11 2008-09-11 Formas solidas de moduladores selectivos de receptor de androgenos.
MX2012013653A MX336760B (es) 2007-09-11 2008-09-11 Formas solidas de moduladores selectivos de receptor de androgenos.
MX2017007289A MX360801B (es) 2007-09-11 2008-09-11 Formas solidas de moduladores selectivos de receptor de androgenos.
MX2018014065A MX2018014065A (es) 2007-09-11 2010-03-11 Formas solidas de moduladores selectivos de receptor de androgenos.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
MX2016010097A MX351941B (es) 2007-09-11 2008-09-11 Formas sólidas de moduladores selectivos de receptor de andrógenos.
MX2010002784A MX2010002784A (es) 2007-09-11 2008-09-11 Formas solidas de moduladores selectivos del receptor de androgenos.
MX2012013650A MX341090B (es) 2007-09-11 2008-09-11 Formas solidas de moduladores selectivos de receptor de androgenos.

Family Applications After (2)

Application Number Title Priority Date Filing Date
MX2017007289A MX360801B (es) 2007-09-11 2008-09-11 Formas solidas de moduladores selectivos de receptor de androgenos.
MX2018014065A MX2018014065A (es) 2007-09-11 2010-03-11 Formas solidas de moduladores selectivos de receptor de androgenos.

Country Status (20)

Country Link
US (1) US7977386B2 (es)
EP (2) EP2205552B1 (es)
JP (3) JP5452492B2 (es)
KR (3) KR101580905B1 (es)
CN (3) CN101855198B (es)
AU (1) AU2008298901C1 (es)
CA (3) CA2886501C (es)
CY (1) CY1120107T1 (es)
DK (1) DK2205552T3 (es)
EA (1) EA018611B1 (es)
ES (1) ES2665007T3 (es)
HR (1) HRP20180500T1 (es)
HU (1) HUE036762T2 (es)
IL (2) IL204352A (es)
LT (1) LT2205552T (es)
MX (6) MX351941B (es)
NO (1) NO2205552T3 (es)
PL (1) PL2205552T3 (es)
PT (1) PT2205552T (es)
WO (1) WO2009036206A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7919647B2 (en) 2000-08-24 2011-04-05 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US7855229B2 (en) * 2000-08-24 2010-12-21 University Of Tennessee Research Foundation Treating wasting disorders with selective androgen receptor modulators
US20070161608A1 (en) * 2001-12-06 2007-07-12 Dalton James T Selective androgen receptor modulators for treating muscle wasting
US8853266B2 (en) * 2001-12-06 2014-10-07 University Of Tennessee Research Foundation Selective androgen receptor modulators for treating diabetes
US9889110B2 (en) 2004-06-07 2018-02-13 University Of Tennessee Research Foundation Selective androgen receptor modulator for treating hormone-related conditions
US9884038B2 (en) 2004-06-07 2018-02-06 University Of Tennessee Research Foundation Selective androgen receptor modulator and methods of use thereof
US20110237664A1 (en) * 2004-06-07 2011-09-29 Dalton James T Selective androgen receptor modulators for treating diabetes
US9844528B2 (en) 2006-08-24 2017-12-19 University Of Tennessee Research Foundation SARMs and method of use thereof
US9730908B2 (en) 2006-08-24 2017-08-15 University Of Tennessee Research Foundation SARMs and method of use thereof
US10010521B2 (en) 2006-08-24 2018-07-03 University Of Tennessee Research Foundation SARMs and method of use thereof
HRP20180500T1 (hr) * 2007-09-11 2018-06-01 Gtx, Inc. Kristalni polimorf selektivnih modulatora androgena (r) ili (s)-n-(4-cijano-3-(trifluorometil)fenil)-3-(4-cijanofenoksi)-2-hidroksi-2-metilpropanamida
US7968603B2 (en) 2007-09-11 2011-06-28 University Of Tennessee Research Foundation Solid forms of selective androgen receptor modulators
CN103002737A (zh) * 2010-01-11 2013-03-27 Gtx公司 治疗睑板腺功能障碍的方法
US10987334B2 (en) 2012-07-13 2021-04-27 University Of Tennessee Research Foundation Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs)
PT2872482T (pt) 2012-07-13 2020-09-22 Oncternal Therapeutics Inc Método de tratamento de cancro de mama com modulador seletivo do recetor de andrógeno (sarm)
US9969683B2 (en) 2012-07-13 2018-05-15 Gtx, Inc. Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS)
US10258596B2 (en) 2012-07-13 2019-04-16 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US9622992B2 (en) 2012-07-13 2017-04-18 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US10314807B2 (en) 2012-07-13 2019-06-11 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US9744149B2 (en) 2012-07-13 2017-08-29 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
CN110563607B (zh) * 2019-10-25 2022-07-08 许昌远志生物科技有限公司 一种mk-2866的精制方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050038110A1 (en) * 2000-08-24 2005-02-17 Steiner Mitchell S. Selective androgen receptor modulators and methods of use thereof
US20070173546A1 (en) * 2000-08-24 2007-07-26 Dalton James T Selective androgen receptor modulators and method of use thereof
US7645898B2 (en) * 2000-08-24 2010-01-12 University Of Tennessee Research Foundation Selective androgen receptor modulators and method of use thereof
US7622503B2 (en) * 2000-08-24 2009-11-24 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
EP1401801B1 (en) * 2000-08-24 2006-11-02 The University Of Tennessee Research Corporation Selective androgen receptor modulators and methods of use thereof
US7919647B2 (en) * 2000-08-24 2011-04-05 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US7547728B2 (en) * 2001-12-06 2009-06-16 University Of Tennessee Research Foundation Treating muscle wasting with selective androgen receptor modulators
US7026500B2 (en) * 2000-08-24 2006-04-11 University Of Tennessee Research Foundation Halogenated selective androgen receptor modulators and methods of use thereof
US7253210B2 (en) * 2002-10-15 2007-08-07 University Of Tennessee Research Foundation Methylene-bridged selective androgen receptor modulators and methods of use thereof
US7855229B2 (en) * 2000-08-24 2010-12-21 University Of Tennessee Research Foundation Treating wasting disorders with selective androgen receptor modulators
MXPA03002495A (es) * 2000-09-21 2004-05-05 Bristol Myers Squibb Co Proceso para preparacion de compuestos de n-(fenil sustituido)-3-alquil, aril- y heteroarilsulfonil-2-hidroxi-2-alquil- y haloalquilpropanamida.
US8853266B2 (en) * 2001-12-06 2014-10-07 University Of Tennessee Research Foundation Selective androgen receptor modulators for treating diabetes
US20070161608A1 (en) * 2001-12-06 2007-07-12 Dalton James T Selective androgen receptor modulators for treating muscle wasting
EP1487458B1 (en) * 2002-02-28 2011-11-16 University Of Tennessee Research Foundation Multi-substituted selective androgen receptor modulators and methods of use thereof
EP2457892A1 (en) * 2003-01-13 2012-05-30 University of Tennessee Research Foundation Large-scale synthesis of selective androgen receptor modulators
CA2535953C (en) * 2003-10-14 2012-07-03 Gtx, Inc. Treating bone-related disorders with selective androgen receptor modulators
JP2009506119A (ja) * 2005-08-31 2009-02-12 ユニバーシティ オブ テネシー リサーチ ファウンデーション 選択的アンドロゲン受容体モジュレーターを用いる腎疾患、熱傷、創傷および脊髄損傷の処置
TW200730505A (en) * 2005-12-07 2007-08-16 Merck & Co Inc Polymorphs of an androgen receptor modulator
CN1825959A (zh) * 2006-03-02 2006-08-30 复旦大学 一种基于自适应多步搜索的图像跟踪算法
US7968603B2 (en) * 2007-09-11 2011-06-28 University Of Tennessee Research Foundation Solid forms of selective androgen receptor modulators
HRP20180500T1 (hr) * 2007-09-11 2018-06-01 Gtx, Inc. Kristalni polimorf selektivnih modulatora androgena (r) ili (s)-n-(4-cijano-3-(trifluorometil)fenil)-3-(4-cijanofenoksi)-2-hidroksi-2-metilpropanamida

Also Published As

Publication number Publication date
MX2010002784A (es) 2011-06-01
AU2008298901A1 (en) 2009-03-19
JP5599380B2 (ja) 2014-10-01
ES2665007T3 (es) 2018-04-24
JP2010539181A (ja) 2010-12-16
WO2009036206A1 (en) 2009-03-19
LT2205552T (lt) 2018-04-10
HUE036762T2 (hu) 2018-07-30
MX351941B (es) 2017-11-03
EA018611B1 (ru) 2013-09-30
CN101855198A (zh) 2010-10-06
KR101580905B1 (ko) 2015-12-29
CN103073450B (zh) 2014-12-03
MX341090B (es) 2016-08-08
EP2871177B1 (en) 2019-07-17
PT2205552T (pt) 2018-04-24
MX360801B (es) 2018-11-16
IL251483A0 (en) 2017-05-29
KR101691877B1 (ko) 2017-01-02
EP2205552A4 (en) 2012-04-18
PL2205552T3 (pl) 2018-07-31
EP2205552A1 (en) 2010-07-14
CA2886501A1 (en) 2009-03-19
CA2709118A1 (en) 2009-03-19
CA2709118C (en) 2018-03-13
JP2014133744A (ja) 2014-07-24
NO2205552T3 (es) 2018-07-28
CA2886498C (en) 2017-09-26
EP2205552B1 (en) 2018-02-28
MX2018014065A (es) 2020-09-02
CA2886498A1 (en) 2009-03-19
AU2008298901B2 (en) 2013-05-09
CN103553966A (zh) 2014-02-05
CN103073450A (zh) 2013-05-01
CY1120107T1 (el) 2018-12-12
EA201070350A1 (ru) 2010-12-30
CN101855198B (zh) 2013-07-10
AU2008298901C1 (en) 2013-10-03
CA2886501C (en) 2018-03-27
US7977386B2 (en) 2011-07-12
JP2012067118A (ja) 2012-04-05
KR20170001736A (ko) 2017-01-04
DK2205552T3 (en) 2018-04-16
KR20160003335A (ko) 2016-01-08
IL204352A (en) 2013-10-31
CN103553966B (zh) 2016-09-07
EP2871177A1 (en) 2015-05-13
US20090088480A1 (en) 2009-04-02
JP5727636B2 (ja) 2015-06-03
KR20100090239A (ko) 2010-08-13
HRP20180500T1 (hr) 2018-06-01
JP5452492B2 (ja) 2014-03-26

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